Elevated ghrelin levels in the peritoneal fluid of patients with endometriosis: associations with vascular endothelial growth factor (VEGF) and inflammatory cytokines

Fertility and Sterility

Volumn 92, Issue 6, 2009, Pages 1844-1849

  Dziunycz, Piotr ^a   Milewski, Łukasz ^a   Radomski, Dariusz ^b   Barcz, Ewa ^c   Kamiński, Paweł ^c   Roszkowski, Piotr I ^c   Malejczyk, Jacek ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

Endometriosis; ghrelin; inflammatory cytokines; VEGF

Indexed keywords

CYTOKINE; GHRELIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

ADULT; ARTICLE; ASPIRATION; CASE CONTROL STUDY; CLINICAL ARTICLE; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC TEST; DISEASE ASSOCIATION; ENDOMETRIOSIS; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; LAPAROSCOPIC SURGERY; PERITONEAL FLUID; PRIORITY JOURNAL; UNIVERSITY HOSPITAL;

ADULT; ASCITIC FLUID; BODY MASS INDEX; CYTOKINES; ENDOMETRIOSIS; FEMALE; GHRELIN; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; NEOVASCULARIZATION, PATHOLOGIC; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70749143588     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.09.002     Document Type: Article

References (48)

1. Giudice L.C., and Kao L.C. Endometriosis. Lancet 364 (2004) 1789-1799
2. Gazvani R., and Templeton A. New considerations for the pathogenesis of endometriosis. Int J Gynaecol Obstet 76 (2002) 117-126
3. Nisolle M., and Donnez J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril 68 (1997) 585-596
4. Sampson J.A. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obst Gynecol 14 (1927) 442-469
5. Harada T., Iwabe T., and Terakawa N. Role of cytokines in endometriosis. Fertil Steril 76 (2001) 1-10
6. Matarese G., De Placido G., Nikas Y., and Alviggi C. Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?. Trends Mol Med 9 (2003) 223-228
7. Harada T., Kaponis A., Iwabe T., Taniguchi F., Makrydimas G., Sofikitis N., et al. Apoptosis in human endometrium and endometriosis. Hum Reprod Update 10 (2004) 29-38
8. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 6 (2000) 45-55
9. Becker C.M., and D'Amato R.J. Angiogenesis and antiangiogenic therapy in endometriosis. Microvasc Res 74 (2007) 121-130
10. Dmowski W.P. Immunological aspects of endometriosis. Int J Gynaecol Obstet 50 Suppl 1 (1995) 3-10
11. Ho H.N., Wu M.Y., and Yang Y.S. Peritoneal cellular immunity and endometriosis. Am J Reprod Immunol 38 (1997) 400-412
12. Nothnick W.B. Treating endometriosis as an autoimmune disease. Fertil Steril 76 (2001) 223-231
13. Matarese G., Alviggi C., Sanna V., Howard J.K., Lord G.M., Carravetta C., et al. Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab 85 (2000) 2483-2487
14. De Placido G., Alviggi C., Carravetta C., Pisaturo M.L., Sanna V., Wilding M., et al. The peritoneal fluid concentration of leptin is increased in women with peritoneal but not ovarian endometriosis. Hum Reprod 16 (2001) 1251-1254
15. Mahutte N.G., Matalliotakis I.M., Goumenou A.G., Vassiliadis S., Koumantakis G.E., and Arici A. Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis. Hum Reprod 18 (2003) 1205-1209
16. La Cava A., Alviggi C., and Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med 82 (2004) 4-11
17. Budak E., Fernández Sánchez M., Bellver J., Cerveró A., Simón C., and Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril 85 (2006) 1563-1581
18. Mitchell M., Armstrong D.T., Robker R.L., and Norman R.J. Adipokines: implications for female fertility and obesity. Reproduction 130 (2005) 583-597
19. Kojima M., and Kangawa K. Ghrelin: structure and function. Physiol Rev 85 (2005) 495-522
20. van der Lely A.J., Tschöp M., Heiman M.L., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25 (2004) 426-457
21. Gnanapavan S., Kola B., Bustin S.A., Morris D.G., McGee P., Fairclough P., et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87 (2002) 2988-2991
22. García M.C., Lopez M., Alvarez C.V., Casanueva F., Tena-Sempere M., and Dieguez C. Role of ghrelin in reproduction. Reproduction 133 (2007) 531-540
23. Barreiro M.L., and Tena-Sempere M. Ghrelin and reproduction: a novel signal linking energy status and fertility?. Mol Cell Endocrinol 226 (2004) 1-9
24. Dixit V.D., Schaffer E.M., Pyle R.S., Collins G.D., Sakthivel S.K., Palaniappan R., et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 114 (2004) 57-66
25. Li W.G., Gavrila D., Liu X., Wang L., Gunnlaugsson S., Stoll L.L., et al. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 109 (2004) 2221-2226
26. Granado M., Priego T., Martín A.I., Villanúa M.A., and López-Calderón A. Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab 288 (2005) E486-E492
27. American Fertility Society. Revised American Fertility Society classification of endometriosis. Fertil Steril 43 (1985) 351-352
28. Tanaka K., Minoura H., Isobe T., Yonaha H., Kawato H., Wang D.F., et al. Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 88 (2003) 2335-2340
29. Tawadros N., Salamonsen L.A., Dimitriadis E., and Chen C. Facilitation of decidualization by locally produced ghrelin in the human endometrium. Mol Hum Reprod 13 (2007) 483-489
30. Breen E.C. VEGF in biological control. J Cell Biochem 102 (2007) 1358-1367
31. Li A., Cheng G., Zhu G.H., and Tarnawski A.S. Ghrelin stimulates angiogenesis in human microvascular endothelial cells: implications beyond GH release. Biochem Biophys Res Commun 353 (2007) 238-243
32. Konturek P.C., Brzozowski T., Walter B., Burnat G., Hess T., Hahn E.G., et al. Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide. Eur J Pharmacol 536 (2006) 171-181
33. Conconi M.T., Nico B., Guidolin D., Baiguera S., Spinazzi R., Rebuffat P., et al. Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides 25 (2004) 2179-2185
34. Tropea A., Tiberi F., Minici F., Orlando M., Gangale M.F., Romani F., et al. Ghrelin affects the release of luteolytic and luteotropic factors in human luteal cells. J Clin Endocrinol Metab 9 (2007) 3239-3245
35. Donnez J., Smoes P., Gillerot S., Casanas-Roux F., and Nisolle M. Vascular endothelial growth factor (VEGF) in endometriosis. Hum Reprod 13 (1998) 1686-1690
36. Tan X.-J., Lang J.-H., Liu D.-Y., Shen K., Leng J.-H., and Zhu L. Expression of vascular endothelial growth factor and thrombospondin-1 mRNA in patients with endometriosis. Fertil Steril 78 (2002) 148-153
37. Gilabert-Estellés J., Ramón L.A., España F., Gilabert J., Vila V., Réganon E., et al. Expression of angigenic factors in endometriosis: relationship to fibrynolytic and metalloproteinase systems. Hum Reprod (2007) 2120-2127
38. Khan K.N., Masuzaki H., Fujishita A., Kitajima M., Sekine I., and Ishimaru T. Higher activity by opaque endometriotic lesions than nonopaque lesions. Acta Obstet Gynecol Scand 83 (2004) 375-382
39. McLaren J., Prentice A., Charnock-Jones D.S., and Smith S.K. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Hum Reprod 11 (1996) 220-223
40. Kalu E., Sumar N., Giannopoulos T., Patel P., Croucher C., Sherriff E., et al. Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis. J Obstet Gynaecol Res 33 (2007) 490-495
41. Pupo-Noguieira A., de Oliveira R.M., Petta C.A., Podgaec S., Dias Jr. J.A., and Abrao M.S. Vascular endothelial growth factor concentrations in the serum and peritoneal fluid of women with endometriosis. Int J Gynecol Obstet 99 (2007) 33-37
42. Mahnke J.L., Dawood M.Y., and Huang J.-C. Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis. Fertil Steril 73 (2000) 166-170
43. Dembinski A., Warzecha Z., Ceranowicz P., Tomaszewska R., Stachura J., Konturek S.J., et al. Ghrelin attenuates the development of acute pancreatitis in rat. J Physiol Pharmacol 54 (2003) 561-573
44. Wu R., Dong W., Zhou M., Zhang F., Marini C.P., Ravikumar T.S., et al. Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med 176 (2007) 805-813
45. Ataseven H., Bahcecioglu I.H., Kuzu N., Yalniz M., Celebi S., Erensoy A., et al. The levels of ghrelin, leptin, TNF-alpha, and IL-6 in liver cirrhosis and hepatocellular carcinoma due to HBV and HDV infection. Mediators Inflamm 2006 (2006) 78380
46. Oral E., Olive D.L., and Arici A. The peritoneal environment in endometriosis. Hum Reprod Update 2 (1996) 385-398
47. Cheong Y.C., Shelton J.B., Laird S.M., Richmond M., Kudesia G., Li T.C., et al. IL-1, IL-6 and TNF-α concentrations in the peritoneal fluid of women with pelvic adhesions. Hum Reprod 17 (2002) 69-75
48. Kawamura K., Sato N., Fukuda J., Kodama H., Kumagai J., Tanikawa H., et al. Ghrelin inhibits the development of mouse preimplantation embryos in vitro. Endocrinology 144 (2003) 2623-2633