Reflection paper on the use of third and fourth generation cephalosporins in food producing animals in the European Union: Development of resistance and impact on human and animal health

Journal of Veterinary Pharmacology and Therapeutics

Volumn 32, Issue 6, 2009, Pages 515-533

  Greko, Christina ^a  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA LACTAMASE AMPC; BETA LACTAMASE CTX M; BETA LACTAMASE SHV; BETA LACTAMASE TEM 1; CEFACETRILE; CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOTIN; CEFAPIRIN; CEFAZOLIN; CEFEPIME; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEFPIROME; CEFQUINOME; CEFTIOFUR; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; EXTENDED SPECTRUM BETA LACTAMASE; LATAMOXEF; PENICILLIN BINDING PROTEIN 2A; UNCLASSIFIED DRUG;

ACINETOBACTER; ANIMAL HEALTH; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACTERIAL CELL WALL; BACTERIAL CHROMOSOME; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIUM ISOLATION; COLIFORM BACTERIUM; DRUG CLASSIFICATION; DRUG INDICATION; DRUG MECHANISM; DRUG UTILIZATION; ENTEROBACTERIACEAE; ENVIRONMENTAL EXPOSURE; ESCHERICHIA COLI; EUROPEAN UNION; FOOD INDUSTRY; GENE AMPLIFICATION; GENETIC ANALYSIS; HOSPITAL INFECTION; HUMAN; INTEGRON; KLEBSIELLA PNEUMONIAE; LACTATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROFLORA; MILK; MULTIDRUG RESISTANCE; NONHUMAN; OFF LABEL DRUG USE; PENICILLIN RESISTANCE; PLASMID; PRACTICE GUIDELINE; PREVALENCE; PRIORITY JOURNAL; PSEUDOMONAS; PUBLIC HEALTH; REVIEW; SALMONELLA; SEPTICEMIA; SEROTYPE; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; TRANSPOSON; UNCERTAINTY;

ANIMALS; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; EUROPEAN UNION; FOOD CONTAMINATION; HUMANS;

ANIMALIA; ENTEROBACTERIACEAE;

EID: 70449704652     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2009.01075.x     Document Type: Review

References (139)

1. CMY-2 mediated cephalosporin resistance in a multiresistant Salmonella enterica serovar Heidelberg isolate stemming from the importation of a boar by Denmark from Canada. Antimicrobial Agents and Chemotherapy, 48, 1916 1917.
2. AFSSA (2005) Suivi des ventes de médicaments vété rinaires contenant des antibiotiques en France en 2005. Available at: http://www.afssa.fr.
3. Ahmed, A.M. Shimamoto, T. (2008) Emergence of a cefepime- & cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37. International Journal of Antimicrobial Agents, 32, 256 261.
4. Alcaine, S.D., Sukhnan, S.S., Warnick, L.D., Su, W.-L., McGann, P., McDonough, P. Wiedmann, M. (2005) Ceftiofur-resistant Salmonella strains isolated from dairy farms represent multiple widely distributed subtypes that evolved by independent horizontal gene transfer. Antimicrobial Agents and Chemotherapy, 49, 4061 4067.
5. Allen, K.J. Poppe, C. (2002) Occurence and characterization of resistance to extended spectrum cephalosporins mediated by beta-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Canadian Journal of Veterinary Research, 66, 137 144.
6. Alvarez, M., Tran, J.H., Chow, N. Jacoby, G.A. (2004) Epidemiology of conjugative plasmid-mediated AmpC beta-lactamases in the United States. Antimicrobial Agents and Chemotherapy, 48, 533 537.
7. Ambler, R.P. (1980) The structure of beta-lactamases. Philosophical Transactions of the Royal Society B Biological Sciences, 289, 321 331.
8. Anonymous (2003) Memorandum 2003:9a: Recommendations for the Use of Antimicrobial Agents in the Treatment of the Most Significant Infectious Diseases in Animals, Memorandum to the Ministry of Agriculture & Forestry, Helsinki. Available at: http://wwwb.mmm.fi/julkaisut/tyoryhmamuistiot/2003/ tr2003-9a.pdf.
9. Anonymous (2005) Guidelines for ATC Classification and DDD Assignment. WHO Collaborating Centre for Drug Statistics Methodology. Available at: http://www.whocc.no/atcddd/.
10. Anonymous (2006a) EARSS (European Antimicrobial Resistance Surveillance System) Annual Report 2005. Available at: http://www.rivm.nl/earss.
11. Anonymous (2006b) Report of the Task Force of Zoonoses Data Collection including a proposal for a harmonized monitoring scheme of antimicrobial resistance in Salmonella in fowl (Gallus gallus), turkeys and pigs and Campylobacter jejuni and C. coli in broilers. The EFSA Journal, 403, 1 16. Available at: http://www.efsa.europa.eu.
12. Anonymous (2008) Foodborne antimicrobial resistance as a biological hazard. Scientific opinion of the panel of biological hazards. The EFSA Journal, 765, 2 87. Available at: http://www.efsa.europa.eu.
13. Arlet, G., Barret, T.J., Butaye, P., Cloekaert, A., Mulvey, M.R. White, D.G. (2006) Salmonella resistant to extended spectrum cephalosporins: prevalence and epidemiology. Microbes and Infection, 8, 1945 1954.
14. Asensio, A., Guerrero, A., Quereda, C., Lizan, M. Martinez-Ferrer, M. (1996) Colonisation and infection with methicillin-resistant Staphylococcus aureus associated factors and eradication. Infection Control and Hospital Epidemiology, 17, 20 28.
15. Batchelor, M., Clifton-Hadley, F.A., Stallwood, A.D., Piba, G.A., Davies, R.H. Liebana, E. (2005a) Detection of multiple cephalosporin-resistant Escherichia coli from a cattle faecal sample in Great Britain. Microbial Drug Resistance, 11, 58 61.
16. CTX-M genes in clinical Salmonella isolates recovered from humans in England and Wales from 1992 to 2003. Antimicrobial Agents and Chemotherapy, 49, 1319 1322.
17. Batchelor, M., Threlfall, E.J. Liebana, E. (2005c) Cephalosporin resistance among animal associated Enterobacteria: a current perspective. Expert Reviews on Anti-Infective Therapy, 3, 403 417.
18. Ben-Ami, R., Schwaber, M.J., Navon-Venezia, S., Schwartz, D., Giladi, M., Chmelnitsky, I., Leavitt, A. Carmeli, Y. (2006) Influx of extended-spectrum beta-lactamase-producing Enterobacteriaceae into the hospital. Clinical Infectious Diseases, 42, 925 934.
19. Berge, A.C.B., Adaska, J.M. Sischo, W.M. (2004) Use of antibiotic susceptibility patterns and pulsed-field gel electrophoresis to compare historic and contemporary isolates of multidrug-resistant Salmonella enterica. Applied and Environmental Microbiology, 70, 318 323.
20. Berge, A.C., Moore, D.A. Sischo, W.M. (2006) Field trial evaluating the influence of prophylactic and therapeutic antimicrobial administration on antimicrobial resistance of fecal Escherichia coli in dairy calves. Applied and Environmental Microbiology, 72, 3872 3878.
21. Bertrand, S., Weill, F.-X., Cloeckaert, A., Vrints, M., Mairaux, E., K., P., Dierick, K., Wildemauve, C., Godard, C., Butaye, P., Imberechts, H., Grimont, P.A. Collard, J.-M. (2006) Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2) producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in belgium and France (2000 to 2003). Journal of Clinical Microbiology, 44, 2897 2903.
22. Biedenbach, D.J., Toleman, M., Walsh, T.R. Jones, R.N. (2006) Analysis of Salmonella spp. with resistance to extended-spectrum cephalosporins and fluoroquinolones in North Americaand Latin America: report from the SENTRY antimicrobial surveillance program (1997-2004). Diagnostic Microbiology and Infectious Diseases, 54, 13 21.
23. Blanc, V., Mesa, R., Saco, M., Lavilla, S., Prats, G., Miro, E., Navarro, F., Cortes, P. Llagostera, M. (2006) ESBL- and plasmidic class C betalactamase producing E. coli strains isolated from poultry, pig and rabbit farms. Veterinary Microbiology, 118, 299 304.
24. Blásquez, J., Morosini, M.-I., Negri, M.-C. Baquero, F. (2000) Selection of naturally occurring extended-spectrum TEM betalactamase variants by fluctuating beta-lactam pressure. Antimicrobial Agents and Chemotherapy, 44, 2182 2184.
25. Boyce, J., Cookson, B., Christiansen, K., Hori, S., Vuopio-Varkila, J., Kocagöz, S., Öztop, A.Y., Vandenbroucke-Grauls, C.M.J.E., Harbart, S. Pittet, D. (2005) Meticillin-resistant Staphylococcus aureus. The Lancet Infectious Diseases, 5, 653 663.
26. Bradford, P.A., Petersen, P.J., Fingerman, I.M. White, D.G. (1999) Characterization of expanded spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease. Journal of Antimicrobial Chemotherapy, 44, 607 610.
27. Brinas, L., Zarazaga, M., Saenz, Y., Ruiz-Larrera, F. Torres, C. (2002) beta-lactamase characterization in ampicillin-resistant Escherichia coli isolates obtained from foods, humans and healthy animals. Antimicrobial Agents and Chemotherapy, 46, 3156 3163.
28. Brinas, L., Moreno, M.A., Teshager, T., Zarazaga, M., Saenz, Y., Porrero, M.C., Domingues, L. Torres, C. (2003a) beta-lactmase characterization in Escherichia coli isolates with diminished susceptibility or resistance to extended spectrum cephalosporins recovered from sick animals in Spain. Microbial Drug resistance, 9, 201 209.
29. Brinas, L., Moreno, M.A., Zarazaga, M., Porrero, M.C., Saenz, Y., Garcia, M., Domingues, L. Torres, C. (2003b) Detection of CMY-2, CTX-M-14 and SHV-12 beta-lactamases in Escherichia coli faecal sample isolates from healthy chickens. Antimicrobial Agents and Chemotherapy, 47, 2056 2058.
30. Brinas, L., Moreno, M.A., Teshager, T., Saenz, Y., Porrero, M.C., Domingues, L. Torres, C. (2005) Monitoring and characterization of extended-spectrum beta-lactamases in Escherichia coli strains from healthy and sick animals in Spain in 2003. Antimicrobial Agents and Chemotherapy, 49, 1262 1264.
31. Bush, K., Jacoby, G.A. Medeiros, A.A. (1995) A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrobial Agents and Chemotherapy, 39, 1211 1233.
32. Canton, R. Coque, T.M. (2006) The CTX-M beta-lactamase pandemic. Current Opinion in Microbiology, 9, 466 475.
33. Carattoli, A. (2008) Animal reservoirs for extended spectrum beta-lactamase producers. Clinical Microbiology and Infection, 14 (Suppl. 117 123.
34. Carattoli, A., Tosini, F., Giles, W.P., Rupp, M.E., Hinrichs, S.H., Angulo, F., Barrett, T.J. Fey, P.D. (2002) Characterization of plasmids carrying CMY-2 from expanded spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998. Antimicrobial Agents and Chemotherapy, 46, 1269 1272.
35. Cavaco, L.M., Abatih, E., Aarestrup, F.M. Guardabassi, L. (2008) Selection and persistence of CTX-M-producing Escherichia coli in the intestinal flora of pigs treated with amoxicillin, ceftiofur, or cefquinome. Antimicrobial Agents Chemotherapy, 52, 3612 3616.
36. Chaslus-Dancla, E., Pohla, P., Meurisse, M., Marin, M. Lafont, J.P. (1991) High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides, gentamicin and apramycin. Antimicrobial Agents and Chemotherapy, 35, 590 591.
37. Chen, S., Zhao, S., White, D.G., Schroeder, C.M., Lu, R., Yang, H., McDermott, P.F., Ayers, S. Meng, J. (2004) Characterization of multiple-antimicrobial-resistant Salmonella serovars isolated from retail meats. Applied and Environmental Microbiology, 70, 1 7.
38. Cheung, T.K.M., Y.W., C., Chu, M.Y., Choi, H.M., Yung, R.W.H.Y. Kam, K.M. (2005) Plasmid-mediated resistance to ciprofloxacin and cefotaxime in clinical isolates of Salmonella enterica serotype enteritidis in Hong Kong. Journal of Antimicrobial Chemotherapy, 56, 586 589.
39. Chiu, C.H., Su, L.H., Chia, J.H., Wu, T.L., Lee, Y.S. Ou, J.T. (2004) Isolation of Salmonella enterica serotype choleresuis resistant to ceftriaxone and ciprofloxacin. The Lancet, 363, 1285 1286.
40. Coenen, S., Ferench, M., Dvorakova, K., Hendrickx, E., Suetens, C. Goosens, H. (2006) European surveillance of antimicrobial consumption (ESAC): outpatient cephalosporin use in Europe. Journal of Antimicrobial Chemotherapy, 58, 401 407. (Pubitemid 44294954)
41. Corpet, D.E. (1988) Antibiotic resistance from food. New England Journal of Medicine, 318, 1206 1207.
42. DANMAP 2006 (2007) Use of antimicrobial agents and occurrence of resistance in bacteria from food animals, foods and humans in Denmark. Available at: http://www.dfvf.dk.
43. Devasia, R.A., Varma, J.K., Whichard, J., Gettner, S., Cronquist, A.B., Hurd, S., Segler, S., Smith, K., Hoeffer, D., Shifferaw, B., Angulo, F.J. Jones, T.F. (2005) Antimicrobial use and outcomes in patients with multidrug-resistant and pansusceptible Salmonella Newport infections. Microbial Drug Resistance, 11, 371 377.
44. Donaldson, S.C., Straley, B.A., Hegde, V., Sawant, A.A., DebRoy, C. Jayarao, B.M. (2006) Molecular epidemiology of ceftiofur-resistant Escherichia coli isoslates from dairy calves. Applied and Environmental Microbiology, 72, 3940 3948.
45. Dunne, E.F., Fey, P.D., Kludt, P., Reporter, R., Mostashari, F., Shillam, P., Wicklund, J., Miller, C., Holland, B., Stamey, K., Barrett, T.J., Rasheed, J.K., Tenover, F.C., Ribot, E.M. Angulo, F.J. (2000) Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. Journal of the American Medical Association, 284, 3151 3156.
46. Erskine, R., Bartlett, P., VanLente, J.L. Phipps, C.R. (2002) Efficacy of systemic ceftiofur as a therapy for severe clinical mastitis in dairy cattle. Journal of Dairy Science, 85, 2571 2575.
47. Espie, E., De-Valk, H., Vallliant, V., Quelquejeu, N., Le-Querrec, F. Weill, F.X. (2004) An outbreak of multidrug-resistant Salmonella enterica serotype Newport infections linked to the consumption of imported horse meat in France. Epidemiology and Infection, 133, 373 376.
48. Federal Veterinary Association and the Working Group of Chief Veterinary Officers (2000) Guidelines for prudent use of antimicrobial substances in veterinary medicine. Deutsches Tierärzteblatt, 48 (Suppl. 11 1 12.
49. Ferech, M., Coenen, S., Malhotra-Kumar, S., Dvorakova, K., Hendrickx, E., Suetens, C. Goossens, H. (2006) European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe. Journal of Antimicrobial Chemotherapy, 58, 401 407. (Pubitemid 44294954)
50. Fey, P.D., Safranek, T.J., Rupp, M.E., Dunne, E.F., Ribot, E., Iwen, P.C., Bradford, P.A., Angulo, F.J. Hinrichs, S.H. (2000) Ceftriaxone-resistant salmonella infection acquired by a child from cattle [see comments]. New England Journal of Medicine, 342, 1242 1249.
51. FINRES-vet 2005-2006. Finnish veterinary antimicrobial resistance monitoring and consumption of antimicrobial agents. Evira publications 22/2007. Available at: http://www.evira.fi.
52. Frye, J.G. Fedorka-Cray, P.J. (2007) Prevalence, distribution and characterisation of ceftiofur resistance in Salmonella enterica isolated from animals in the USA from 1999 to 2003. International Journal of Antimicrobial Agents, 30, 134 142.
53. FVE (1999) Antibiotic Resistance & Prudent Use of Antibiotics in Veterinary Medicine. Federation of veterinarians of Europe. Available at: http://www.fve.org/papers/pdf/vetmed/position-papers/antibioen.pdf.
54. Giguère, S. (2006) Antimicrobial drug use in horses. In Antimicrobial Therapy in Veterinary Medicine, 4th edn. Eds Giguère, S., Prescott, J.F., Baggot, J.D., Walker, R.D. Dowling, P.M., pp. 449 462. Blackwell publishing Ltd, Oxford.
55. Girlich, D., Poirel, L., Carattoli, A., Kempf, I., Lartigue, M.-F., Bertini, A. Nordmann, P. (2007) Extended-Spectrum beta-lactamase CTX-M-1 in Escherichia coli in healthy poultry in France. Applied Environmental Microbiology, 73, 4681 4685.
56. Gniadkowski, M. (2001) Evolution and epidemiology of extended-spectrum beta-lactamase (ESBLs) and ESBL-producing organisms. Clinical Microbiology and Infection, 7, 597 608.
57. Gniadkowski, M. (2008) Evolution of extended-spectrum beta-lactamases by mutation. Clinical Microbiology and Infection, 14 (Suppl. 1 11 32.
58. Gootz, T.D. (2004) Global dissemination of beta-lactamases mediating resistance to cephalosporins and carbapenems. Expert Reviews on Anti-infective Therapy, 2, 317 327.
59. Gray, J.T., Hungerford, L.L., Fedorka-Key, P.J. Headrick, M.L. (2004) Extended-spectrum-cephalosporin resistance in Salmonella enterica isolates of animal origin. Antimicrobial Agents and Chemotherapy, 48, 3179 3181.
60. Guardabassi, L., Stegger, M. Skov, R. (2007) Retrospective detection of methicillin resistant and susceptible Staphylococcus aureus ST398 in Danish slaughter pigs. Veterinary Microbiology, 122, 384 386.
61. Gupta, A., Fontana, J., Crowe, C., Bolstorff, B., Stout, A., Van Duyne, S., Hekstra, M.P., Whichard, J.M., Barrett, T.J. Angulo, F.J. (2003) Emergence of multidrug-resistant Salmonella enterica serotype Newport infections resistant to extended spectrum cephalosporins in the United States. Journal of Infectious Diseases, 188, 1707 1716.
62. Hasman, H., Mevius, D., Veldman, K., Olesen, I. Aarestrup, F.M. (2005) beta-lactamases among extended spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in the Netherlands. Journal of Antimicrobial Chemotherapy, 56, 115 121.
63. Hopkins, K.L., Liebana, E., Villa, L., Batchelor, M., Threlfall, E.J. Carattoli, A. (2006) Replicon typing of plasmids carrying CTX-M or CMY beta-lactamases circulating among Salmonella and Escherichia coli isolates. Antimicrobial Agents and Chemotherapy, 50, 3203 3206.
64. Hornish, R.E. Kotarski, S.F. (2002) Cephalosporins in veterinary medicine - ceftiofur use in food animals. Current Topics in Medicinal Chemistry, 2, 717 731.
65. Horton, J.M., Sing, R.F. Jenkins, S.G. (1999) Multidrug-resistant Salmonella associated with AmpC hyperproduction. Clinical Infectious Diseases, 29, 1348.
66. Hunter, J.E.B., Bennett, M., Hart, C.A., Shelley, J.C. Walton, J.R. (1994) Apramycin-resistant Escherichia coli isolated from pigs and a stockman. Epidemiology and Infection, 112, 473 480.
67. Jacoby, G.A. (2006) beta-lactamase nomenclature. Antimicrobial Agents and Chemotherapy, 50, 1123 1129.
68. Jacoby, G.A. Munoz-Price, L.S. (2005) The new beta-lactamases. New England Journal of Medicine, 352, 380 391.
69. Jorgensen, C.J., Cavaco, L.M., Hasman, H., Emborg, H.-D. Guardabassi, L. (2007) Occurence of CTX-M-1-producing Escherichia coli in pigs with ceftioufur. Journal of Antimicrobial Chemotherapy, 59, 1040 1042.
70. Kahlmeter, G. (2008) Breakpoints for intravenously used cephalosporins in Enterobacteriaceae- EUCAST and CLSI breakpoints. Clinical Microbiology and Infection, 14 (Suppl. 1 169 174.
71. KNMvD (2007) De formularia. Richtlijnen voor verantwoord antibioticumgebruik. Koninklijke Nederlandse Maatschappij voor Diergeneeskunde. Available at: http://www.knmvd.nl/resources/AMGATE-7364-1-TICH-R2361006779334/.
72. Ko, W.C., Yan, J.J., Yu, W.L., Lee, H.C., Lee, N.Y., Wang, L.R. Chuang, Y.C. (2005) A new therapeutic challenge for old pathogens: community acquired invasive infections caused by ceftriaxone- and ciprofloxacin resistance Salmonella enterica serotype Choleraesuis. Clinical Infectious Diseases, 40, 315 318.
73. Koeck, J.L., Arlet, G., Philippon, A., Basnaciogullari, H., Vu-Thien, H., Buisson, Y. Cavallo, J.D. (1997) A plasmid-mediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg. FEMS Microbiology Letters, 152, 255 260.
74. Kojima, A., Ishii, K., Esaki, H., Asai, T., Oda, C., Tamura, Y., Takahashi, T. Yamaguchi, K. (2005) Extended-spectrum-beta-lactamase producing Escherichia coli strains isolated from farm animals from 1999 to 2002: report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program. Antimicrobial Agents and Chemotherapy, 49, 3533 3537.
75. Kruse, H. Sørum, H. (1994) Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments. Applied Environmental Microbiology, 60, 4015 4021.
76. Le Turnier, S., Nordmann, P., Eb, F. Mammeri, H. (2009) Potential evolution of hydrolysis spectrum for AmpC β-lactamase of Escherichia coli. Journal of Antimicrobial Chemotherapy, 63, 216 218.
77. Leonard, F.C. Markey, B.K. (2008) Meticillin resistant Staphylococcus aureus in animals: a review. Veterinary Journal, 175, 27 36.
78. Lester, C.H., Moller, N.-F., Sorensen, T.L., Monnet, D.L. Hammerum, A.M. (2006) In vivo transfer of the vanA resistance gene from an Enterococcus faecium isolate of animal origin to an E. faecium isolate of human origin in the intestines of human volunteers. Antimicrobial Agents and Chemotherapy, 50, 596 599.
79. Levy, S.B., FitzGerald, G.B. Macone, A.B. (1976) Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature, 260, 40 42.
80. Li, X.Z., Mehrotra, M., Ghimire, S. Adewoye, L. (2007) beta-Lactam resistance and beta-lactamases in bacteria of animal origin. Veterinary Microbiology, 121, 197 214.
81. Liebana, E., Gibbs, M., Clouthing, C., Barker, L., Clifton-Hadley, F.A., Pleydell, E., Abdalhamid, B., Hanson, N.D., Martin, L., Poppe, C. Davies, R. (2004) Characterization of beta-lacamses responsible for resistance to extended spectrum cephalosporins in Escherichia coli and Salmonella enterica strains from food-producing animals in the United Kingdom. Microbial Drug Resistance, 10, 1 9.
82. Liebana, E., Batchelor, M., Hopkins, K.L., Clifton-Hadley, F.A., Teale, C.J., Foster, A., Barker, L., Therlfall, E.J. Davies, R.H. (2006) Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance. Journal of Clinical Microbiology, 44, 1630 1634.
83. Livermore, D.M. Brown, D.F.J. (2001) Detection of beta-lactamase mediated resistance. Journal of Antimicrobial Chemotherapy, 48, 59 64.
84. Livermore, D.M., Canton, R., Gniadkowski, M., Nordmann, P., Rossolini, G., Arlet, G., Ayala, J., Coque, T.M., Kern-Zdanowicz, I., Luzzaro, F., Poirel, L. Woodford, N. (2007) CTX-M: changing the face of ESBLs in Europe. Journal of Antimicrobial Chemotherapy, 59, 165 174.
85. Lopes, V.C., Wedel, S.D., Bender, J.B., Smith, K.E., Leano, F.T., Boxrud, D.J., Lauer, D.C., Velayudhan, B.T. Nagarja, K.V. (2006) Emergence of multidrug-resistant Salmonella enterica serotype Newport in Minnesota. Clinical Infectious Diseases, 43, 210 213.
86. Lowrance, T.C., Loneragan, G.H., Kunze, D.J., Platt, T.M., Ives, S.E., Scott, H.M., Norby, B., Echeverry, A. Brashears, M.M. (2007) Changes in antimicrobial susceptibility in a population of Escherichia coli isolated from feedlot cattle administered ceftiofur crystalline-free acid. American Journal of Veterinary Research, 68, 501 507.
87. Machado, E., Coque, T.M., Cantón, R., Sousa, J.C. Peixe, L. (2008) Antibiotic resistance integrons and extended-spectrum [beta]-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal. Journal of Antimicrobial Chemotherapy, 62, 296 302.
88. Mammeri, H., Poirel, L. Nordmann, P. (2007) Extension of the hydrolysis spectrum of AmpC beta-lactamase of Escherichia coli due to amino acid insertion in the H-10 helix. Journal of Antimicrobial Chemotherapy, 60, 490 494.
89. Mammeri, H., Eb, F., Berkani, A. Nordmann, P. (2008) Molecular characterization of AmpC-producing Escherichia coli clinical isolates recovered in a French hospital. Journal of Antimicrobial Chemotherapy, 61, 498 503.
90. MARAN (2005) Monitoring of Antimicrobial Resistance and Antibiotic Usage in the Netherlands in 2004. Available at: http://www.cidc-lelystad.nl.
91. Medeiros, A.A. (1997) Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics. Clinical Infectious Diseases, 24 (Suppl. 1 S19 S45.
92. Meunier, D., Jouy, E., lazizzera, C., Kobisch, M. Madec, J.-Y. (2006) CTX-M-1- and CTX-M-15-type beta-lactamases in clinical Escherichia coli isolates recovered from food-producing animals in France. International Journal of Antimicrobial Agents, 28, 402 407.
93. Michael, G.B., Butaye, P., Cloeckaert, A. Schwartz, S. (2006) Genes and mutations conferring antimicrobial resistance in Salmonella: and update. Microbes and Infection, 8, 1898 1914.
94. Mirelis, B., Navarro, F., Miró, E., Mesa, R.J., Coll, P. Prats, G. (2003) Community transmission of extended-spectrum beta-lactamase. Emerging Infectious Diseases, 9, 1024 1025.
95. Miriagou, V., Tasios, P.T., Legakis, N.J. Tzouvelekis, L.S. (2004) Expanded-spectrum cephalosporin resistance in non-typhoid Salmonella. International Journal of Antimicrobial Agents, 23, 547 555.
96. Moreno, M.A., Teschager, A., Porreno, C.M., Garcia, M., Escudero, E., Torres, C. Domiguez, L. (2007) Abundance and phenotypic diversity of Escherichia coli isolates with diminished susceptibility to expanded-spectrum cephalosporins in faeces from healthy food animals after slaughter. Veterinary Microbiology, 120, 363 369.
97. Mulvey, M.R., Susky, E., McCracken, M., Morck, D.W. Read, R.R. (2008) Similar cefoxitin-resistance plasmids circulating in Escherichia coli from human and animal sources. Veterinary Microbiology, 134, 279 287.
98. de Neeling, A.J., van den Broek, M.J., Spalburg, E.C., van Santen-Verheuvel, M.G., Dam-Deisz, W.D., Boshuizen, H.C., van de Giessen, A.W., van Duijkeren, E. Huijsdens, X.W. (2007) High prevalence of methicillin resistant Staphylococcus aureus in pigs. Veterinary Microbiology, 122, 366 372.
99. Nikolich, M.P., Hong, G., Shoemaker, N.B. Salyers, A.A. (1994) Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock. Applied and Environmental Microbiology, 60, 3255 3260.
100. Passantino, A. (2007) Ethical aspects for veterinarians regarding antimicrobial drug use in Italy. International Journal of Antimicrobial Agents, 29, 240 244.
101. Paterson, D.L. Bonomo, R.A. (2005) Extended spectrum beta-lactamases: a clinical update. Clinical Microbiology Reviews, 18, 657 686.
102. Pfaller, M.A. Segreti, J. (2006) Overview of the epidemiological profile and laboratory detection of extended spectrum beta-lactamases. Clinical Infectious Diseases, 42, S153 S163.
103. Pitout, J.D.D., Reisbig, M.D., Mulvey, M., Chui, L., Loue, M., Crowe, L., Church, D.L., Elsayed, S., Gregson, D., Ahmed, R., Tilley, P. Hanson, N.D. (2003) Association between handling of pet treats and infection with Salmonella enterica serotype Newport expressing the AmpC beta-lactamase, CMY-2. Journal of Clinical Microbiology, 41, 4578 4582.
104. Politi, L., Tassios, P.T., Lambiri, M., Kansouzidou, A., Pasiotou, M., Vatopoulos, A.C., Mellou, K., Legakis, N.J. Tzouvelekis, L.S. (2005) Repeated occurrence of diverse extended-spectrum beta-lactamases in minor serotypes of food-borne Salmonella enterica subsp enterica. Journal of Clinical Microbiology, 43, 3453 3456.
105. Pomba, C., Coelho Baptista, B., Diniz da Fonseca, J. Duarte Cor, J. (2008) First description of CTX-M-1- and CMY-2-producing Escherichia coli isolates recovered from coli-septicemic broilers in Portugal. Proceedings from ASM Conference on Antimicrobial Resistance in Zoonotic Bacteria and Foodborne Pathogens, A45, Copenhagen, Denmark.
106. Poppe, C., Martin, L.C., Reid-Smith, R., Boerlin, P., McEwen, S.A., Prescott, J.F. Forward, K.R. (2005) Acquisition of resistance to extended-spectrum cephalosporins by Salmonella enterica serovar Newport and Escherichia coli in the turkey poult intestinal tract. Applied and Environmental Microbiology, 71, 1184 1192.
107. Poutrel, B., Stegemann, M.R., Roy, O., Pothier, F., Tilt, N. Payne-Johnson, M. (2008) Evaluation of the efficacy of systemic danofloxacin in the treatment of induced acute Escherichia coli bovine mastitis. Journal of Dairy Research, 75, 310 318.
108. Quale, J., Landman, D.M., Bradford, P.A., Visalli, M., Ravishankar, J., Flores, C., Mayorga, D., Vangala, K. Adedeji, A. (2002) Molecular epidemiology of a city-wide outbreak of extended-spectrum beta-lactamase producing Klebsiella pneumoniae infection. Clinical Infectious Diseases, 35, 834 841.
109. Rantala, M., Kaartinen, L., Välimäki, E., Stryrman, M., Hiekkaranta, M., Niemi, A., Saari, L. Pyörälä, S. (2002) Efficacy and pharmacokinetics of enrofloxacin and flunixin meglumine for treatment of cows with experimentally induced Escherichia coli mastitis. Journal of Veterinary Pharmacology and Therapeutics, 25, 251 258.
110. Riano, I., Moreno, M.A., Teshager, T., Saenz, Y., Dominguez, L. Torres, C. (2006) Detection and characterization of extended-spectrum beta-lactamases in Salmonella enterica strains of healthy food animals in Spain. Journal of Antimicrobial Chemotherapy, 58, 844 847.
111. Robicsek, A., Jacoby, G.A. Hooper, D.C. (2006a) The worldwide emergence of plasmid mediated quinolone resistance. The Lancet Infectious Diseases, 6, 629 640.
112. Robicsek, A., Strahilevitz, J., Jacoby, G.A., Macielag, M., Abbanat, D., Park, C.H., Bush, K. Hooper, D.C. (2006b) Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine, 12, 83 88.
113. Rodriguez-Bano, J. Navarro, M.D. (2008) Extended spectrum beta-lactamases in ambulatory care: a clinical perspective. Clinical Microbiology and Infection, 14 (Suppl. 1 104 110.
114. Sampimon, O.C., Olde Riekerink, R.G.M. Lam, T.J.G.M. (2008) Prevalence of subclinical mastitis pathogens and adoption of udder health management practices on Dutch dairy farms: preliminary results. Proceedings from Mastitis Control: From Science to Practice, pp. 39 46, Haag, the Netherlands.
115. Saurina, G., Quale, J.M., Manikal, V.M., Qydna, E. Landman, D. (2000) Antimicrobial resistance in Enterobacteriaceae i Brooklyn, N.Y.: epidemiology and relation to antibiotic usage patterns. Journal of Antimicrobial Chemotherapy, 45, 895 898.
116. Schwaber, M. Carmeli, Y. (2007) Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteremia: a systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 60, 913 920.
117. Shiraki, Y., Shibata, N., Doi, Y. Arakawa, Y. (2004) Escherichia coli producing CTX-M-2 beta-lactamase in cattle in Japan. Emerging Infectious Diseases, 10, 69 75.
118. Shpigel, N., Levin, D., Winkler, M., Saran, A., Ziv, G. Bottner, A. (1997) Efficacy of cefquinome for treatment of cows with mastitis experimentally induced using Escherichia coli. Journal of Dairy Science, 80, 318 323.
119. Smet, A., Martel, A., Persoons, D., Dewulf, J., Heyndrickx, M., Catry, B., Herman, L., Haesebrouck, F. Butaye, P. (2008) Diversity of extended-spectrum beta-lactamases and class C beta-lactamases among cloacal Escherichia coli Isolates in Belgian broiler farms. Antimicrobial Agents and Chemotherapy, 52, 1238 1243.
120. Su, L.-H., Chiu, C.-H., Chu, C., Wang, M.-H., Chia, J.-H. Wu, T.-L. (2003) In vivo acquisition of ceftriaxone resistance in Salmonella enterica serotype anatum. Antimicrobial Agents and Chemotherapy, 47, 563 567.
121. SVARM. 2006 2007) Swedish Veterinary Antimicrobial Resistance Monitoring 2006. The National Veterinary Institute (SVA), Uppsala, Sweden. Available at: http://www.sva.se.
122. Tacconelli, E., De Angelis, G., Cataldo, M.A., Pozzi, E. Cauda, R. (2008) Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 61, 26 38.
123. Teale, C.J., Barker, A.P., Foster, E., Liebana, E., Batchelor, M., Livermore, D.M. Therlfall, E.J. (2005) Extended spectrum beta-lactamases detected in E. coli recovered from calves in Wales. Veterinary Record, 156, 186 187.
124. Tragesser, L.A., Wittum, T.E., Funk, J.A., Winokur, P.L. Rajala-Schultz, P.J. (2006) Association between ceftiofur use and isolation of Escherichia coli with reduced susceptibility to ceftriaxone from fecal samples of dairy cows. American Journal of Veterinary Research, 67, 1696 1700.
125. Tschäpe, H. (1994) The spread of plasmids as a function of bacterial adaptability. FEMS Microbiology Letters, 15, 23 32.
126. Urbanek, K., Kolar, M., Loveckova, Y., Strojil, J. Santava, L. (2007) Influence of third-generation cephalosporin utilization on the occurrence of ESBL-positive Klebsiella pneumoniae strains. Journal of Clinical Pharmacology and Therapeutics, 32, 403 408.
127. Valverde, A., Coque, T.M., Sánchez-Moreno, M.P., Rollán, A., Baquero, F. Cantón, R. (2004) Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain. Journal of Clinical Microbiology, 42, 4769 4775.
128. Vander Stichele, R.H., Elseviers, M.M., Ferech, M., Blot, S. Goossens, H. (2006) Hospital consumption of antibiotics in 15 European countries: results of the ESAC retrospective data collection (1997-2002). Journal of Antimicrobial Chemotherapy, 58, 159 167. (Pubitemid 44295000)
129. Vo, A.T.T., van-Duijkeren, E., Fluit, A.C. Gaastra, W. (2007) Characteristics of extended spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumonia isolated from horses. Veterinary Microbiology, 124, 248 255.
130. Wachino, J., Kurokawa, H., Suzuki, S., Yamane, K., Shibata, N., Kimura, K., Ike, Y. Arakawa, Y. (2006) Horizontal transfer of blaCMY-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19. Antimicrobial Agents and Chemotherapy, 50, 534 541.
131. Weese, J.S., Baptiste, K.E., Baverud, V. Toutain, P.L. (2008) Guidelines for antimicrobial use in horses. In Guide to Antimicrobial Use in Animals. Eds Guardabassi, L., Jensen, L.B. Kruse, H., pp. 161 182. Blackwell publishing Ltd, Oxford.
132. Weill, F.X., Lailler, R., Praud, K., Kerouanton, A., Fabre, L., Brisabois, A., Grimont, P.A.D. Clockaert, A. (2004) Emergence of extended-spectrum-beta-lactamase (CTX-M-9)-producing multiresistant strains in Salmonella enterica serotype Virchow in poultry and humans in France. Journal of Clinical Microbiology, 42, 5767 5773.
133. White, D.G., Zhao, S., Sudler, R., Ayers, S., Friedman, S., Chen, S., McDermott, P.F., Wagner, D.D. Meng, J. (2001) The isolation of antibiotic-resistant salmonella from retail ground meat. New England Journal of Medicine, 345, 1147 1154.
134. Winokur, P.L., Brueggemann, A., DeSalvo, D.L., Hoffmann, L., Apley, M.D., Uhlenhopp, E.K., Pfaller, M.A. Doern, G.V. (2000) Animal and human multidrug-resistant, cephalosporin-resistant salmonella isolates expressing a plasmid-mediated CMY-2 AmpC beta-lactamase. Antimicrobial Agents and Chemotherapy, 44, 2777 2783.
135. Winokur, P.L., Vonstein, D.L., Hoffmann, L., Uhlenhopp, E.K. Doern, G.V. (2001) Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans. Antimicrobial Agents and Chemotherapy, 45, 2716 2722.
136. Witte, W., Strommenger, B., Stanek, C. Cuny, C. (2007) Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerging Infectious Diseases, 13, 255 258.
137. Yan, J.-J., Chiou, C.-S., Lauderdale, T.-L.Y., Tsai, S.-T. Wu, J.-J. (2005) Cephalosporin and ciprfloxacin resistance in Salmonella, Taiwan. Emerging Infectious Diseases, 11, 947 950.
138. CMY genes in Escherichia coli and Salmonella isolates from food animals and ground meat. Antimicrobial Agents and Chemotherapy, 45, 3647 3650.
139. Zhao, S., Qaiyumi, S., Friedman, S., Singh, R., Foley, S.L., White, D.G., McDermott, P.F., Donkar, T., Bolin, C., Munro, S., Baron, E.J. Walker, R.D. (2003) Characterization of Salmonella enterica serotype Newport isolated from humans and food animals. Journal of Clinical Microbiology, 41, 5366 5371.