Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of artemisia annua samples

Phytochemical Analysis

Volumn 8, Issue 5, 1997, Pages 223-227

  Kohler, Marcel ^a   Haerdi, Werner ^a   Christen, Philippe ^a   Veuthey, Jean Luc ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Artemisia annua; Artemisinic acid; Artemisinin; Evaporative light scattering detector; Supercritical fluid chromatography; Supercritical fluid extraction

Indexed keywords

ANTENNAS; CARBON DIOXIDE; EFFLUENT TREATMENT; GAS CHROMATOGRAPHY; LIGHT SCATTERING; PLANT EXTRACTS; SUPERCRITICAL FLUIDS;

AERIAL PARTS; ARTEMISIA ANNUA; ARTEMISINIC ACID; ARTEMISININ; EVAPORATIVE LIGHT SCATTERING DETECTORS; EXTRACTION CONDITIONS; MILD EXTRACTION; QUANTITATIVE DETERMINATIONS; SUPER CRITICAL FLUID CHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

SUPERCRITICAL FLUID EXTRACTION;

ARTEMISIA ANNUA EXTRACT; ARTEMISINIC ACID; ARTEMISININ; CARBON DIOXIDE;

ARTICLE; LIGHT SCATTERING; SUPERCRITICAL FLUID CHROMATOGRAPHY; SUPERCRITICAL FLUID EXTRACTION;

ARTEMISIA;

EID: 0030802007     PISSN: 09580344     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1565(199709/10)8:5<223::AID-PCA370>3.0.CO;2-A     Document Type: Article

References (30)

1. Acton, N., Klayman, D. L. and Rollman, I. J. (1985). Reductive electrochemical HPLC assay for artemisinin (qinghaosu). Planta Med. 51, 445-446.
2. Avery, M. A., Jennings-White, C. and Chong, W. K. M. (1987). The total synthesis of (+)-artemisinin and (+)-9-desmethyl-artemisinin. Tetrahedron Lett. 28, 4629-4632.
3. Castañeda-Acosta, J., Cain, A. W., Fischer, N. H. and Knopf, F. C. (1995). Extraction of bioactive sesquiterpene lactones from Magnolia grandiflora using supercritical carbon dioxide and near-critical propane. J. Agric. Food Chem. 43, 63-68.
4. Castioni, P., Christen, P. and Veuthey, J. L. (1995). L'extraction en phase supercritique des substances d'origine végétale. Analusis. 23, 95-106.
5. Charles, D. J., Simon, J. E., Wood, K. E. and Heinstein, P. (1990). Germplasm variation in artemisinin content of Artemisia annua using an alternative method of artemisinin analysis from crude plant extracts. J. Nat. Prod. 53, 157-160.
6. Delabays, N., Benakis, A. and Collet, G. (1993). Selection and breeding for high artemisinin (Qinghaosu) yielding strains of Artemisia annua. Acta Hort. 330, 203-207.
7. Dreux, M. and Lafosse, M. (1990). La diffusion de lumière par microparticules solides ou liquides en phase gazeuse: un nouveau mode de détection pour la CLHP et la CPS. Spectra 2000 151, 16-21.
8. Duke, M. V., Paul, R. N., Elsohly, H. N., Sturtz, G. and Duke, S. O. (1994). Localization of artemisinin and artemisitene in foliar tissues of glanded and glandless biotypes of Artemisia annua L. Int. J. Plant Sci. 155, 365-372.
9. Ferreira, J. F. S., Charles, D. J., Wood, K., Janick, J. and Simon, J. E. (1994). A comparison of gas chromatography and high performance liquid chromatography for artemisinin analyses. Phytochem. Anal. 5, 116-120.
10. Hawthorne, S. (1993). Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation. Blackie, Glasgow.
11. Jaziri, M., Diallo, B., Vanhaelen, M., Homès, J., Yoshimatsu, K. and Shimomura, K. (1993). Immunodetection of artemisinin in Artemisia annua cultivated in hydroponic conditions. Phytochemistry 33, 821-826.
12. King, J. and France, I. E. (1992). Basic principles of analytical supercritical fluid extraction. In Analysis with Supercritical Fluids: Extraction and Chromatography (Wenclawiak, B. ed), pp. 32-60. Springer, Berlin.
13. King, M. B. and Bott, T. R. (1995). Extraction of Natural Products Using Near Critical Solvents. Blackie, Glasgow.
14. Klayman, D. L., Lin, A. J., Acton, N., Scovill, J. P., Hoch, J. M., Milhous, W. K. and Theoharides, A. D. (1984). Isolation of artemisinin (Qinghaosu) from Artemisia annua growing in the United States. J. Nat. Prod. 47, 715-717.
15. Kohler, M., Haerdi, W. and Veuthey, J. L. (1996). Analysis by SFC (capillary and packed) of artemisinin and artemisinic acid in Artemisia annua L. Proc. 18th Int. Symp. Capillary Chromatography. Riva del Garda, Italy, 20-24 May 1996. pp. 1776-1782.
16. Kohler, M., Haerdi, W., Christen, P. and Veuthey, J. L. (1997a). Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide. J. Chromatogr. A. in press.
17. Kohler, M., Haerdi, W., Christen, P. and Veuthey, J. L. (1997b). Determination of artemisinin and artemisinic acid by capillary and packed SFC. J. High Resol. Chromatogr. 20, 62-66.
18. Nair, M. S. R., and Basile, D. V. (1993). Bioconversion of arteannuin B to artemisinin. J. Nat. Prod. 56, 1559-1566.
19. Paris-Paslawska, M. M. (1993). Artémisinine et Dérivés, Nouveaux Médicaments Antipaludiques. Thesis 2575 of University of Geneva, Switzerland, pp. 36-39 and pp. 74-78.
20. Pras, N., Visser, J. F., Batterman, S., Woerdenbag, H. J. and Malingré, T. M. (1991). Laboratory selection of Artemisia annua L. for high artemisinin yielding types. Phytochem. Anal. 2, 80-83.
21. Ranasinghe, A., Sweatlock, J. D. and Cooks, G. (1993). A rapid screening method for artemisinin and its congeners using MS/MS; search for new analogues in Artemisia annua. J. Nat. Prod. 56, 552-563.
22. Schmid, G. and Hofheinz, W. (1983). Total synthesis of qinghaosu. J. Am. Chem. Soc. 105, 624-625.
23. Shah, S. and Taylor, L. T. (1990). Comparison of the efficiency of packed and capillary columns to be used in supercritical fluid chromatography for the analysis of nonvolatile compounds. Chromatographia 29, 453-458.
24. Sipahimalani, A. T., Fulzele, D. P. and Heble, M. R. (1991). Rapid method for the detection and determination of artemisinin by gas chromatography. J. Chromatogr. 538, 452-455.
25. Smith, R. M. and Burford, R. D. (1992a). Optimization of supercritical fluid extraction of volatile constituents from a model plant matrix. J. Chromatogr. 600, 175-181.
26. Smith, R. M. and Burford, R. D. (1992b). Supercritical fluid extraction and gas chromatographic determination of the sesquiterpene lactone parthenolide on the medicinal herb feverfew (Tanacetum parthenium). J. Chromatogr. 627, 255-261.
27. Vandenberghe, D. R., Vergauwe, A. N., Von Montagu, M. and Van den Eeckhout, E. G. (1995). Simultaneous determination of artemisinin and its bioprecursors in Artemisia annua. J. Nat. Prod. 58, 798-803.
28. Woerdenbag, H. J., Lugt, C. B. and Pras, N. (1990). Artemisia annua L.: a source of novel antimalarial drugs. Pharm. Weekbl. Sci. ed. 12, 169-181.
29. Woerdenbag, H. J., Pras, N., Bos, R., Visser, J. F., Hendriks, H. and Malingré, T. M. (1991). Analysis of artemisinin and related sesquiterpenoids from Artemisia annua L. by combined gas chromatography/mass spectrometry. Phytochem. Anal. 2, 215-219.
30. Zhao, S. S. and Zeng, M. Y. (1985). Spektrometrische Hochdruck-Flüssigkeits-chromatographische (HPLC) Untersuchungen zur Analytik von Qinghaosu. Planta Med. 51, 233-237.