Further studies on the mechanism of rabies virus neutralization by a viral glycoprotein-specific monoclonal antibody, #1-46-12

Microbiology and Immunology

Volumn 49, Issue 8, 2005, Pages 721-731

  Irie, Takashi ^a   Kawai, Akihiko ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Escape mutants; Glycoprotein mutant; Monoclonal antibody; Neutralization mechanism; Neutralizing monoclonal antibody; Rabies virus; Virus neutralization

Indexed keywords

EPITOPE; GUANINE NUCLEOTIDE BINDING PROTEIN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; VIRUS GLYCOPROTEIN;

ANTIGEN BINDING; ARTICLE; CONFORMATION; MOLECULE; NONHUMAN; PROTEIN BINDING; RABIES VIRUS; SOLUBILITY; VIRUS INFECTIVITY; VIRUS NEUTRALIZATION; WILD TYPE;

RABIES VIRUS;

EID: 24744453522     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2005.tb03663.x     Document Type: Article

References (14)

1. Burton, D.R., Saphire, E.O., and Parren, P.W.H.I. 2001. A model for neutralization of viruses based on antibody coating of the virion surface. Curr. Topics Microbiol. Immunol. 260: 109-143.
2. Flamand, A., Raux, H., Gaudin, Y., and Ruigrok, R.W. 1993. Mechanism of rabies virus neutralization. Virology 194: 302-313.
3. Gaudin, Y., Tuffereau, C., Segretain, D., Knossow, M., and Flamand, A. 1991. Reversible conformational changes and fusion activity of rabies virus glycoprotein. J. Virol. 65: 4853-4859.
4. Hanlon, C.A., DeMattos, C.A., DeMattos, C.C., Niezgoda, M., Hooper, D.C., Koprowski, H., Notkins, A., and Rupprecht, C.E. 2001. Experimental utility of rabies virus-neutralizing human monoclonal antibodies in post-exposure prophylaxis. Vaccine 19: 3834-3842.
5. Irie, T., and Kawai, A. 2002. Studies on the different conditions for rabies virus neutralization by monoclonal antibodies #1-46-12 and #7-1-9. J. Gen. Virol. 83: 3045-3053.
6. Irie, T., Matsuda, Y., Honda, Y., Morimoto, K., and Kawai, A. 2002. Studies on the escape mutants of rabies virus which are resistant to neutralization by a highly conserved conformational epitope-specific monoclonal antibody #1-46-12. Microbiol. Immunol. 46: 449-461.
7. Kawai, A., and Morimoto, K. 1994. Functional aspects of lyssavirus proteins. Curr. Topics Microbiol. Immunol. 187: 27-42.
8. Kawai, A., and Takeuchi, K. 1992. Temperature-sensitivity of the replication of rabies virus (HEP-Flury strain) in BHK-21 cells. I. Alteration of viral RNA synthesis at the elevated temperature. Virology 186: 524-532.
9. Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
10. Lafon, M. 2002. Immunology, p. 354-369. In Jackson, A.C., and Wunner, W.H. (eds), Rabies, Chapter 10, Academic Press, San Diego.
11. Louie, R.E., Dobkin, M.B., Meyer, P., Chin, B., Roby, R.E., Hammer, A.H., and Cabasso, V.J. 1975. Measurement of rabies antibody: comparison of the mouse neutralization test (MNT) with the rapid fluorescent focus inhibition test (RFFIT). J. Biol. Standard. 3: 365-373.
12. Schumacher, C.L., Dietzschold, B., Ertl, H.C., Niu, H.S., Rupprecht, C.E., and Koprowski, H. 1989. Use of mouse anti-rabies monoclonal antibodies in postexposure treatment of rabies. J. Clin. Invest. 83: 971-975.
13. Wunner, W.H. 2002. Rabies virus, p. 23-77. In Jackson, A.C., and Wunner, W.H. (eds), Rabies, Chapter 2, Academic Press, San Diego.
14. Wunner, W.H., Dietzschold, B., Smith, C.L., Lafon, M., and Golub, E. 1985. Antigenic variants of CVS rabies virus with altered glycosylation sites. Virology 140: 1-12.