Decrease in FASN expression in adipose tissue of hypertensive individuals

American Journal of Hypertension

Volumn 22, Issue 12, 2009, Pages 1258-1262

  Mayas, María D ^a   Ortega, Francisco J ^a   Gómez Huelgas, Ricardo ^b   Roca, Nuria ^b   Fernández Real, José M ^a   Tinahones, Francisco J ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID SYNTHASE;

ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HYPERTENSION; LAPAROSCOPIC SURGERY; MALE; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE; ADULT; AGED; BLOOD PRESSURE; FATTY ACID SYNTHETASE COMPLEX; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 70450222908     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2009.178     Document Type: Article

References (27)

1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42:1206-1252.
2. Ferrannini E, Natali A, Capaldo B, Lehtovirta M, Jacob S, Yki-Järvinen H. Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). Hypertension 1997; 30:1144-1149.
3. Xu T, Ju Z, Tong W, Hu W, Liu Y, Zhao L, Zhang Y. Relationship of C-reactive protein with hypertension and interactions between increased C-reactive protein and other risk factors on hypertension in Mongolian people, China. Circ J 2008; 72:1324-1328.
4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ; National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289:2560-2572. (Pubitemid 37430158)
5. Katagiri H, Yamada T, Oka Y. Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. Circ Res 2007; 101:27-39.
6. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116:3015-3025.
7. Mobbs CV, Makimura H. Block the FAS, lose the fat. Nat Med 2002; 8:335-336.
8. Semenkovich CF. Regulation of fatty acid synthase (FAS). Prog Lipid Res 1997; 36:43-53.
9. Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab 2002; 282:E46-E51.
10. Wang S, Ma A, Song S, Quan Q, Zhao X, Zheng X. Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. Hypertens Res 2008; 31:623-632.
11. Foy CG, Hsu FC, Haffner SM, Norris JM, Rotter JI, Henkin LF, Bryer-Ash M, Chen YD, Wagenknecht LE. Visceral fat and prevalence of hypertension among African Americans and Hispanic Americans: findings from the IRAS family study. A m J Hypertens 2008; 21:910-916.
12. Berndt J, Kovacs P, Ruschke K, Klöting N, Fasshauer M, Schön MR, Körner A, Stumvoll M, Blüher M. Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. Diabetologia 2007; 50:1472-1480.
13. Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets 2004; 5:241-250.
14. Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89:2595-2600.
15. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med 2007; 356:213-215. Erratum in N Engl J Med 2007; 356:973.
16. Letexier D, Pinteur C, Large V, Fréring V, Beylot M. Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue. J Lipid Res 2003; 44:2127-2134.
17. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda F P. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288:2379-2381.
18. Medina-Gomez G, Gray S, Vidal-Puig A. Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgammacoactivator-1 (PGC1). Public Health Nutr 2007; 10:1132-1137.
19. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002; 45: 1201-1210.
20. Pausova Z. From big fat cells to high blood pressure: a pathway to obesity-associated hypertension. Curr Opin Nephrol Hypertens 2006; 15:173-178.
21. Skurk T, Alberti-Huber C, Herder C, Hauner H. Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 2007; 92:1023-1033.
22. Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, García-Almeida JM, García-Serrano S, García-Arnés J, García-Fuentes E. Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity (Silver Spring) 2009; 17:240-246.
23. Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, Soos MA, Maslen GL, Williams TD, Lewis H, Schafer AJ, Chatterjee VK, O'Rahilly S. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 1999; 402:880-883.
24. López M, Lelliott CJ, Vidal-Puig A. Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. Bioessays 2007; 29:248-261.
25. Ussher JR, Lopaschuk GD. The malonyl CoA axis as a potential target for treating ischaemic heart disease. Cardiovasc Res 2008; 79:259-268.
26. Cuthbert KD, Dyck JR. Malonyl-CoA decarboxylase is a major regulator of myocardial fatty acid oxidation. Curr Hypertens Rep 2005; 7:407-411.
27. Tanner HA. Bioenergetics in the pathogenesis, progression and treatment of cardiovascular disorders. Med Hypotheses 1995; 44:347-358.