Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6519-6522

  Eiter, Lauren C ^a   Hall, Nathan W ^a   Day, Cynthia S ^a   Saluta, Gilda ^b   Kucera, Gregory L ^b   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (ACRIDIN 9 YLAMINO)ETHYL] 1,3 DIMETHYLTHIOUREA; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA; GOLD DERIVATIVE; PLATINUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; LUNG NON SMALL CELL CANCER; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SUBSTITUTION REACTION;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CHELATING AGENTS; COORDINATION COMPLEXES; DNA ADDUCTS; DNA, BACTERIAL; DRUG SCREENING ASSAYS, ANTITUMOR; GOLD; HUMANS; LIGANDS; MICE; MYCOBACTERIUM TUBERCULOSIS; ORGANOGOLD COMPOUNDS; PLATINUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA; VERO CELLS;

EID: 71049166377     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9012856     Document Type: Article

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