Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone

American Journal of Veterinary Research

Volumn 69, Issue 5, 2008, Pages 586-595

  Enouri, Saad S ^a   Kerr, Carolyn L ^a   McDonell, Wayne N ^a   Dyson, Doris H ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; HYDROMORPHONE; ISOFLURANE; KETAMINE; LIDOCAINE; MEDETOMIDINE; MELOXICAM; OXYGEN; PROPOFOL; THIOPENTAL;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; ATRIOVENTRICULAR BLOCK; CARDIOPULMONARY HEMODYNAMICS; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DOG; HEART INDEX; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PREMEDICATION; RANDOMIZATION; REFERENCE VALUE; SEDATION; SINUS ARRHYTHMIA; VETERINARY MEDICINE;

ANESTHETICS, INTRAVENOUS; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BODY TEMPERATURE; CARDIAC OUTPUT; CROSS-OVER STUDIES; DIAZEPAM; DOGS; HEART RATE; HYDROMORPHONE; HYPNOTICS AND SEDATIVES; KETAMINE; MALE; MEDETOMIDINE; PREANESTHETIC MEDICATION; PROPOFOL; RANDOM ALLOCATION; THIOPENTAL;

ANIMALIA; CANIS FAMILIARIS;

EID: 44349158929     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.69.5.586     Document Type: Article

References (55)

1. Simon F, Romvary A, Mora S. Clinical investigations of medetomidine in dogs. Acta Vet Scand Suppl 1989;85:161-165.
2. Vaha-Vahe T. Clinical evaluation of medetomidine, a novel sedative and analgesic drug for dogs and cats. Acta Vet Scand 1989;30:267-273
3. Vainio O, Vaha-Vahe T, Palmu L. Sedative and analgesic effects of medetomidine in dogs. J Vet Pharmacol Ther 1989;12:225-231.
4. Virtanen R. Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand Suppl 1989;85:29-37.
5. Pypendop BH, Verstegen JP. Hemodynamic effects of medetomidine in the dog: a dose titration study. Vet Surg 1998;27:612-622.
6. Pypendop B, Serteyn D, Verstegen J. Hemodynamic effects of medetomidine-midazolam-butorphanol and medetomidine-midazolam-buprenorphine combinations and reversibility by atipamezole in dogs. Am J Vet Res 1996;57:724-730.
7. Ko JC, Fox SM, Mandsager RE. Sedative and cardiorespiratory effects of medetomidine, medetomidine-butorphanol, and medetomidine-ketamine in dogs. J Am Vet Med Assoc 2000;216:1578-1583.
8. Kuo WC, Keegan RD. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res 2004;65:931-937.
9. Dyson DH, Maxie MG, Schnurr D. Morbidity and mortality associated with anesthetic management in small animal veterinary practice in Ontario. J Am Anim Hosp Assoc 1998;34:325-335.
10. Clarke KW, Hall LW. A survey of anaesthesia in small animal practice: AVA/BSAVA report. J Vet Anaesth 1990;17:4-10.
11. Savola JM. Cardiovascular actions of medetomidine and their reversal by atipamezole. Acta Vet Scand Suppl 1989;85:39-47.
12. Vickery RG, Maze M. Action of the stereoisomers of medetomidine, in halothane-anesthetized dogs. Acta Vet Scand Suppl 1989;85:71-76.
13. Bloor BC, Frankland M, Alper G, et al. Hemodynamic and sedative effects of dexmedetomidine in dog. J Pharmacol Exp Ther 1992;263:690-697.
14. Flacke WE, Flacke JW, Bloor BC, et al. Effects of dexmedetomidine on systemic and coronary hemodynamics in the anesthetized dog. J Cardiothorac Vasc Anesth 1993;7:41-49.
15. Pypendop BH, Verstegen JP. Cardiovascular effects of romifidine in dogs. Am J Vet Res 2001;62:490-495.
16. Sinclair MD, McDonell WN, O'Grady M, et al. The cardiopulmonary effects of romifidine in dogs with and without prior or concurrent administration of glycopyrrolate. Vet Anaesth Analg 2002;29:1-13.
17. Haskins SC, Farver TB, Patz JD. Ketamine in dogs. Am J Vet Res 1985;46:1855-1860.
18. Haskins SC, Patz JD, Farver TB. Xylazine and xylazine-ketamine in dogs. Am J Vet Res 1986;47:636-641.
19. Goodchild CS, Serrao JM. Cardiovascular effects of propofol in the anaesthetized dog. Br J Anaesth 1989;63:87-92.
20. Morgan DW, Legge K. Clinical evaluation of propofol as an intravenous anaesthetic agent in cats and dogs. Vet Rec 1989;124:31-33.
21. Turner DM, Ilkiw JE. Cardiovascular and respiratory effects of three rapidly acting barbiturates in dogs. Am J Vet Res 1990;51:598-604.
22. Weaver BM, Raptopoulos D. Induction of anaesthesia in dogs and cats with propofol. Vet Rec 1990;126:617-620.
23. Hellyer PW, Freeman LC, Hubbell JA. Induction of anesthesia with diazepam-ketamine and midazolam-ketamine in Greyhounds. Vet Surg 1991;20:143-147.
24. Robertson SA, Johnston S, Beemsterboer J. Cardiopulmonary, anesthetic, and postanesthetic effects of intravenous infusions of propofol in Greyhounds and non-Greyhounds. Am J Vet Res 1992;53:1027-1032.
25. Bufalari A, Short CE, Giannoni C, et al. Comparative responses to propofol anaesthesia alone and with alpha 2-adrenergic medications in a canine model. Acta Vet Scand 1996;37:187-201.
26. Muir WW III, Gadawski JE. Respiratory depression and apnea induced by propofol in dogs. Am J Vet Res 1998;59:157-161.
27. Quandt JE, Robinson EP, Rivers WJ, et al. Cardiorespiratory and anesthetic effects of propofol and thiopental in dogs. Am J Vet Res 1998;59:1137-1143.
28. 2O-anesthetized dogs: a preliminary study. Can J Vet Res 2000;64:249-253.
29. White KL, Shelton K, Taylor PM. Comparison of diazepam-ketamine and thiopentone for induction of anaesthesia in healthy dogs. Vet Anaesth Analg 2001;28:42-48.
30. Ewing KK, Mohammed HO, Scarlett JM, et al. Reduction of isoflurane anesthetic requirement by medetomidine and its restoration by atipamezole in dogs. Am J Vet Res 1993;54:294-299.
31. Boyd CJ, McDonell WN, Valliant A. Comparative hemodynamic effects of halothane and halothane-acepromazine at equipotent doses in dogs. Can J Vet Res 1991;55:107-112.
32. Haskins S, Pascoe PJ, Ilkiw JE, et al. Reference cardiopulmonary values in normal dogs. Comp Med 2005;55:156-161.
33. Ko JC, Bailey JE, Pablo LS, et al. Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. Am J Vet Res 1996;57:535-540.
34. Greene SA, Hartsfield SM, Tyner CL. Cardiovascular effects of butorphanol in halothane-anesthetized dogs. Am J Vet Res 1990;51:1276-1279.
35. Murrell JC, Hellebrekers LJ. Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. Vet Anaesth Analg 2005;32:117-127.
36. Sinclair MD. A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J 2003;44:885-897.
37. Smith LJ, Yu JK, Bjorling DE, et al. Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs. J Am Vet Med Assoc 2001;218:1101-1105.
38. Hellebrekers LJ, Sap R. Medetomidine as a premedicant for ketamine, propofol or fentanyl anaesthesia in dogs. Vet Rec 1997; 140:545-548.
39. Hellebrekers LJ, van Herpen H, Hird JF, et al. Clinical efficacy and safety of propofol or ketamine anaesthesia in dogs premedicated with medetomidine. Vet Rec 1998;142:631-634.
40. Lemke KA. Perioperative use of selective alpha-2 agonists and antagonists in small animals. Can Vet J 2004;45:475-480.
41. Granholm M, McKusick BC, Westerholm FC, et al. Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. Vet Rec 2007;160:891-897.
42. Haskins SC, Patz JD. Ketamine in hypovolemic dogs. Crit Care Med 1990;18:625-629.
43. Haskins SC, Farver TB, Patz JD. Cardiovascular changes in dogs given diazepam and diazepam-ketamine. Am J Vet Res 1986;47:795-798.
44. Ko JC, Nicklin CF, Melendaz M, et al. Effects of a microdose of medetomidine on diazepam-ketamine induced anesthesia in dogs. J Am Vet Med Assoc 1998;213:215-219.
45. Vainio O. Propofol infusion anesthesia in dogs premedicated with medetomidine. J Assoc Vet Anaesth 1991;18:35-37.
46. Kojima K, Nishimura R, Mutoh T, et al. Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs. Am J Vet Res 2002; 63:1671-1679.
47. Lin HC. Pharmacology. In: Thurmon JC, Tranquilli WJ, Benson GJ, eds. Essentials of small animal anesthesia & analgesia. Philadelphia: Lippincott Williams & Wilkins, 1999;126-191.
48. Bufalari A, Miller SM, Short CE, et al. The use of propofol for induction of anaesthesia in dogs premedicated with acepromazine, butorphanol and acepromazine-butorphanol. N Z Vet J 1997;45:129-134.
49. Bloor BC, Abdul-Rasool I, Temp J, et al. The effects of medetomidine, an alpha 2-adrenergic agonist, on ventilatory drive in the dog. Acta Vet Scand Suppl 1989;85:65-70.
50. Alibhai HI, Clarke KW, Lee YH, et al. Cardiopulmonary effects of combinations of medetomidine hydrochloride and atropine sulphate in dogs. Vet Rec 1996;138:11-13.
51. Ko JC, Fox SM, Mandsager RE. Effects of preemptive atropine administration on incidence of medetomidine-induced bradycardia in dogs. J Am Vet Med Assoc 2001;218:52-58.
52. Kuusela E, Raekallio M, Väisänen M, et al. Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia. Am J Vet Res 2001;62:1073-1080.
53. Ko JC, Weil AB, Kitao T, et al. Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation. Vet Ther 2007;8:51-60.
54. Ko JC, Payton ME, White AG, et al. Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs. J Am Anim Hosp Assoc 2006;42:18-27.
55. Haskins SC. Inhalational anesthetics. Vet Clin North Am Small Anim Pract 1992;22:297-307.