Simple and rapid micro-scale quantification of artemisinin in living Artemisia annua L. by improved gas chromatography with electron-capture detection

Biomedical Chromatography

Volumn 23, Issue 10, 2009, Pages 1101-1107

  Liu, Shuoqian ^a   Tian, Na ^a   Li, Juan ^a   Huang, Jianan ^a   Liu, Zhonghua ^a  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

A. annua; Chromatographic analysis; Determine; ECD; GC; Qinghaosu

Indexed keywords

BIOCHEMISTRY; DISEASES; GAS CHROMATOGRAPHY; QUALITY CONTROL;

A ANNUA; ARTEMISIA ANNUA; ARTEMISININ; COMBINATION THERAPY; DETERMINE; ECD; ELECTRON CAPTURE DETECTION; GC; QINGHAOSU; SIMPLE++;

CHROMATOGRAPHIC ANALYSIS;

ACETIC ACID ETHYL ESTER; ARTEMISININ;

ARTEMISIA ANNUA; ARTICLE; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SYNTHESIS; ELECTRON CAPTURE DETECTION; FLOWER; GAS CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; NONHUMAN; PLANT LEAF; SEPARATION TECHNIQUE;

ARTEMISIA ANNUA;

EID: 70549106481     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1230     Document Type: Article

References (33)

1. Abdin MZ, Israr M, Rehman RU and Jain SK. Artemisinin, a novel antimalarial drug: biochemical and molecular approaches for enhanced production. Planta Medica 2003; 69: 289. (Pubitemid 36577992)
2. Acton N, Klayman DL and Rollman IJ. Reductive electrochemical HPLC assay for artemisinin (qinghaosu). Planta Medica 1985; 51: 445. (Pubitemid 16253787)
3. Avery BA, Venkatesh KK and Avery MA. Rapid determination of artemisinin and related analogues using high-performance liquid chromatography and an evaporative light scattering detector. Journal of Chromatography B 1999; 730: 71.
4. Bhandari P, Gupta AP, Singh B and Kaul VK. Simultaneous densitometric determination of artemisinin, artemisinic acid and arteannuin-B in Artemisia annua using reversed-phase thin layer chromatography. Journal of Separation Science 2005; 28: 2288. (Pubitemid 41763059)
5. Bilia AR, Melillo MP, Bergonzi MC and Vincieri FF. Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine 2006; 13: 487.
6. Charles DJ, Simon JE, Wood KV and Heinstein P. Germplasm variation in artemisinin content of Artemisia annua using an alternative method of artemisinin analysis from crude plant extracts. Journal of Natural Products 1990; 53: 157. (Pubitemid 20152052)
7. Christen P and Veuthey JL. New trends in extraction, identification and quantification of artemisinin and its derivatives. Current Medicinal Chemistry 2001; 8: 1827. (Pubitemid 33134073)
8. Covello PS, Teoh KH, Polichuk DR, Reed DW and Nowak G. Functional genomics and the biosynthesis of artemisinin. Phytochemistry 2007; 68: 1864.
9. Delabays N, Simonnet X and Gaudin M. The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Current Medicinal Chemistry 2001; 8: 1795. (Pubitemid 33134071)
10. Dost K and Davidson G. Analysis of artemisinin by a packed-column supercritical fluid chromatography-atmospheric pressure chemical ionisation mass spectrometry technique. Analyst 2003; 128: 1037. (Pubitemid 37026262)
11. Duke MV, Paul RN, elSohly HN, Sturtz G and Duke SO. Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L. International Journal of Plant Sciences 1994; 155: 272.
12. elSohly HN, Croom EM and elSohly MA. Analysis of the antimalarial sesquiterpene artemisinin in Artemisia annua by high-performance liquid chromatography (HPLC) with postcolumn derivatization and ultraviolet detection. Pharmaceutical Research 1987; 4: 258.
13. Ferreira JFS, Charles DJ, Wood K, Simon JE and Janick J. A comparison of gas chromatography and high performance liquid chromatography for artemisinin analyses. Phytochemical Analysis 1994; 5: 116. (Pubitemid 24120384)
14. Gabriels M and Plaizier-Vercammen JA. Densitometric thin-layer chromatographic determination of artemisinin and its lipophilic derivatives, artemether and arteether. Journal of Chromatographic Science 2003; 41: 359.
15. Gabriels M and Plaizier-Vercammen J. Development of a reversed-phase thin-layer chromatographic method for artemisinin and its derivatives. Journal of Chromatographic Science 2004; 42: 341.
16. Greenwood B. Progress in malaria control in endemic areas. Travel Medicine and Infectious Disease 2008; 6: 173.
17. Liu CZ, Zhou HY and Zhao Y. An effective method for fast determination of artemisinin in Artemisia annua L. by high performance liquid chromatography with evaporative light scattering detection. Analytica Chimica Acta 2007; 581: 298. (Pubitemid 44841958)
18. Liu H, Li Q, Li S, Zou Y and Gu A. The rapid determination of artemisinin by post-column derivatization high-performance liquid chromatography using matrix solid-phase dispersion method. Journal of Chromatographic Science 2008a; 46: 122.
19. Liu S, Tian N, Liu Z, Huang J, Li J and Ferreira JF. Affordable and sensitive determination of artemisinin in Artemisia annua L. by gas chromatography with electron-capture detection. Journal of Chromatography A 2008b; 1190: 302.
20. Lommen WJ, Schenk E, Bouwmeester HJ and Verstappen FW. Trichome dynamics and artemisinin accumulation during development and senescence of Artemisia annua leaves. Planta Medica 2006; 72: 336.
21. Lommen WJ, Elzinga S, Verstappen FW and Bouwmeester HJ. Artemisinin and sesquiterpene precursors in dead and green leaves of Artemisia annua L. crops. Planta Medica 2007; 73: 1133. (Pubitemid 47401301)
22. Ma C, Wang H, Lu X, Xu G and Liu B. Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry. Journal of Chromatography A 2008; 1186: 412.
23. Marcel Kohler, Werner Haerdi and Philippe Christen JV. Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples. Phytochemical Analysis 1998; 8: 223.
24. Marchand E, Atemnkeng MA, Vanermen S and Plaizier-Vercammen J. Development and validation of a simple thin layer chromatographic method for the analysis of artemisinin in Artemisia annua L. plant extracts. Biomedical Chromatography 2008; 22: 454-459. (Pubitemid 351722144)
25. Mount DL, Todd GD and Navaratnam V. Packed-column supercritical fluid chromatography of artemisinin (qinghaosu) with electron-capture detection. Journal of Chromatography B 1995; 666: 183.
26. Olliaro PL and Taylor WR. Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: a review. Journal of Postgraduate Medicine 2004; 50: 40.
27. Peng CA, Ferreira JF and Wood AJ. Direct analysis of artemisinin from Artemisia annua L. using high-performance liquid chromatography with evaporative light scattering detector, and gas chromatography with flame ionization detector. Journal of Chromatography A 2006; 1133: 254.
28. Sipahimalani AT, Fulzele DP and Heble MR. Rapid method for the detection and determination of artemisin by gas chromatography. Journal of Chromatography 1991; 538: 452.
29. Theoharides AD, Smyth MH, Ashmore RW, Halverson JM, Zhou ZM, Ridder WE and Lin AJ. Determination of dihydroqinghaosu in blood by pyrolysis gas chromatography/mass spectrometry. Analytical Chemistry 1988; 60: 115.
30. Van Nieuwerburgh FC, Vande Casteele SR, Maes L, Goossens A, Inze D, Van Bocxlaer J amd Deforce DL. Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography- electrospray quadrupole time-of-flight tandem mass spectrometry. Journal of Chromatography A 2006; 1118: 180. (Pubitemid 43795003)
31. Woerdenbag HJ, Pras N, Bos R, Visser JF, Hendricks H and Malingré TM. Analysis of artemisinin and related sesquiterpenoids from Artemisia annua L. by combined gas chromatography/mass spectrometry. Phytochemical Analysis 1991; 2: 215.
32. Zhao SS and Zeng MY. Spektrometrische hochdruck- flussigkeitschromatographische (HPLC) untersuchungen zur analytik von qinghaosu. Planta Medica 1985; 51: 233.
33. Ziffer H, Highet RJ and Klayman DL. Artemisinin: an endoperoxidic antimalarial from Artemisia annua L. Fortschritte der Chemie Organischer Naturstoffe 1997; 72: 121.