Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia

American Journal of Pathology

Volumn 156, Issue 4, 2000, Pages 1299-1306

  Keijzer, Richard ^a,b   Liu, Jason ^a   Deimling, Julie ^a   Tibboel, Dick ^b   Post, Martin ^a  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONGENITAL DIAPHRAGM HERNIA; CONGENITAL MALFORMATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG DEVELOPMENT; LUNG HYPOPLASIA; LUNG MALFORMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033843372     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65000-6     Document Type: Article

References (25)

1. A population-based study of congenital diaphragmatic hernia
2. Contemporary controversies in the management of congenital diaphragmatic hernia
3. Congenital diaphragmatic hernia survival and use of extracorpcreal life support at selected level III nurseries with multimodality support
4. Congenital diaphragmatic hernia: Survival treated with very delayed surgery, spontaneous respiration, and no chest tube
5. Congenital diaphragmatic hernia: A cause of persistent pulmonary hypertension of the newborn which lacks an effective therapy
6. Fetal diaphragmatic hernia: Pathophysiology, natural history, and outcome
7. Pathogenesis of nitrofen-induced congenital diaphragmatic hernia in fetal rats
8. Experimental study on embryogenesis of congenital diaphragmatic hernia
9. Nitrofen dose-dependent gestational day-specific murine lung hypoplasia and left-sided diaphragmatic hernia
10. Nitrofen-induced diaphragmatic hernias in rats: An animal model
11. Experimentally induced congenital diaphragmatic hernia in rats
12. Antisense oligodeoxynucleotides targeting PDGF-B mRNA inhibit cell proliferation during embryonic rat lung development
13. Distribution and metabolism of the teratogen nitrofen (2, 4-dichloro-4'-nitro dephenyl ether) in pregnant rats
14. Mechanism of nitrofen teratogenesis
15. A nuclear antigen associated with cell proliferation and blast transformation
16. Identification of programmea cell death in situ via specific labeling of nuclear DNA fragmentation
17. Embryology of congenita diaphragmatic hernia
18. Lung hypoplasia in congenital diaphragmatic hernia: A quantitative study of airway, artery, and alveolar development
19. Hypoplasia of lung with congenital diaphragmatic hernia
20. Prenatal hormones alter antioxidant enzymes and lung histology in rats with congenital diaphragmatic hernia
21. Development of body cavities, primitive mesenteries, and the diaphragm
22. Etiological aspects of congenital diaphragmatic hernia: Results of a case comparison study
23. Etiologic and genetic factors in congenital diaphragmatic hernia
24. Congenital diaphragmatic defects and associated syndromes, malformations, and chromosome anomalies: A retrospective study of 60 patients and literature review