Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients

Journal of Cancer Research and Clinical Oncology

Volumn 133, Issue 12, 2007, Pages 945-950

  Wedding, Ulrich ^a,b   Röhrig, Bernd ^c   Klippstein, Almuth ^a   Pientka, Ludger ^b   Höffken, Klaus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Activities of daily living; Cancer; Comorbidity; Functional status; Geriatric assessment; Geriatric oncology

Indexed keywords

ACUTE LEUKEMIA; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER SURVIVAL; CARCINOMA; CARDIA CARCINOMA; CHRONIC LEUKEMIA; COLORECTAL CARCINOMA; COMORBIDITY; CONFIDENCE INTERVAL; DAILY LIFE ACTIVITY; DISEASE SEVERITY; ESOPHAGUS CANCER; FEMALE; FOLLOW UP; FUNCTIONAL DISEASE; HEMATOLOGIC MALIGNANCY; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HUMAN ACTIVITIES; INSTRUMENTAL ACTIVITIES OF DAILY LIVING; LUNG CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MULTIVARIATE ANALYSIS; PANCREAS CANCER; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RATING SCALE; SARCOMA; SOLID TUMOR; STOMACH CARCINOMA; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; UNIVARIATE ANALYSIS; WORLD HEALTH ORGANIZATION;

ACTIVITIES OF DAILY LIVING; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; COMORBIDITY; FEMALE; GERIATRIC ASSESSMENT; HEALTH STATUS INDICATORS; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PROGNOSIS; QUALITY OF LIFE; SURVIVAL ANALYSIS;

EID: 34648864233     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0233-x     Document Type: Article

References (32)

1. Boulos DL, Groome PA, Brundage MD et al (2006) Predictive validity of five comorbidity indices in prostate carcinoma patients treated with curative intent. Cancer 106(8):1804-1814
2. Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW (2005) Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. Jama 294(6):716-724
3. Buccheri G, Ferrigno D, Tamburini M (1996) Karnofsky ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. Eur J Cancer 32A(7):1135-1141
4. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373-383
5. Edwards BK, Howe HL, Ries LA et al (2002) Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on US cancer burden. Cancer 94(10):2766-2792
6. Extermann M, Overcash J, Lyman GH, Parr J, Balducci L (1998) Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 16(4):1582-1587
7. Extermann M, Aapro M, Bernabei R et al (2005) Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 55(3):241-252
8. Feinstein AR (1970) The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis 23:455-469
9. Firat S, Bousamra M, Gore E, Byhardt RW (2002a) Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 52(4):1047-1057
10. Firat S, Byhardt RW, Gore E (2002b) Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 54(2):357-364
11. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G (2004) Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 59(3):255-263
12. Friedrich C, Kolb G, Wedding U, Pientka L (2003) Comprehensive geriatric assessment in the elderly cancer patient. Onkologie 26(4):355-360
13. Gross CP, McAvay GJ, Krumholz HM, Paltiel AD, Bhasin D, Tinetti ME (2006) The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening. Ann Int Med 145(9):646-653
14. Hurria A, Gupta S, Zauderer M, et al (2005) Developing a cancer-specific geriatric assessment: a feasibility study. Cancer 104(9):1998-2005
15. Jemal A, Siegel R, Ward E et al (2006) Cancer statistics, 2006. CA Cancer J Clin 56(2):106-130
16. Karnofsky DA, Adelmann WH, Craver FL (1948) The use of nitrogen mustard in the palliative treatment of carcinoma. Cancer 1:634-656
17. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179-186
18. Linn BS, Linn MW, Gurel L (1968) Cumulative illness rating scale. J Am Geriatr Soc 16(5):622-626
19. Mahoney FI, Barthel DW (1965a) Functional evaluation. Md Med J 14:61-65
20. Mahoney FI, Barthel DW (1965b) Functional evaluation: the barthel index. Md State Med J 14:61-65
21. Maione P, Perrone F, Gallo C et al (2005) Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol 23(28):6865-6872
22. Nagel G, Wedding U, Rohrig B, Katenkamp D (2004) The impact of comorbidity on the survival of postmenopausal women with breast cancer. J Cancer Res Clin Oncol 130(11):664-670
23. Read WL, Tierney RM, Page NC et al (2004) Differential prognostic impact of comorbidity. J Clin Oncol 22(15):3099-3103
24. Repetto L, Venturino A, Vercelli M et al (1998) Performance status and comorbidity in elderly cancer patients compared with young patients with neoplasia and elderly patients without neoplastic conditions (see comments). Cancer 82(4):760-765
25. Repetto L, Fratino L, Audisio RA et al (2002) Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol 20(2):494-502
26. Rubenstein LZ, Siu AL, Wieland D (1989) Comprehensive geriatric assessment: toward understanding its efficacy. Aging (Milano) 1(2):87-98
27. Satariano WA, Ragland DR (1994) The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Int Med 120(2):104-110
28. Truong PT, Kader HA, Lacy B et al (2005) The effects of age and comorbidity on treatment and outcomes in women with endometrial cancer. Am J Clin Oncol 28(2):157-164
29. Turner NJ, Haward RA, Mulley GP, Selby PJ (1999) Cancer in old age-is it inadequately investigated and treated? BMJ 319(7205):309-312
30. Wedding U, Rohrig B, Klippstein A, Fricke HJ, Sayer HG, Hoffken K (2006) Impairment in functional status and survival in patients with acute myeloid leukaemia. J Cancer Res Clin Oncol 132(10):665-671
31. World-Health-Organisation (1979) WHO handbook for reporting results of cancer treatment. WHO, Geneva
32. Yancik R, Wesley MN, Ries LA, Havlik RJ, Edwards BK, Yates JW (2001) Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. Jama 285(7):885-892