Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice

Liver International

Volumn 29, Issue 9, 2009, Pages 1316-1325

  Jahnel, Jörg ^a   Fickert, Peter ^a   Langner, Cord ^b   Högenauer, Christoph ^a   Silbert, Dagmar ^a   Gumhold, Judith ^a   Fuchsbichler, Andrea ^b   Trauner, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Bile acid transport and metabolism; Colitis; Mdr2 knockout mice; Primary sclerosing cholangitis

Indexed keywords

ABC TRANSPORTER G5; ABC TRANSPORTER G8; BILE ACID; BILE SALT EXPORT PUMP; CARRIER PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A11; DEXTRAN SULFATE; FARNESOID X RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; ORGANIC SOLUTE TRANSPORTER ALPHA; ORGANIC SOLUTE TRANSPORTER BETA; PHOSPHOLIPID; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; SODIUM TAUROCHOLIC ACID COTRANSPORTER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE COMPOSITION; BILE DUCT INJURY; BILE SECRETION; CHOLESTASIS; CONTROLLED STUDY; DISEASE ASSOCIATION; GENETIC PREDISPOSITION; HETEROZYGOSITY; HYPOTHESIS; INFLAMMATION; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; SCLEROSING CHOLANGITIS; ULCERATIVE COLITIS; ANIMAL; BACTERIAL TRANSLOCATION; BILE; BILE DUCT; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; COLITIS; DRUG EFFECT; GENETICS; LIVER; METABOLISM; PATHOLOGY; SECRETION;

ANIMALS; BACTERIAL TRANSLOCATION; BILE; BILE ACIDS AND SALTS; BILE DUCTS; CARRIER PROTEINS; CHOLANGITIS, SCLEROSING; COLITIS; DEXTRAN SULFATE; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; PHOSPHOLIPIDS; RNA, MESSENGER;

EID: 70449732768     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02044.x     Document Type: Article

References (50)

1. Broome U, Bergquist A. Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer. Semin Liver Dis 2006; 26: 31-41.
2. Chapman R, Cullen S. Etiopathogenesis of primary sclerosing cholangitis. World J Gastroenterol 2008; 14: 3350-9.
3. O'Mahony CA, Vierling J.M. Etiopathogenesis of primary sclerosing cholangitis. Semin Liver Dis 2006; 26: 3-21.
4. Worthington J, Cullen S, Chapman R. Immunopathogenesis of primary sclerosing cholangitis. Clin Rev Allergy Immunol 2005; 28: 93-103.
5. Vierling J.M. Animal models for primary sclerosing cholangitis. Best Pract Res Clin Gastroenterol 2001; 15: 591-610.
6. Mayer L. Redefining autoimmunity. Gastroenterology 2003; 125: 1574.
7. Nakanuma Y, Zen Y. Pathology and immunopathology of immunoglobulin G4-related sclerosing cholangitis: the latest addition to the sclerosing cholangitis family. Hepatol Res 2007; 37(Suppl. 3): S478-86.
8. Lee YM, Kaplan M.M. Primary sclerosing cholangitis. N Engl J Med 1995; 332: 924-33.
9. Grant AJ, Lalor PF, Salmi M, Jalkanen S, Adams D.H. Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease. Lancet 2002; 359: 150-7.
10. Adams DH, Eksteen B. Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease. Nat Rev Immunol 2006; 6: 244-51.
11. Berg R.D. Bacterial translocation from the gastrointestinal tract. Trends Microbiol 1995; 3: 149-54.
12. Sartor RB, Bond TM, Schwab J.H. Systemic uptake and intestinal inflammatory effects of luminal bacterial cell wall polymers in rats with acute colonic injury. Infect Immun 1988; 56: 2101-8.
13. Trauner M, Fickert P, Stauber R.E. Inflammation-induced cholestasis. J Gastroenterol Hepatol 1999; 14: 946-59.
14. Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther 2002; 303: 273-81.
15. Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C. Repression of farnesoid X receptor during the acute phase response. J Biol Chem 2003; 278: 8988-95.
16. Geier A, Fickert P, Trauner M. Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 574-85.
17. Green RM, Beier D, Gollan J.L. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996; 111: 193-8.
18. Beigneux AP, Moser AH, Shigenaga JK, Grunfeld C, Feingold K.R. The acute phase response is associated with retinoid X receptor repression in rodent liver. J Biol Chem 2000; 275: 16390-9.
19. Kawaguchi T, Sakisaka S, Mitsuyama K, et al. Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicular multispecific organic anion transporter in a rat model of colitis. Hepatology 2000; 31: 1285-95.
20. Lora L, Mazzon E, Martines D, et al. Hepatocyte tightjunctional permeability is increased in rat experimental colitis. Gastroenterology 1997; 113: 1347-54.
21. Trauner M, Fickert P,Wagner M. MDR3 (ABCB4) defects: a paradigm for the genetics of adult cholestatic syndromes. Semin Liver Dis 2007; 27: 77-98.
22. Lazaridis KN, Strazzabosco M, Larusso N.F. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 2004; 127: 1565-77.
23. Hartmann G, Kim H, Piquette-Miller M. Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int Immunopharmacol 2001; 1: 189-99.
24. Lee JM, Trauner M, Soroka CJ, et al. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000; 118: 163-72.
25. Okayasu I, Hatakeyama S, Yamada M, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990; 98: 694-702.
26. Vowinkel T, Kalogeris TJ, Mori M, Krieglstein CF, Granger D.N. Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Dig Dis Sci 2004; 49: 556-64.
27. Van Nieuwkerk CM, Elferink RP, Groen AK, et al. Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 1996; 111: 165-71.
28. Wagner M, Fickert P, Zollner G, et al. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 2003; 125: 825-38.
29. Livak KJ, Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-8.
30. Fickert P, Zollner G, Fuchsbichler A, et al. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 2001; 121: 170-83.
31. Wenzl HH, Schimpl G, Feierl G, Steinwender G. Time course of spontaneous bacterial translocation from gastrointestinal tract and its relationship to intestinal microflora in conventionally reared infant rats. Dig Dis Sci 2001; 46: 1120-6.
32. Trauner M, Arrese M, Lee H, Boyer JL, Karpen S.J. Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 1998; 101: 2092-100.
33. Thummel KE, Wilkinson G.R. In vitro and in vivo drug interactions involving human CYP3A. Annu Rev Pharmacol Toxicol 1998; 38: 389-430.
34. Fujiyama N, Shitara Y, Ito K, Masubuchi Y, Horie T. Downregulation of hepatic transporters for BSP in rats with indomethacin-induced intestinal injury. Biol Pharm Bull 2007; 30: 556-61.
35. Tjandra K, Le T, Swain M.G. Experimental colitis attenuates development of toxin-induced cholangitis in rats. Dig Dis Sci 2002; 47: 1216-23.
36. Piquette-Miller M, Pak A, Kim H, Anari R, Shahzamani A. Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. PharmRes 1998; 15: 706-11.
37. Vos TA, Hooiveld GJ, Koning H, et al. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and downregulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 1998; 28: 1637-44.
38. Chaluvadi MR, Nyagode BA, Kinloch RD, Morgan E.T. TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease. Biochem Pharmacol 2009; 77: 464-71.
39. Kitajima S, Takuma S, Morimoto M. Tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine DSS-induced colitis. J Vet Med Sci 1999; 61: 67-70.
40. Lam P, Wang R, Ling V. Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry 2005; 44: 12598-605.
41. Weidenbach H, Leiz S, Nussler AK, et al. Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats. J Hepatol 2000; 32: 708-17.
42. Sheth S, Shea JC, Bishop MD, et al. Increased prevalence of CFTR mutations and variants and decreased chloride secretion in primary sclerosing cholangitis. Hum Genet 2003; 113: 286-92.
43. Colombo C, Battezzati PM, Strazzabosco M, Podda M. Liver and biliary problems in cystic fibrosis. Semin Liver Dis 1998; 18: 227-35.
44. Blanco PG, Zaman MM, Junaidi O, et al. Induction of colitis in cftr(/( mice results in bile duct injury. Am J Physiol Gastrointest Liver Physiol 2004; 287: G491-6.
45. Karlsen TH, Schrumpf E, Boberg K.M. Genetic epidemiology of primary sclerosing cholangitis. World J Gastroenterol 2007; 13: 5421-31.
46. Jacquemin E, Cresteil D, Manouvrier S, Boute O, Hadchouel M. Heterozygous non-sense mutation of the MDR3 gene in familial intrahepatic cholestasis of pregnancy. Lancet 1999; 353: 210-1.
47. Schneider G, Paus TC, Kullak-Ublick GA, et al. Linkage between a new splicing site mutation in the MDR3 alias ABCB4 gene and intrahepatic cholestasis of pregnancy. Hepatology 2007; 45: 150-8.
48. Oude Elferink RP, Ottenhoff R, Van Wijland M, et al. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 1995; 95: 31-8.
49. Hoekstra H, Porte RJ, Tian Y, et al. Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr21/( mice. Hepatology 2006; 43: 1022-31.
50. Hofmann A.F.The continuing importance of bile acids in liver and intestinal diseaseArch Intern Med 1999; 159: 2647-58.