메뉴 건너뛰기




Volumn 66, Issue 21, 2009, Pages 1950-1953

Homotaurine: A failed drug for Alzheimer's disease and now a nutraceutical for memory protection

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CHOLINESTERASE INHIBITOR; ESTROGEN; HOMOTAURINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPNOTIC AGENT; MEMANTINE; NEUROLEPTIC AGENT; NUTRACEUTICAL; PLACEBO; SEDATIVE AGENT; TAU PROTEIN; UNCLASSIFIED DRUG; VIVIMIND;

EID: 70449623037     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp080576     Document Type: Note
Times cited : (13)

References (30)
  • 1
    • 70449673783 scopus 로고    scopus 로고
    • Cost of bringing new drugs to market rising rapidly
    • Moran M. Cost of bringing new drugs to market rising rapidly. Psychiatr News. 2003; 38:25.
    • (2003) Psychiatr News , vol.38 , pp. 25
    • Moran, M.1
  • 3
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer's disease in the US population: Prevalence estimates using the 2000 census
    • Herbert LE, Scherr PA, Bienias JL et al. Alzheimer's disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003; 60:1119-1122
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Herbert, L.E.1    Scherr, P.A.2    Bienias, J.L.3
  • 4
    • 21544467552 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for patients with Alzheimer's disease: Systematic review of randomised clinical trials
    • Kaduszkiewicz H, Zimmermann T, Beck-Bornholdt HP et al. Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials. BMJ. 2005; 331:321-327 (Pubitemid 41113141)
    • (2005) British Medical Journal , vol.331 , Issue.7512 , pp. 321-323
    • Kaduszkiewicz, H.1    Zimmermann, T.2    Beck-Bornholdt, H.-P.3    Van Bussche, H.D.4
  • 6
    • 14844292105 scopus 로고    scopus 로고
    • Emerging prospects for the disease-modifying treatment of Alzheimer's disease
    • Walker LC, Ibegbu CC, Todd CW et al. Emerging prospects for the disease-modifying treatment of Alzheimer's disease. Biochem Pharmacol. 2005; 69:1001-8.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1001-1008
    • Walker, L.C.1    Ibegbu, C.C.2    Todd, C.W.3
  • 8
    • 56749091391 scopus 로고    scopus 로고
    • Longitudinal multimodal imaging in mild to moderate Alzheimer disease: A pilot study with memantine
    • Schmidt R, Ropele S, Pendl B et al. Longitudinal multimodal imaging in mild to moderate Alzheimer disease: a pilot study with memantine. J Neurol Neurosurg Psychiatry. 2008; 79:1312-1317
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 1312-1317
    • Schmidt, R.1    Ropele, S.2    Pendl, B.3
  • 9
    • 28844456475 scopus 로고    scopus 로고
    • The development of anti-amyloid therapy for Alzheimer's disease: From secretase modulators to polymerisation inhibitors
    • Aisen PS. The development of anti-amyloid therapy for Alzheimer's disease: from secretase modulators to polymerisation inhibitors. CNS Drugs. 2005; 19:989-996
    • (2005) CNS Drugs , vol.19 , pp. 989-996
    • Aisen, P.S.1
  • 10
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998; 4:97-100.
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3
  • 12
    • 0028831582 scopus 로고
    • Relative roles of plaques and tangles in the dementia of Alzheimer's disease: Correlations using three sets of neuropathological criteria
    • Nagy Z, Esiri MM, Jobst KA et al. Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. Dementia. 1995; 6:21-31.
    • (1995) Dementia , vol.6 , pp. 21-31
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 13
    • 17944382037 scopus 로고    scopus 로고
    • Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
    • Lewis I, Dickson DW, Lin WL et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001; 293:1487-1491
    • (2001) Science , vol.293 , pp. 1487-1491
    • Lewis, I.1    Dickson, D.W.2    Lin, W.L.3
  • 14
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
    • DOI 10.1126/science.1062097
    • Götz J, Chen F, van Dorpe J et al. Formation of neurofibrillary tangles in P301I tau transgenic mice induced by Abeta 42 fibrils. Science. 2001; 293:1491-1495 (Pubitemid 32807681)
    • (2001) Science , vol.293 , Issue.5534 , pp. 1491-1495
    • Gotz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 15
    • 0035949274 scopus 로고    scopus 로고
    • Untangling the relation between β-amyloid and tau
    • News
    • Love R. Untangling the relation between β-amyloid and tau. Lancet. 2001; 358:645. News.
    • (2001) Lancet , vol.358 , pp. 645
    • Love, R.1
  • 16
    • 70449630517 scopus 로고    scopus 로고
    • OVOS Natural Health accessed 2009 Jan 30
    • OVOS Natural Health. Vivimind information. www.vivimind.com/information. aspx (accessed 2009 Jan 30).
    • Vivimind Information
  • 17
    • 84891830122 scopus 로고    scopus 로고
    • accessed 2009 Jan 30
    • Alzheimer Research Forum. Drugs in clinical trials. www.alzforum.org/drg/ drc/detail.asp?id=84 (accessed 2009 Jan 30).
    • Drugs in Clinical Trials
  • 19
    • 28844467064 scopus 로고    scopus 로고
    • GAG mimetics: Potential to modify underlying disease process in AD
    • Gervais F. GAG mimetics: potential to modify underlying disease process in AD. Neurobiol Aging. 2004; 25(suppl 2):S11-2.
    • (2004) Neurobiol Aging , vol.25 , Issue.SUPPL. 2
    • Gervais, F.1
  • 20
    • 33845388059 scopus 로고    scopus 로고
    • A Phase II study targeting amyloid-β with 3APS in mild-to-moderate Alzheimer disease
    • DOI 10.1212/01.wnl.0000244346.08950.64, PII 0000611420061128000011
    • Aisen PS, Saumier D, Briand R et al. A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology. 2006; 67:1757-1763 (Pubitemid 44900749)
    • (2006) Neurology , vol.67 , Issue.10 , pp. 1757-1763
    • Aisen, P.S.1    Saumier, D.2    Briand, R.3    Laurin, J.4    Gervais, F.5    Tremblay, P.6    Garceau, D.7
  • 23
    • 35748977086 scopus 로고    scopus 로고
    • Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau
    • DOI 10.1186/1750-1326-2-17
    • Santa-Maria I, Hernández F, Del Rio J et al. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol Neurodegener. 2007; 2:17. (Pubitemid 350046026)
    • (2007) Molecular Neurodegeneration , vol.2 , Issue.1 , pp. 17
    • Santa-Maria, I.1    Hernandez, F.2    Del Rio, J.3    Moreno, F.J.4    Avila, J.5
  • 24
    • 70449687384 scopus 로고    scopus 로고
    • accessed 2009 Jul 23
    • Silcoff S. A memory drug by any other name. www.financialpost.com/ analysis/columnist/story.html?id=934555cf-fcd2-4c49-804c-2d7e6cc65878&k= 81018 (accessed 2009 Jul 23).
    • A Memory Drug by Any Other Name
    • Silcoff, S.1
  • 25
    • 33745305193 scopus 로고    scopus 로고
    • New Canadian natural health product regulations: A qualitative study of how CAM practitioners perceive they will be impacted
    • DOI 10.1186/1472-6882-6-18
    • Moss K, Boon H, Ballantyne P et al. New Canadian natural health product regulations: a qualitative study of how CAM practitioners perceive they will be impacted. BMC Complement Altern Med. 2006; 6:18. (Pubitemid 43933652)
    • (2006) BMC Complementary and Alternative Medicine , vol.6 , pp. 18
    • Moss, K.1    Boon, H.2    Ballantyne, P.3    Kachan, N.4
  • 26
    • 33748770115 scopus 로고    scopus 로고
    • Comparison of verbal claims for natural health products made by health food stores staff versus pharmacists in Ontario, Canada
    • Koren G, Oren D, Rouleau M et al. Comparison of verbal claims for natural health products made by health food stores staff versus pharmacists in Ontario, Canada. Can J Clin Pharmacol. 2006; 13:e251-6. (Pubitemid 44406022)
    • (2006) Canadian Journal of Clinical Pharmacology , vol.13 , Issue.2
    • Koren, G.1    Oren, D.2    Rouleau, M.3    Carmeli, D.4    Matsui, D.5
  • 27
    • 84887881714 scopus 로고    scopus 로고
    • accessed 2009 Jan 30
    • Agriculture and Agri-Food Canada. Functional foods and nutraceuticals. www4.agr.gc.ca/AAFC-AAC/display-afficher.do?id=1170856376710&lang=eng (accessed 2009 Jan 30).
    • Functional Foods and Nutraceuticals
  • 29
    • 43949115541 scopus 로고    scopus 로고
    • Herbal medicine in the United States: Review of efficacy, safety, and regulation
    • Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation. J Gen Intern Med. 2008; 23:854-859
    • (2008) J Gen Intern Med , vol.23 , pp. 854-859
    • Bent, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.