Thymulin and zinc (Zn2+)-mediated inhibition of endotoxin-induced production of proinflammatory cytokines and NF-κB nuclear translocation and activation in the alveolar epithelium: Unraveling the molecular immunomodulatory, anti-inflammatory effect of thymulin/Zn2+ in vitro

Molecular Immunology

Volumn 47, Issue 2-3, 2009, Pages 205-214

  Haddad, John J ^a,b  

^a AMERICAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Lebanon)

^b UNIVERSITY OF BALAMAND   (Lebanon)

Author keywords

Anti inflammatory; cAMP; Cytokine; FATEII; Inflammation; NF B; Thymulin; Zinc

Indexed keywords

BUCLADESINE; CYCLIC AMP; CYTOKINE; ENDOTOXIN; FORSKOLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NUCLEOTIDE; PEPTIDE HORMONE; THYMULIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ZINC; ANTIINFLAMMATORY AGENT; AUTACOID; DNA; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA BINDING; DOWN REGULATION; FEMALE; FETUS; IMMUNOMODULATION; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; DRUG EFFECT; EPITHELIUM; IMMUNOLOGY; LUNG ALVEOLUS; METABOLISM; PROTEIN BINDING; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BUCLADESINE; CELL NUCLEUS; CYCLIC AMP; CYTOKINES; DNA; ENDOTOXINS; EPITHELIUM; FORSKOLIN; IMMUNOMODULATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; NF-KAPPA B; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; THYMIC FACTOR, CIRCULATING; ZINC;

EID: 70450257811     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.09.034     Document Type: Article

References (44)

1. Bach J., Bardenne M., Pleau J., and Rosa J. Biochemical characterization of a serum thymic factor. Nature 266 (1977) 55-57
2. + transport in rat fetal distal lung epithelial cells. J. Physiol. 532 (2001) 105-113
3. Bao S., and Knoell D.L. Zinc modulates cytokine-induced lung epithelial cell barrier permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 291 6 (2006) L1132-L1141
4. Brown O.A., Sosa Y.E., Dardenne M., Pléau J., and Goya R.G. Growth hormone-releasing activity of thymulin on pituitary somatotropes is age dependent. Neuroendocrinology 69 (1999) 20-27
5. Brown O.A., Sosa Y.E., Dardenne M., Pléau J.M., and Goya R.G. Studies on the gonadotropin-releasing activity of thymulin: changes with age. J. Gerontol. A: Biol. Sci. Med. Sci. 55 (2000) B170-B176
6. Clerici C., and Planès C. Gene regulation in the adaptive process to hypoxia in lung epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 296 (2009) L267-L274
7. Dardenne M. Role of thymic peptides as transmitters between the neuroendocrine and immune systems. Ann. Med. 2 (1999) 34-39
8. Dardenne M., Pleau J.M., and Bach J.F. Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS). J. Immunol. 17 (1980) 83-94
9. Dardenne M., Pleau J.M., Savino W., Prasad A.S., and Bach J.F. Biochemical and biological aspects of the interaction between thymulin and zinc. Prog. Clin. Biol. Res. 380 (1993) 23-32
10. Dardenne M., Saadé N., and Safieh-Garabedian B. Role of thymulin or its analogue as a new analgesic molecule. Ann. N. Y. Acad. Sci. 1088 (2006) 153-163
11. Haddad J.J. Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for nuclear factor-κB. Crit. Care 6 (2002) 481-490
12. Haddad J.J. Recombinant TNF-α mediated regulation of the IκB-α/NF-κB signaling pathway: evidence for the enhancement of pro- and anti-inflammatory cytokines in alveolar epithelial cells. Cytokine 17 (2002) 301-310
13. 2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 278 (2000) L492-L503
14. Haddad J.J., and Land S.C. Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IκB-α/NF-κB-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium. Am. J. Respir. Cell. Mol. Biol. 26 (2002) 114-126
15. 2+ in the alveolar epithelium: amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitive pathway. Biochem. Biophys. Res. Commun. 274 (2000) 500-505
16. Haddad J.J., Olver R.E., and Land S.C. Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. J. Biol. Chem. 275 (2000) 21130-21139
17. + conductance in fetal alveolar cells. Biochem. Biophys. Res. Commun. 281 (2001) 987-992
18. Haddad J.J., Saadé N.E., and Safieh-Garabedian B. Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis. J. Neuroimmunol. 133 (2002) 1-19
19. Haddad J.J., Saadé N.E., and Safieh-Garabedian B. Redox regulation of TNF-α biosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an IκB-α/NF-κB-independent pathway in alveolar epithelial cells. Cell. Signal. 14 (2002) 211-218
20. Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Lauterbach R. Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IκB/NF-κB-sensitive pathway in the alveolar epithelium. Int. Immunopharmacol. 2 (2002) 1567-1583
21. Haddad J.J., Land S.C., Tarnow-Mordi W.O., Zembala M., Kowalczyk D., and Lauterbach R. Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-alpha) biosynthesis in alveolar epithelial cells. J. Pharmacol. Exp. Ther. 300 (2002) 559-566
22. Hadley A.J., Rantle C.M., and Buckingham J.C. Thymulin stimulates corticotrophin release and cyclic nucleotide formation in the rat anterior pituitary gland. Neuroimmunomodulation 4 (1997) 62-69
23. Henriques-Coelho T., Oliveira S.M., Moura R.S., Roncon-Albuquerque Jr. R., Neves A.L., Santos M., Nogueira-Silva C., La Fuente Carvalho F., Brandão-Nogueira A., Correia-Pinto J., and Leite-Moreira A.F. Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway. Endocrinology 149 (2008) 4367-4373
24. Kanaan S.A., Safieh-Garabedian B., Karam M., Khansa H., Jabbur S.J., Jurjus A.R., and Saade N.E. Thymulin reduces the hyperalgesia and cytokine upregulation induced by cutaneous leishmaniasis in mice. Brain Behav. Immun. 16 (2002) 450-460
25. Lucas R., Verin A.D., Black S.M., and Catravas J.D. Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem. Pharmacol. 77 (2009) 1763-1772
26. Lunin S.M., Khrenov M.O., Novoselova T.V., Parfenyuk S.B., and Novoselova E.G. Thymulin, a thymic peptide, prevents the overproduction of pro-inflammatory cytokines and heat shock protein Hsp70 in inflammation-bearing mice. Immunol. Invest. 37 (2008) 858-870
27. Millington G., and Buckingham J.C. Thymic peptides and neuroendocrine-immune communication. J. Endocriol. 133 (1992) 163-168
28. Mocchegiani E., Provinciali M., Di Stefano G., Nobilini A., Caramia G., Santarelli L., Tibaldi A., and Fabris N. Role of the low zinc bioavailability on cellular immune effectiveness in cystic fibrosis. Clin. Immunol. Immunopathol. 75 (1995) 214-224
29. Mutchnick M.G., Good A.E., Barlas N., and Trainin N. Thymic humoral factor effect on intracellular lymphocyte cAMP in patients with ankylosing spondylitis. J. Rheumatol. 9 (1982) 627-629
30. Prasad A.S. Zinc and immunity. Mol. Cell. Biochem. 188 (1998) 63-69
31. Prasad A.S. Zinc: mechanisms of host defense. J. Nutr. 137 (2007) 1345-1349
32. Prasad A.S. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp. Gerontol. 43 (2008) 370-377
33. Qi X.F., Kim D.H., Yoon Y.S., Li J.H., Song S.B., Jin D., Huang X.Z., Teng Y.C., and Lee K.J. The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-κB in HaCaT keratinocytes. Mol. Immunol. 46 (2009) 1925-1934
34. Reggiani P.C., Morel G.R., Cónsole G.M., Barbeito C.G., Rodriguez S.S., Brown O.A., Bellini M.J., Pléau J.M., Dardenne M., and Goya R.G. The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin. Ann. N. Y. Acad. Sci. 1153 (2009) 98-106
35. Rinaldi-Garaci C., Jezzi T., Baldassarre A.M., Dardenne M., Bach J.F., and Garaci E. Effect of thymulin on intracellular cyclic nucleotides and prostaglandins E2 in peanut agglutinin-fractionated thymocytes. Eur. J. Immunol. 15 (1985) 548-552
36. Saadé N.E., Atweh S.F., Jabbur S.J., Dardenne M., Bach J.F., and Safieh-Garabedian B. A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin. Neuroscience 119 (2003) 155-165
37. Safieh-Garabedian B., Ahmed K., Khamashta M.A., Taub N.A., and Hughes G.R. Thymulin modulates cytokine release by peripheral blood mononuclear cells: a comparison between healthy volunteers and patients with systemic lupus erythematosus. Int. Arch. Allergy Immunol. 101 (1993) 126-131
38. Safieh-Garabedian B., Jalakhian R.H., Saadé N.E., Haddad J.J., Jabbur S.J., and Kanaan S.A. Thymulin reduces hyperalgesia induced by peripheral endotoxin injection in rats and mice. Brain Res. 717 (1996) 179-183
39. Safieh-Garabedian B., Dardenne M., Pléau J.M., and Saadé N.E. Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. Br. J. Pharmacol. 136 (2002) 947-955
40. Safieh-Garabedian B., Ochoa-Chaar C.I., Poole S., Massaad C.A., Atweh S.F., Jabbur S.J., and Saadé N.E. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 121 (2003) 865-873
41. Senftleben U., Li Z.W., Baud V., and Karin M. IKKβ is essential for protecting T cells from TNFα-induced apoptosis. Immunity 14 (2001) 217-230
42. Wall E.A., Zavzavadjian J.R., Chang M.S., Randhawa B., Zhu X., Hsueh R.C., Liu J., Driver A., Bao X.R., Sternweis P.C., Simon M.I., and Fraser I.D. Suppression of LPS-induced TNF-α production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci. Signal. 2 (2009) ra28
43. Yang J.P., Merin J.P., Nakano T., Kato T., Kitade Y., and Okamoto T. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett. 361 (1995) 89-96
44. Yasuda J., Nishioka W., Sakudo A., Yama S., Setoguchi R., Saeki K., Matsumoto Y., Awaya A., and Onodera T. Suppressor mechanism of serum thymic factor on tumor necrosis factor-α-induced apoptosis in the mouse pancreatic beta-cell line. Biochem. Biophys. Res. Commun. 311 (2003) 501-505