Electrophilic affibodies forming covalent bonds to protein targets

Journal of Biological Chemistry

Volumn 284, Issue 47, 2009, Pages 32906-32913

  Holm, Lotta ^a   Moody, Paul ^a   Howarth, Mark ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINO ACIDS; ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES; CELL MEMBRANES; CHEMICAL DETECTION; COVALENT BONDS; MAMMALS;

ANTIBODY AFFINITY; ANTIBODY BINDING SITES; BIOLOGY AND MEDICINE; COVALENT BOND FORMATION; CROSS REACTIVITY; OPTIMAL COMBINATION; ORDERS OF MAGNITUDE; PROTEIN DETECTION;

SCAFFOLDS (BIOLOGY);

ACRYLAMIDE; AFFIBODY; CYSTEINE; HISTIDINE; IMMUNOGLOBULIN; LYSINE; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; CELL LYSATE; CELL SURFACE; CONTROLLED STUDY; COVALENT BOND; CROSS REACTION; ELECTROPHILIC STRESS; IMMUNOASSAY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEIN TARGETING; SENSITIVITY ANALYSIS;

MAMMALIA;

EID: 70450231599     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.034322     Document Type: Article

References (47)

1. Parekh, D. J., Ankerst, D. P., Troyer, D., Srivastava, S., and Thompson, I. M. (2007) J. Urol. 178, 2252-2259
2. Georganopoulou, D. G., Chang, L., Nam, J. M., Thaxton, C. S., Mufson, E. J., Klein, W. L., and Mirkin, C. A. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 2273-2276
3. Cheng, M. M., Cuda, G., Bunimovich, Y. L., Gaspari, M., Heath, J. R., Hill, H. D., Mirkin, C. A., Nijdam, A. J., Terracciano, R., Thundat, T., and Ferrari, M. (2006) Curr. Opin. Chem. Biol. 10, 11-19
4. Jackson, T. M., and Ekins, R. P. (1986) J. Immunol. Methods 87, 13-20
5. Zheng, G., Patolsky, F., Cui, Y., Wang, W. U., and Lieber, C. M. (2005) Nat. Biotechnol. 23, 1294-1301
6. Nam, J. M., Stoeva, S. I., and Mirkin, C. A. (2004) J. Am. Chem. Soc. 126, 5932-5933
7. Maynard, J. A., Maassen, C. B., Leppla, S. H., Brasky, K., Patterson, J. L., Iverson, B. L., and Georgiou, G. (2002) Nat. Biotechnol. 20, 597-601
8. Weisman, L. E. (2009) Curr. Opin. Mol. Ther. 11, 208-218
9. Houk, K. N., Leach, A. G., Kim, S. P., and Zhang, X. (2003) Angew. Chem. Int. Ed. Engl. 42, 4872-4897
10. Schwesinger, F., Ros, R., Strunz, T., Anselmetti, D., Güntherodt, H. J., Honegger, A., Jermutus, L., Tiefenauer, L., and Pluckthun, A. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 9972-9977
11. Foote, J., and Eisen, H. N. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1254-1256
12. Griffiths, A. D., and Duncan, A. R. (1998) Curr. Opin. Biotechnol. 9, 102-108
13. Lipovsek, D., and Plückthun, A. (2004) J. Immunol. Methods 290, 51-67
14. Boder, E. T., Midelfort, K. S., and Wittrup, K. D. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 10701-10705
15. Fleet, G. W., Knowles, J. R., and Porter, R. R. (1972) Biochem. J. 128, 499-508
16. Barbas, C. F., 3rd, Heine, A., Zhong, G., Hoffmann, T., Gramatikova, S., Björnestedt, R., List, B., Anderson, J., Stura, E. A., Wilson, I. A., and Lerner, R. A. (1997) Science 278, 2085-2092
17. Chmura, A. J., Orton, M. S., and Meares, C. F. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8480-8484
18. Nishiyama, Y., Mitsuda, Y., Taguchi, H., Planque, S., Salas, M., Hanson, C. V., and Paul, S. (2007) J. Biol. Chem. 282, 31250-31256
19. Trisler, K., Looger, L. L., Sharma, V., Baker, M., Benson, D. E., Trauger, S., Schultz, P. G., and Smider, V. V. (2007) J. Biol. Chem. 282, 26344-26353
20. Orlova, A., Feldwisch, J., Abrahmsén, L., and Tolmachev, V. (2007) Cancer Biother. Radiopharm. 22, 573-584
21. Li, X., and Liu, D. R. (2004) Angew. Chem. Int. Ed. Engl. 43, 4848-4870
22. Levitsky, K., Boersma, M. D., Ciolli, C. J., and Belshaw, P. J. (2005) Chembiochem. 6, 890-899
23. Fry, D. W., Bridges, A. J., Denny, W. A., Doherty, A., Greis, K. D., Hicks, J. L., Hook, K. E., Keller, P. R., Leopold, W. R., Loo, J. A., McNamara, D. J., Nelson, J. M., Sherwood, V., Smaill, J. B., Trumpp-Kallmeyer, S., and Dobrusin, E. M. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 12022-12027
24. Cohen, M. S., Zhang, C., Shokat, K. M., and Taunton, J. (2005) Science 308, 1318-1321
25. Tsukiji, S., Miyagawa, M., Takaoka, Y., Tamura, T., and Hamachi, I. (2009) Nat. Chem. Biol. 5, 341-343
26. Gama, L., and Breitwieser, G. E. (2002) Methods Mol. Biol. 182, 77-83
27. Högbom, M., Eklund, M., Nygren, P. A., and Nordlund, P. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3191-3196
28. Beckett, D., Kovaleva, E., and Schatz, P. J. (1999) Protein Sci. 8, 921-929
29. Platani, M., Goldberg, I., Lamond, A. I., and Swedlow, J. R. (2002) Nat. Cell Biol. 4, 502-508
30. Howarth, M., and Ting, A. Y. (2008) Nat. Protoc. 3, 534-545
31. Ahmed, A. K., Schaffer, S. W., and Wetlaufer, D. B. (1975) J. Biol. Chem. 250, 8477-8482
32. Eklund, M., Axelsson, L., Uhlén, M., and Nygren, P. A. (2002) Proteins 48, 454-462
33. Wahlberg, E., Lendel, C., Helgstrand, M., Allard, P., Dincbas-Renqvist, V., Hedqvist, A., Berglund, H., Nygren, P. A., and Härd, T. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3185-3190
34. LoPachin, R. M., Barber, D. S., and Gavin, T. (2008) Toxicol. Sci. 104, 235-249
35. Hober, S., Nord, K., and Linhult, M. (2007) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 848, 40-47
36. Deisenhofer, J. (1981) Biochemistry 20, 2361-2370
37. Ji, L. L., Katz, A., Fu, R., Griffiths, M., and Spencer, M. (1993) J. Appl. Physiol. 74, 788-792
38. Fukuchi, S., and Nishikawa, K. (2001) J. Mol. Biol. 309, 835-843
39. Schmidt, B., Ho, L., and Hogg, P. J. (2006) Biochemistry 45, 7429-7433
40. Alberini, C. M., Bet, P., Milstein, C., and Sitia, R. (1990) Nature 347, 485-487
41. Allain, J. P. (2003) Transfus. Clin. Biol. 10, 1-5
42. Qiu, J., and Hanash, S. (2009) Clin. Lab. Med. 29, 31-46
43. Jung, Y., Lee, J. M., Kim, J. W., Yoon, J., Cho, H., and Chung, B. H. (2009) Anal. Chem. 81, 936-942
44. Evans, M. J., Saghatelian, A., Sorensen, E. J., and Cravatt, B. F. (2005) Nat. Biotechnol. 23, 1303-1307
45. Way, J. C. (2000) Curr. Opin. Chem. Biol. 4, 40-46
46. Erlanson, D. A., Braisted, A. C., Raphael, D. R., Randal, M., Stroud, R. M., Gordon, E. M., and Wells, J. A. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 9367-9372
47. Lendel, C., Dincbas-Renqvist, V., Flores, A., Wahlberg, E., Dogan, J., Nygren, P. A., and Härd, T. (2004) Protein Sci. 13, 2078-2088