Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: Results with two different total dose, fractionation, and overall treatment time schedules

International Journal of Radiation Oncology Biology Physics

Volumn 44, Issue 4, 1999, Pages 879-886

  Le Péchoux, Cécile ^a   Le Deley, Marie Cécile ^a   Delaloge, Suzette ^b   Lartigau, Eric ^a   Levy Piedbois, Christine ^a   Bonvalot, Sylvie ^a   Le Cesne, Axel ^a   Missenard, Gilles ^a   Terrier, Philippe ^a   Vanel, Daniel ^a   Genin, Jean ^a   Fontaine, Françoise ^a  

^a Inst G   (France)

^b HÔPITAL PAUL BROUSSE   (France)

Author keywords

Combined modality treatment; Hyperfractionated accelerated radiotherapy; Radiotherapy; Soft tissue sarcoma; Surgery

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CONTROL; CANCER SURVIVAL; CONSERVATIVE TREATMENT; DOSE RESPONSE; EXCISION; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; SOFT TISSUE SARCOMA; SURGICAL TECHNIQUE;

ADOLESCENT; ADULT; AGED; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; EXTREMITIES; FEMALE; HUMANS; MALE; MIDDLE AGED; RADIATION INJURIES; RETROSPECTIVE STUDIES; SARCOMA; SURVIVAL RATE;

EID: 0032980250     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00077-2     Document Type: Article

References (43)

1. Simon M.A., Enneking W.F. The management of soft tissue sarcoma of the extremities. J Bone Joint Surg. 58A:1976;317-327.
2. Suit H.D., Proppe K.H., Mankin H.J., et al. Preoperative radiation therapy for sarcoma of soft tissue. Cancer. 47:1981;2269-2274.
3. Lindberg R.D., Martin R.G., Romsdahl M.M., et al. Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas. Cancer. 47:1981;2391-2397.
4. Rosenberg S.A., Tepper J., Gladstein E., et al. The treatment of soft tissue sarcomas of the extremities Prospective evaluation of limb sparing surgery plus radiation therapy compared with amputation and the role of adjuvant chemotherapy . Ann Surg. 196:1982;305-315.
5. Tepper J.E., Suit H.D. Radiation therapy alone for sarcoma of soft tissue. Cancer. 56:1985;475-479.
6. Leibel S.A., Tranbaugh R.F., Wara W.M., et al. Soft tissue sarcoma of the extremities Survival and patterns of failure with conservative surgery and postoperative irradiation compared to surgery alone . Cancer. 50:1982;1076-1083.
7. Suit H.D., Mankin H.J., Wood W.C., et al. Preoperative, intraoperative and postoperative radiation in the treatment of primary soft tissue sarcoma. Cancer. 55:1985;2659-2667.
8. Shray M.F., Gunderson L.L., Sim F.H., et al. Soft tissue sarcoma Integration of brachytherapy, resection and external irradiation . Cancer. 66:1990;451-456.
9. Habrand J.L., Gerbaulet A., Pejovic M.H., et al. Twenty years experience of interstitial iridium brachytherapy in the management of soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 20:1991;405-411.
10. Thomas L., Delannes M., Stôckle E., et al. Intraoperative interstitial iridium brachytherapy in the management of soft tissue sarcomas Preliminary results of a feasibility phase II study . Radiother Oncol. 3:1994;99-105.
11. Goffman T., Tochner Z., Gladstein E. Primary treatment of large and massive adult sarcomas with iododeoxyuridine and aggressive hyperfractionated irradiation. Cancer. 67:1991;572-576.
12. Weichselbaum R.R., Beckett M.A., Vijayakumar S., et al. Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy. Int J Radiat Oncol Biol Phys. 19:1990;313-319.
13. Todoroki T., Suit H.D. Effect of fractionated irradiation prior to conservative and radical surgery on therapeutic gain in a spontaneous fibrosarcoma of the C3H mouse. J Surg Oncol. 31:1986;279-286.
14. Allam A., Perez L.A., Huang P., et al. The effect of the overall treatment time of fractionated irradiation on the tumor control probability of a human soft tissue sarcoma xenograft in nude mice. Int J Radiat Oncol Biol Phys. 32:1995;105-111.
15. Stuschke M., Budach V., Klaes W., et al. Radiosensitivity, repair capacity, and stem cell fraction in human soft tissue tumors An in vitro study using multicellular spheroids and the colony assay . Int J Radiat Oncol Biol Phys. 23:1992;69-80.
16. Carabell S.C., Goodman R.L. Radiation therapy for soft tissue sarcomas. Semin Oncol. 8:1981;201-206.
17. Bujko K., Suit H.D., Springfield D.S., et al. Wound healing after preoperative radiation for sarcoma of soft tissues. Surg Gynecol Obstet. 176:1993;124-134.
18. Herbert S.H., Corn B.W., Solin L.J., et al. Limb preserving treatment for soft tissue sarcomas of the extremities The significance of surgical margins . Cancer. 72:1993;1230-1238.
19. Stinson S.F., Delaney T.F., Greenberg J., et al. Acute and long term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 21:1991;1493-1499.
20. Lambin P., Malaise E.P., Joiner M.C. Mégafractionnement une méthode pour agir sur les tumeurs intrinsèquement radiorésistantes? Bull Cancer. 80:1993;417-423.
21. Kaplan E., Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 53:1958;457-481.
22. Schemper M., Smith T.L. A note on quantifying follow-up in studies of failure time. Controlled Clin Trials. 17:1996;343-346.
23. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 50:1966;163-170.
24. Cox D.R. Regression models and life tables (with discussion). J R Statist Soc B. 34:1972;187-220.
25. Gaynor J.J., Tan C.T., Casper E.S., et al. Refinement of clinicopathologic staging for localised soft tissue sarcoma of the extremity A study of 423 adults . J Clin Oncol. 10:1992;1317-1329.
26. Ravaud A., Bui N.B., Coindre J.M., et al. Prognostic variables for the selection of patients with operable soft tissue sarcomas to be considered in adjuvant chemotherapy trials. Br J Cancer. 66:1992;961-969.
27. Collin C., Godbold J., Hadju S., et al. Localised extremity soft tissue sarcoma An analysis of factors affecting survival . J Clin Oncol. 5:1987;601-612.
28. Le Vay J., O'Sullivan B., Catton C., et al. Outcome and prognostic factors in soft tissue sarcoma of the adult. Int J Radiat Oncol Biol Phys. 27:1993;1091-1099.
29. Coindre J.M., Terrier P., Bui N.B., et al. Pronostic factors in adult patients with locally controlled soft tissue sarcoma A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group . J Clin Oncol. 14:1996;869-877.
30. Wiklund T.A., Alvegard T.A., Mouridsen H.T., et al. Marginal surgery and postoperative radiotherapy in soft tissue sarcomas. Eur J Cancer. 29A:1993;306-309.
31. Suit H.D., Mankin H.J., Wood W.C., et al. Treatment of the patient with stage Mo soft tissue sarcoma. J Clin Oncol. 6:1988;854-862.
32. Dinges S., Budach V., Budach W., et al. Local recurrences of soft tissue sarcomas in adults A retrospective analysis of prognostic factors in 102 cases after surgery and radiation therapy . Eur J Cancer. 30A:1994;1636-1642.
33. Pisters P.W.T., Harrison L.B., Leung D.H.Y., et al. Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma. J Clin Oncol. 14:1996;859-868.
34. Yang J.C., Chang A.E., Baker A.R., et al. Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol. 16:1998;197-203.
35. Fagundes H.M., Lai P.P., Dehner L.P., et al. Postoperative radiotherapy for malignant fibrous histiocytoma. Int J Radiat Oncol Biol Phys. 23:1992;615-619.
36. Cany L., Bui N.B., Stöckle E., et al. Chimiotherapie d'induction et traitement combiné conservateur des sarcomes des tissus mous de l'adulte. Bull Cancer. 79:1992;1077-1085.
37. Markhede G., Angervall L., Stener B. A multivariate analysis of the prognosis after surgical treatment of malignant soft-tissue tumors. Cancer. 49:1982;1721-1733.
38. Stotter A.T., A'Hern R.P., Fisher C., et al. The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival. Cancer. 65:1990;1119-1129.
39. Singer S., Corson J.M., Gonin R., et al. Prognostic factors predictive of survival and local recurrence for extremity soft tissue sarcoma. Ann Surg. 219:1994;165-173.
40. Fein D.A., Lee W.R., Lanciano R.M., et al. Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation Do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control? Int J Radiat Oncol Biol Phys. 32:1995;969-976.
41. Robinson M., Barr L., Fisher C., et al. Treatment of extremity soft tissue sarcomas with surgery and radiotherapy. Radiother Oncol. 18:1990;221-233.
42. Serpell J.W., Ball A.B.S., Robinson M.H., et al. Factors influencing local recurrence and survival in patients with soft tissue sarcoma of the upper limb. Br J Surg. 78:1991;1368-1372.
43. Robinson M., Cassoni A., Harmer C., et al. High dose hyperfractionated radiotherapy in the treatment of extremity soft tissue sarcomas. Radiother Oncol. 22:1991;118-126.