L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure

Hepatology

Volumn 30, Issue 3, 1999, Pages 636-640

  Rose, Christopher ^a   Michalak, Adrianna ^a   Rao, K V Rama ^a   Quack, Günter ^b   Kircheis, Gerald ^b   Butterworth, Roger F ^a,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

^c Neuroscience Research Unit   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID; AMMONIA; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; ISOLEUCINE; LEUCINE; ORNITHINE ASPARTATE; TAURINE; VALINE; WATER;

AMMONIA BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BRAIN EDEMA; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; COLORIMETRY; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERAMMONEMIA; INTRAVENOUS DRUG ADMINISTRATION; ION EXCHANGE; LIVER FAILURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT;

AMMONIA; ANIMALS; BRAIN EDEMA; DIPEPTIDES; GLUTAMIC ACID; LIVER FAILURE, ACUTE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032868948     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300311     Document Type: Article

References (20)

1. Holmin T, Agardh CD, Alinder G, Herlin P, Hultberg B. The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat. Eur J Clin Invest 1983;13:215-220.
2. Mans AM, Saunders SJ, Kirsch RE, Biebuyck R. Correlation of plasma and brain amino acid and putative neurotransmitter alterations during acute hepatic coma in the rat. J Neurochem 1979;32:285-292.
3. Swain M, Buttenvorth RF, Blei AT. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. HEPATOLOGY 1992;15:449-453.
4. Swain M, Bergeron M, Audet R, Blei AT, Buttenvorth RF. Monitoring of neurotransmitter amino acids via an indwelling cisterna magna catheter: a comparisons of two rodent models of fulminant hepatic failure. HEPATOLOGY 1992;16:1028-1035.
5. Ganz R, Swain M, Traber P, Dal Canto M, Buttenvorth, RF. Blei AT. Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure. Metab Brain Dis 1989;4:213-223.
6. Norenberg MD, Baker L, Norenberg LOB, Blicharsda J, Bruce-Gregarios JH, Neary-JT. Ammonia-induced astrocyte swelling in primary culture. Neurochem Res 1991;16:833-836.
7. Jenkins JG, Glasgow JF, Black GW, Fannin TF, Hicks EM, Keilty SR, Crean PM. Reye's syndrome: assessment of intracranial pressure monitoring. Br Med J 1987;294:337-338.
8. Brusilow SW. Inborn errors of urea synthesis. In: Lloyd J, Scriver C, eds. Genetic and Metabolic Disease in Pediatrics. London: Butterworths, 1985:140-165.
9. Staedt U, Leweling H, Gladisch R, Kortsik C, Hagmüller E, Holm E. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J Hepatol 1993;19:424-430.
10. Kircheis G, Nilius R, Held C, Berndt H, Buchner M, Gortelmeyer R, et al. Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. HEPATOLOGY 1997;25:1351-1360.
11. Rose C, Michalak A, Pannunzio P, Therrien G, Quack G, Kircheis G, Butterworth RE L-Omithine-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action. Metab Brain Dis 1998;12:24-32.
12. Blei AT, Omary R, Butterworth RE Animal models of hepatic encephalopathies. In: Boulton AA, Baker GB, Butterworth RE eds. Neuromethods 22. Totowa, NJ: Humana Press, 1992:183-222.
13. Lee SH, Fisher B. Porta-caval shunt in the rat. Surgery 1961;50:668-672.
14. Spink DC, Swann JW, Snead OC, Waniewski RA, Martin DL. Analysis of aspartate and glutamate in human çerebrospinal fluid by high-performance liquid chromatography with automated precolumn derivatization. Anal Biochem 1986;158:79-86.
15. Dienst SG. An ion exchange method for plasma ammonia concentration. J Lab Clin Med 1961;58:149-155.
16. Marmarou A, Poll W, Shulman K, Bhagavan H. A simple gravimetric technique for measurement of cerebral edema. J Neurosurg 1978;49:530-537.
17. Girard G, Butterworth RE Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain and skeletal muscle. Dig Dis Sci 1992;37:1121-1126.
18. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with Folin phenol reagent. J Biol Chem 1951;193:265-275.
19. Levin LH, Koehler RC, Brusilow SW, Jones J, Traystman RJ. Elevated brain water during urease-induced hyperammonemia in dogs. In: Hoff JT, Betz AL, eds. Intracranial Pressure VII. Berlin: Springer-Verlag, 1989:1032-1034.
20. Takahashi H, Koehler RC, Brusilow SW, Traystman RJ. Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemicrats. Am J Physiol 1991;281:H826-H829.