Monocyte toll-like receptor 4 expression and LPS-induced cytokine production increase during gestational aging

Pediatric Research

Volumn 58, Issue 1, 2005, Pages 121-124

  Förster Waldl, Elisabeth ^a   Sadeghi, Kambis ^a   Tamandl, Dietmar ^a   Gerhold, Bernadette ^a   Hallwirth, Ulrike ^a   Rohrmeister, Klaudia ^a   Hayde, Michael ^a   Prusa, Andrea R ^a   Herkner, Kurt ^a,b   Boltz Nitulescu, George ^a   Pollak, Arnold ^a   Spittler, Andreas ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BACTERIAL INFECTION; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFANT; MONOCYTE; NEWBORN; NEWBORN INFECTION; NUCLEOTIDE SEQUENCE; PREMATURITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD; VERY LOW BIRTH WEIGHT;

ANTIGENS, CD14; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FETAL BLOOD; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, VERY LOW BIRTH WEIGHT; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, FLUORESCENCE; MONOCYTES; NEUTROPHILS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 22044458575     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000163397.53466.0F     Document Type: Article

References (28)

1. Kaftan H, Kinney JS 1998 Early onset neonatal bacterial infections. Semin Perinatol 22:15-24
2. Lott JW 2003 Neonatal bacterial sepsis. Crit Care Nurs Clin North Am 15:35-46
3. Lewis DB, Wilson CB 1995 Developmental immunology and role of host defences in neonatal susceptibility to infection. In: Remington JS, Klein JO (eds) Infectious Diseases of the Fetus and Newborn Infant. Saunders, Philadelphia, pp 20-99
4. Cairo MS 1989 Neonatal neutrophil host defence. Prospects for immunologic enhancement during neonatal sepsis. Am J Dis Child 143:40-56
5. Chalmers IM, Janossy G, Contreras M, Navarrete C 1998 Intracellular cytokine profile of cord and adult blood lymphocytes. Blood 92:11-18
6. Hallwirth U, Pomberger G, Zaknun D, Szepfalusi Z, Horcher E, Pollak A, Roth E, Spittler A 2002 Monocyte phagocytosis as a reliable parameter for predicting early-onset sepsis in very low birth weight infants. Early Hum Dev 67:1-9
7. Anderson KV, Bokla L, Nusslein-Volhard C 1984 Establishment of dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature 311:223-227
8. Akira S 2001 Toll-like receptor and innate immunity. Adv Immunol 78:1-56
9. Beutler B 2002 Toll-like receptors: how they work and what they do. Curr Opin Hematol 9:2-10
10. Medzhitov R 2001 Toll-like receptors and innate immunity. Nat Rev Immunol 1:135-145
11. Underhill DM, Ozinsky A 2002 Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 14:103-110
12. Harju K, Glumoff V, Hallman M 2001 Ontogeny of Toll-like receptors Tlr2 and Tlr4 in mice. Pediatr Res 49:81-83
13. Spittler A, Reissner CM, Oehler R, Gornikiewicz A, Gruenberger T, Manhart N, Brodowicz T, Mittlboeck M, Boltz-Nitulescu G, Roth E 1999 Immunomodulatory effects of glycine on LPS-treated monocytes: reduced TNF-alpha production and accelerated IL-10 expression. FASEB J 13:563-571
14. Edwards WH 2002 Preventing nosocomial bloodstream infection in very low birth weight infants. Semin Neonatol 7:325-333
15. Auriti C, Maccallini A, Di Liso G, Di Ciommo V, Ronchetti MP, Orzalesi M 2003 Risk factors for nosocomial infections in a neonatal intensive-care unit. J Hosp Infect 53:25-30
16. Kilbride HW, Powers R, Wirtschafter DD, Sheehan MB, Charsha DS, LaCorte M, Finer N, Goldmann DA 2003 Evaluation and development of potentially better practices to prevent neonatal nosocomial bacteremia. Pediatrics 111:504-518
17. Spittler A, Razenberger M, Kupper H, Kaul M, Hackl W, Boltz-Nitulescu G, Függer R, Roth E 2000 Relationship between IL-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production. Clin Infect Dis 31:1338-1342
18. Medzhitov R, Janeway CA Jr 1997 Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9:4-9
19. Gengenbacher D, Salm H, Vogt A, Schneider H 1998 Detection of cell surface determinants for anti-Leu M3 (CD14), MY9 (CD33) and MY4 (CD14) and phagocytic function of cord blood monocytes in the course of gestational age. Bone Marrow Transplant 22:S48-S51
20. Hallwirth U, Pomberger G, Pollak A, Roth E, Spittler A 2004 Monocyte switch in neonates: high phagocytic capacity and low HLA-DR expression in VLBWI are inverted during gestational aging. Pediatr Allergy Immunol 15:513-516
21. Mills EL 1983 Mononuclear phagocytes in the newborn: their relation to the state of relative immunodeficiency. Am J Pediatr Hematol Oncol 5:189-198
22. Poltorak A, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B 1998 Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
23. Agnese DM, Calvano JE, Hahm SJ, Coyle SM, Corbett SA, Calvano SE, Lowry SF 2002 Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of Gram-negative infections. J Infect Dis 186:1522-1525
24. Feterowski C, Emmanuilidis K, Miethke T, Gerauer K, Rump M, Ulm K, Holzmann B, Weighardt H 2003 Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis. Immunology 109:426-431
25. Heine H, Lien E 2003 Toll-like receptors and their function in innate and adaptive immunity. Int Arch Allergy Immunol 130:180-192
26. Weimann E, Rutkowski S, Reisbach G 1998 G-CSF, GM-CSF and IL-6 levels in cord blood: diminished increase of G-CSF and IL-6 in pre-terms with perinatal infection compared to term neonates. J Perinat Med 26:211-218
27. Blanco-Quiros A, Arranz E, Solis G, Villar A, Ramos A, Coto D 2000 Cord blood interleukin-10 levels are increased in pre-term newborns. Eur J Pediatr 159:420-423
28. Dembinski J, Behrendt D, Martini R, Heep A, Bartmann P 2003 Modulation of pro- and anti-inflammatory cytokine production in very pre-term infants. Cytokine 21:200-206