Dopamine D1 and D2 antagonists block L-DOPA-induced air-stepping in decerebrate neonatal rats

Developmental Brain Research

Volumn 100, Issue 1, 1997, Pages 130-132

  McCrea, Anne E ^a   Stehouwer, Donald J ^a   Van Hartesveldt, Carol ^a  

^a University of Florida ^*  (United States)

Author keywords

Air stepping; Decerebrate; Development; Dopamine; Locomotion; SCH 23390; Spiperone

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR BLOCKING AGENT; LEVODOPA; SPIPERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECEREBRATION; DOSE RESPONSE; FOREBRAIN; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOTYPY; SUBCUTANEOUS DRUG ADMINISTRATION;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; ANIMALS, NEWBORN; DECEREBRATE STATE; LEVODOPA; MOTOR ACTIVITY; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SPIPERONE; STEREOTYPED BEHAVIOR;

ANIMALIA;

EID: 0030968966     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(97)00027-8     Document Type: Article

References (20)

1. Arnaiz, C.O., Taylor, L.L., Stehouwer, D.J. and Van Hartesveldt, C., An aromatic L-amino acid decarboxylase inhibitor blocks L-DOPA-induced air-stepping in neonatal rats, Dev. Brain Res., 94 (1996) 234-237.
2. Cheramy, A., Leviel, V. and Glowinski, J., Dendritic release of dopamine in the substantia nigra, Nature, 289 (1981) 537-542.
3. Costall, B., Naylor, R.J. and Olley, J.E., Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain, Neuropharmacology, 11 (1972) 645-663.
4. Crocker, A.D., A new view of the role of dopamine receptors in the regulation of muscle tone, Clin. Exp. Pharmacol. Physiol., 22 (1995) 846-850.
5. Double, K.L. and Crocker, A.D., Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone, Proc. Natl. Acad. Sci. USA, 92 (1995) 1669-1673.
6. Ellenbroek, B.A., Van Den Hoven, J. and Cools, A.R., The nucleus accumbens and forelimb muscular rigidity in rats, Exp. Brain Res., 72 (1988) 299-304.
7. Iwahara, T., Van Hartesveldt, C., Garcia-Rill, E. and Skinner, R.D., L-DOPA-induced air-stepping in decerebrate developing rats, Dev. Brain Res., 58 (1991) 257-264.
8. Kaplan, J.M. and Sodersten, P., Apomorphine suppresses ingestive behaviour in chronic decerebrate rats, NeuroReport, 5 (1994) 1839-1840.
9. Kaplan, J.M., Hao, J. and Sodersten, P., Apomorphine induces ejaculation in chronic decerebrate rats, Neurosci. Lett., 129 (1991) 205-208.
10. Kellogg, C. and Lundborg, P., Ontogenetic variations in responses to L-DOPA and monoamine receptor-stimulating agents, Psychopharmacologia, 23 (1972) 187-200.
11. Kellogg, C. and Lundborg, P., Production of [3H] catecholamines in the brain following the peripheral administration of 3H DOPA during pre- and postnatal development, Brain Res., 36 (1972) 333-342.
12. Kiehn, O. and Kjaerulff, O., Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat, J. Neuropkysiol., 75 (1996) 1472-1482.
13. Meyer, M.E., Cottrell, G.A. and Van Hartesveldt, C., Intracerebral haloperidol potentiates the dorsal immobility response in the rat, Pharmacol. Biochem. Behav., 44 (1993) 157-160.
14. Randall, P.K. and Giniger, E.L., L-DOPA-induced locomotor activity in the neonatal rat; mediation by a descending adrenergic system. Paper presented at the Meeting of the International Society for Developmental Psychobiology, 1974.
15. Rao, P.A., Molinoff, P.B. and Joyce, J.N., Ontogeny of dopamine D1 and D2 receptor subtypes in the basal ganglia: a quantitative autoradiographic study, Dev. Brain Res., 60 (1991) 161-177.
16. Robertson, G.S. and Robertson, H.A., Evidence that L-DOPA-induced rotational behavior is dependent on both striatal and nigral mechanisms, J. Neurosci., 9 (1989) 3326-3331.
17. 125I] iodosulpiride, Neuroscience, 28 (1989) 673-700.
18. Sickles, A.E., Stehouwer, D.J. and Van Hartesveldt, C., Dopamine D1 and D2 antagonists block L-DOPA-induced air-stepping in neonatal rats, Dev. Brain Res., 68 (1992) 17-22.
19. Smith, J.C., Feldman, J.L. and Schmidt,B.J., Neural mechanisms generating locomotion studied in mammalian brain stem-spinal cord in vitro, FASEB J., 2 (1988) 2283-2288.
20. Van Hartesveldt, C., Sickles, A.E., Porter, J.D. and Stehouwer, D.J., L-DOPA-induced air-stepping in developing rats, Dev. Brain Res., 58 (1991) 251-255.