Selection and affinity maturation of human antibodies against rabies virus from a scFv gene library using ribosome display

Journal of Biotechnology

Volumn 144, Issue 4, 2009, Pages 253-258

  Zhao, Xiao Ling ^a   Chen, Wei Qiang ^a   Yang, Zhi Hua ^a   Li, Jing Mei ^b   Zhang, Su Juan ^b   Tian, Lu Fang ^c  

^a INSTITUTE OF HEALTH AND ENVIRONMENTAL MEDICINE   (China)

^b Chinese PLA 254 Hospital   (China)

^c SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Affinity maturation; Human antibody; Rabies virus; Ribosome display

Indexed keywords

AFFINITY MATURATION; ANTIBODY FRAGMENT; BINDING ACTIVITIES; GENE LIBRARIES; HIGH AFFINITY; HUMAN ANTIBODIES; HUMAN ANTIBODY; IN-VITRO; MOLECULAR EVOLUTION; MONOCLONAL ANTIBODIES (MABS); POST-EXPOSURE; RAPID ISOLATION; RIBOSOME DISPLAY; SEQUENCE ANALYSIS; SINGLE CHAIN VARIABLE FRAGMENTS;

MOLECULAR BIOLOGY;

MONOCLONAL ANTIBODIES;

MESSENGER RNA; RABIES IMMUNOGLOBULIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY AFFINITY; ANTIBODY ISOLATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE LIBRARY; GENE MUTATION; IN VITRO STUDY; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABIES VIRUS; RIBOSOME; VIRAL GENETICS;

ANTIBODIES, VIRAL; ANTIBODY AFFINITY; BIOTECHNOLOGY; GENE LIBRARY; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; RABIES VIRUS; RIBOSOMES; RNA, MESSENGER; SELECTION, GENETIC; VIRAL PROTEINS;

RABIES VIRUS;

EID: 70450233495     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.09.022     Document Type: Article

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