Asparagine-linked oligosaccharides present on a non-consensus amino acid sequence in the CH1 domain of human antibodies

Journal of Biological Chemistry

Volumn 284, Issue 47, 2009, Pages 32493-32506

  Valliere Douglass, John F ^a   Kodama, Paul ^a   Mujacic, Mirna ^a   Brady, Lowell J ^a   Wang, Wes ^a   Wallace, Alison ^a   Yan, Boxu ^a   Reddy, Pranhitha ^a   Treuheit, Michael J ^a   Balland, Alain ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ASPARAGINE RESIDUE; ASPARAGINYL; CATION EXCHANGE CHROMATOGRAPHY; HPLC-MS; HUMAN ANTIBODIES; MAP DATA; N-LINKED; OLIGOSACCHARIDE STRUCTURE; RECOMBINANT ANTIBODY; SITE DIRECTED MUTAGENESIS; WILD TYPES;

AMINATION; AMINES; AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; ESTERIFICATION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACHINERY; OLIGOSACCHARIDES; ORGANIC ACIDS;

ANTIBODIES;

ASPARAGINE LINKED OLIGOSACCHARIDE; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ION EXCHANGE CHROMATOGRAPHY; MASS SPECTROMETRY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ANTIBODIES; ASPARAGINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHYMOTRYPSIN; GLYCOSYLATION; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; OLIGOSACCHARIDES; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; TRYPSIN;

EID: 70450270692     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014803     Document Type: Article

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