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Volumn 17, Issue 4, 2002, Pages 453-462

Clinical efficacy of L-ornithine-L-aspartate in the management of hepatic encephalopathy

Author keywords

Hepatic encephalopathy; Hyperammonemia, placebo controlled clinical trials; L ornithine L aspartate

Indexed keywords

AMMONIUM CHLORIDE; ORNITHINE ASPARTATE; PLACEBO; PROTEIN;

EID: 0036988608     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021934607762     Document Type: Conference Paper
Times cited : (66)

References (22)
  • 1
    • 0001844560 scopus 로고
    • The theoretic therapy of hepatic encephalopathy
    • Conn, H.O., and Bircher, J., (eds.), Medi-Ed Press, East Lansing, MI
    • Conn, H.O. (1994). The theoretic therapy of hepatic encephalopathy. In: Conn, H.O., and Bircher, J., (eds.), Hepatic Encephalopathy: Syndromes and Therapies, Medi-Ed Press, East Lansing, MI, pp. 135-148.
    • (1994) Hepatic Encephalopathy: Syndromes and Therapies , pp. 135-148
    • Conn, H.O.1
  • 2
    • 12244292155 scopus 로고
    • Ammonia in liver and extrahepatic tissues: An overview of metabolism and toxicity in mammals
    • Butterworth, R.F., Pomier-Layrargues, G. (eds.), Humana Press, Clifton
    • Cooper, A.J.L., Lai, J.C.R., and Gelbard, A.S. (1989). Ammonia in liver and extrahepatic tissues: An overview of metabolism and toxicity in mammals. In: Butterworth, R.F., Pomier-Layrargues, G. (eds.), Hepatic Encephalopathy: Pathophysiology and Treatment, Humana Press, Clifton, pp. 27-48.
    • (1989) Hepatic Encephalopathy: Pathophysiology and Treatment , pp. 27-48
    • Cooper, A.J.L.1    Lai, J.C.R.2    Gelbard, A.S.3
  • 3
    • 12244295726 scopus 로고    scopus 로고
    • Placebo-controlled, double-blind evaluation of L-ornithine-L-aspartate (LOLA) granules in patients with cirrhosis and subclinical (SHE) or mild overt hepatic encephalopathy (HE)
    • abstract
    • Fleig, W.E., Kircheis, G., Spengler, U., Zeuzem, S.T., Görtelmeyer, R., and The German-Austrian-Swiss Multicenter Study Group (1999). Placebo-controlled, double-blind evaluation of L-ornithine-L-aspartate (LOLA) granules in patients with cirrhosis and subclinical (SHE) or mild overt hepatic encephalopathy (HE). J. Hepatol. 30(Suppl. 1):65 (abstract).
    • (1999) J. Hepatol. , vol.30 , Issue.SUPPL. 1 , pp. 65
    • Fleig, W.E.1    Kircheis, G.2    Spengler, U.3    Zeuzem, S.T.4    Görtelmeyer, R.5
  • 4
    • 0020617293 scopus 로고
    • Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver
    • Häussinger, D. (1983). Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur. J. Biochem. 133:269-274.
    • (1983) Eur. J. Biochem. , vol.133 , pp. 269-274
    • Häussinger, D.1
  • 5
    • 0021329772 scopus 로고
    • 4-induced liver cell necrosis with no effect on urea synthesis
    • 4-induced liver cell necrosis with no effect on urea synthesis. Chem. Biol. Interact. 48:191-194.
    • (1984) Chem. Biol. Interact. , vol.48 , pp. 191-194
    • Häussinger, D.1    Gerok, W.2
  • 6
    • 0017088686 scopus 로고
    • Der Einfluß von Ornithin-Aspartat auf die experimentell erzeugte Hyperammoniämie. Klinisch-experimentelle Studie
    • Henglein-Ottermann, D. (1976). Der Einfluß von Ornithin-Aspartat auf die experimentell erzeugte Hyperammoniämie. Klinisch-experimentelle Studie. Therapie der Gegenwart 115:1504-1518.
    • (1976) Therapie der Gegenwart , vol.115 , pp. 1504-1518
    • Henglein-Ottermann, D.1
  • 7
    • 0025647946 scopus 로고
    • Hyperammonaemia causes many of the changes found after portacaval shunting
    • Jessy, J., Mans, A.M., DeJoseph, M.R., and Hawkins, R.A. (1990). Hyperammonaemia causes many of the changes found after portacaval shunting. Biochem. J. 272:311-317.
    • (1990) Biochem. J. , vol.272 , pp. 311-317
    • Jessy, J.1    Mans, A.M.2    DeJoseph, M.R.3    Hawkins, R.A.4
  • 8
    • 0023789866 scopus 로고
    • Ammonia and glutamine metabolism in human liver slices: New aspects of the pathogenesis of hyperammonemia in chronic liver disease
    • Kaiser, S., Gerok, W., and Häussinger, D. (1988). Ammonia and glutamine metabolism in human liver slices: New aspects of the pathogenesis of hyperammonemia in chronic liver disease. Eur. J. Clin. Invest. 18:535-542.
    • (1988) Eur. J. Clin. Invest. , vol.18 , pp. 535-542
    • Kaiser, S.1    Gerok, W.2    Häussinger, D.3
  • 9
    • 12244288585 scopus 로고
    • Die Klinik der akuten Leberinsuffizienz
    • Kalk, H. (1958). Die Klinik der akuten Leberinsuffizienz. Gastroenterologia 90:271-290.
    • (1958) Gastroenterologia , vol.90 , pp. 271-290
    • Kalk, H.1
  • 10
    • 0003242345 scopus 로고    scopus 로고
    • Correlation between pharmacokinetic aspects and clinical efficacy of L-ornithine-L-aspartate (OA): Results of randomized, controlled clinical trials
    • abstract
    • Kircheis, G., Metz, M., Frey, S., and Seiller, E. (1996). Correlation between pharmacokinetic aspects and clinical efficacy of L-ornithine-L-aspartate (OA): Results of randomized, controlled clinical trials. J. Hepatol. 25(Suppl. 1):131 (abstract).
    • (1996) J. Hepatol. , vol.25 , Issue.SUPPL. 1 , pp. 131
    • Kircheis, G.1    Metz, M.2    Frey, S.3    Seiller, E.4
  • 11
    • 0031003989 scopus 로고    scopus 로고
    • Therapeutic efficacy of L-ornithine-L-aspartate infusion concentrate in patients with liver cirrhosis and hepatic encephalopathy: A placebo-controlled double-blind study
    • Kircheis, G., Nilius, R., Berndt, H., Buchner, M., Held, C., Hendricks, R., et al. (1997). Therapeutic efficacy of L-ornithine-L-aspartate infusion concentrate in patients with liver cirrhosis and hepatic encephalopathy: A placebo-controlled double-blind study. Hepatology 25:1351-1360.
    • (1997) Hepatology , vol.25 , pp. 1351-1360
    • Kircheis, G.1    Nilius, R.2    Berndt, H.3    Buchner, M.4    Held, C.5    Hendricks, R.6
  • 12
    • 0015502970 scopus 로고
    • Therapie der schweren hyperammoniämie
    • Leonhardt, H., and Bungert, H.J. (1972). Therapie der schweren Hyperammoniämie. Med. Klin. 67:1052-1056.
    • (1972) Med. Klin. , vol.67 , pp. 1052-1056
    • Leonhardt, H.1    Bungert, H.J.2
  • 13
    • 0020045422 scopus 로고
    • Modifications de l'amino-acidémie des cirrhotiques sous l'influence de sels d'ornithine
    • Molimard, R., Charpentier, C., and Lemonnier, F. (1982). Modifications de l'amino-acidémie des cirrhotiques sous l'influence de sels d'ornithine. Ann. Nutr. Metab. 26:25-36.
    • (1982) Ann. Nutr. Metab. , vol.26 , pp. 25-36
    • Molimard, R.1    Charpentier, C.2    Lemonnier, F.3
  • 15
    • 0003382789 scopus 로고
    • Treatment of hepatic encephalopathy. New perspectives on old ideas
    • Pomier-Layrargues, G., and Butterworth, R.F. (eds.), Mumana Press, Clifton, New Jersey
    • Pomier-Layrargues, G., Giguere, J.F., Lavoie, J., and Butterworth, R.F. (1989) Treatment of hepatic encephalopathy. New perspectives on old ideas. In: Pomier-Layrargues, G., and Butterworth, R.F. (eds.), Hepatic Encephalopathy. Pathophysiology and Treatment, Mumana Press, Clifton, New Jersey, pp. 469-481.
    • (1989) Hepatic Encephalopathy. Pathophysiology and Treatment , pp. 469-481
    • Pomier-Layrargues, G.1    Giguere, J.F.2    Lavoie, J.3    Butterworth, R.F.4
  • 16
    • 0004151535 scopus 로고    scopus 로고
    • Treatment with L-ornithine-L-aspartate infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis
    • abstract
    • Reynolds, N., Downie, S., Smith, K., Kircheis, G., and Rennie, M.J. (1999). Treatment with L-ornithine-L-aspartate infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis. J. Hepatol. 30(Suppl. 1):65 (abstract).
    • (1999) J. Hepatol. , vol.30 , Issue.SUPPL. 1 , pp. 65
    • Reynolds, N.1    Downie, S.2    Smith, K.3    Kircheis, G.4    Rennie, M.J.5
  • 17
    • 0030879021 scopus 로고    scopus 로고
    • Treatment of Hepatic Encephalopathy
    • Riordan, S., and Williams, R. (1997). Treatment of Hepatic Encephalopathy. New Engl. J. Med. 337:473-478.
    • (1997) New Engl. J. Med. , vol.337 , pp. 473-478
    • Riordan, S.1    Williams, R.2
  • 18
    • 0027715183 scopus 로고
    • Effects of ornithine aspartate on plasma ammmonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design
    • Staedt, U., Leweling, H., Gladisch, R., Kortsik, C., Hagmüller, E., and Holm, E. (1993). Effects of ornithine aspartate on plasma ammmonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J. Hepatol. 19:424-430.
    • (1993) J. Hepatol. , vol.19 , pp. 424-430
    • Staedt, U.1    Leweling, H.2    Gladisch, R.3    Kortsik, C.4    Hagmüller, E.5    Holm, E.6
  • 19
    • 0032079801 scopus 로고    scopus 로고
    • Oral L-ornithine-Laspartate therapy of chronic hepatic encephalopathy: Results of a placebo-controlled double-blind study
    • Stauch, S., Kircheis, G., Adler, G., Beckh, K., Ditschuneit, H., Görtelmeyer, R., et al. (1998). Oral L-ornithine-Laspartate therapy of chronic hepatic encephalopathy: Results of a placebo-controlled double-blind study. J. Hepatol. 28:856-864.
    • (1998) J. Hepatol. , vol.28 , pp. 856-864
    • Stauch, S.1    Kircheis, G.2    Adler, G.3    Beckh, K.4    Ditschuneit, H.5    Görtelmeyer, R.6
  • 20
    • 0024402230 scopus 로고
    • Functional hepatocyte heterogeneity: Vascular oxoglutarate is almost exclusively taken up by perivenous glutamine-synthetase-containing hepatocytes
    • Stoll, B., and Häussinger, D. (1989). Functional hepatocyte heterogeneity: Vascular oxoglutarate is almost exclusively taken up by perivenous glutamine-synthetase-containing hepatocytes. Eur. J. Biochem. 181:709-716.
    • (1989) Eur. J. Biochem. , vol.181 , pp. 709-716
    • Stoll, B.1    Häussinger, D.2
  • 21
    • 0026101649 scopus 로고
    • Functional hepatocyte heterogeneity in glutamate, aspartate and α-ketoglutarate uptake: A histoautoradiographical study
    • Stoll, B., McNelly, S., Buscher, H.P., and Häussinger, D. (1991). Functional hepatocyte heterogeneity in glutamate, aspartate and α-ketoglutarate uptake: A histoautoradiographical study. Hepatology 13:247-253.
    • (1991) Hepatology , vol.13 , pp. 247-253
    • Stoll, B.1    McNelly, S.2    Buscher, H.P.3    Häussinger, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.