IL-4-/- mice with lethal Mesocestoides corti infections - Reduced Th2 cytokines and alternatively activated macrophages

Parasite Immunology

Volumn 31, Issue 12, 2009, Pages 741-749

  O'Connell, A E ^a   Kerepesi, L A ^a   Vandergrift, G L ^b   Herbert, D R ^c   Van Winkle, T J ^d   Hooper, D C ^a   Pearce, E J ^d   Abraham, D ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b APPLIED BIOSYSTEMS   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alternatively activated macrophages; Classically activated macrophages; Interleukin 4; Mesocestoides corti

Indexed keywords

ARGINASE 1; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CESTODIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOSTIMULATION; INFLAMMATORY CELL; LETHALITY; LIVER; LIVER GRANULOMA; MACROPHAGE; MACROPHAGE ACTIVATION; MESOCESTOIDEA; MESOCESTOIDES CORTI; MESOCESTOIDES CORTI INFECTION; MONOCYTE; MORTALITY; MOUSE; NONHUMAN; PARASITE IMMUNITY; PERITONEUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN CELL; TH1 CELL; TH2 CELL; THORACIC CAVITY; WILD TYPE;

ANIMALS; CESTODE INFECTIONS; HOST-PARASITE INTERACTIONS; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-5; LIVER; MACROPHAGE ACTIVATION; MACROPHAGES; MESOCESTOIDES; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; SPLEEN; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

CESTODA; MESOCESTOIDES CORTI; MUS;

EID: 71049173226     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2009.01151.x     Document Type: Article

References (30)

1. Pollacco S, Nicholas WL, Mitchell GF Stewart AC. T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda). Int J Parasitol 1978 8 : 457 462.
2. Specht D Widmer EA. Response of mouse liver to infection with tetrathyridia of Mesocestoides (Cestoda). J Parasitol 1972 58 : 431 437.
3. Rawat J, Dixon JB, Macintyre AR, McGarry HF Taylor MJ. IL-4 dependent resistance to the tapeworm Mesocestoides corti (Cestoda) in mice. Parasite Immunol 2003 25 : 553 557.
4. Reed SG Scott P. T-cell and cytokine responses in leishmaniasis. Curr Opin Immunol 1993 5 : 524 531.
5. Urban JF Jr., Madden KB, Svetic A, et al. The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev 1992 127 : 205 220.
6. Volkmann L, Saeftel M, Bain O, Fischer K, Fleischer B Hoerauf A. Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis. Infect Immun 2001 69 : 2950 2956.
7. Johnson EH, Schynder-Candrian S, Rajan TV, Nelson FK, Lustigman S Abraham D. Immune responses to third stage larvae of Onchocerca volvulus in interferon-gamma and interleukin-4 knockout mice. Parasite Immunol 1998 20 : 319 324.
8. La Flamme AC, Patton EA, Bauman B Pearce EJ. IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis. J Immunol 2001 166 : 1903 1911.
9. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003 3 : 23 35.
10. Loke P, MacDonald AS, Robb A, Maizels RM Allen JE. Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact. Eur J Immunol 2000 30 : 2669 2678.
11. Nair MG, Cochrane DW Allen JE. Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunol Lett 2003 85 : 173 180.
12. Nair MG, Gallagher IJ, Taylor MD, et al. Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infect Immun 2005 73 : 385 394.
13. Raes G, De Baetselier P, Noel W, Beschin A, Brombacher F Hassanzadeh Gh G. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol 2002 71 : 597 602.
14. Stein M, Keshav S, Harris N Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992 176 : 287 292.
15. Donnelly S, O'Neill SM, Sekiya M, Mulcahy G Dalton JP. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun 2005 73 : 166 173.
16. Herbert DR, Holscher C, Mohrs M, et al. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 2004 20 : 623 635. (Pubitemid 38659504)
17. Anthony RM, Urban JF Jr., Alem F, et al. Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med 2006 12 : 955 960.
18. Jenkins P, Dixon JB, Rakha NK Carter SD. Regulation of macrophage-mediated larvicidal activity in Echinococcus granulosus and Mesocestoides corti (Cestoda) infection in mice. Parasitology. 1990 100 (Pt 2 309 315.
19. Sheehan DC Hrapchak BB. Chapter 10, Connective Tissue and Muscle Stains. Theory and Practice of Histotechnology, 2nd edn. Battelle Press, Columbus, OH, USA, 1980, p. 189.
20. Kaviratne M, Hesse M, Leusink M, et al. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-β independent. J Immunol 2004 173 : 4020 4029.
21. Loke P, MacDonald AS Allen JE. Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of naive CD4(+) T cells. Eur J Immunol 2000 30 : 1127 1135.
22. Rotman HL, Schnyder-Candrian S, Scott P, Nolan TJ, Schad GA Abraham D. IL-12 eliminates the Th-2 dependent protective immune response of mice to larval Strongyloides stercoralis. Parasite Immunol 1997 19 : 29 39.
23. Brunet LR, Finkelman FD, Cheever AW, Kopf MA Pearce EJ. IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis. J Immunol 1997 159 : 777 785.
24. Metwali A, Elliott D, Blum AM, et al. The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J Immunol 1996 157 : 4546 4553.
25. Patton EA, La Flamme AC, Pedras-Vasoncelos JA Pearce EJ. Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis. Infect Immun 2002 70 : 177 184.
26. La Flamme AC, Patton EA Pearce EJ. Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice. Infect Immun 2001 69 : 7445 7452.
27. Patton EA, Brunet LR, La Flamme AC, Pedras-Vasconcelos J, Kopf M Pearce EJ. Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent. Infect Immun 2001 69 : 589 592.
28. Pedras-Vasconcelos JA, Brunet LR Pearce EJ. Profound effect of the absence of IL-4 on T cell responses during infection with Schistosoma mansoni. J Leukoc Biol 2001 70 : 737 744.
29. Pearce EJ, Cheever A, Leonard S, et al. Schistosoma mansoni in IL-4-deficient mice. Int Immunol 1996 8 : 435 444.
30. Hesse M, Modolell M, La Flamme AC, et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of l-arginine metabolism. J Immunol 2001 167 : 6533 6544.