Discovery of potential ZAP-70 kinase inhibitors: Pharmacophore design, database screening and docking studies

European Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2009, Pages 4793-4800

  Sanam, Ramadevi ^a,b   Vadivelan, S ^a   Tajne, Sunita ^a   Narasu, Lakshmi ^b   Rambabu, G ^a   Jagarlapudi, Sarma A R P ^a  

^a GVK BIOSCIENCES PVT LTD   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Docking; HypoGen model; Pharmacophore; Virtual screening; ZAP 70

Indexed keywords

PROTEIN KINASE INHIBITOR; PROTEIN KINASE ZAP 70; UNCLASSIFIED DRUG; ZAP 70 KINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CATALYST; DATA BASE; DRUG SCREENING; DRUG STRUCTURE; MOLECULAR DOCKING; MOLECULAR INTERACTION; PHARMACOPHORE; PREDICTION; SCORING SYSTEM;

COMPUTER SIMULATION; DRUG DESIGN; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; SMALL MOLECULE LIBRARIES; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 70449674920     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.07.018     Document Type: Article

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