Bone Fractures Following External Beam Radiotherapy and Limb-Preservation Surgery for Lower Extremity Soft Tissue Sarcoma: Relationship to Irradiated Bone Length, Volume, Tumor Location and Dose

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 4, 2009, Pages 1119-1124

  Dickie, Colleen I ^a   Parent, Amy L ^a   Griffin, Anthony M ^b,c   Fung, Sharon ^d   Chung, Peter W M ^a,c   Catton, Charles N ^a,c   Ferguson, Peter C ^b,c   Wunder, Jay S ^b,c   Bell, Robert S ^b,c   Sharpe, Michael B ^a,c   O'Sullivan, Brian ^a,c  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Bone fractures; Extremity; Radiotherapy; Sarcoma

Indexed keywords

BONE FRACTURE; BONE FRACTURES; DOSE DISTRIBUTIONS; EXTERNAL BEAM RADIOTHERAPY; FIELD SIZE; FRACTURE LOCATION; FRACTURE RISKS; KNEE JOINT; LOWER EXTREMITY; MEAN DOSE; RADIATION-INDUCED; RADIOGRAPHIC IMAGES; RANDOM SAMPLE; SOFT TISSUE SARCOMA; TUMOR LOCATION; TUMOR SIZE;

JOINTS (ANATOMY); PATIENT MONITORING; RADIOTHERAPY; RISK ANALYSIS; SURGERY; TUMORS;

BONE;

ADULT; AGE DISTRIBUTION; ARTICLE; BONE RADIOGRAPHY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FEMUR FRACTURE; FEMUR NECK FRACTURE; FRACTURE; HUMAN; KNEE; LEG FRACTURE; LEG LENGTH; LIMB SALVAGE; MALE; MAXIMUM PERMISSIBLE DOSE; METATARSAL BONE; PATELLA FRACTURE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION FIELD; RADIATION INJURY; RANDOM SAMPLE; RISK ASSESSMENT; RISK FACTOR; SOFT TISSUE SARCOMA; TIBIA FRACTURE; TUMOR LOCALIZATION; TUMOR VOLUME; FIBULA; LEG INJURY; MIDDLE AGED; PATHOLOGY; SALVAGE THERAPY; SARCOMA; SEX DIFFERENCE;

FEMALE; FEMORAL FRACTURES; FIBULA; FRACTURES, BONE; HUMANS; LEG INJURIES; MALE; MIDDLE AGED; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RISK ASSESSMENT; SALVAGE THERAPY; SARCOMA; SEX FACTORS; TIBIAL FRACTURES; TUMOR BURDEN;

EID: 70449731210     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.12.006     Document Type: Article

References (21)

1. O'Sullivan B., Davis A.M., Turcotte R., et al. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: A randomised trial. Lancet 359 (2002) 2235-2241
2. Rosenberg S.A., Tepper J., Glatstein E., et al. The treatment of soft-tissue sarcomas of the extremities: Prospective randomized evaluations of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy. Ann Surg 196 (1982) 305-315
3. Yang J.C., Chang A.E., Baker A.R., et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16 (1998) 197-203
4. Alektiar K.M., Brennan M.F., and Singer S. Influence of site on the therapeutic ratio of adjuvant radiotherapy in soft-tissue sarcoma of the extremity. Int J Radiat Oncol Biol Phys 63 (2005) 202-208
5. Lin P.P., Schupak K.D., Boland P.J., et al. Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma. Cancer 82 (1998) 2356-2365
6. Cannon C.P., Ballo M.T., Zagars G.K., et al. Complications of combined modality treatment of primary lower extremity soft-tissue sarcomas. Cancer 107 (2006) 2455-2461
7. Davis A.M., O'Sullivan B., Turcotte R., et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother Oncol 75 (2005) 48-53
8. Helmstedter C.S., Goebel M., Zlotecki R., et al. Pathologic fractures after surgery and radiation for soft tissue tumors. Clin Orthop Relat Res (2001) 165-172
9. Holt G.E., Griffin A.M., Pintilie M., et al. Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy. J Bone Joint Surg Am 87 (2005) 315-319
10. Livi L., Santoni R., Paiar F., et al. Late treatment-related complications in 214 patients with extremity soft-tissue sarcoma treated by surgery and postoperative radiation therapy. Am J Surg 191 (2006) 230-234
11. Moreno A., Clemente J., Crespo C., et al. Pelvic insufficiency fractures in patients with pelvic irradiation. Int J Radiat Oncol Biol Phys 44 (1999) 61-66
12. Song Y., Wang S., Chan M., et al. Femoral fracture risk assessment after intensity modulated radiation therapy (IMRT) for the treatment of soft tissue sarcoma using a novel mathematical model. Conf Proc IEEE Eng Med Biol Soc 1 (2006) 95-98
13. Lin P.P., Boland P.J., and Healey J.H. Treatment of femoral fractures after irradiation. Clin Orthop Relat Res (1998) 168-178
14. Bell R.S., O'Sullivan B., Nguyen C., et al. Fractures following limb-salvage surgery and adjuvant irradiation for soft-tissue sarcoma. Clin Orthop Relat Res (1991) 265-271
15. Wagner L.M., Neel M.D., Pappo A.S., et al. Fractures in pediatric Ewing sarcoma. J Pediatr Hematol Oncol 23 (2001) 568-571
16. Roebuck D.J. Skeletal complications in pediatric oncology patients. Radiographics 19 (1999) 873-885
17. Duffy G.P., Wood M.B., Rock M.G., et al. Vascularized free fibular transfer combined with autografting for the management of fracture nonunions associated with radiation therapy. J Bone Joint Surg Am 82 (2000) 544-554
18. Le Pechoux C., Le Deley M.C., Delaloge S., et al. Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: Results with two different total dose, fractionation, and overall treatment time schedules. Int J Radiat Oncol Biol Phys 44 (1999) 879-886
19. Alektiar K.M., Hong L., Brennan M.F., et al. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: Preliminary results. Int J Radiat Oncol Biol Phys 68 (2007) 458-464
20. Griffin A.M., Euler C.I., Sharpe M.B., et al. Radiation planning comparison for superficial tissue avoidance in radiotherapy for soft tissue sarcoma of the lower extremity. Int J Radiat Oncol Biol Phys 67 (2007) 847-856
21. Hong L., Alektiar K.M., Hunt M., et al. Intensity-modulated radiotherapy for soft tissue sarcoma of the thigh. Int J Radiat Oncol Biol Phys 59 (2004) 752-759