Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung

Journal of Pediatric Surgery

Volumn 44, Issue 11, 2009, Pages 2092-2095

  Doi, Takashi ^a,b   Hajduk, Piotr ^a,b   Puri, Prem ^a,b  

^a OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Congenital diaphragmatic hernia; Hypoplastic lung; Nitrofen; Slit 2; Slit 3

Indexed keywords

MESSENGER RNA; NITROFEN; OLIVE OIL; ROUNDABOUT RECEPTOR; SLIT PROTEIN; SLIT2 PROTEIN; SLIT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONGENITAL DIAPHRAGM HERNIA; CONTROL GROUP; CONTROLLED STUDY; FEMALE; FETUS; FETUS LUNG; GENE EXPRESSION; GESTATIONAL AGE; LUNG DEVELOPMENT; LUNG HYPOPLASIA; MALE; MORPHOGENESIS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RANK SUM TEST; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; STUDENT T TEST; UPREGULATION;

ANIMALS; FEMALE; FETAL ORGAN MATURITY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HERNIA, DIAPHRAGMATIC; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PHENYL ETHERS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 70449793517     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2009.02.068     Document Type: Article

References (19)

1. Stage G., Fenton A., and Jaffray B. Nihilism in the 1990s; the true mortality of congenital diaphragmatic hernia. Pediatrics 112 (2003) 532-535
2. Doyle N.M., and Lally K.P. The CDH Study Group and advance in the clinical care of the patient with congenital diaphragmatic hernia. Semin Perinatol 28 (2004) 174-184
3. Grosche J.R., Islam S., and Boulanger S.C. Congenital diaphragmatic hernia. Am J Surg 190 (2005) 324-332
4. Taira Y., Yamataka T., Miyazaki E., et al. Comparison of the pulmonary vasculature in newborns and stillborns with congenital diaphragmatic hernia. Pediatr Surg Int 14 (1998) 30-35
5. Montedonico S., Nakazawa N., Puri P., et al. Congenital diaphragmatic hernia and retinoids: searching for an etiology. Pediatr Surg Int 24 7 (2008) 755-761
6. Noble B.R., Babiuk R.P., Clugston R.D., et al. Mechanisms of the congenital diaphragmatic hernia-inducing teratogen nitrofen. Am J Physiol Lung Cell Mol Physiol 293 (2007) L1079-L1087
7. Whitford K.L., Marillat V., Stein E., et al. Regulation of cortical dendrite development by Slit-Robo instructions. Neuron 33 (2002) 47-61
8. Holmes G.P., Negus K., Burridge L., et al. Distinct but overlapping patterns of two vertebrate Slit homologs implies functional roles in CNS development and organogenesis. Mech Dev 79 (1998) 57-72
9. Wu J.Y., Feng L., Park H.T., et al. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410 (2001) 948-952
10. Greenberg J.M., Thompson F.Y., Brooks S.K., et al. Slit and Robo expression in the developing mouse lung. Dev Dyn 230 2 (2004) 350-360
11. Cordoso W.V. Molecular regulation of lung development. Annu Rev Physiol 63 (2001) 471-494
12. Hogan B.L. Morphogenesis. Cell 96 (1999) 225-233
13. Rajagopal J., and Kinane T.B. Is there more to lung development than steroids and surfactant. Pediatrics 106 (2000) 1103-1104
14. Bagri A., Marin O., Plump A.S., et al. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron 33 (2002) 233-248
15. Warburton D., Schwarz M., Tefft D., et al. The molecular basis of lung morphogenesis. Mech Dev 92 (2000) 55-81
16. Holmes G., and Niswander L. Expression of Slit-2 and Slit-3 during chick development. Dev Dyn 222 (2001) 301-307
17. Yuan W., Rao Y., Babiuk R.P., et al. A genetic model for central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proc Natl Acad Sci U S A 100 9 (2003) 5217-5222
18. Keijzer R., Liu J., Deimling J., et al. Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia. Am J Pathol 156 4 (2000) 1299-1306
19. Xian J., Clark K.J., Fordham R., et al. Inadequate lung development and bronchial hyperplasia in mice with a target deletion in the Dutt/Robo1 gene. Proc Natl Acad Sci U S A 98 (2001) 15062-15066