Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome

Medical Hypotheses

Volumn 74, Issue 1, 2010, Pages 145-146

  Liu, Cong ^a   Cui, Jianguo ^a   Sun, Quan ^a   Cai, Jianming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; CYTOKINE; HYDROGEN; HYDROXYL RADICAL; PEROXYNITRITE; THIOL DERIVATIVE;

ACUTE RADIATION SYNDROME; ANTIOXIDANT ACTIVITY; ARTICLE; ATOMIC BOMB; BRAIN ISCHEMIA; CANCER RADIOTHERAPY; CELL DAMAGE; CELL PROTECTION; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; HYPERTENSION; IONIZING RADIATION; MALIGNANT NEOPLASTIC DISEASE; NAUSEA; NEUROPROTECTION; NUCLEAR INDUSTRY; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; REPERFUSION INJURY; STROKE; VOMITING;

ACUTE RADIATION SYNDROME; ANTIOXIDANTS; APOPTOSIS; FREE RADICALS; GASES; HUMANS; HYDROGEN; HYDROXYL RADICAL; MODELS, THEORETICAL; OXIDATIVE STRESS; PEROXYNITROUS ACID; RADIATION PROTECTION; REPERFUSION INJURY; RISK;

EID: 70450247040     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.07.017     Document Type: Article

References (17)

1. Ohsawa I., Ishikawa M., Takahashi K., Watanabe M., et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13 6 (2007) 688-694
2. Katherine C., Wood, and Mark T.G. The hydrogen highway to reperfusion therapy. Nat Med 13 (2007) 673-674
3. Hayashida K., Sano M., Ohsawa I., et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Biochem Biophys Res Commun 373 1 (2008) 30-35
4. Buchholz B.M., Kaczorowski D.J., Sugimoto R., et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant 8 10 (2008) 2015-2024
5. Abraini J.H., Gardette-Chauffour M.C., Martinez E., et al. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture. J Appl Physiol 76 (1994) 1113-1118
6. Burdelya L.G., Krivokrysenko V.I., Tallant T.C., et al. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320 (2008) 226-230
7. Damron T.A., Spadaro J.A., Horton J.A., Margulies B.S., Strauss J.A., and Farnum C.E. Novel radioprotectant drugs for sparing radiation-induced damage to the physis. Int J Radiat Biol 80 3 (2004) 217-228
8. Vijayalaxmi, Reiter R.J., Tan D.X., Herman T.S., and Thomas Jr. C.R. Melatonin as a radioprotective agent: a review. Int J Radiat Oncol Biol Phys 59 3 (2004) 639-653
9. Shirazi A., Ghobadi G., and Ghazi-Khansari M. A radiobiological review on melatonin: a novel radioprotector. J Radiat Res 48 4 (2007) 263-272
10. Yan S.X., Hong X.Y., Hu Y., and Liao K.H. Tempol, one of nitroxides, is a novel ultraviolet-A1 radiation protector for human dermal fibroblasts. J Dermatol Sci 37 3 (2005) 137-143
11. Gridley D.S., Makinde A.Y., Luo X., Rizvi A., Crapo J.D., Dewhirst M.W., et al. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Res 27 5A (2007) 3101-3109
12. Hospers G.A., Eisenhauer E.A., and de Vries E.G. The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects. Br J Cancer 80 5-6 (1999) 629-638
13. Whitnall M.H., Villa V., Seed T.M., Benjack J., et al. Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice. Immunopharmacol Immunotoxicol 27 1 (2005) 15-32
14. Maclachlan T., Narayanan B., Gerlach V.L., et al. Human fibroblast growth factor 20 (FGF-20; CG53135-05): a novel cytoprotectant with radioprotective potential. Int J Radiat Biol 81 8 (2005) 567-579
15. Margulies B.S., Damron T.A., and Allen M.J. The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro. J Orthop Res 26 11 (2008) 1512-1519
16. Gosselin T.K., and Mautner B. Amifostine as a radioprotectant. Clin J Oncol Nurs 6 3 (2002) 175-176 p. 180
17. Genvresse I., Lange C., Schanz J., et al. Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study. Anticancer Drugs 12 4 (2001) 345-349