메뉴 건너뛰기




Volumn 14, Issue 4, 2009, Pages 332-338

Neither K + channels nor PI3K/Akt mediates the vasodilative effect of nebivolol on different types of rat arteries

Author keywords

Nebivolol; PI3K AKT; Potassium channels; Rat artery

Indexed keywords

1L 6 HYDROXYMETHYL CHIRO INOSITOL 2 2 O METHYL 3 O OCTADECYLCARBONATE; 4 AMINOPYRIDINE; BARIUM CHLORIDE; GLIBENCLAMIDE; IBERIOTOXIN; N(G) NITROARGININE METHYL ESTER; NEBIVOLOL; PHENYLEPHRINE; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 70449657424     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248409350138     Document Type: Article
Times cited : (6)

References (27)
  • 1
    • 39749168348 scopus 로고    scopus 로고
    • Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: A meta-analysis
    • Van Bortel LM, Fici F., Mascagni F. Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis. Am J Cardiovasc Drugs. 2008 ; 8 (1). 35-44.
    • (2008) Am J Cardiovasc Drugs , vol.8 , Issue.1 , pp. 35-44
    • Van Bortel, L.M.1    Fici, F.2    Mascagni, F.3
  • 2
    • 53849090642 scopus 로고    scopus 로고
    • Nebivolol: A highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide
    • Gupta S., Harold MW Nebivolol: a highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide. Cardiovasc Ther. 2008 ; 26 (3). 189-202.
    • (2008) Cardiovasc Ther , vol.26 , Issue.3 , pp. 189-202
    • Gupta, S.1    Harold, M.W.2
  • 3
    • 0035979349 scopus 로고    scopus 로고
    • Nebivolol reverses endothelial dysfunction in essential hypertension: A randomized, double blind, crossover study
    • Tzemos N., Lim PO, MacDonald TM Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double blind, crossover study. Circulation. 2001 ; 104 (5). 511-514.
    • (2001) Circulation , vol.104 , Issue.5 , pp. 511-514
    • Tzemos, N.1    Lim, P.O.2    MacDonald, T.M.3
  • 4
    • 33747796660 scopus 로고    scopus 로고
    • Nebivolol: A novel beta-blocker with nitric oxide-induced vasodilatation
    • DOI 10.2147/vhrm.2006.2.3.303
    • Weiss R. Nebivolol: a novel beta-blocker with nitric oxide-induced vasodilatation. Vasc Health Risk Manag. 2006 ; 2 (3). 303-308. (Pubitemid 44275465)
    • (2006) Vascular Health and Risk Management , vol.2 , Issue.3 , pp. 303-308
    • Weiss, R.1
  • 5
    • 80052399313 scopus 로고    scopus 로고
    • Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker
    • Ignarro LJ Experimental evidences of nitric oxide-dependent vasodilatory activity of nebivolol, a third-generation beta-blocker. Blood Press Suppl. 2004 ; 1: 2-16.
    • (2004) Blood Press Suppl , vol.1 , pp. 2-16
    • Ignarro, L.J.1
  • 6
    • 0032841990 scopus 로고    scopus 로고
    • The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension
    • Dawes M., Brett SE, Chowienczyk PJ, Mant TG, Ritter JM The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension. Br J Clin Pharmacol. 1999 ; 48 (3). 460-463.
    • (1999) Br J Clin Pharmacol , vol.48 , Issue.3 , pp. 460-463
    • Dawes, M.1    Brett, S.E.2    Chowienczyk, P.J.3    Mant, T.G.4    Ritter, J.M.5
  • 7
    • 33745967267 scopus 로고    scopus 로고
    • Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells
    • Ladage D., Brixius K., Hoyer H., et al. Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol. 2006 ; 33 (8). 720-724.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , Issue.8 , pp. 720-724
    • Ladage, D.1    Brixius, K.2    Hoyer, H.3
  • 8
    • 0033542414 scopus 로고    scopus 로고
    • Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    • Fulton D., Gratton JP, McCabe TJ, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999 ; 399 (6736). 597-601.
    • (1999) Nature , vol.399 , Issue.6736 , pp. 597-601
    • Fulton, D.1    Gratton, J.P.2    McCabe, T.J.3
  • 9
    • 0033857388 scopus 로고    scopus 로고
    • Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
    • Luo Z., Fujio Y., Kureishi Y., et al. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest. 2000 ; 106 (4). 493-499.
    • (2000) J Clin Invest , vol.106 , Issue.4 , pp. 493-499
    • Luo, Z.1    Fujio, Y.2    Kureishi, Y.3
  • 10
    • 0033007361 scopus 로고    scopus 로고
    • + channels and sodium pump in the vasodilation induced by acetylcholine, nitric oxide, and cyclic GMP in the rabbit aorta
    • DOI 10.1016/S0306-3623(98)00259-6, PII S0306362398002596
    • Ferrer M., Marin J., Encabo A., Alonso MJ, Balfagon G. Role of K+ channels and sodium pump in the vasodilation induced by acetylcholine, nitric oxide, and cyclic GMP in the rabbit aorta. Gen Pharmacol. 1999 ; 33 (1). 35-41. (Pubitemid 29292430)
    • (1999) General Pharmacology , vol.33 , Issue.1 , pp. 35-41
    • Ferrer, M.1    Marin, J.2    Encabo, A.3    Alonso, M.J.4    Balfagon, G.5
  • 11
    • 0030615191 scopus 로고    scopus 로고
    • The involvement of KCa, KATP and KV channels in vasorelaxing responses to acetylcholine in rat aortic rings
    • Satake N., Shibata M., Shibata S. The involvement of KCa, KATP and KV channels in vasorelaxing responses to acetylcholine in rat aortic rings. Gen Pharmacol. 1997 ; 28 (3). 453-457.
    • (1997) Gen Pharmacol , vol.28 , Issue.3 , pp. 453-457
    • Satake, N.1    Shibata, M.2    Shibata, S.3
  • 12
    • 0028220671 scopus 로고
    • Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
    • Bolotina VM, Najibi S., Palacino PJ, Pagano PJ, Cohen RA Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature. 1994 ; 368 (6474). 850-853.
    • (1994) Nature , vol.368 , Issue.6474 , pp. 850-853
    • Bolotina, V.M.1    Najibi, S.2    Palacino, P.J.3    Pagano, P.J.4    Cohen, R.A.5
  • 13
    • 0027893205 scopus 로고
    • Potassium channel-mediated relaxation to acetylcholine in rabbit arteries
    • Cowan CL, Palacino JJ, Najibi S., Cohen RA Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J Pharmacol Exp Ther. 1993 ; 266 (3). 1482-1489.
    • (1993) J Pharmacol Exp Ther , vol.266 , Issue.3 , pp. 1482-1489
    • Cowan, C.L.1    Palacino, J.J.2    Najibi, S.3    Cohen, R.A.4
  • 14
    • 0033840401 scopus 로고    scopus 로고
    • Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries
    • Altwegg LA, dĝUscio LV, Barandier C., Cosentino F., Yang Z., L?1/4scher TF Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries. J Cardiovasc Pharmacol. 2000 ; 36 (3). 316-320.
    • (2000) J Cardiovasc Pharmacol , vol.36 , Issue.3 , pp. 316-320
    • Altwegg, L.A.1    Dĝuscio, L.V.2    Barandier, C.3    Cosentino, F.4    Yang, Z.5
  • 15
    • 35048860080 scopus 로고    scopus 로고
    • Nebivolol and carvedilol induce NO-dependent coronary vasodilatation that is unlikely to be mediated by extracellular ATP in the isolated guinea pig heart
    • Kozlovski VI, Lomnicka M., Chlopicki S. Nebivolol and carvedilol induce NO-dependent coronary vasodilatation that is unlikely to be mediated by extracellular ATP in the isolated guinea pig heart. Pharmacol Rep. 2006 ; 58 (suppl): 103-110.
    • (2006) Pharmacol Rep , vol.58 , pp. 103-110
    • Kozlovski, V.I.1    Lomnicka, M.2    Chlopicki, S.3
  • 16
    • 0036908156 scopus 로고    scopus 로고
    • No-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT1A-receptors
    • Chlopicki S., Kozlovski VI, Gryglewski RJ No-dependent vasodilation induced by nebivolol in coronary circulation is not mediated by beta-adrenoceptors or by 5 HT1A-receptors. J Physiol Pharmacol. 2002 ; 53 (4 pt 1). 615-624.
    • (2002) J Physiol Pharmacol , vol.53 , Issue.4 , pp. 615-624
    • Chlopicki, S.1    Kozlovski, V.I.2    Gryglewski, R.J.3
  • 17
    • 65349146446 scopus 로고    scopus 로고
    • Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta
    • Tran Quang T., Rozec B., Audigane L., Gauthier C. Investigation of the different adrenoceptor targets of nebivolol enantiomers in rat thoracic aorta. Br J Pharmacol. 2009 ; 156 (4). 601-608.
    • (2009) Br J Pharmacol. , vol.156 , Issue.4 , pp. 601-608
    • Tran Quang, T.1    Rozec, B.2    Audigane, L.3    Gauthier, C.4
  • 18
    • 0033615069 scopus 로고    scopus 로고
    • The Akt kinase signals directly to endothelial nitric oxide synthase
    • Michell BJ, Griffiths JE, Mitchelhill KI, et al. The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol. 1999 ; 9 (15). 845-848.
    • (1999) Curr Biol , vol.9 , Issue.15 , pp. 845-848
    • Michell, B.J.1    Griffiths, J.E.2    Mitchelhill, K.I.3
  • 19
    • 7044249064 scopus 로고    scopus 로고
    • Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt
    • Ferro A., Coash M., Yamamoto T., Rob J., Ji Y., Queen L. Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt. Br J Pharmacol. 2004 ; 143 (3). 397-403.
    • (2004) Br J Pharmacol , vol.143 , Issue.3 , pp. 397-403
    • Ferro, A.1    Coash, M.2    Yamamoto, T.3    Rob, J.4    Ji, Y.5    Queen, L.6
  • 20
    • 34548800397 scopus 로고    scopus 로고
    • Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation
    • Santhanam AV, Viswanathan S., Dikshit M. Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation. Eur J Pharmacol. 2007 ; 572 (2-3). 189-196.
    • (2007) Eur J Pharmacol , vol.572 , Issue.2 , pp. 189-196
    • Santhanam, A.V.1    Viswanathan, S.2    Dikshit, M.3
  • 21
    • 0035980110 scopus 로고    scopus 로고
    • Hsp90 ensures the transition from the early Ca2+dependent to the late phosphorylation dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells
    • Brouet A., Sonveaux P., Dessy C., Balligand JL, Feron O. Hsp90 ensures the transition from the early Ca2+dependent to the late phosphorylation dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. J Biol Chem. 2001 ; 276 (35). 32663-32669.
    • (2001) J Biol Chem , vol.276 , Issue.35 , pp. 32663-32669
    • Brouet, A.1    Sonveaux, P.2    Dessy, C.3    Balligand, J.L.4    Feron, O.5
  • 22
    • 0035834823 scopus 로고    scopus 로고
    • Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins
    • Brouet A., Sonveaux P., Dessy C., Moniotte S., Balligand JL, Feron O. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res. 2001 ; 89 (10). 866-873.
    • (2001) Circ Res , vol.89 , Issue.10 , pp. 866-873
    • Brouet, A.1    Sonveaux, P.2    Dessy, C.3    Moniotte, S.4    Balligand, J.L.5    Feron, O.6
  • 23
    • 24044493513 scopus 로고    scopus 로고
    • Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol
    • Dessy C., Saliez J., Ghisdal P., et al. Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol. Circulation. 2005 ; 112 (8). 1198-1205.
    • (2005) Circulation , vol.112 , Issue.8 , pp. 1198-1205
    • Dessy, C.1    Saliez, J.2    Ghisdal, P.3
  • 24
    • 33646823953 scopus 로고    scopus 로고
    • Characterization of nitric oxide release by nebivolol and its metabolites
    • Maffei A., Vecchione C., Aretini A., et al. Characterization of nitric oxide release by nebivolol and its metabolites. Blood Vessels. 2006 ; 19 (6). 579-586.
    • (2006) Blood Vessels , vol.19 , Issue.6 , pp. 579-586
    • Maffei, A.1    Vecchione, C.2    Aretini, A.3
  • 25
    • 37749014543 scopus 로고    scopus 로고
    • Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery
    • Cairrao E., Alvarez E., Santos-Silva AJ, Verde I. Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery. Naunyn Schmiedebergs Arch Pharmacol. 2008 ; 376 (5). 375-383.
    • (2008) Naunyn Schmiedebergs Arch Pharmacol , vol.376 , Issue.5 , pp. 375-383
    • Cairrao, E.1    Alvarez, E.2    Santos-Silva, A.J.3    Verde, I.4
  • 26
    • 0034786038 scopus 로고    scopus 로고
    • Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel
    • Deenadayalu VP, White RE, Stallone JN, Gao X., Garcia AJ Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol. 2001 ; 281 (4). H1720 - H1727.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , Issue.4
    • Deenadayalu, V.P.1    White, R.E.2    Stallone, J.N.3    Gao, X.4    Garcia, A.J.5
  • 27
    • 12844250891 scopus 로고    scopus 로고
    • The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery
    • Georgescua A., Pluteanub F., Flontab ML, Badilac E., Dorobantuc M., Popova D. The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery. Eur J Pharmacol. 2005 ; 508 (1-3). 159-166.
    • (2005) Eur J Pharmacol , vol.508 , Issue.1-3 , pp. 159-166
    • Georgescua, A.1    Pluteanub, F.2    Flontab, M.L.3    Badilac, E.4    Dorobantuc, M.5    Popova, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.