Human cecal bile acids: Concentration and spectrum

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 293, Issue 1, 2007, Pages

  Hamilton, James P ^a,f   Xie, Guofeng ^a   Raufman, Jean Pierre ^a   Hogan, Susan ^b   Griffin, Terrance L ^c   Packard, Christine A ^c   Chatfield, Dale A ^c   Hagey, Lee R ^d   Steinbach, Joseph H ^d   Hofmann, Alan F ^d,e  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b State of Maryland   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bile acid deconjugation; Bile acid dehydroxylation; Intestinal bile acids; Mass spectrometry of bile acids

Indexed keywords

3ALPHA HYDROXY BILE ACID; BILE ACID; CHENODEOXYCHOLIC ACID; DEOXYCHOLIC ACID; LITHOCHOLIC ACID; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ARTICLE; CAUSE OF DEATH; CECUM; CONTROLLED STUDY; DRUG INTOXICATION; ENZYME ASSAY; GAS CHROMATOGRAPHY; HOMICIDE; HUMAN; HUMAN TISSUE; INJURY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SUICIDE;

BILE ACIDS AND SALTS; CECUM; CHENODEOXYCHOLIC ACID; CHOLIC ACIDS; CHROMATOGRAPHY, LIQUID; DEOXYCHOLIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTROINTESTINAL CONTENTS; HUMANS; LITHOCHOLIC ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; URSODEOXYCHOLIC ACID;

EID: 34547096042     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00027.2007     Document Type: Article

References (49)

1. Aldini R, Roda A, Montagnani M, Cerrè C, Pellicciari R, Roda E. Relationship between intestinal absorption of bile acids with a steroid or side-chain modification. Steroids 61: 590-597, 1996.
2. Breuer NF, Rampton DS, Tammar A, Murphy GM, Dowling RH. Effect of colonic perfusion with sulfated and nonsulfated bile acids on mucosal structure and function in the rat. Gastroenterology 84: 969-977, 1983.
3. Breuer N, Jaekel S, Dommes P, Goebell H. Fecal bile acid excretion pattern in cholecystectomized patients. Dig Dis Sci 31: 953-960, 1986.
4. Chadwick VS, Gaginella TS, Carlson GL, Debongnie JC, Phillips SF, Hofmann AF. Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon. J Lab Clin Med 94: 661-674, 1979.
5. Chen G, Zhang D, Jing N, Falany CN, Radominska-Pandya A. Human gastrointestinal sulfotransferases: identification and distribution. Toxicol Appl Pharmacol 187: 186-197, 2003.
6. 2H-ethanol. Oxidoreduction of isomeric 3-hydroxycholanoic acids and reduction of 3-oxo-4-cholenoic acid. Eur J Biochem 26: 251-258, 1972.
7. Del Vecchio S, Ostrow JD, Mukerjee P, Ton-Nu HT, Schteingart CD, Hofmann AF, Cerrè C, Roda A. A method for removal of surface active impurities and calcium from conjugated bile salt preparations: comparison with silicic acid chromatography. J Lipid Res 36: 2639-2650, 1995.
8. - cotransport system. J Clin Invest 75: 462-471, 1985.
9. Eneroth P, Gordon B, Ryhage R, Sjövall J. Identification of mono- and dihydroxy bile acids in human feces by gas-liquid chromatography and mass spectrometry. J Lipid Res 7: 511-523, 1966.
10. Evans DF, Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29: 1035-1041, 1988.
11. Freel R, Hatch M, Earnest DL, Goldner AM. Role of tight-junctional pathways in bile salt-induced increases in colonic permeability. Am J Physiol Gastrointest Liver Physiol 245: G816-G823, 1983.
12. Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW, Eichelbaum M, Siegmund W, Schrenk D. The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol 157: 1575-1580, 2000.
13. Gordon SJ, Kinsey MD, Magen JS, Joseph RE, Kowlessar OD. Structure of bile acids associated with secretion in the rat cecum. Gastroenterology 77: 38-44, 1979.
14. Goto J, Kato H, Hasegawa F, Nambara T. Synthesis of monosulfates of unconjugated and conjugated bile acids. Chem Pharm Bull (Tokyo) 27: 1402-1411, 1979.
15. Goto T, Myint KT, Sato K, Wada O, Kakiyama G, Iida T, Hishinuma T, Mano N, Goto J. LC/ESI-tandem mass spectrometric determination of bile acid 3-sulfates in human urine. 3beta-Sulfooxy-12alpha-hydroxy-5beta-cholanoic acid is an abundant nonamidated sulfate. J Chromatogr B Analyt Technol Biomed Life Sci 846: 69-77.
16. Gurantz D, Hofmann AF. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol Gastrointest Liver Physiol 247: G736-G748, 1984.
17. Hofmann AF. The function of bile salts in fat absorption: the solvent properties of dilute micellar solutions of conjugated bile salts. Biochem J 89: 57-68, 1963.
18. Hofmann AF. Intestinal absorption of bile acids and biliary constituents: the intestinal component of the enterohepatic circulation and the integrated system. In: Physiology of the Gastrointestinal Tract (3rd ed., vol. 2), edited by Johnson LR, Alpers DH, Christensen J, Jacobson ED, and Walsh JH. New York: Raven, 1994, p. 1845-1865.
19. 2+ ions. J Lipid Res 33: 617-626, 1992.
20. Hofmann AF, Poley JR. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology 62: 918-934, 1972.
21. Huang XP, Heyman M, Nath K, Castagna M, Desjeux J. Distinct signaling mediates chloride secretion induced by tumor promoter bile salts and phorbol esters in human colonic cells. Int J Oncol 6: 1159-1163, 1995.
22. Keely S, Scharl M, Bertelsen LS, Hagey LR, Barrett KE, Hofmann AF. Bile acid induced secretion in polarized monolayers of T84 colonic epithelial cells: structure-activity relationships. Am J Physiol Gastrointest Liver Physiol 292: G290-G297, 2007.
23. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 2: 10-32, 1987.
24. Lapré JA, De Vries HT, Termont DSML, Kleibeuker JH, De Vries EGE, van der Meer R. Mechanism of the protective effect of supplemental dietary calcium on cytolytic activity of fecal water. Cancer Res 53: 248-253, 1993.
25. Marcus SN, Schteingart CD, Marquez ML, Hofmann AF, Xia Y, Steinbach JH, Ton-Nu HT, Lillienau J, Angellotti MA, Schmassmann A. Active absorption of conjugated bile acids in vivo. Kinetic parameters and molecular specificity of the ileal transport system in the rat. Gastroenterology 100: 212-221, 1991.
26. Marschall HU, Broomè U, Einarsson C, Alvelius G, Thomas HG, Matern S. Isoursodeoxycholic acid: metabolism and therapeutic effects in primary biliary cirrhosis. J Lipid Res 42: 735-742, 2001.
27. Marschall HU, Roeb E, Yildiz Y, Busch N, Nguyen H, Purucker E, Thomas HG, Matern S. Study of human isoursodeoxycholic acid metabolism. J Hepatol 26: 863-870, 1997.
28. Matoba N, Une M, Hoshita T. Identification of unconjugated bile acids in human bile. J Lipid Res 27: 1154-1162, 1986.
29. Mauricio A, Slawik M, Heitzmann D, von Hahn T, Warth R, Bleich M, Greger R. Deoxycholic acid (DOC) affects the transport properties of distal colon. Pflügers Arch 439: 532-540, 2000.
30. Mekhjian HS, Phillips SF, Hofmann AF. Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest 50: 1569-1577, 1971.
31. Meier PJ, Stieger B. Bile salt transporters. Annu Rev Physiol 64: 635-661, 2002.
32. -- secretion induced by taurodeoxycholate from colon mucosa. Biol Cell 95: 115-122, 2003.
33. Northfield TC, McColl I. Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine. Gut 14: 513-518, 1973.
34. Phillips SF, Giller J. The contribution of the colon to electrolyte and water conservation in man. J Lab Clin Med 81: 733-746, 1973.
35. Poley JR, Hofmann AF. Role of fat maldigestion in pathogenesis of steatorrhea in ileal resection. Fat digestion after two sequential test meals with and without cholestyramine. Gastroenterology 70: 1125-1129, 1976.
36. Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey LR, Macdonald EA, Hofmann AF. A simple and accurate enzymatic method for measurement of total fecal bile acids in patients with severe fat malabsorption. J Lab Clin Med 141: 411-418, 2003.
37. Potter G, Sellin J, Burlingame S. Bile acid stimulation of cyclic AMP and ion transport in developing rabbit colon. J Pediatr Gastroenterol Nutr 13: 335-341, 1991.
38. Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformation by intestinal bacteria. J Lipid Res 47: 24-59, 2006.
39. Roda A, Minutello A, Angellotti MA, Fini A. Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC. J Lipid Res 31: 1433-1443, 1990.
40. Roovers R, Evrard E, Vanderhaeghe H. An improved method for measuring human blood bile acids. Clin Chim Acta 19: 449-457, 1986.
41. Rossi SS, Converse JL, Hofmann AF. High pressure liquid chromatographic analysis of conjugated bile acids in human bile: simultaneous resolution of sulfated and unsulfated lithocholyl amidates and the common conjugated bile acids. J Lipid Res 28: 589-595, 1987.
42. Schiff ER, Small NC, Dietschy JM. Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat. J Clin Invest 51: 1351-1362, 1972.
43. Setchell KDR, Street JM, Sjövall J. Fecal bile acids. In: The Bile Acids: Chemistry, Physiology, Metabolism, edited by Setchell KDR, Kritchevsky D, and Nair PP. New York: Plenum, 1988.
44. Shefer S, Salen G, Hauser S, Dayal B, Batta AK. Metabolism of iso-bile acids in the rat. J Biol Chem 257: 1401-1406, 1982.
45. Stiehl A, Raedsch R, Rudolph G, Gundert-Remy U, Senn M. Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients. Hepatology 5: 492-495, 1985.
46. Takikawa H, Beppu T, Seyama Y. Profiles of bile acids and their glucuronide and sulphate conjugates in the serum, urine, and bile from patients undergoing bile drainage. Gut 26: 38-42, 1985.
47. Tanida N, Hikasa Y, Hosomi M, Satomi M, Oohama I, Shimoyama T. Fecal bile acid analysis in healthy Japanese subjects using a lipophilic anion exchanger, capillary column gas chromatography, and mass spectrometry. Gastroenterol Jpn 16: 363-371, 1981.
48. Tserng KY, Hachey DL, Klein PD. An improved procedure for the synthesis of glycine and taurine conjugates of bile acids. J Lipid Res 18: 404-407, 1977.
49. Wang Q, Bhardwaj RK, Herrera-Ruiz D, Hanna NN, Hanna IT, Gudmundsson OS, Buranachokpaisan T, Hidalgo IJ, Knipp GT. Expression of multiple drug resistance conferring proteins in normal Chinese and Caucasian small and large intestinal tissue samples. Mol Pharm 1: 447-454, 2004.