Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis

Journal of Molecular Signaling

Volumn 4, Issue , 2009, Pages 6-

  Hirakawa, Yasuko ^a   Nary, Laura J ^a   Medh, Rheem D ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 71049122684     PISSN: None     EISSN: 17502187     Source Type: Journal    
DOI: 10.1186/1750-2187-4-6     Document Type: Article

References (39)

1. Ploner C, Schmidt S, Presul E, Renner K, Schröcksnadel K, Rainer J, Riml S, Kofler R. Glucocorticoid-induced apoptosis and glucocorticoid resistance in acute lymphoblastic leukemia. The Journal of steroid biochemistry and molecular biology 2005, 93(2-5):153-160.
2. Herold MJ, McPherson KG, Reichardt HM. Glucocorticoids in T cell apoptosis and function. Cell Mol Life Sci 2006, 63(1):60-72. 10.1007/s00018-005-5390-y, 16314919.
3. Schoneveld OJ, Gaemers IC, Lamers WH. Mechanisms of glucocorticoid signalling. Biochim Biophys Acta 2004, 1680(2):114-128.
4. Kingsbury TJ, Cunningham KW. A conserved family of calcineurin regulators. Genes Dev 2000, 14(13):1595-1604. 316734, 10887154.
5. Fuentes JJ, Pritchard MA, Planas AM, Bosch A, Ferrer I, Estivill X. A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet 1995, 4(10):1935-1944. 10.1093/hmg/4.10.1935, 8595418.
6. Medh RD, Webb MS, Miller AL, Johnson BH, Fofanov Y, Li T, Wood TG, Luxon BA, Thompson EB. Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics 2003, 81(6):543-555. 10.1016/S0888-7543(03)00045-4, 12782123.
7. Thompson EB, Webb MS, Miller AL, Fofanov Y, Johnson BH. Identification of genes leading to glucocorticoid-induced leukemic cell death. Lipids 2004, 39(8):821-825.
8. Rothermel BA, Vega RB, Williams RS. The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc Med 2003, 13(1):15-21. 10.1016/S1050-1738(02)00188-3, 12554096.
9. Zhao Y, Tozawa Y, Iseki R, Mukai M, Iwata M. Calcineurin activation protects T cells from glucocorticoid-induced apoptosis. Journal of Immunology 1995, 154(12):6346-6354. 7539018.
10. Fruman DA, Mather PE, Burakoff SJ, Bierer BE. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. European Journal of Immunology 1992, 22(10):2513-2517. 10.1002/eji.1830221008, 1382988.
11. Ermak G, Davies KJ. DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease?. IUBMB Life 2003, 55(1):29-31. 10.1080/1521654031000066820, 12716059.
12. Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 2000, 9(11):1681-1690. 10.1093/hmg/9.11.1681, 10861295.
13. Park J, Oh Y, Chung KC. Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep 2009, 42(1):6-15.
14. Riper DV, Jayakumar L, Latchana N, Bhoiwala D, Mitchell AN, Valenti JW, Crawford DR. Regulation of vascular function by RCAN1 (ADAPT78). Arch Biochem Biophys 2008, 472(1):43-50. 10.1016/j.abb.2008.01.029, 18294449.
15. Porta S, Marti E, de la Luna S, Arbones ML. Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain. Eur J Neurosci 2007, 26(5):1213-1226. 10.1111/j.1460-9568.2007.05749.x, 17767500.
16. Harris CD, Ermak G, Davies KJ. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci 2005, 62(21):2477-2486. 10.1007/s00018-005-5085-4, 16231093.
17. Lin HY, Michtalik HJ, Zhang S, Andersen TT, Van Riper DA, Davies KK, Ermak G, Petti LM, Nachod S, Narayan AV. Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radic Biol Med 2003, 35(5):528-539. 10.1016/S0891-5849(03)00358-7, 12927602.
18. Lange AW, Molkentin JD, Yutzey KE. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol 2004, 266(2):346-360. 10.1016/j.ydbio.2003.10.036, 14738882.
19. Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel-Duby R, Williams RS. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res 2000, 87(12):E61-68.
20. Ermak G, Harris CD, Davies KJ. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J 2002, 16(8):814-824. 10.1096/fj.01-0846com, 12039863.
21. Narayan AV, Stadel R, Hahn AB, Bhoiwala DL, Cornielle G, Sarazin E, Koleilat I, Crawford DR, , . Center for I, Microbial Disease TAMCANYUSA Redox response of the endogenous calcineurin inhibitor Adapt 78. Free Radic Biol Med 2005, 39(6):719-727. 10.1016/j.freeradbiomed.2005.03.036, 16109302.
22. U M, Shen L, Oshida T, Miyauchi J, Yamada M, Miyashita T. Identification of novel direct transcriptional targets of glucocorticoid receptor. Leukemia 2004, 18(11):1850-1856. 10.1038/sj.leu.2403516, 15385927.
23. Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol 2003, 4(9):874-881. 10.1038/ni966, 12925851.
24. Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci USA 2006, 103(19):7327-7332. 1464340, 16648267, 10.1073/pnas.0509340103.
25. Abbasi S, Lee JD, Su B, Chen X, Alcon JL, Yang J, Kellems RE, Xia Y. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J Biol Chem 2006, 281(12):7717-7726. 10.1074/jbc.M510775200, 16415348.
26. Genescà L, Aubareda A, Fuentes JJ, Estivill X, De La Luna S, Pérez-Riba M. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J 2003, 374(Pt 2):567-575. 1223619, 12809556, 10.1042/BJ20030267.
27. Hilioti Z, Gallagher DA, Low-Nam ST, Ramaswamy P, Gajer P, Kingsbury TJ, Birchwood CJ, Levchenko A, Cunningham KW. GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev 2004, 18(1):35-47. 314273, 14701880, 10.1101/gad.1159204.
28. Liu Q, Busby JC, Molkentin JD. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol 2009, 11(2):154-161. 2656285, 19136967, 10.1038/ncb1823.
29. Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. J Biol Chem 2008, 283(6):3392-3400. 10.1074/jbc.M706707200, 18056702.
30. Pfaffl MW, , . Institute of Physiology FMLWCoL, Food Sciences TUoMGpwd A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29(9):e45. 55695, 11328886, 10.1093/nar/29.9.e45.
31. Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD. Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells. Biochem Biophys Res Commun 2006, 344(2):491-499. 10.1016/j.bbrc.2006.03.169, 16630563.
32. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000, 351(Pt 1):95-105. 1221339, 10998351, 10.1042/0264-6021:3510095.
33. Iwata M, Ohoka Y, Kuwata T, Asada A. Regulation of T cell apoptosis via T cell receptors and steroid receptors. Stem Cells 1996, 14(6):632-641. 10.1002/stem.140632, 8948021.
34. Yoshida NL, Miyashita T, U M, Yamada M, Reed JC, Sugita Y, Oshida T. Analysis of gene expression patterns during glucocorticoid-induced apoptosis using oligonucleotide arrays. Biochemical and biophysical research communications 2002, 293(4):1254-1261.
35. Minami T, Horiuchi K, Miura M, Abid MR, Takabe W, Noguchi N, Kohro T, Ge X, Aburatani H, Hamakubo T. Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem 2004, 279(48):50537-50554. 10.1074/jbc.M406454200, 15448146.
36. Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H. Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res 2006, 4(11):811-820. 10.1158/1541-7786.MCR-06-0126, 17114339.
37. Miller AL, Webb MS, Copik AJ, Wang Y, Johnson BH, Kumar R, Thompson EB. p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Molecular endocrinology 2005, 19(6):1569-1583. 10.1210/me.2004-0528, 15817653.
38. Cai B, Chang SH, Becker EB, Bonni A, Xia Z, , . Toxicology Program DoE, Occupational Health Sciences UoWSWUSA p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem 2006, 281(35):25215-25222. 10.1074/jbc.M512627200, 16818494.
39. Norman MR, Thompson EB. Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Research 1977, 37(10):3785-3791.