Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma

Journal of Surgical Research

Volumn 157, Issue 2, 2009, Pages 199-207

  Palmieri, Vincenzo O ^a   Grattagliano, Ignazio ^a   Minerva, Francesco ^a   Pollice, Silvana ^a   Palasciano, Giuseppe ^a   Portincasa, Piero ^a  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

microsomal function; mitochondrial function; radiofrequency ablation; stable isotopes; trans arterial chemoembolization

Indexed keywords

4 ACETANISIDINE C 13; KETOISOCAPROATE C 13; RADIOISOTOPE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; CANCER PATIENT; CHEMOEMBOLIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DEMETHYLATION; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER MICROSOME; LIVER MITOCHONDRION; MALE; METABOLISM; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; TREATMENT OUTCOME;

ACETAMIDES; ADULT; AGED; AGED, 80 AND OVER; BREATH TESTS; CARBON ISOTOPES; CARCINOMA, HEPATOCELLULAR; CATHETER ABLATION; CHEMOEMBOLIZATION, THERAPEUTIC; FEMALE; HUMANS; KETO ACIDS; LIVER; LIVER FUNCTION TESTS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOCHONDRIA, LIVER; TREATMENT OUTCOME;

EID: 70450247162     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.09.029     Document Type: Article

References (42)

1. Bosch F.X., Ribes J., Cleries R., et al. Epidemiology of hepatocellular carcinoma. Clin Liver Dis 9 (2005) 191
2. Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma. Lancet 362 (2003) 1907
3. Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. CA Cancer J Clin 55 (2005) 74
4. Levi F., Lucchini F., Negri E., et al. Cancer mortality in Europe, 1995-1999, and an overview of trends since 1960. Int J Cancer 110 (2004) 155
5. Mcglynn K.A., Tsao L., Hsing A.W., et al. International trends and patterns of primary liver cancer. Int J Cancer 94 (2001) 290
6. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35 (2001) 421
7. Casaril A., Abu H.M., Harb A., et al. The safety of radiofrequency thermal ablation in the treatment of liver malignancies. Eur J Surg Oncol (2007) in press
8. Cormier J.N., Thomas K.T., Chari R.S., et al. Management of hepatocellular carcinoma. J Gastrointest Surg 10 (2006) 761
9. Lau H., Man K., St F., et al. Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy. Br J Surg 84 (1997) 1255
10. Lauterburg B.H. Assessment of liver function prior to hepatic resection. Swiss Surg 5 (1999) 92
11. Luketic V.A., Ml S., Fisher R.A., et al. Hepatic lidocaine metabolism is useful in the selection of patients in need of liver transplantation. Transplant Proc 25 (1993) 1072
12. Petrolati A., Festi D., De Berardinis G., et al. 13C-methacetin breath test for monitoring hepatic function in cirrhotic patients before and after liver transplantation. Aliment Pharmacol Ther 18 (2003) 785
13. Calvisi D.F., Simile M.M., Ladu S., et al. Altered methionine metabolism and global DNA methylation in liver cancer: Relationship with genomic instability and prognosis. Int J Cancer 121 (2007) 2410
14. Capuano F., Varone D., D'eri N., et al. Oxidative phosphorylation and F(O)F(1) ATP synthase activity of human hepatocellular carcinoma. Biochem Mol Biol Int 38 (1996) 1013
15. Chang B., Nishikawa M., Nishiguchi S., et al. L-carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int J Cancer 113 (2005) 719
16. Nishikawa M., Nishiguchi S., Shiomi S., et al. Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma. Cancer Res 61 (2001) 1843
17. Witschi A., Mossi S., Meyer B., et al. Mitochondrial function reflected by the decarboxylation of [13C]ketoisocaproate is impaired in alcoholics. Alcohol Clin Exp Res 18 (1994) 951
18. Matsumoto K., Suehiro M., Iio M., et al. [13C] methacetin breath test for evaluation of liver damage. Dig Dis Sci 32 (1987) 344
19. Lauterburg B.H., Liang D., Schwarzenbach F.A., et al. Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17 (1993) 418
20. Portincasa P., Grattagliano I., Lauterburg B.H., et al. Liver breath tests noninvasively predict higher stages of non-alcoholic steatohepatitis. Clin Sci 111 (2006) 135
21. Lauterburg B.H., Grattagliano I., Gmur R., et al. Noninvasive assessment of the effect of xenobiotics on mitochondrial function in human beings: Studies with acetylsalicylic acid and ethanol with the use of the carbon 13-labeled ketoisocaproate breath test. J Lab Clin Med 125 (1995) 378
22. Winchell H.S., Stahelin H., Kusubov N., et al. Kinetics of CO2-HCO3 minus in normal adult males. J Nucl Med 11 (1970) 711
23. Capuano F., Guerrieri F., and Papa S. Oxidative phosphorylation enzymes in normal and neoplastic cell growth. J Bioenerg Biomembr 29 (1997) 379
24. Hugo-Wissemann D., Anundi I., Lauchart W., et al. Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes. Hepatology 13 (1991) 297
25. Krahenbuhl S., Stucki J., and Reichen J. Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis. Hepatology 15 (1992) 1160
26. Pl P. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res 22 (1978) 190
27. Koike K. Hepatitis C virus contributes to hepatocarcinogenesis by modulating metabolic and intracellular signaling pathways. J Gastroenterol Hepatol 22 (2007) S108
28. Furutani T., Hino K., Okuda M., et al. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 130 (2006) 2087
29. Wheelhouse N.M., Lai P.B., Wigmore S.J., et al. Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver. Br J Cancer 92 (2005) 1268
30. Kotake K., Nonami T., Kurokawa T., et al. Human livers with cirrhosis and hepatocellular carcinoma have less mitochondrial DNA deletion than normal human livers. Life Sci 64 (1999) 1785
31. Nagao M., and Tanaka K. FAD-dependent regulation of transcription, translation, post-translational processing, and post-processing stability of various mitochondrial acyl-CoA dehydrogenases and of electron transfer flavoprotein and the site of holoenzyme formation. J Biol Chem 267 (1992) 17925
32. Llovet J.M., Bru C., and Bruix J. Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis 19 (1999) 329
33. Huang S.K. Advances in applications of radiofrequency current to catheter ablation therapy. Pacing Clin Electrophysiol 14 (1991) 28
34. Itoh T., Orba Y., Takei H., et al. Immunohistochemical detection of hepatocellular carcinoma in the setting of ongoing necrosis after radiofrequency ablation. Mod Pathol 15 (2002) 110
35. Kim Sk, Lim Hk, Kim Yh, et al. Hepatocellular carcinoma treated with radiofrequency ablation: Spectrum of imaging findings. Radiographics 23 (2003) 107
36. Kuromatsu R., Tanaka M., Shimauchi Y., et al. Light and electron microscopic analyses of immediate and late tissue damage caused by radiofrequency ablation in porcine liver. Int J Mol Med 11 (2003) 199
37. Nath S., Redick J.A., Whayne J.G., et al. Ultrastructural observations in the myocardium beyond the region of acute coagulation necrosis following radiofrequency catheter ablation. J Cardiovasc Electrophysiol 5 (1994) 838
38. Klatt S., Taut C., Mayer D., et al. Evaluation of the 13C-methacetin breath test for quantitative liver function testing. Z Gastroenterol 35 (1997) 609
39. Aninat C., Piton A., Glaise D., et al. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34 (2006) 75
40. Villeneuve J.P., and Pichette V. Cytochrome P450 and liver diseases. Curr Drug Metab 5 (2004) 273
41. Grattagliano I., Portincasa P., Cocco T., et al. Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats. Exp Gerontol 39 (2004) 1323
42. Schnegg M., and Lauterburg B.H. Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance. J Hepatol 3 (1986) 164