Cellular repair strategies in Parkinson's disease

Therapeutic Advances in Neurological Disorders

Volumn 2, Issue 1, 2009, Pages 51-60

  Winner, Beate ^a   Vogt Weisenhorn, Daniela M ^b   Lie, Chichung D ^b   Blümcke, Ingmar ^c   Winkler, Jürgen ^c  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Alpha synuclein; Neurodegeneration; Neurogenesis; Stem cells; Transplantation

Indexed keywords

NEUROTOXIN;

BRAIN DEPTH STIMULATION; CELL POPULATION; CELL REGENERATION; CELL TRANSPLANTATION; CLINICAL TRIAL; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; HUMAN; MOLECULAR BIOLOGY; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; STEM CELL; SUBSTANTIA NIGRA;

EID: 70449645446     PISSN: 17562856     EISSN: None     Source Type: Journal    
DOI: 10.1177/1756285608100324     Document Type: Review

References (67)

1. Ahlskog, J.E. (2007) Beating a dead horse: dopamine and Parkinson disease, Neurology 69: 1701-1711.
2. Baker, S.A., Baker, K.A. and Hagg, T. (2004) Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone, Eur J Neurosci 20: 575-579.
3. Belin, A.C. and Westerlund, M. (2008) Parkinson's disease: a genetic perspective, FEBS J 275: 1377-1383.
4. Bjorklund, A., Dunnett, S.B., Brundin, P., Stoessl, A.J., Freed, C.R., Breeze, R.E. et al. (2003) Neural transplantation for the treatment of Parkinson's disease, Lancet Neurol 2: 437-445.
5. Borta, A. and Hoglinger, G.U. (2007) Dopamine and adult neurogenesis, J Neurochem 100: 587-595.
6. Braak, H. and Del Tredici, K. (2008) Assessing fetal nerve cell grafts in Parkinson's disease, Nat Med 14: 483-485.
7. Castelo-Branco, G. and Arenas, E. (2006) Function of Wnts in dopaminergic neuron development, Neurodegener Dis 3: 5-11.
8. Chen, Y., Ai, Y., Slevin, J.R., Maley, B.E. and Gash, D.M. (2005) Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor, Exp Neurol 196: 87-95.
9. Doetsch, F. (2003) A niche for adult neural stem cells, Curr Opin Genet Dev 13: 543-550.
10. Freed, C.R., Greene, P.E., Breeze, R.E., Tsai, W.Y., Dumouchel, W., Kao, R. et al. (2001) Transplantation of embryonic dopamine neurons for severe Parkinson's disease, N Engl J Med 344: 710-719.
11. Gage, F.H. (2000) Mammalian neural stem cells, Science 287: 1433-1438.
12. Gasser, T. (2007) Update on the genetics of Parkinson's disease, Mov Disord 22: S343-S350.
13. Hagell, P. and Brundin, P. (2001) Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease, J Neuropathol Exp Neurol 60: 741-752.
14. Harding, A.J. and Halliday, G.M. (2001) Cortical Lewy body pathology in the diagnosis of dementia, Acta Neuropathol (Berl) 102: 355-363.
15. Hauser, R.A., Freeman, T.B., Snow, B.J., Nauert, M., Gauger, L., Kordower, J.H. et al. (1999) Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease, Arch Neurol 56: 179-187.
16. Hoglinger, G.U., Rizk, P., Muriel, M.P., Duyckaerts, C., Oertel, W.H., Caille, I. et al. (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson disease, Nat Neurosci 7: 726-735.
17. Huisman, E., Uylings, H.B. and Hoogland, P.V. (2004) A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease, Mov Disord 19: 687-692.
18. Kawasaki, H., Mizuseki, K., Nishikawa, S., Kaneko, S., Kuwana, Y., Nakanishi, S. et al. (2000) Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity, Neuron 28: 31-40.
19. Kordower, J.H., Chu, Y., Hauser, R.A., Freeman, T.B. and Olanow, C.W. (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease, Nat Med 14: 504-506.
20. Kordower, J.H., Freeman, T.B., Snow, B.J., Vingerhoets, F.J., Mufson, E.J., Sanberg, P.R. et al. (1995) Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease, N Engl J Med 332: 1118-1124.
21. Lee, S.H., Lumelsky, N., Studer, L., Auerbach, J.M. and McKay, R.D. (2000) Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cell, Nat Biotechnol 18: 675-679.
22. Li, J.Y., Englund, E., Holton, J.L., Soulet, D., Hagell, P., Lees, A.J. et al. (2008) Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation, Nat Med 14: 501-503.
23. Lie, D.C., Dziewczapolski, G., Willhoite, A.R., Kaspar, B.K., Shults, C.W. and Gage, F.H. (2002) The adult substantia nigra contains progenitor cells with neurogenic potential, J Neurosci 22: 6639-6649.
24. Lindvall, O., Sawle, G., Widner, H., Rothwell, J.C., Bjorklund, A., Brooks, D. et al. (1994) Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease, Ann Neurol 35: 172-180.
25. Maciaczyk, J., Singec, I., Maciaczyk, D. and Nikkhah, G. (2008) Combined use of BDNF, ascorbic acid, low oxygen, and prolonged differentiation time generates tyrosine hydroxylase-expressing neurons after long-term in vitro expansion of human fetal midbrain precursor cells, Exp Neurol 213: 354-362.
26. Mao, L., Lau, Y.S., Petroske, E. and Wang, J.Q. (2001) Profound astrogenesis in the striatum of adult mice following nigrostriatal dopaminergic lesion by repeated MPTP administration, Brain Res Dev Brain Res 131: 57-65.
27. Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjorklund, L. et al. (2005) Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with parkinson's disease, Brain 128: 1498-1510.
28. Mendez, I., Vinuela, A., Astradsson, A., Mukhida, K., Hallett, P., Robertson, H. et al. (2008) Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years, Nat Med 14: 507-509.
29. Meredith, G.E., Sonsalla, P.K. and Chesselet, M.F. (2008) Animal models of Parkinson's disease progression, Acta Neuropathol 115: 385-398.
30. Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E. et al. (2006) Exogenous induction of cerebral betaamyloidogenesis is governed by agent and host, Science 313: 1781-1784.
31. Meyer-Luehmann, M., Spires-Jones, T.L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A. et al. (2008) Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease, Nature 451: 720-724.
32. Ming, G.L. and Song, H. (2005) Adult neurogenesis in the mammalian central nervous system, Annu Rev Neurosci 28: 223-250.
33. Mohapel, P., Frielingsdorf, H., Haggblad, J., Zachrisson, O. and Brundin, P. (2005) Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions, Neuroscience 132: 767-776.
34. Olanow, C.W., Goetz, C.G., Kordower, J.H., Stoessl, A.J., Sossi, V., Brin, M.F. et al. (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease, Ann Neurol 54: 403-414.
35. Olanow, C.W., Kordower, J.H. and Freeman, T.B. (1996) Fetal nigral transplantation as a therapy for Parkinson's disease, Trends Neurosci 19: 102-109.
36. Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G. et al. (2003) Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis, Nature 422: 688-694.
37. Prakash, N. and Wurst, W. (2006) Genetic networks controlling the development of midbrain dopaminergic neurons, J Physiol 575: 403-410.
38. Prakash, N. and Wurst, W. (2007) A Wnt signal regulates stem cell fate and differentiation in vivo, Neurodegener Dis 4: 333-338.
39. Reimers, D., Herranz, A.S., Diaz-Gil, J.J., Lobo, M.V., Paino, C.L., Alonso, R. et al. (2006) Intrastriatal infusion of liver growth factor stimulates dopamine terminal sprouting and partially restores motor function in 6-hydroxydopamine-lesioned rats, J Histochem Cytochem 54: 457-465.
40. Shan, X., Chi, L., Bishop, M., Luo, C., Lien, L., Zhang, Z. et al. (2006) Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of MPTP-induced Parkinson's disease-like mice, Stem Cells 24: 1280-1287.
41. Shults, C.W. (2006) Lewy bodies, Proc Natl Acad Sci U S A 103: 1661-1668.
42. Siebzehnrubl, F. and Blumcke, I. (2008) Neurogenesis in the human hippocampus and its relevance to temporal lobe epilepsies, Epilepsia 49: 55-65.
43. Siebzehnrubl, F.A., Jeske, I., Muller, D., Buslei, R., Coras, R., Hahnen, E. et al. (2008) Spontaneous in vitro transformation of adult neural precursors into stem-like cancer cells, Brain Pathol 2008 Jul 10 [Epub ahead of print].
44. Smidt, M.P. and Burbach, J.P. (2007) How to make a mesodiencephalic dopaminergic neuron, Nat Rev Neurosci 8: 21-32.
45. Spillantini, M., Schmidt, M., Lee, V.-Y., Trojanowski, J., Jakes, R. and Goedert, M. (1997) A-synuclein in Lewy bodies, Nature 388: 839-840.
46. Steiner, B., Winter, C., Hosman, K., Siebert, E., Kempermann, G., Petrus, D.S. et al. (2006) Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease, Exp Neurol 199: 291-300.
47. Sulzer, D. (2007) Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease, Trends in Neurosciences 30: 244-250.
48. Takagi, Y., Takahashi, J., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y. et al. (2005) Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model, J Clin Invest 115: 102-109.
49. Takahashi, J. (2007) Stem cell therapy for Parkinson's disease, Expert Rev Neurother 7: 667-675.
50. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell 131: 861-872.
51. Takeda, A., Mallory, M., Sundsmo, M., Honer, W., Hansen, L. and Masliah, E. (1998) Abnormal accumulation of Nacp/α-Synuclein in neurodegenerative disorders, Am J Pathol 152: 367-372.
52. Terzioglu, M. and Galter, D. (2008) Parkinson's disease: genetic versus toxin-induced rodent models, FEBS J 275: 1384-1391.
53. Thomas, B. and Beal, M.F. (2007) Parkinson's disease, Hum Mol Genet 16 Spec No. 2: R183-R194.
54. Trenkwalder, C., Schwarz, J., Gebhard, J., Ruland, D., Trenkwalder, P., Hense, H.W. et al. (1995) Starnberg trial on epidemiology of parkinsonism and hypertension in the elderly. Prevalence of Parkinson's disease and related disorders assessed by a door-to-door survey of inhabitants older than 65 years, Arch Neurol 52: 1017-1022
55. Trojanowski, J.Q. and Lee, V.M. (1998) Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia, Arch Neurol 55: 151-152.
56. van Kampen, J.M. and Eckman, C.B. (2006) Dopamine D 3 receptor agonist delivery to a model of Parkinson's disease restores the nigrostriatal pathway and improves locomotor behavior, J Neurosci 26: 7272-7280.
57. van Kampen, J.M. and Robertson, H.A. (2005) A possible role for dopamine D 3 receptor stimulation in the induction of neurogenesis in the adult rat substantia nigra, Neuroscience 136: 381-386.
58. Wakabayashi, K., Matsumoto, K., Takayama, K., Yoshimoto, M. and Takahashi, H. (1997) NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease, Neurosci Lett 239: 45-48.
59. Walton, N.M., Sutter, B.M., Chen, H.X., Chang, L.J., Roper, S.N., Scheffler, B. et al. (2006) Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain, Development 133: 3671-3681.
60. Wenning, G.K., Odin, P., Morrish, P., Rehncrona, S., Widner, H., Brundin, P. et al. (1997) Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease, Ann Neurol 42: 95-107.
61. Wernig, M., Zhao, J.P., Pruszak, J., Hedlund, E., Fu, D., Soldner, F. et al. (2008) Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease, Proc Natl Acad Sci USA 105: 5856-5861.
62. Winner, B., Couillard-Despres, S., Geyer, M., Aigner, R., Bogdahn, U., Aigner, L. et al. (2008) Dopaminergic lesion enhances growth factor-induced striatal neuroblast migration, J Neuropathol Exp Neurol 67: 105-116.
63. Winner, B., Geyer, M., Couillard-Despres, S., Aigner, R., Bogdahn, U., Aigner, L. et al. (2006) Striatal deafferentation increases dopaminergic neurogenesis in the adult olfactory bulb, Exp Neurol 197: 113-121.
64. Yamada, M., Onodera, M., Mizuno, Y. and Mochizuki, H. (2004) Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice, Neuroscience 124: 173-181.
65. Yoshimi, K., Ren, Y.R., Seki, T., Yamada, M., Ooizumi, H., Onodera, M. et al. (2005) Possibility for neurogenesis in substantia nigra of Parkinsonian brain, Ann Neurol 58: 31-40.
66. Yu, J., Vodyanik, M.A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J.L., Tian, S. et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells, Science 318: 1917-1920.
67. Zhao, C., Teng, E.M., Summers, R.G., Jr., Ming, G.L. and Gage, F.H. (2006) Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus, J Neurosci 26: 3-11.