Relation of urokinase-type plasminogen activator expression to presence and severity of atherosclerotic lesions in human coronary arteries

Thrombosis and Haemostasis

Volumn 79, Issue 3, 1998, Pages 579-586

  Kienast, Joachim ^a   Padró, Teresa ^a   Steins, Martin ^a   Li, Chang Xun ^a   Schmid, Kurt W ^a   Hammel, Dieter ^a   Scheld, Hans H ^a   Van De Loo, Jürgen C W ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1; UROKINASE;

ARTERY INTIMA; ARTERY MEDIA; ARTICLE; ATHEROGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE;

EID: 0031885829     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1614949     Document Type: Article

References (53)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-9.
2. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94: 2493-503.
3. Libby P. Molecular basis of the acute coronary syndromes. Circulation 1995; 91: 2844-50.
4. Davis MJ, Thomas AC. Plaque fissuring: the cause of acute myocardial infarction, sudden ischemic death, and crescendo angina. Br Heart J 1985; 53: 363-73.
5. Jonasson L, Holm J, Skalli O, Bondjers G, Hansson GK. Regional accumulation of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 1986; 6: 131-8.
6. Welgus HG, Campbell EJ, Curry JD, Eisen AZ, Senior RM, Wilhelm SM, Goldberg GI. Neutral metalloproteinases produced by human mononuclear phagocytes: enzyme profile, regulation and cellular differentiation. J Clin Invest 1990; 86: 1496-502.
7. Fuster V, Stein B, Ambrose JA, Badimon L, Badimon JJ, Chesebro JH. Atherosclerotic plaque rupture and thrombosis. Circulation 1990; 82 (Supp II): 47-59.
8. Vassalli JD. The urokinase receptor. Fibrinolysis 1994; 8 (Suppl): 172-81.
9. Vassalli JD, Sappino AP, Belin D. The plasminogen activator/plasmin system. J Clin Invest 1991; 88: 1067-72.
10. Reuning U, Bang NU. Regulation of the urokinase-type plasminogen activator receptor on vascular smooth muscle cells is under control of thrombin and other mitogens. Arterioscler Thromb 1992; 12: 1161-70.
11. Lundgren CH, Sawa H, Sobel BE, Fujii S. Modulation of expression of monocyte/macrophage plasminogen activator activity and its implications for attenuation of vasculopathy. Circulation 1994; 90: 1927-34.
12. Odekon LE, Blasi F, Rifkin D. Requirement for receptor-bound urokinase in plasmin dependent cellular conversion of latent TGF-β to TGF-β. J Cell Physiol 1994; 158: 398-407.
13. Falcone DJ, McCaffrey TA, Haimovitz-Friedman A, Vergilio JA, Nicholson AC. Macrophage and foam cell release matrix-bound growth factors. Role of plasminogen activation. J Biol Chem 1993; 268: 11951-8.
14. De Petro G, Copeta A, Barlati S. Urokinase-type and tissue-type plasminogen activators as growth factors of human fibroblasts. Exp Cell Res 1994; 213: 286-94.
15. Kanse SM, Kost C, Benzakour O, Kanthou C, Lijnen R, Preissner KT. Urokinase-type plasminogen activator in vasoproliferative disorders: Induction of vascular smooth muscle cell proliferation indicates a novel mechanism of action. Thromb Haemost 1997; Suppl: 582 (Abstract).
16. Clowes AW, Clowes MM, Au YPT, Reidy MA, Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res 1990; 67: 61-7.
17. More RS, Underwood MJ. Brack MJ, de Bono DP, Gershlick AH. Changes in vessel wall plasminogen activator activity and smooth muscle cell proliferation and activation after arterial injury. Cardiovasc Res 1995; 29: 22-6.
18. Reidy MA, Irvin C, Lindner V. Migration of arterial wall cells. Expression of plasminogen activators and inhibitors in injured rat arteries. Circ Res 1996; 78: 405-14.
19. Kenagy RD. Vergel S, Mattsson E, Bendeck M, Reidy MA. Clowes AW. The role of plasminogen, plasminogen activators and matrix metalloproteinases in primate arterial smooth muscle cell migration. Arterioscler Thromb Vasc Biol 1996; 16: 1373-82.
20. Carmeliet P, Collen D. Gene manipulation and transfer of the plasminogen and coagulation system in mice. Semin Thromb Hemostas 1996; 22: 525-42.
21. Padró T, Emeis JJ, Steins M, Schmid KW, Kienast J. Quantification of plasminogen activators and their inhibitors in the aortic vessel wall in relation to the presence and severity of atherosclerotic disease. Arterioscler Thromb Vasc Biol 1995; 15: 893-902.
22. Lupu F, Heim DA, Bachmann F, Hurni M, Kakkar VV, Kruithof EKO. Plasminogen activator expression in human atherosclerotic lesions. Arterioscler Thromb Vasc Biol 1995; 15: 1444-55.
23. Schneiderman J, Bordin GM, Engelberg I, Adar R, Seiffert D, Thinnes T, Bernstein EF, Dilley RB, Loskutoff D. Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. J Clin Invest 1995; 96: 639-45.
24. Underwood MJ, de Bono DP. Increased fibrinolytic activity in the intima of atheromatous coronary arteries: protection at a price. Cardiovasc Res 1993; 27: 882-5.
25. Raghunath PN, Tomaszewski JE, Brady ST, Caron RJ, Okada SS, Barnathan ES. Plasminogen activator system in human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1995; 15: 1432-43.
26. Ronne E, Hoyer-Hansen G; Brünner N, Pedersen H, Rank F, Osborne CK, Clark GM, Dano K, Grondahl-Hansen J. Urokinase receptor in breast cancer tissue extracts. Enzyme-linked immunosorbent assay with a combination of mono-and polyclonal antibodies. Breast Cancer Res Treat 1995; 33: 199-207.
27. Camiolo SM, Siuta MR, Madeja JM. Improved medium for extraction of plasminogen activator from tissue. Prep Biochem 1982; 12: 297-305.
28. Reilly JM, Sicard GA, Lucore CL. Abnormal expression of plasminogen activators in aortic aneurysmal and occlusive disease. J Cardiovasc Surg 1994; 19: 865-72.
29. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Kleuk DC. Measurement of protein using bicinchonimc acid. Anal Biochem 1985; 150: 76-85.
30. Pannell R, Gurewich V. Activation of plasminogen by single-chain urokinase or by two-chain urokinase. A demonstration that single-chain urokinase has a low catalytic-activity. Blood 1987; 69: 22-6.
31. Nauland U, Rijken DC. Activation of thrombin-inactivated single-chain urokinase-type plasminogen activator by dipeptidyl peptidase I. Eur J Biochem 1994; 223: 497-501.
32. Powell-Jones CHJ. Rapid SDS-PAGE zymography of plasminogen activators. Thromb Res 1988; 49: 299-302.
33. Medcalf RL, Van der Berg E, Schleuning WD. Glucocorticoid modulated gene expression of tissue and urinary type plasminogen activator and plasminogen activator inhibitor 1 and 2. J Cell Biol 1988; 106: 971-8.
34. Cox KH, de Leon DV, Angerer LM, Angerer RC. Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev Biol 1984; 101: 485-502.
35. Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D. Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization. J Clin Invest 1988; 82: 1134-43.
36. Höltke HJ, Kessler C. Non-radioactive labeling of RNA transcripts in vitro with the hapten digoxigenin (DIG); hybridization and ELISA based detection. Nucl Acid Res 1990; 18: 5843-51.
37. Bankfalvi A, Navabi H, Bier B, Böcker W, Jasani B, Schmid KW. Wet autoclave pretreatment for antigen retrieval in diagnostic immunohistochemistry. J Pathol 1994; 174: 223-8.
38. Siegel S, Castellan J.N. Nonparametric statistics for the behavioral sciences. Singapore: McGraw-Hill Book Co; 1988: 190-223.
39. Besser D, Verde P, Nagamine Y, Blasi F. Signal transduction and the UPA/UPAR system. Fibrinolysis 1996; 10: 215-37.
40. Robbie LA, Booth NA, Brown PAJ, Bennett B. Inhibitors of fibrinolysis are elevated in atherosclerotic plaque. Arterioscler Thromb Vasc Biol 1996; 16: 539-45.
41. Falkenberg M, Tjärnström J, Örtenwall P, Olausson M, Risberg B. Localization of fibrinolytic activators and inhibitors in normal and atherosclerotic vessels. Thromb Haemost 1996; 75: 933-8.
42. Conese M, Blasi F. Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation. Biol Chem Hoppe-Seyler 1995; 376: 143-55.
43. Wilhelm S, Wilhelm O, Schmitt M, Graeff H. Inactivation of receptor-bound pro-urokinase-type plasminogen activator (pro-uPA) by thrombin and thrombin/ thrombomodulin complex. Biol Chem Hoppe-Seyler 1994; 375: 603-8.
44. Dechend R, Mo X, Schulz W, Gross M, Praus M, Dietz R. Thrombin receptor and urokinase-type plasminogen activator are colocalized in vascular smooth muscle cells derived from human carotid atherosclerotic plaques. Fibrinolysis 1996; 10: 41-5.
45. Padró T, Steins M, Hammel D, Kienast J. Atherosclerosis-related alterations of the plasminogen activator/plasmin system in vascular wall: studies in human coronary arteries. Thromb Haemost 1993; 69: 971 (Abstract).
46. Grondahl-Hansen J, Kirkeby LT, Ralfkiaer E, Kristensen P, Lund LR, Dano K. Urokinase-type plasminogen activator in endothelial cells during acute inflammation of the appendix. Am J Pathol 1989; 135: 631-6.
47. Bacharach E, Itin A, Keshet E. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc Natl Acad Sci USA 1992; 89: 10686-90.
48. Dollery CM, McEwan J, Henney AM. Matrix metalloproteinases and cardiovascular disease. Circ Res 1995; 77: 863-8.
49. Fuster V, Badimón L, Badimón JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part one). N Engl J Med 1992; 326: 242-50.
50. Fuster V, Badimón L, Badimón JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (part two). N Engl J Med 1992; 326: 310-8.
51. Juhan-Vague I, Alessi MC. Plasminogen activator inhibitor 1 and athero-thrombosis. Thromb Haemost 1993; 70: 138-43.
52. Hamsten A, de Faire U, Walldius G, Dahlen G, Szamosi A, Landou C, Blombäck M, Wiman B. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 1987; 2: 3-9.
53. Gram J, Jespersen J. A selective depression of tissue plasminogen activator (t-PA) activity in euglobulins characterizes a risk group among survivors of acute myocardial infarction. Thromb Haemost 1987; 57: 137-9.