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Volumn 46, Issue 3, 2009, Pages 241-247

A critical analysis of studies assessing L-ornithine-L-aspartate (LOLA) in hepatic encephalopathy treatment

Author keywords

Dipeptides; Hepatic encephalopathy

Indexed keywords

ORNITHINE ASPARTATE; PLACEBO;

EID: 70449623959     PISSN: 00042803     EISSN: 16784219     Source Type: Journal    
DOI: 10.1590/S0004-28032009000300019     Document Type: Article
Times cited : (18)

References (73)
  • 1
    • 0029829142 scopus 로고    scopus 로고
    • Contrasting effects of thioacetamide-induced liver damage on the brain uptake indices of ornithine, arginine and lysine: Modulation by treatment with ornithine aspartate
    • Albrecht J, Hilgier W, Januszewski S, Quack G. Contrasting effects of thioacetamide-induced liver damage on the brain uptake indices of ornithine, arginine and lysine: modulation by treatment with ornithine aspartate. Metab Brain Dis. 1996;11:229-237 (Pubitemid 126738977)
    • (1996) Metabolic Brain Disease , vol.11 , Issue.3 , pp. 229-237
    • Albrecht, J.1    Hilgier, W.2    Januszewski, S.3    Quack, G.4
  • 2
    • 0014687312 scopus 로고
    • Experiences with ornithine-aspartate in liver diseases
    • Aschke J. Experiences with ornithine-aspartate in liver diseases. Med Welt. 1969;22:657-662
    • (1969) Med Welt , vol.22 , pp. 657-662
    • Aschke, J.1
  • 3
    • 0014203467 scopus 로고
    • Effect of ornithine-aspartate mixture on 15N-ammonia incorporation into urea in intact mice
    • Balestrieri C, De Cristofaro D, Cittadini D. Effect of ornithine-aspartate mixture on 15N-ammonia incorporation into urea in intact mice. Life Sci. 1967;6:337-340
    • (1967) Life Sci , vol.6 , pp. 337-340
    • Balestrieri, C.1    De Cristofaro, D.2    Cittadini, D.3
  • 4
    • 3042763028 scopus 로고    scopus 로고
    • Because hepatic encephalopathy is a frequent contributing factor. Patients with liver cirrhosis are poorer drivers
    • Because hepatic encephalopathy is a frequent contributing factor. Patients with liver cirrhosis are poorer drivers. MMW Fortschr Med. 2003;145:61.
    • (2003) MMW Fortschr Med , vol.145 , pp. 61
  • 5
    • 0036988606 scopus 로고    scopus 로고
    • Pathophysiology of hepatic encephalopathy: A new look at ammonia
    • DOI 10.1023/A:1021989230535
    • Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metab Brain Dis. 2002;17:221-227 (Pubitemid 36204752)
    • (2002) Metabolic Brain Disease , vol.17 , Issue.4 , pp. 221-227
    • Butterworth, R.F.1
  • 6
    • 1442338658 scopus 로고    scopus 로고
    • Brain edema in acute liver failure
    • Butterworth RF. Brain edema in acute liver failure. Indian J Gastroenterol. 2003;22(Suppl 2):s59-61.
    • (2003) Indian J Gastroenterol , vol.22 , Issue.SUPPL. 2
    • Butterworth, R.F.1
  • 7
    • 0141995051 scopus 로고    scopus 로고
    • Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: Potential for improvement following their removal by liver assist devices
    • Butterworth RF. Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices. Liver Int. 2003;23(Suppl 3):5-9.
    • (2003) Liver Int , vol.23 , Issue.SUPPL. 3 , pp. 5-9
    • Butterworth, R.F.1
  • 8
    • 34548092918 scopus 로고    scopus 로고
    • Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy
    • 22
    • Chen MF, Li RC, Chen CH, Gao XC. [Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25:718-9, 22.
    • (2005) Di Yi Jun Yi Da Xue Xue Bao , vol.25 , pp. 718-719
    • Chen, M.F.1    Li, R.C.2    Chen, C.H.3    Gao, X.C.4
  • 9
    • 0034702126 scopus 로고    scopus 로고
    • Chronic liver diseases. Hepatic encephalopathy too frequently overlooked?
    • Chronic liver diseases. Hepatic encephalopathy too frequently overlooked? MMW Fortschr Med. 2000;142:56-57
    • (2000) MMW Fortschr Med , vol.142 , pp. 56-57
  • 10
    • 21644488628 scopus 로고    scopus 로고
    • Cirrhotic liver gives up in breaking up of ammonia. Poison for the brain
    • Cirrhotic liver gives up in breaking up of ammonia. Poison for the brain. MMW Fortschr Med. 2004;146:51.
    • (2004) MMW Fortschr Med , vol.146 , pp. 51
  • 11
    • 0035987908 scopus 로고    scopus 로고
    • Proton MR spectroscopy of neurometabolites in hepatic encephalopathy during L-ornithine-L-aspartate treatment - Results of a pilot study
    • DOI 10.1023/A:1015468112686
    • Delcker A, Turowski B, Mihm U, Raab P, Rusch O, Pilatus U, et al. Proton MR spectroscopy of neurometabolites in hepatic encephalopathy during L-ornithine- L-aspartate treatment--results of a pilot study. Metab Brain Dis. 2002;17:103-111 (Pubitemid 34655049)
    • (2002) Metabolic Brain Disease , vol.17 , Issue.2 , pp. 103-111
    • Delcker, A.1    Turowski, B.2    Mihm, U.3    Raab, P.4    Rusch, O.5    Pilatus, U.6    Zeuzem, S.7    Zanella, F.E.8
  • 12
    • 0035576812 scopus 로고    scopus 로고
    • Alterations in expression of genes coding for key astrocytic proteins in acute liver failure
    • Desjardins P, Belanger M, Butterworth RF. Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. J Neurosci Res. 2001;66:967-971
    • (2001) J Neurosci Res , vol.66 , pp. 967-971
    • Desjardins, P.1    Belanger, M.2    Butterworth, R.F.3
  • 13
    • 0030606537 scopus 로고    scopus 로고
    • Hepatic minimal encephalopathy. The most frequently overlooked, clinically occult "metabolic syndrome" on the cirrhosis patient
    • Eisenburg J. Hepatic minimal encephalopathy. The most frequently overlooked, clinically occult "metabolic syndrome" on the cirrhosis patient. Fortschr Med. 1996;114:141
    • (1996) Fortschr Med , vol.114 , pp. 141
    • Eisenburg, J.1
  • 14
    • 18844401894 scopus 로고    scopus 로고
    • Recovery from Parkinson syndrome and prolonged visually evoked potentials in hepatic encephalopathy
    • Finsterer J, Bernauer E. Recovery from Parkinson syndrome and prolonged visually evoked potentials in hepatic encephalopathy. Metab Brain Dis. 2005;20:55-60.
    • (2005) Metab Brain Dis , vol.20 , pp. 55-60
    • Finsterer, J.1    Bernauer, E.2
  • 17
    • 0027368467 scopus 로고
    • Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid?
    • Evidence-Based Medicine Working Group
    • Guyatt GH, Sackett DL, Cook DJ. Users' guides to the medical literature. II. How to use an article about therapy or prevention. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA. 1993;270:2598-2601
    • (1993) JAMA , vol.270 , pp. 2598-2601
    • Guyatt, G.H.1    Sackett, D.L.2    Cook, D.J.3
  • 18
    • 0024969892 scopus 로고
    • Amino acids prevent hepatic encephalopathy. Ornithine-aspartate in hyperammonemia-results of a study
    • Hartung HD. Amino acids prevent hepatic encephalopathy. Ornithine-aspartate in hyperammonemia-results of a study. Fortschr Med. 1989;107:56.
    • (1989) Fortschr Med , vol.107 , pp. 56
    • Hartung, H.D.1
  • 19
    • 17844380013 scopus 로고    scopus 로고
    • Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS)
    • Hass HG, Nagele T, Seeger U, Hosl F, Gregor M, Kaiser S. Detection of subclinical and overt hepatic encephalopathy and treatment control after L-ornithine-L-aspartate medication by magnetic resonance spectroscopy ((1)H-MRS). Z Gastroenterol. 2005;43:373-378
    • (2005) Z Gastroenterol , vol.43 , pp. 373-378
    • Hass, H.G.1    Nagele, T.2    Seeger, U.3    Hosl, F.4    Gregor, M.5    Kaiser, S.6
  • 20
    • 0017088686 scopus 로고
    • Influence of ornithine aspartate on the experimentally induced hyperammoniemia. Clinico-experimental study
    • Henglein-Ottermann D. Influence of ornithine aspartate on the experimentally induced hyperammoniemia. Clinico-experimental study. Ther Ggw. 1976;115:1504-1518
    • (1976) Ther Ggw , vol.115 , pp. 1504-1518
    • Henglein-Ottermann, D.1
  • 21
    • 70449678860 scopus 로고    scopus 로고
    • Ornithine aspartate (OA) promotes amino acid (AA) retention in the peripheral tissues of patients with liver cirrhosis A double-blind randomized crossover study
    • Holm E, Hess Y, Leweling H, Barth H-O, Hagmüller E. Ornithine aspartate (OA) promotes amino acid (AA) retention in the peripheral tissues of patients with liver cirrhosis A double-blind randomized crossover study. JPEN J Parenter Enteral Nutr. 2000;15:368.
    • (2000) JPEN J Parenter Enteral Nutr , vol.15 , pp. 368
    • Holm, E.1    Hess, Y.2    Leweling, H.3    Barth, H.-O.4    Hagmüller, E.5
  • 22
    • 85047088128 scopus 로고    scopus 로고
    • Clinical control study of L-ornithine-L-aspartate in the treatment of subclinical hepatic encephalopathy
    • Hong Y, Yang ZB, Wang YF. Clinical control study of L-ornithine-L- aspartate in the treatment of subclinical hepatic encephalopathy. West China Med J. 2003;18:509-510
    • (2003) West China Med J , vol.18 , pp. 509-510
    • Hong, Y.1    Yang, Z.B.2    Wang, Y.F.3
  • 23
    • 0015919610 scopus 로고
    • Clinical experiences in liver diseases (especially in patients with fatty liver due to alcoholism and food poisoning) under monotherapy with ornithine aspartate
    • Hunold W. Clinical experiences in liver diseases (especially in patients with fatty liver due to alcoholism and food poisoning) under monotherapy with ornithine aspartate. Z Allgemeinmed. 1973;49:469-472
    • (1973) Z Allgemeinmed , vol.49 , pp. 469-472
    • Hunold, W.1
  • 24
    • 0035294243 scopus 로고    scopus 로고
    • In liver cirrhosis, not every "ammonia lowering drug" improves neuropsychiatric deficit
    • In liver cirrhosis, not every "ammonia lowering drug" improves neuropsychiatric deficit. MMW Fortschr Med. 2001;143(9):58.
    • (2001) MMW Fortschr Med , vol.143 , Issue.9 , pp. 58
  • 25
    • 0022644772 scopus 로고
    • A comparative study of free amino acid levels in serum and cerebral cortex in hepatic failure rats
    • Ito M, Matsumoto H, Kikuchi S, Yachi A. A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats. No To Shinkei. 1986;38:63-68 (Pubitemid 16178723)
    • (1986) Brain and Nerve , vol.38 , Issue.1 , pp. 63-68
    • Ito, M.1    Matsumoto, H.2    Kikuchi, S.3    Yachi, A.4
  • 27
    • 0029795002 scopus 로고    scopus 로고
    • Review article. Pathogenesis and treatment of chronic hepatic encephalopathy
    • Jalan R, Seery JP, Taylor-Robinson SD. Review article. Pathogenesis and treatment of chronic hepatic encephalopathy. Aliment Pharmacol Ther. 1996;10:681-697
    • (1996) Aliment Pharmacol Ther , vol.10 , pp. 681-697
    • Jalan, R.1    Seery, J.P.2    Taylor-Robinson, S.D.3
  • 28
    • 0041506991 scopus 로고    scopus 로고
    • Intracranial hypertension in acute liver failure: Pathophysiological basis of rational management
    • DOI 10.1055/s-2003-42645
    • Jalan R. Intracranial hypertension in acute liver failure: pathophysiological basis of rational management. Semin Liver Dis. 2003;23:271-282 (Pubitemid 37052452)
    • (2003) Seminars in Liver Disease , vol.23 , Issue.3 , pp. 271-282
    • Jalan, R.1
  • 29
    • 0003242345 scopus 로고    scopus 로고
    • Correlation between pharmacokinetic aspects and clinical efficacy of L-ornithine-L-aspartate (OA): Results of randomized, controlled clinical trials
    • Kircheis G, Metz M, Frey S, Seiller E. Correlation between pharmacokinetic aspects and clinical efficacy of L-ornithine-L-aspartate (OA): results of randomized, controlled clinical trials. J Hepatol. 1996;25(Suppl 1):s131.
    • (1996) J Hepatol , vol.25 , Issue.SUPPL. 1
    • Kircheis, G.1    Metz, M.2    Frey, S.3    Seiller, E.4
  • 32
    • 0036988608 scopus 로고    scopus 로고
    • Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy
    • DOI 10.1023/A:1021934607762
    • Kircheis G, Wettstein M, Dahl S, Haussinger D. Clinical efficacy of L-ornithine- L-aspartate in the management of hepatic encephalopathy. Metab Brain Dis. 2002;17:453-462 (Pubitemid 36204774)
    • (2002) Metabolic Brain Disease , vol.17 , Issue.4 , pp. 453-462
    • Kircheis, G.1    Wettstein, M.2    Vom Dahl, S.3    Haussinger, D.4
  • 33
    • 0032885699 scopus 로고    scopus 로고
    • L-Ornithine aspartate - A rationale for its use in combination with chemotherapy, radiation, and hyperthermia in oncology
    • Kleef R, Scheller A. L-ornithine aspartate - a rationale for its use in combination with chemotherapy, radiation, and hyperthermia in oncology. Forsch Komplementarmed. 1999;6:216. (Pubitemid 29459413)
    • (1999) Forschende Komplementarmedizin , vol.6 , Issue.4 , pp. 216
    • Kleef, R.1
  • 34
    • 0035857035 scopus 로고    scopus 로고
    • Chronic liver diseases. The nihilism has gone
    • Koczorek M. Chronic liver diseases. The nihilism has gone. MMW Fortschr Med. 2001;143(51/52):14.
    • (2001) MMW Fortschr Med , vol.143 , Issue.51-52 , pp. 14
    • Koczorek, M.1
  • 35
    • 0013895304 scopus 로고
    • Clinical study on the effects of L-ornithine-L-aspartate on liver dysfunction
    • Kosozu K. Clinical study on the effects of L-ornithine-L-aspartate on liver dysfunction. Iryo. 1966;20:339-346
    • (1966) Iryo , vol.20 , pp. 339-346
    • Kosozu, K.1
  • 36
    • 33646415644 scopus 로고    scopus 로고
    • Pharmacokinetics and bioavailability study of L-ornithine- L-aspartate in healthy volunteers - A comparative study of two oral formulations
    • Kowalski P, Bieniecki M. Pharmacokinetics and bioavailability study of L-ornithine- L-aspartate in healthy volunteers - a comparative study of two oral formulations. J Pharm Biomed Anal. 2006;41:1061-1064
    • (2006) J Pharm Biomed Anal , vol.41 , pp. 1061-1064
    • Kowalski, P.1    Bieniecki, M.2
  • 37
    • 32544452854 scopus 로고    scopus 로고
    • Validated method for L-ornithine-L-aspartate analysis in human plasma by capillary electrophoresis
    • DOI 10.1002/bmc.551
    • Kowalski P, Bieniecki M, Oledzka I, Lamparczyk H. Validated method for L-ornithine-L-aspartate analysis in human plasma by capillary electrophoresis. Biomed Chromatogr. 2006;20:185-194 (Pubitemid 43230871)
    • (2006) Biomedical Chromatography , vol.20 , Issue.2 , pp. 185-194
    • Kowalski, P.1    Bieniecki, M.2    Oledzka, I.3    Lamparczyk, H.4
  • 38
    • 0028504395 scopus 로고
    • Ornithine aspartate in hepatic encephalopathy: An established new therapeutic approach. Overview and results of current randomized studies
    • Jena
    • Kruger B, Held C, Kircheis G. Ornithine aspartate in hepatic encephalopathy: an established new therapeutic approach. Overview and results of current randomized studies. Z Arztl Fortbild (Jena). 1994;88:673-679
    • (1994) Z Arztl Fortbild , vol.88 , pp. 673-679
    • Kruger, B.1    Held, C.2    Kircheis, G.3
  • 39
    • 70449625891 scopus 로고
    • Ammonia-lowering effect of ornithine-aspartate infusion in cirrhotic patients with hepatic encephalopathy
    • Lang I, Feher J, Gogl A, Varga L, Varga L, Pronai L, Werling K. Ammonia-lowering effect of ornithine-aspartate infusion in cirrhotic patients with hepatic encephalopathy. Gut. 1994;35(Suppl 4):s158.
    • (1994) Gut , vol.35 , Issue.SUPPL. 4
    • Lang, I.1    Feher, J.2    Gogl, A.3    Varga, L.4    Varga, L.5    Pronai, L.6    Werling, K.7
  • 40
    • 70449673224 scopus 로고
    • Effects of ornithine aspartate (OA) on plasma ammonia and plasma amino acids (AA) in patients with liver cirrhosis. A double-blind, randomized study using a four-fold crossover design
    • Leweling H, Gladisch R, Staedt U, Wolters U, Holm E. Effects of ornithine aspartate (OA) on plasma ammonia and plasma amino acids (AA) in patients with liver cirrhosis. A double-blind, randomized study using a four-fold crossover design. Hepatology. 1990;10(Suppl 1):s13.
    • (1990) Hepatology , vol.10 , Issue.SUPPL. 1
    • Leweling, H.1    Gladisch, R.2    Staedt, U.3    Wolters, U.4    Holm, E.5
  • 41
    • 2242430639 scopus 로고    scopus 로고
    • The response to combined therapy of hepatic encephalopathy in patients with hepatic cirrhosis
    • Mosk
    • Maev IV, V'Iuchnova E S, Lebedeva EG, Iakovenko EI, Dicheva DT. The response to combined therapy of hepatic encephalopathy in patients with hepatic cirrhosis. Klin Med (Mosk). 2002;80:42-45
    • (2002) Klin Med , vol.80 , pp. 42-45
    • Maev, I.V.1    V'Iuchnova, E.S.2    Lebedeva, E.G.3    Iakovenko, E.I.4    Dicheva, D.T.5
  • 42
    • 27644541547 scopus 로고    scopus 로고
    • Effect of ascorbic acid, α-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats
    • Maneesh M, Jayalekshmi H. Effect of ascorbic acid, alpha-tocopherol, lecithin and L-ornithine-L-aspartate on ethanol induced hypoproteinemia and hyperlipidemia in rats. Indian J Physiol Pharmacol. 2005;49:422-426 (Pubitemid 41565801)
    • (2005) Indian Journal of Physiology and Pharmacology , vol.49 , Issue.4 , pp. 422-426
    • Maneesh, M.1    Jayalekshmi, H.2
  • 43
    • 0014615469 scopus 로고
    • On the therapy of liver diseases with ornithine aspartate
    • Melzer H, Weber D, Wotzka R. On the therapy of liver diseases with ornithine aspartate. Med Klin. 1969;64:1541-1544
    • (1969) Med Klin , vol.64 , pp. 1541-1544
    • Melzer, H.1    Weber, D.2    Wotzka, R.3
  • 44
    • 1442314219 scopus 로고    scopus 로고
    • Newer aspects of hepatic encephalopathy
    • Mullen KD. Newer aspects of hepatic encephalopathy. Indian J Gastroenterol. 2003;22(Suppl 2):s17-s20.
    • (2003) Indian J Gastroenterol , vol.22 , Issue.SUPPL. 2
    • Mullen, K.D.1
  • 45
    • 0015218890 scopus 로고
    • Effect of ornithine-aspartate on fecal excretion of mevalonate metabolites and the reticuloendothelial system
    • Nakamura H, Ishikawa M. Effect of ornithine-aspartate on fecal excretion of mevalonate metabolites and the reticuloendothelial system. Igaku To Seibutsugaku. 1971;83:213-215
    • (1971) Igaku To Seibutsugaku , vol.83 , pp. 213-215
    • Nakamura, H.1    Ishikawa, M.2
  • 46
    • 70449628049 scopus 로고
    • Improvement of hepatic encephalopathy (HE) in cirrhotic patients by treatment with L-ornithine-L-aspartate (OA) infusion concentrate. Results of a placebo-controlled, double-blind clinical trial
    • Nilius R, Kircheis G. Improvement of hepatic encephalopathy (HE) in cirrhotic patients by treatment with L-ornithine-L-aspartate (OA) infusion concentrate. Results of a placebo-controlled, double-blind clinical trial. J Hepatol. 1992;16(Suppl 1):s39.
    • (1992) J Hepatol , vol.16 , Issue.SUPPL. 1
    • Nilius, R.1    Kircheis, G.2
  • 47
    • 14944382711 scopus 로고    scopus 로고
    • Minimal hepatic encephalopathy: Diagnosis, clinical significance and recommendations
    • DOI 10.1016/j.jhep.2004.11.028, Management of Liver Diseases 2005
    • Ortiz M, Jacas C, Cordoba J. Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol. 2005;42(Suppl 1):s45-s53. (Pubitemid 40364603)
    • (2005) Journal of Hepatology , vol.42 , Issue.SUPPL. 1
    • Ortiz, M.1    Jacas, C.2    Cordoba, J.3
  • 48
    • 0014502789 scopus 로고
    • Personal experiences in the treatment of internal diseases with ornithine aspartate
    • Perinovic M, Robovic Z, Grujic M, Ljubojevic S. Personal experiences in the treatment of internal diseases with ornithine aspartate. Med Arh. 1969;23(3):29-32.
    • (1969) Med Arh , vol.23 , Issue.3 , pp. 29-32
    • Perinovic, M.1    Robovic, Z.2    Grujic, M.3    Ljubojevic, S.4
  • 49
    • 0029173719 scopus 로고
    • The treatment of hepatic encephalopathy with Hepa-Mertz
    • Podymova SD, Bueverov AO, Nadinskaia M. The treatment of hepatic encephalopathy with Hepa-Mertz. Ter Arkh. 1995;67(6):45-47
    • (1995) Ter Arkh , vol.67 , Issue.6 , pp. 45-47
    • Podymova, S.D.1    Bueverov, A.O.2    Nadinskaia, M.3
  • 50
    • 0030451813 scopus 로고    scopus 로고
    • Subclinical hepatic encephalopathy
    • Quero JC, Schalm SW. Subclinical hepatic encephalopathy. Semin Liver Dis. 1996;16:321-328
    • (1996) Semin Liver Dis , vol.16 , pp. 321-328
    • Quero, J.C.1    Schalm, S.W.2
  • 52
    • 0015524880 scopus 로고
    • Confirmation of a liver-protecting action of L-ornithine-L-aspartate using the experimental model of hypokalaemic liver damage
    • Raab W. Confirmation of a liver-protecting action of L-ornithine-L- aspartate using the experimental model of hypokalaemic liver damage. Wien Klin Wochenschr. 1972;84:348-349
    • (1972) Wien Klin Wochenschr , vol.84 , pp. 348-349
    • Raab, W.1
  • 53
    • 70449643383 scopus 로고    scopus 로고
    • The effect of L-Ornithine- L-asparate on tips patients undergoing glutamine challenge
    • Rees CJ, Oppong K, Al-Mardini H, Hudson M, Rose J. The effect of L-Ornithine- L-asparate on tips patients undergoing glutamine challenge. Eur J Gastroenterol Hepatol. 1996;8(Suppl 5):s16.
    • (1996) Eur J Gastroenterol Hepatol , vol.8 , Issue.SUPPL. 5
    • Rees, C.J.1    Oppong, K.2    Al-Mardini, H.3    Hudson, M.4    Rose, J.5
  • 54
    • 0033795334 scopus 로고    scopus 로고
    • Effect of L-ornithine- L-aspartate on patients with and without TIPS undergoing glutamine challenge: A double blind, placebo controlled trial
    • Rees CJ, Oppong K, Al Mardini H, Hudson M, Record CO. Effect of L-ornithine- L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut. 2000;47:571-574
    • (2000) Gut , vol.47 , pp. 571-574
    • Rees, C.J.1    Oppong, K.2    Al Mardini, H.3    Hudson, M.4    Record, C.O.5
  • 55
    • 0004151535 scopus 로고    scopus 로고
    • Treatment with L-ornithine-L-aspartate (LOLA) infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis
    • Reynolds N, Downie S, Smith K, Kircheis G, Rennie MJ. Treatment with L-ornithine-L-aspartate (LOLA) infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis. J Hepatol. 1999;30(Suppl 1):65.
    • (1999) J Hepatol , vol.30 , Issue.SUPPL. 1 , pp. 65
    • Reynolds, N.1    Downie, S.2    Smith, K.3    Kircheis, G.4    Rennie, M.J.5
  • 57
    • 0031852152 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: Therapeutic efficacy and mechanism of action
    • DOI 10.1023/A:1020613314572
    • Rose C, Michalak A, Pannunzio P, Therrien G, Quack G, Kircheis G, Butterworth RF. L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis. 1998;13:147-157 (Pubitemid 28350749)
    • (1998) Metabolic Brain Disease , vol.13 , Issue.2 , pp. 147-157
    • Rose, C.1    Michalak, A.2    Pannunzio, P.3    Therrien, G.4    Quack, G.5    Kircheis, G.6    Butterworth, R.F.7
  • 58
    • 0032868948 scopus 로고    scopus 로고
    • L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure
    • DOI 10.1002/hep.510300311
    • Rose C, Michalak A, Rao KV, Quack G, Kircheis G, Butterworth RF. L-ornithine- L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure. Hepatology. 1999;30:636-640 (Pubitemid 29409406)
    • (1999) Hepatology , vol.30 , Issue.3 , pp. 636-640
    • Rose, C.1    Michalak, A.2    Rao, K.V.R.3    Quack, G.4    Kircheis, G.5    Butterworth, R.F.6
  • 59
    • 0014430143 scopus 로고
    • Intravenous administration of ornithine aspartate to patients with hepatic diseases
    • Schafer W. Intravenous administration of ornithine aspartate to patients with hepatic diseases. Munch Med Wochenschr. 1968;110:2521-2525
    • (1968) Munch Med Wochenschr , vol.110 , pp. 2521-2525
    • Schafer, W.1
  • 60
    • 0013895305 scopus 로고
    • Study of the treatment of liver damage due to several causes in tuberculosis, using ornithine-aspartate
    • Seki S. Study of the treatment of liver damage due to several causes in tuberculosis, using ornithine-aspartate. Iryo. 1966;20:354-363
    • (1966) Iryo , vol.20 , pp. 354-363
    • Seki, S.1
  • 62
    • 0015317745 scopus 로고
    • Influence of ornithine-aspartate on the increased GOT activity in bovine serum
    • Sommer H, Unglaub W. Influence of ornithine-aspartate on the increased GOT activity in bovine serum. Berl Munch Tierarztl Wochenschr. 1972;85:123-125
    • (1972) Berl Munch Tierarztl Wochenschr , vol.85 , pp. 123-125
    • Sommer, H.1    Unglaub, W.2
  • 63
    • 0027715183 scopus 로고
    • Effects of ornithine aspartate on plasma ammonia and plasma and amino acids in patients with cirrhosis. a double-blind, randomized study using a four-fold crossover design
    • Staedt U, Leweling H, Gladisch R, Kortsik C, Hagmuller E, Holm E. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol. 1993;19:424-430 (Pubitemid 24029921)
    • (1993) Journal of Hepatology , vol.19 , Issue.3 , pp. 424-430
    • Staedt, U.1    Leweling, H.2    Gladisch, R.3    Kortsik, C.4    Hagmuller, E.5    Holm, E.6
  • 65
    • 0017143887 scopus 로고
    • Intravenous loading with arginine-hydrochloride and ornithine-aspartate in siblings of two families, presenting a familial neurological syndrome associated with cystinuria
    • Strauven T, Mardens Y, Clara R, Terheggen H. Intravenous loading with arginine-hydrochloride and ornithine-aspartate in siblings of two families, presenting a familial neurological syndrome associated with cystinuria. Biomedicine. 1976;24: 191-199
    • (1976) Biomedicine , vol.24 , pp. 191-199
    • Strauven, T.1    Mardens, Y.2    Clara, R.3    Terheggen, H.4
  • 66
    • 0015221975 scopus 로고
    • Our clinical experience with ornithine aspartate
    • Szirmai E. Our clinical experience with ornithine aspartate. Minerva Med. 1971;62:2376-2382
    • (1971) Minerva Med , vol.62 , pp. 2376-2382
    • Szirmai, E.1
  • 67
    • 1442338728 scopus 로고    scopus 로고
    • Hepatic encephalopathy syndromes
    • Tandon BN. Hepatic encephalopathy syndromes. Indian J Gastroenterol. 2003;22(Suppl 2):s4-s6.
    • (2003) Indian J Gastroenterol , vol.22 , Issue.SUPPL. 2
    • Tandon, B.N.1
  • 68
    • 0031024941 scopus 로고    scopus 로고
    • L-Ornithine vs. L-ornithine-L-aspartate as a treatment for hyperammonemia-induced encephalopathy in rats
    • DOI 10.1016/S0168-8278(97)80024-4
    • Vogels BA, Karlsen OT, Mass MA, Bovee WM, Chamuleau RA. L-ornithine vs. L-ornithine-L-aspartate as a treatment for hyperammonemia-induced encephalopathy in rats. J Hepatol. 1997;26:174-182 (Pubitemid 27072619)
    • (1997) Journal of Hepatology , vol.26 , Issue.1 , pp. 174-182
    • Vogels, B.A.P.M.1    Karlsen, O.T.2    Maas, M.A.W.3    Bovee, W.M.M.J.4    Chamuleau, R.A.F.M.5
  • 69
    • 1842870753 scopus 로고    scopus 로고
    • Researching progress on prognosis judgment of hepatic failure
    • Wang Y. Researching progress on prognosis judgment of hepatic failure. Zhonghua Gan Zang Bing Za Zhi. 2002;10:471-473
    • (2002) Zhonghua Gan Zang Bing Za Zhi , vol.10 , pp. 471-473
    • Wang, Y.1
  • 70
    • 1542515164 scopus 로고    scopus 로고
    • Minimal Hepatic Encephalopathy Impairs Fitness to Drive
    • DOI 10.1002/hep.20095
    • Wein C, Koch H, Popp B, Oehler G, Schauder P. Minimal hepatic encephalopathy impairs fitness to drive. Hepatology. 2004;39:739-745 (Pubitemid 38337653)
    • (2004) Hepatology , vol.39 , Issue.3 , pp. 739-745
    • Wein, C.1    Popp, B.2    Koch, H.3    Oehler, G.4    Schauder, P.5
  • 73
    • 0015306484 scopus 로고
    • Further clinical experiences with ornithine aspartate in liver diseases
    • Wotzka R, Weber D. Further clinical experiences with ornithine aspartate in liver diseases. Ther Ggw. 1972;111:400-412
    • (1972) Ther Ggw , vol.111 , pp. 400-412
    • Wotzka, R.1    Weber, D.2


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