Analgesic, anticonvulsant and anti-inflammatory activities of some synthesized benzodiazipine, triazolopyrimidine and bis-imide derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 4787-4792

  Said, Said A ^a   Amr, Abd El Galil E ^b   Sabry, Nermien M ^b   Abdalla, Mohamed M ^c  

^a ZAGAZIG UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c Univet Pharmaceutical Co   (Egypt)

Author keywords

4 Phenyl but 3 en 2 one; Pharmacological screening; Triazolopyrimidines derivatives

Indexed keywords

2 (6 METHYL 4 PHENYL 1,4 DIHYDRO PYRIMIDIN 2 YLAMINO) BENZO[DE]ISOQUINOLINE 1,3 DIONE; 2,6 BIS (6 METHYL 4 PHENYL 1,4 DIHYDRO PYRIMIDIN 2 YLAMINO)PYRROLO[3,4-F]ISOINDOLE 1,3,5,7 TETRAONE; 3,6 DIMETHYL 1,4 DIPHENYL 4,5 DIHYDRO 1H INDAZOLE; 4 METHYL 2 OXO 6 PHENYL CYCLOHEX 3 ENECARBOXYLIC ACID ETHYL ESTER; 5 METHYL 7 PHENYL 7,8 DIHYDRO 2H [1,2,4]TRIAZOLO[4,3-A]PYRIMIDINE 3 THIONE; 6 METHYL 1 MORPHOLIN 4 YLMETHYL 4 PHENYL 3,4 DIHYDRO 1H PYRIMIDINE 2 THIONE; 6 METHYL 1,4 DIPHENYL 1,2,4,5 TETRAHYDRO INDAZOL 3 ONE; 7 METHYL 5 PHENYL 2 THIOXO 2,4A,5,6 TETRAHYDRO 3H QUINAZOLIN 4 ONE; 7 METHYL 5 PHENYL 4,5 DIHYDRO [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; IMIDE; PREDENSILONE; PREDNISOLONE; PROSTAGLANDIN E2; PYRIMIDINE DERIVATIVE; THIOXOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VALDECOXIB;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; LD 50; MOUSE; NONHUMAN; RAT; SPECTROSCOPY;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICONVULSANTS; AZO COMPOUNDS; DRUG DESIGN; FEMALE; IMIDES; ISOXAZOLES; LETHAL DOSE 50; MALE; MASS SPECTROMETRY; MICE; MOLECULAR STRUCTURE; PREDNISONE; PYRIMIDINES; RATS; SULFONAMIDES;

EID: 70450222126     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.07.013     Document Type: Article

References (36)

1. Amr A.E., Nehad A.A., and Abdalla M.M. Bioorg. Med. Chem. 14 (2006) 373-380
2. Amr A.E., and Abdalla M.M. Bioorg. Med. Chem. 14 (2006) 4341-4352
3. Amr A.E., Nermien M.S., Abdalla M.M., and Bakr F.A. Eur. J. Med. Chem. 44 (2009) 725-735
4. Amr A.E., Korany A.A., and Abdalla M.M. Eur. J. Med. Chem. 44 (2009) 901-909
5. Amr A.E., Abo-Ghalia M.H., and Abdalla M.M. Arch. Pharm. Chem. Life Sci. 340 (2007) 304-309
6. Issa M.F., Amr A.E., Nermien M.S., and Abdalla M.M. Arch. Pharm. Chem. Life Sci. 341 (2008) 174-180
7. El-Farargy A.F., Hamad M.M., Said S.A., Ahmed A.F.S., and El-Gendy G.M. Pak. J. Sci. Ind. Res. 35 (1992) 19-28
8. Hamad M.M., Said S.A., and El-Ekyabi Y.M. Monatsh. Chem. 127 (1996) 549-555
9. Clark J., Shohhet M.S., Korakas D., and Varvounis G. J. Heterocycl. Chem. 30 (1993) 1065-1072
10. Kogowwra I.Y., Yimatsusita N.N., and Pfkador J.K. Eur. J. Med. Chem. 28 (1993) 769-781
11. Tozkoparan B., Ertan M., Kelicen P., and Demirdamar R. Farmaco 54 (1999) 588-593
12. Quiroga J., Insuasty B., Craz S., Herrandez P., Bolafios A., Moreno R., Hormoza A., and De Almeidas R.H. J. Heterocycl. Chem. 35 (1998) 1333-1338
13. Santagati M., Modica M., Santagati A., Russo F., and Spampinato S. Pharmazie 51 (1996) 7-15
14. Ahluwalia V.K., Chopra M., and Chandra R. J. Chem. Res (s) (2000) 162-163
15. Nargund L.V.G., Badiger V.V., and Yarnal S.U. Eur. J. Med. Chem. 29 (1994) 245-247
16. Vanlaar M., Volerts E., and Verbaten M. Psychopharmacology 154 (2001) 189-197
17. Danel K., Pedersen E.B., and Nielsen C. J. Med. Chem. 41 (1998) 191-198
18. Nehad A.A., Nermien M.S., Ashraf M.M., and Abdulla M.M. Monatsh. Chem. 138 (2007) 715-721
19. Ahmed F.A.S., Abdulla M.M., Amr A.E., and Azza A.H. Monatsh. Chem. 138 (2007) 1019-1027
20. Hammam A.G., Fahmy A.F.M., Amr A.E., and Mohamed A.M. Indian J. Chem. 42B (2003) 1985-1993
21. Amr A.E., Hegab M.I., Ibrahim A.A., and Abdalah M.M. Monatsh. Chem. 134 (2003) 1395-1409
22. Amr A.E., and Abdulla M.M. Indian J. Heterocycl. Chem. 12 (2002) 129-134
23. Nehad A.A., Amr A.E., and Alhusien A.I. Monatsh. Chem. 138 (2007) 559-567
24. Amr A.E., Nermien M.S., and Abdulla M.M. Monatsh. Chem. 138 (2007) 699-707
25. Amr A.E., Ashraf M.M., Salwa F.M., Nagla A.A., and Hammam A.G. Bioorg. Med. Chem. 14 (2006) 5481-5488
26. Amr A.E., Sayed H.H., and Abdulla M.M. Arch. Pharm. Chem. Life Sci. 338 (2005) 433-440
27. Nehad A.A. Scientia Pharm. 74 (2005) 193-216
28. Sammour M.A., and Soliman S. U.A.R.J. Chem. 13 (1970) 7-24
29. Rashad A.E., Heikal O.A., El-Nezhawy A.O.H., and Abdel-Megeid F.M.E. Heteroatom Chem. 16 (2005) 226-234
30. Mudaliar C.D., Nivalkar K.R., and Mashraqui S.H. Org. Prep. Proc. Int. 29 (1997) 584-587
31. Litchfield J., and Wilcoxon F.J. Pharmacol. Exp. Ther. 96 (1949) 99-113
32. Winter C.A., Risely E.A., and Nuss G.W. Proc. Soc. Exp. Bio. Med. 111 (1962) 541-545
33. Herrmann F., Lindemann A., Gamss J., and Mertelsmann R. Eur. J. Immunol. 20 (1999) 2513-2517
34. Austen K.F., and Brocklehurst W.E. J. Exp. Med. 113 (1961) 521-525
35. Tgolsen A., Rofland G.H., Berge O.G., and Hole K. J. Pharmacol. Exp. Ther. 25 (1991) 241-250
36. Dunm R., and Fielding S. Drug Dev. Res. 10 (1987) 177-188