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Volumn 10, Issue 10, 2009, Pages 906-922

First-line treatment of multiple myeloma in elderly patients: The GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) multiple myeloma working party perspective

Author keywords

Autologous transplantation; Bendamustine; Bortezomib; Cyclophosphamide; Dexamethasone; Doxorubicin; Elderly; Lenalidomide; Myeloma; Reduced intensity allogeneic transplantation; Thalidomide

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA2B INTERFERON; BENDAMUSTINE; BETA 2 MICROGLOBULIN; BORTEZOMIB; CARMUSTINE; CLARITHROMYCIN; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; ENOXAPARIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LENALIDOMIDE; MELPHALAN; PAMIDRONIC ACID; PLACEBO; PREDNISONE; RECOMBINANT ALPHA2 INTERFERON; THALIDOMIDE; VINCRISTINE; ZOLEDRONIC ACID;

EID: 70450209034     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945009789577936     Document Type: Review
Times cited : (6)

References (114)
  • 1
    • 7944239595 scopus 로고    scopus 로고
    • A population study to define the incidence and survival of multiple myeloma in a National Health Service Region in UK
    • DOI 10.1111/j.1365-2141.2004.05207.x
    • Phekoo KJ, Schey SA, Richards MA, Bevan DH, Bell S, Gillett D, et al. A population study to define the incidence and survival of multiple myeloma in a National Health Service Region in UK. Br J Haematol 2004; 127: 299-330 (Pubitemid 39468943)
    • (2004) British Journal of Haematology , vol.127 , Issue.3 , pp. 299-304
    • Phekoo, K.J.1    Schey, S.A.2    Richards, M.A.3    Bevan, D.H.4    Bell, S.5    Gillett, D.6    Moller, H.7
  • 3
    • 16544371710 scopus 로고    scopus 로고
    • Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration
    • DOI 10.1200/JCO.2004.02.175
    • Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 2004; 22: 4626-4631 (Pubitemid 41185131)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.22 , pp. 4626-4631
    • Talarico, L.1    Chen, G.2    Pazdur, R.3
  • 4
    • 43249125513 scopus 로고    scopus 로고
    • Myeloma in patients younger than age 50 years presents with more favourable features and shows better survival: An analysis of 10 549 patients from the International Myeloma Working Group
    • Ludwig H, Durie BG, Bolejack V, Turesson I, Kyle RA, Blade J. Myeloma in patients younger than age 50 years presents with more favourable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group. Blood 2008; 111: 4039-4047
    • (2008) Blood , vol.111 , pp. 4039-4047
    • Ludwig, H.1    Durie, B.G.2    Bolejack, V.3    Turesson, I.4    Kyle, R.A.5    Blade, J.6
  • 5
    • 41949114641 scopus 로고    scopus 로고
    • Recent major improvement in long-term survival of younger patients with multiple myeloma
    • Brenner H, Gondos A, Pulte D. Recent major improvement in long-term survival of younger patients with multiple myeloma. Blood 2008; 111: 2521-2526
    • (2008) Blood , vol.111 , pp. 2521-2526
    • Brenner, H.1    Gondos, A.2    Pulte, D.3
  • 9
    • 1842782762 scopus 로고    scopus 로고
    • Lymphoma and myeloma in older patients
    • Westin EH, Longo DL. Lymphoma and myeloma in older patients. Semin Oncol 2004; 31: 198-205.
    • (2004) Semin Oncol , vol.31 , pp. 198-205
    • Westin, E.H.1    Longo, D.L.2
  • 10
    • 34648864233 scopus 로고    scopus 로고
    • Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients
    • DOI 10.1007/s00432-007-0233-x
    • Wedding U, Rohrig B, Klippstein A, Pientka L, Hoffken K. Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients. J Cancer Res Clin Oncol 2007; 133: 945-950 (Pubitemid 47561710)
    • (2007) Journal of Cancer Research and Clinical Oncology , vol.133 , Issue.12 , pp. 945-950
    • Wedding, U.1    Rohrig, B.2    Klippstein, A.3    Pientka, L.4    Hoffken, K.5
  • 11
    • 22144472629 scopus 로고    scopus 로고
    • The adverse prognostic impact of advanced age in multiple myeloma
    • DOI 10.1080/10428190500085024
    • Mileshkin L, Prince HM. The adverse prognostic impact of advanced age in multiple myeloma. Leuk Lymphoma 2005; 46: 951-966 (Pubitemid 40975015)
    • (2005) Leukemia and Lymphoma , vol.46 , Issue.7 , pp. 951-966
    • Mileshkin, L.1    Prince, H.M.2
  • 13
    • 33947654352 scopus 로고    scopus 로고
    • The treatment of the elderly multiple myeloma patients
    • DOI 10.1080/10428190601059852, PII 773541544
    • Cavallo F, Ambrosini MT, Rus C, Boccadoro M, Palumbo A. The treatment of the elderly multiple myeloma patients. Leuk Lymphoma 2007; 48: 469-480 (Pubitemid 46487753)
    • (2007) Leukemia and Lymphoma , vol.48 , Issue.3 , pp. 469-480
    • Cavallo, F.1    Ambrosini, M.T.2    Rus, C.3    Boccadoro, M.4    Palumbo, A.5
  • 14
    • 55749114563 scopus 로고    scopus 로고
    • Advances in therapy of multiple myeloma
    • Bladé J, Rosiñol L. Advances in therapy of multiple myeloma. Curr Opin Oncol 2008; 20: 697-704.
    • (2008) Curr Opin Oncol , vol.20 , pp. 697-704
    • Bladé, J.1    Rosiñol, L.2
  • 15
    • 62549132481 scopus 로고    scopus 로고
    • Treatment of newly diagnosed myeloma
    • Palumbo A, Rajkumar SV. Treatment of newly diagnosed myeloma. Leukemia 2009; 23: 449-456
    • (2009) Leukemia , vol.23 , pp. 449-456
    • Palumbo, A.1    Rajkumar, S.V.2
  • 17
    • 54049131660 scopus 로고    scopus 로고
    • Frontline treatment of multiple myeloma in elderly patients
    • Moreau P, Hulin C, Facon T. Frontline treatment of multiple myeloma in elderly patients. Blood Rev 2008; 22: 303-309
    • (2008) Blood Rev , vol.22 , pp. 303-309
    • Moreau, P.1    Hulin, C.2    Facon, T.3
  • 18
    • 45249113030 scopus 로고    scopus 로고
    • Task Force Geriatrische Onkologie of the DGHO, OGHO, DGG and AIO. Modern treatment options for elderly patients with multiple myeloma
    • Görner M, Späth-Schwalbe E. Task Force Geriatrische Onkologie of the DGHO, OGHO, DGG and AIO. Modern treatment options for elderly patients with multiple myeloma. Onkologie 2008; 31: 335-342
    • (2008) Onkologie , vol.31 , pp. 335-342
    • Görner, M.1    Späth-Schwalbe, E.2
  • 19
    • 46449135732 scopus 로고    scopus 로고
    • Recent phase III trials in the frontline treatment of multiple myeloma: Evaluating their impact on community practice
    • San Miguel JF, Facon T, Cavo M. Recent phase III trials in the frontline treatment of multiple myeloma: evaluating their impact on community practice. Clin Adv Hematol Oncol 2008; 6 (4 Suppl 10): 1-12.
    • (2008) Clin Adv Hematol Oncol , vol.6 , Issue.4 SUPPL. 10 , pp. 1-12
    • San Miguel, J.F.1    Facon, T.2    Cavo, M.3
  • 20
    • 0038509089 scopus 로고    scopus 로고
    • Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group
    • International Myeloma Working Group
    • International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003; 121: 749-757
    • (2003) Br J Haematol , vol.121 , pp. 749-757
  • 23
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol 2003; 21: 16-19.
    • (2003) J Clin Oncol , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3    Delasalle, K.4    Alexanian, R.5
  • 25
    • 54049130077 scopus 로고    scopus 로고
    • Seven-year median time to progression with thalidomide for smoldering myeloma: Partial response identifies subset requiring earlier salvage therapy for symptomatic disease
    • Barlogie B, van Rhee F, Shaughnessy JD Jr, Epstein J, Yaccoby S, Pineda-Roman M, et al. Seven-year median time to progression with thalidomide for smoldering myeloma: partial response identifies subset requiring earlier salvage therapy for symptomatic disease. Blood 2008; 112: 3122-3125
    • (2008) Blood , vol.112 , pp. 3122-3125
    • Barlogie, B.1    Van Rhee, F.2    Shaughnessy Jr., J.D.3    Epstein, J.4    Yaccoby, S.5    Pineda-Roman, M.6
  • 27
    • 54049124120 scopus 로고    scopus 로고
    • A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma
    • GIMEMA (Italian Group for Adult Hematologic Diseases)/Multiple Myeloma Working Party and the Italian Myeloma Network
    • Musto P, Petrucci MT, Bringhen S, Guglielmelli T, Caravita T, Bongarzoni V, et al. GIMEMA (Italian Group for Adult Hematologic Diseases)/Multiple Myeloma Working Party and the Italian Myeloma Network. A multicenter, randomized clinical trial comparing zoledronic acid versus observation in patients with asymptomatic myeloma. Cancer 2008; 113: 1588-1595
    • (2008) Cancer , vol.113 , pp. 1588-1595
    • Musto, P.1    Petrucci, M.T.2    Bringhen, S.3    Guglielmelli, T.4    Caravita, T.5    Bongarzoni, V.6
  • 28
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma
    • Kyle RA, Yee GC, Somerfield MR, Flynn PJ, Halabi S, Jagannath S, et al. American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. J Clin Oncol 2007; 25: 2464-2472
    • (2007) J Clin Oncol , vol.25 , pp. 2464-2472
    • Kyle, R.A.1    Yee, G.C.2    Somerfield, M.R.3    Flynn, P.J.4    Halabi, S.5    Jagannath, S.6
  • 29
    • 34548564435 scopus 로고    scopus 로고
    • Melphalan: Old and new uses of a still master drug for multiple myeloma
    • Musto P, D'Auria F. Melphalan: old and new uses of a still master drug for multiple myeloma. Exp Opin Invest Drugs 2007; 25: 4459-4465
    • (2007) Exp Opin Invest Drugs , vol.25 , pp. 4459-4465
    • Musto, P.1    D'Auria, F.2
  • 33
    • 0026585927 scopus 로고
    • Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: An overview of published trials
    • Gregory WM, Richards MA, Malpas JS. Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials. J Clin Oncol 1992; 10: 334-342
    • (1992) J Clin Oncol , vol.10 , pp. 334-342
    • Gregory, W.M.1    Richards, M.A.2    Malpas, J.S.3
  • 34
    • 0344076348 scopus 로고    scopus 로고
    • Combination chemotherapy versus melphalan and prednisone as treatment of multiple myeloma: An overview of 6,633 patients from 27 randomized trials
    • Myeloma Trialists' Collaborative Group
    • Myeloma Trialists' Collaborative Group. Combination chemotherapy versus melphalan and prednisone as treatment of multiple myeloma: an overview of 6,633 patients from 27 randomized trials. J Clin Oncol 1998; 16: 3832-3842
    • (1998) J Clin Oncol , vol.16 , pp. 3832-3842
  • 35
    • 33646339149 scopus 로고    scopus 로고
    • Complete response in multiple myeloma: Clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation
    • DOI 10.1002/cncr.21804
    • Kyle RA, Leong T, Li S, Oken MM, Kay NE, Van Ness B, et al. Complete response in multiple myeloma: clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation. Cancer 2006; 106: 1958-1966 (Pubitemid 43673211)
    • (2006) Cancer , vol.106 , Issue.9 , pp. 1958-1966
    • Kyle, R.A.1    Leong, T.2    Li, S.3    Oken, M.H.4    Kay, N.E.5    Van Ness, B.6    Greipp, P.R.7
  • 38
    • 43249097561 scopus 로고    scopus 로고
    • Thalidomide for treatment of multiple myeloma: 10 years later
    • Palumbo A, Facon T, Sonneveld P, Bladè J, Offidani M, Gay F, et al. Thalidomide for treatment of multiple myeloma: 10 years later. Blood 2008; 111: 3968-3977
    • (2008) Blood , vol.111 , pp. 3968-3977
    • Palumbo, A.1    Facon, T.2    Sonneveld, P.3    Bladè, J.4    Offidani, M.5    Gay, F.6
  • 40
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J Clin Oncol 2003; 21: 16-19.
    • (2003) J Clin Oncol , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3    Delasalle, K.4    Alexanian, R.5
  • 42
    • 33644831033 scopus 로고    scopus 로고
    • Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the eastern cooperative oncology group
    • DOI 10.1200/JCO.2005.03.0221
    • Rajkumar SV, Blood E, Vesole D, Fonseca R, Greipp PR. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006; 24: 431-436 (Pubitemid 46630462)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.3 , pp. 431-436
    • Rajkumar, S.V.1    Blood, E.2    Vesole, D.3    Fonseca, R.4    Greipp, P.R.5
  • 43
    • 43749117945 scopus 로고    scopus 로고
    • Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma
    • Rajkumar SV, Rosiñol L, Hussein M, Catalano J, Jedrzejczak W, Lucy L, et al. Multicenter, randomized, double-blind, placebo-controlled study of thalidomide plus dexamethasone compared with dexamethasone as initial therapy for newly diagnosed multiple myeloma. J Clin Oncol 2008; 26: 2171-2177
    • (2008) J Clin Oncol , vol.26 , pp. 2171-2177
    • Rajkumar, S.V.1    Rosiñol, L.2    Hussein, M.3    Catalano, J.4    Jedrzejczak, W.5    Lucy, L.6
  • 44
    • 65349142006 scopus 로고    scopus 로고
    • Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma
    • Ludwig H, Hajek R, Tothova E, Drach J, Adam Z, Labar B, et al. Thalidomide-dexamethasone compared to melphalan-prednisolone in elderly patients with multiple myeloma. Blood 2009; 113: 3435-3442
    • (2009) Blood , vol.113 , pp. 3435-3442
    • Ludwig, H.1    Hajek, R.2    Tothova, E.3    Drach, J.4    Adam, Z.5    Labar, B.6
  • 46
    • 46749133562 scopus 로고    scopus 로고
    • A meta-analysis and systematic review of thalidomide for patients with previously untreated multiple myeloma
    • Hicks LK, Haynes AE, Reece DE, Walker IR, Herst JA, Meyer RM, et al. A meta-analysis and systematic review of thalidomide for patients with previously untreated multiple myeloma. Cancer Treat Rev 2008; 34: 442-452
    • (2008) Cancer Treat Rev , vol.34 , pp. 442-452
    • Hicks, L.K.1    Haynes, A.E.2    Reece, D.E.3    Walker, I.R.4    Herst, J.A.5    Meyer, R.M.6
  • 49
    • 54049135250 scopus 로고    scopus 로고
    • Oral melphalan, prednisone and thalidomide in elderly patients with multiple myeloma: Updated results of a randomised controlled trial
    • Palumbo A, Bringhen S, Liberati AM, Caravita T, Falcone A, Callea V, et al. Oral melphalan, prednisone and thalidomide in elderly patients with multiple myeloma: updated results of a randomised controlled trial. Blood 2008; 112: 3107-3114
    • (2008) Blood , vol.112 , pp. 3107-3114
    • Palumbo, A.1    Bringhen, S.2    Liberati, A.M.3    Caravita, T.4    Falcone, A.5    Callea, V.6
  • 51
    • 68949137225 scopus 로고    scopus 로고
    • Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 Trial
    • May 18. [Epub ahead of print]
    • Hulin C, Facon T, Rodon P, Pegourie B, Benboubker L, Doyen C, et al. Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 Trial. J Clin Oncol 2009 May 18. [Epub ahead of print]
    • (2009) J Clin Oncol
    • Hulin, C.1    Facon, T.2    Rodon, P.3    Pegourie, B.4    Benboubker, L.5    Doyen, C.6
  • 55
    • 42149176608 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Updated time-to-events results and prognostic factors for time to progression
    • Mateos MV, Hernández JM, Hernández MT, Gutiérrez NC, Palomera L, Fuertes M, et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: updated time-to-events results and prognostic factors for time to progression. Haematologica 2008; 93: 560-565
    • (2008) Haematologica , vol.93 , pp. 560-565
    • Mateos, M.V.1    Hernández, J.M.2    Hernández, M.T.3    Gutiérrez, N.C.4    Palomera, L.5    Fuertes, M.6
  • 56
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • VISTA Trial Investigators
    • San Miguel JF, Schlag R, Khuageva NK, Dimopoulos MA, Shpilberg O, Kropff M, et al. VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008; 359: 964-966
    • (2008) N Engl J Med , vol.359 , pp. 964-966
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3    Dimopoulos, M.A.4    Shpilberg, O.5    Kropff, M.6
  • 58
    • 47649104483 scopus 로고    scopus 로고
    • Treatment of plasma cell dyscrasias with lenalidomide
    • Dimopoulos MA, Kastritis E, Rajkumar SV. Treatment of plasma cell dyscrasias with lenalidomide. Leukemia 2008; 22: 1343-1353
    • (2008) Leukemia , vol.22 , pp. 1343-1353
    • Dimopoulos, M.A.1    Kastritis, E.2    Rajkumar, S.V.3
  • 60
    • 67650657867 scopus 로고    scopus 로고
    • Melphalan, Prednisone, and Lenalidomide for newly diagnosed myeloma: Kinetics of neutropenia and thrombocytopenia and time-to-event results
    • Palumbo A, Falco P, Falcone A, Benevolo G, Canepa L, Gay F, et al. Melphalan, Prednisone, and Lenalidomide for newly diagnosed myeloma: kinetics of neutropenia and thrombocytopenia and time-to-event results. Clin Lymphoma Myeloma 2009; 9: 145-150
    • (2009) Clin Lymphoma Myeloma , vol.9 , pp. 145-150
    • Palumbo, A.1    Falco, P.2    Falcone, A.3    Benevolo, G.4    Canepa, L.5    Gay, F.6
  • 63
    • 70149107680 scopus 로고    scopus 로고
    • Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone
    • Mar 26. [Epub ahead of print]
    • Kapoor P, Kumar S, Fonseca R, Lacy MQ, Witzig TE, Hayman SR, et al. Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone. Blood. 2009 Mar 26. [Epub ahead of print]
    • (2009) Blood
    • Kapoor, P.1    Kumar, S.2    Fonseca, R.3    Lacy, M.Q.4    Witzig, T.E.5    Hayman, S.R.6
  • 65
    • 62649122863 scopus 로고    scopus 로고
    • Role of autologous and allogeneic stem cell transplantation in myeloma
    • Bensinger WI. Role of autologous and allogeneic stem cell transplantation in myeloma. Leukemia 2009; 23: 442-448
    • (2009) Leukemia , vol.23 , pp. 442-448
    • Bensinger, W.I.1
  • 67
    • 33751025485 scopus 로고    scopus 로고
    • Autologous stem cell transplantation beyond 60 years of age
    • DOI 10.1038/sj.bmt.1705514, PII 1705514
    • Jantunen E. Autologous stem cell transplantation beyond 60 years of age. Bone Marrow Transplant 2006; 38: 715-720. (Pubitemid 44756440)
    • (2006) Bone Marrow Transplantation , vol.38 , Issue.11 , pp. 715-720
    • Jantunen, E.1
  • 68
    • 34248390575 scopus 로고    scopus 로고
    • Impact of age and serum creatinine value on outcome after autologous blood stem cell transplantation for patients with multiple myeloma
    • DOI 10.1038/sj.bmt.1705627, PII 1705627
    • Gertz MA, Lacy MQ, Dispenzieri A, Hayman SR, Kumar S, Leung N, et al. Impact of age and serum creatinine value on outcome after autologous blood stem cell transplantation for patients with multiple myeloma. Bone Marrow Transplant 2007; 39: 605-611 (Pubitemid 46729052)
    • (2007) Bone Marrow Transplantation , vol.39 , Issue.10 , pp. 605-611
    • Gertz, M.A.1    Lacy, M.Q.2    Dispenzieri, A.3    Hayman, S.R.4    Kumar, S.5    Leung, N.6    Gastineau, D.A.7
  • 71
    • 33646913813 scopus 로고    scopus 로고
    • 2) supported by autologous stem cell transplantation is safe and effective in elderly (>or=65 years) myeloma patients: Comparison with younger patients treated on the same protocol
    • DOI 10.1038/sj.bmt.1705360, PII 1705360
    • Jantunen E, Kuittinen T, Penttila K, Lehtonen P, Mahlamaki E, Nousiainen T. High-dose melphalan (200 mg/m2) supported by autologous stem cell transplantation is safe and effective in elderly (>or=65 years) myeloma patients: comparison with younger patients treated on the same protocol. Bone Marrow Transplant 2006; 37: 917-922 (Pubitemid 43792551)
    • (2006) Bone Marrow Transplantation , vol.37 , Issue.10 , pp. 917-922
    • Jantunen, E.1    Kuittinen, T.2    Penttila, K.3    Lehtonen, P.4    Mahlamaki, E.5    Nousiainen, T.6
  • 72
    • 34249879284 scopus 로고    scopus 로고
    • High dose melphalan or intermediate dose melphalan can be well tolerated and result in good response rates in selected elderly patients with myeloma
    • DOI 10.1016/j.leukres.2006.12.022, PII S0145212607000136
    • Bishton M, Gilyead M, Das Gupta E, Williams C, Russell NH, Byrne JL. High dose melphalan or intermediate dose melphalan can be well tolerated and result in good response rates in selected elderly patients with myeloma. Leuk Res 2007; 31: 1071-1076 (Pubitemid 46873732)
    • (2007) Leukemia Research , vol.31 , Issue.8 , pp. 1071-1076
    • Bishton, M.1    Gilyead, M.2    Das Gupta, E.3    Williams, C.4    Russell, N.H.5    Byrne, J.L.6
  • 74
    • 49149101596 scopus 로고    scopus 로고
    • Autologous stem cell transplantation in patients of 70 years and older with multiple myeloma: Results from a matched pair analysis
    • Kumar SK, Dingli D, Lacy MQ, Dispenzieri A, Hayman SR, Buadi FK, et al. Autologous stem cell transplantation in patients of 70 years and older with multiple myeloma: Results from a matched pair analysis. Am J Hematol 2008; 83: 614-617
    • (2008) Am J Hematol , vol.83 , pp. 614-617
    • Kumar, S.K.1    Dingli, D.2    Lacy, M.Q.3    Dispenzieri, A.4    Hayman, S.R.5    Buadi, F.K.6
  • 78
    • 59049091158 scopus 로고    scopus 로고
    • Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: A systematic review and meta-analysis
    • Kumar A, Kharfan-Dabaja MA, Glasmacher A, Djulbegovic B. Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis. J Natl Cancer Inst 2009; 101: 100-106
    • (2009) J Natl Cancer Inst , vol.101 , pp. 100-106
    • Kumar, A.1    Kharfan-Dabaja, M.A.2    Glasmacher, A.3    Djulbegovic, B.4
  • 79
    • 50849106088 scopus 로고    scopus 로고
    • Allogeneic transplantation in multiple myeloma
    • Gahrton G, Björkstrand B. Allogeneic transplantation in multiple myeloma. Haematologica 2008; 93: 1295-1300
    • (2008) Haematologica , vol.93 , pp. 1295-1300
    • Gahrton, G.1    Björkstrand, B.2
  • 83
    • 55749099328 scopus 로고    scopus 로고
    • A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma
    • Rosiñol L, Pérez-Simón JA, Sureda A, de la Rubia J, de Arriba F, Lahuerta JJ, et al. A prospective PETHEMA study of tandem autologous transplantation versus autograft followed by reduced-intensity conditioning allogeneic transplantation in newly diagnosed multiple myeloma. Blood 2008; 112: 3591-3593
    • (2008) Blood , vol.112 , pp. 3591-3593
    • Rosiñol, L.1    Pérez-Simón, J.A.2    Sureda, A.3    De La Rubia, J.4    De Arriba, F.5    Lahuerta, J.J.6
  • 84
    • 33646401089 scopus 로고    scopus 로고
    • Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma
    • Garban F, Attal M, Michallet M, Hulin C, Bourhis JH, Yakoub-Agha I, et al. Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma. Blood 2006; 107: 3474-3480
    • (2006) Blood , vol.107 , pp. 3474-3480
    • Garban, F.1    Attal, M.2    Michallet, M.3    Hulin, C.4    Bourhis, J.H.5    Yakoub-Agha, I.6
  • 85
    • 65149104407 scopus 로고    scopus 로고
    • Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting
    • Rotta M, Storer BE, Sahebi F, Shizuru JA, Bruno B, Lange T, et al. Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting. Blood 2009; 113: 3383-3391
    • (2009) Blood , vol.113 , pp. 3383-3391
    • Rotta, M.1    Storer, B.E.2    Sahebi, F.3    Shizuru, J.A.4    Bruno, B.5    Lange, T.6
  • 86
    • 55749090051 scopus 로고    scopus 로고
    • Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing non-myeloablative allotransplantation with autologous transplantation in high-risk de novo mult myeloma
    • Moreau P, Garban F, Attal M, Michallet M, Marit G, Hulin C, et al. Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing non-myeloablative allotransplantation with autologous transplantation in high-risk de novo mult myeloma. Blood 2008; 112: 3914-3915
    • (2008) Blood , vol.112 , pp. 3914-3915
    • Moreau, P.1    Garban, F.2    Attal, M.3    Michallet, M.4    Marit, G.5    Hulin, C.6
  • 88
    • 0034933036 scopus 로고    scopus 로고
    • Interferon as therapy for multiple myeloma: An individual patient data overview of 24 randomized trials and 4012 patients
    • The Myeloma Trialists' Collaborative Group
    • The Myeloma Trialists' Collaborative Group. Interferon as therapy for multiple myeloma: an individual patient data overview of 24 randomized trials and 4012 patients. Br J Haematol 2001; 113: 1020-1034
    • (2001) Br J Haematol , vol.113 , pp. 1020-1034
  • 89
    • 0033637036 scopus 로고    scopus 로고
    • Interferon-alpha treatment in multiple myeloma: Meta-analysis of 30 randomized trials among 3948 patients
    • Fritz E, Ludwig H. Interferon-alpha treatment in multiple myeloma: meta-analysis of 30 randomized trials among 3948 patients. Ann Oncol 2000; 11: 1427-1436
    • (2000) Ann Oncol , vol.11 , pp. 1427-1436
    • Fritz, E.1    Ludwig, H.2
  • 90
    • 33646591114 scopus 로고    scopus 로고
    • A randomized trial of maintenance therapy with intron a following high dose melphalan and ABMT in myeloma
    • Cunningham D, Powles R, Malpas J, Raje N, Milan S, Viner C, et al. A randomized trial of maintenance therapy with intron A following high dose melphalan and ABMT in myeloma. Br J Haematol 1998; 102: 195-202.
    • (1998) Br J Haematol , vol.102 , pp. 195-202
    • Cunningham, D.1    Powles, R.2    Malpas, J.3    Raje, N.4    Milan, S.5    Viner, C.6
  • 93
    • 33751164196 scopus 로고    scopus 로고
    • Maintenance therapy with thalidomide improves survival in multiple myeloma patients
    • Attal M, Harousseau JL, Leyvraz S, Doyen C, Hulin C, Benboubker L, et al. Maintenance therapy with thalidomide improves survival in multiple myeloma patients. Blood 2006; 15: 3289-3294
    • (2006) Blood , vol.15 , pp. 3289-3294
    • Attal, M.1    Harousseau, J.L.2    Leyvraz, S.3    Doyen, C.4    Hulin, C.5    Benboubker, L.6
  • 94
    • 41349095233 scopus 로고    scopus 로고
    • Single autologous stem cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: Results of a multicenter randomized clinical trial
    • Abdelkefi A, Ladeb S, Torjman L, Othman TB, Lakhal A, Romdhane NB, et al. Single autologous stem cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a multicenter randomized clinical trial. Blood 2008; 111: 1805-1810
    • (2008) Blood , vol.111 , pp. 1805-1810
    • Abdelkefi, A.1    Ladeb, S.2    Torjman, L.3    Othman, T.B.4    Lakhal, A.5    Romdhane, N.B.6
  • 95
    • 64649083365 scopus 로고    scopus 로고
    • Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure
    • Spencer A, Prince HM, Roberts AW, Prosser IW, Bradstock KF, Coyle L, et al. Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure. J Clin Oncol 2009; 27: 1788-1793
    • (2009) J Clin Oncol , vol.27 , pp. 1788-1793
    • Spencer, A.1    Prince, H.M.2    Roberts, A.W.3    Prosser, I.W.4    Bradstock, K.F.5    Coyle, L.6
  • 96
    • 34648864233 scopus 로고    scopus 로고
    • Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients
    • Wedding U, Röhrig B, Klippstein A, Pientka L, Höffken K. Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients. J Cancer Res Clin Oncol 2007; 133: 945-950
    • (2007) J Cancer Res Clin Oncol , vol.133 , pp. 945-950
    • Wedding, U.1    Röhrig, B.2    Klippstein, A.3    Pientka, L.4    Höffken, K.5
  • 97
    • 0037080281 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: An Italian Group for Geriatric Oncology Study
    • Repetto L, Fratino L, Audisio RA, Venturino A, Gianni W, Vercelli M, et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol 2002; 20: 494-502.
    • (2002) J Clin Oncol , vol.20 , pp. 494-502
    • Repetto, L.1    Fratino, L.2    Audisio, R.A.3    Venturino, A.4    Gianni, W.5    Vercelli, M.6
  • 98
    • 34249774066 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment for older patients with cancer
    • DOI 10.1200/JCO.2007.10.6559
    • Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol 2007; 25: 1824-1831 (Pubitemid 46860271)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.14 , pp. 1824-1831
    • Extermann, M.1    Hurria, A.2
  • 99
  • 100
    • 66849111894 scopus 로고    scopus 로고
    • Emerging combination treatment strategies containing novel agents in newly diagnosed multiple myeloma
    • Mar 14. [Epub ahead of print]
    • Lonial S, Cavenagh J. Emerging combination treatment strategies containing novel agents in newly diagnosed multiple myeloma. Br J Haematol. 2009 Mar 14. [Epub ahead of print]
    • (2009) Br J Haematol
    • Lonial, S.1    Cavenagh, J.2
  • 101
    • 64749099369 scopus 로고    scopus 로고
    • Frontline treatment in elderly patients with multiple myeloma
    • Facon T, San Miguel J, Mateos MV, Hulin C. Frontline treatment in elderly patients with multiple myeloma. Semin Hematol 2009; 46: 133-142
    • (2009) Semin Hematol , vol.46 , pp. 133-142
    • Facon, T.1    San Miguel, J.2    Mateos, M.V.3    Hulin, C.4
  • 102
    • 36749077560 scopus 로고    scopus 로고
    • Autologous stem cell transplantation in the elderly including pre- And post-treatment options
    • Kumar SK, Hayman SR, Kyle RA. Autologous stem cell transplantation in the elderly including pre- and post-treatment options. Bone Marrow Transplant 2007; 40: 1115-1121
    • (2007) Bone Marrow Transplant , vol.40 , pp. 1115-1121
    • Kumar, S.K.1    Hayman, S.R.2    Kyle, R.A.3
  • 103
    • 34548138921 scopus 로고    scopus 로고
    • Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma
    • Kumar S, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Gastineau DA, et al. Impact of lenalidomide therapy on stem cell mobilization and engraftment post-peripheral blood stem cell transplantation in patients with newly diagnosed myeloma. Leukemia 2007; 21: 2035-2042
    • (2007) Leukemia , vol.21 , pp. 2035-2042
    • Kumar, S.1    Dispenzieri, A.2    Lacy, M.Q.3    Hayman, S.R.4    Buadi, F.K.5    Gastineau, D.A.6
  • 104
    • 65149088043 scopus 로고    scopus 로고
    • Reduced intensity allogeneic transplantation for myeloma: Reality bites
    • Stewart AK. Reduced intensity allogeneic transplantation for myeloma: reality bites. Blood 2009; 113: 3135-3136
    • (2009) Blood , vol.113 , pp. 3135-3136
    • Stewart, A.K.1
  • 105
    • 48149114717 scopus 로고    scopus 로고
    • Maintenance treatment in multiple myeloma
    • Harousseau JL. Maintenance treatment in multiple myeloma. Ann Oncol 2008; 19(4): iv54-5.
    • (2008) Ann Oncol , vol.19 , Issue.4
    • Harousseau, J.L.1
  • 106
    • 57349171505 scopus 로고    scopus 로고
    • Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma
    • Moreau P, Coiteux V, Hulin C, Leleu X, van de Velde H, Acharya M, et al. Prospective comparison of subcutaneous versus intravenous administration of bortezomib in patients with multiple myeloma. Haematologica 2008; 93: 1908-1911
    • (2008) Haematologica , vol.93 , pp. 1908-1911
    • Moreau, P.1    Coiteux, V.2    Hulin, C.3    Leleu, X.4    Van De Velde, H.5    Acharya, M.6
  • 108
    • 57449109100 scopus 로고    scopus 로고
    • Influence of pre- And post- transplantation responses on outcome of patients with multiple myeloma: Sequential improvements of response and achievement of complete response are associated with longer survival
    • Lahuerta JJ, Mateos MV, Martínez-López J, Rosiñol L, Sureda A, de la Rubia J, et al. Influence of pre- and post- transplantation responses on outcome of patients with multiple myeloma: sequential improvements of response and achievement of complete response are associated with longer survival. J Clin Oncol 2008; 26: 5775-5782
    • (2008) J Clin Oncol , vol.26 , pp. 5775-5782
    • Lahuerta, J.J.1    Mateos, M.V.2    Martínez-López, J.3    Rosiñol, L.4    Sureda, A.5    De La Rubia, J.6
  • 109
    • 33646339149 scopus 로고    scopus 로고
    • Complete response in multiple myeloma: Clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation
    • Kyle RA, Leong T, Li S, Oken MM, Kay NE, Van Ness B, et al. Complete response in multiple myeloma: clinical trial E9486, an Eastern Cooperative Oncology Group study not involving stem cell transplantation. Cancer 2006; 106: 1958-1966
    • (2006) Cancer , vol.106 , pp. 1958-1966
    • Kyle, R.A.1    Leong, T.2    Li, S.3    Oken, M.M.4    Kay, N.E.5    Van Ness, B.6
  • 110
    • 33845974073 scopus 로고    scopus 로고
    • Complete response in myeloma extends survival without, but not with history of prior monoclonal gammopathy of undetermined significance or smouldering disease
    • Pineda-Roman M, Bolejack V, Arzoumanian V, Anaissie E, van Rhee F, Zangari M, et al. Complete response in myeloma extends survival without, but not with history of prior monoclonal gammopathy of undetermined significance or smouldering disease. Br J Haematol 2007; 136: 393-399
    • (2007) Br J Haematol , vol.136 , pp. 393-399
    • Pineda-Roman, M.1    Bolejack, V.2    Arzoumanian, V.3    Anaissie, E.4    Van Rhee, F.5    Zangari, M.6
  • 111
    • 37249040444 scopus 로고    scopus 로고
    • Benefit of complete response in multiple myeloma limited to high-risk subgroup identified by gene expression profiling
    • Haessler J, Shaughnessy JD Jr, Zhan F, Crowley J, Epstein J, van Rhee F, et al. Benefit of complete response in multiple myeloma limited to high-risk subgroup identified by gene expression profiling. Clin Cancer Res 2007; 13: 7073-7079
    • (2007) Clin Cancer Res , vol.13 , pp. 7073-7079
    • Haessler, J.1    Shaughnessy Jr., J.D.2    Zhan, F.3    Crowley, J.4    Epstein, J.5    Van Rhee, F.6
  • 112
    • 54249092519 scopus 로고    scopus 로고
    • Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: A study of the Intergroupe Francophone du Myélome
    • Decaux O, Lodé L, Magrangeas F, Charbonnel C, Gouraud W, Jézéquel P, et al. Prediction of survival in multiple myeloma based on gene expression profiles reveals cell cycle and chromosomal instability signatures in high-risk patients and hyperdiploid signatures in low-risk patients: a study of the Intergroupe Francophone du Myélome. J Clin Oncol 2008; 26: 4798-4805
    • (2008) J Clin Oncol , vol.26 , pp. 4798-4805
    • Decaux, O.1    Lodé, L.2    Magrangeas, F.3    Charbonnel, C.4    Gouraud, W.5    Jézéquel, P.6
  • 113
    • 56449128746 scopus 로고    scopus 로고
    • New drugs in multiple myeloma: Mechanisms of action and phase I/II clinical findings
    • Ocio EM, Mateos MV, Maiso P, Pandiella A, San-Miguel JF. New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings. Lancet Oncol 2008; 9: 1157-1165
    • (2008) Lancet Oncol , vol.9 , pp. 1157-1165
    • Ocio, E.M.1    Mateos, M.V.2    Maiso, P.3    Pandiella, A.4    San-Miguel, J.F.5


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