Fucoidan-Vitamin C complex suppresses tumor invasion through the basement membrane, with scarce injuries to normal or tumor cells, via decreases in oxidative stress and matrix metalloproteinases

International Journal of Oncology

Volumn 35, Issue 5, 2009, Pages 1183-1189

  Saitoh, Yasukazu ^a   Nagai, Yuko ^a   Miwa, Nobuhiko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

Author keywords

Fucoidan; Invasion; Matrix metalloproteinase; Reactive oxygen species; Tumor cell; Vitamin C

Indexed keywords

ASCORBIC ACID; FUCOIDIN; MATRIX METALLOPROTEINASE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BASEMENT MEMBRANE; CANCER CELL; CANCER INVASION; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENZYME RELEASE; FIBROSARCOMA; HUMAN; HUMAN CELL; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN STABILITY; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASCORBIC ACID; BASEMENT MEMBRANE; CELL LINE; CELL MOVEMENT; HUMANS; MATRIX METALLOPROTEINASES; NEOPLASM INVASIVENESS; OXIDATIVE STRESS; POLYSACCHARIDES;

EID: 70449581219     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000435     Document Type: Article

References (39)

1. Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798, 1991.
2. Behrend L, Henderson G and Zwacka RM: Reactive oxygen species in oncogenic transformation. Biochem Soc Trans 31: 1441-1444, 2003. (Pubitemid 38030996)
3. Amstad P, Crawford D, Muehlematter D, Zbinden I, Larsson R and Cerutti P: Oxidants stress induces the proto-oncogenes, c-fos and c-myc in mouse epidermal cells. Bull Cancer 77: 501-502, 1990. (Pubitemid 20179526)
4. Storz P: Reactive oxygen species in tumor progression. Front Biosci 10: 1881-1896, 2005.
5. Zhang G, Miura Y and Yagasaki K: Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity. Cancer Lett 159: 169-173, 2000.
6. Günther S, Ruhe C, Derikito MG, Böse G, Sauer H and Wartenberg M: Polyphenols prevent cell shedding from mouse mammary cancer spheroids and inhibit cancer cell invasion in confrontation cultures derived from embryonic stem cells. Cancer Lett 250: 25-35, 2007. (Pubitemid 46483841)
7. Mukai M, Shinkai K, Tateishi R, Mori Y and Akedo H: Macrophage potentiation of invasive capacity of rat ascites hepatoma cells. Cancer Res 47: 2167-2171, 1987. (Pubitemid 17074627)
8. Nonaka Y, Iwagaki H, Kimura T, Fuchimoto S and Orita K: Effect of reactive oxygen intermediates on the in vitro invasive capacity of tumor cells and liver metastasis in mice. Int J Cancer 54: 983-986, 1993.
9. Maulik N and Das DK: Redox signaling in vascular angiogenesis. Free Radic Biol Med 33: 1047-1060, 2002.
10. Kageyama K, Onoyama Y, Otani S, Matsui-Yuasa I, Nagao N and Miwa N: Enhanced inhibitory effects of hyperthermia combined with ascorbic acid on DNA synthesis in Ehrlich ascites tumor cells grown at a low cell density. Cancer Biochem Biophys 14: 273-280, 1995.
11. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 9: 44-84, 2007. (Pubitemid 44566469)
12. Saitoh Y, Okayasu H, Xiao L, Harata Y and Miwa N: Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression. Oncol Res 17: 247-255, 2008.
13. Liu JW, Nagao N, Kageyama K and Miwa N: Antimetastatic and anti-invasive ability of phospho-ascorbyl palmitate through intracellular ascorbate enrichment and the resultant antioxidant action. Oncol Res 11: 479-487, 1999.
14. Liu JW, Nagao N, Kageyama K and Miwa N: Anti-metastatic effect of an autooxidation-resistant and lipophilic ascorbic acid derivative through inhibition of tumor invasion. Anticancer Res 20: 113-118, 2000. (Pubitemid 30189741)
15. Nagao N, Nakayama T, Etoh T, Saiki I and Miwa N: Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress. J Cancer Res Clin Oncol 126: 511-518, 2000. (Pubitemid 30645049)
16. Levine M: New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med 314: 892-902, 1986. (Pubitemid 16126118)
17. Levine M, Dhariwal KR, Welch RW, Wang Y and Park JB: Determination of optimal vitamin C requirements in humans. Am J Clin Nutr 62: S1347-S1356, 1995.
18. Sies H and Stahl W: Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 62: S1315-S1321, 1995.
19. Bram S, Froussard P, Guichard M, Jasmin C, Augery Y, Sinoussi-Barre F and Wray W: Vitamin C preferential toxicity for malignant melanoma cells. Nature 284: 629-631, 1980. (Pubitemid 10070873)
20. Bissell MJ, Hatie C, Farson DA, Schwarz RI and Soo WJ: Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus. Proc Natl Acad Sci USA 77: 2711-2715, 1980. (Pubitemid 10057905)
21. Leung PY, Miyashita K, Young M and Tsao CS: Cytotoxic effect of ascorbate and its derivatives on cultured malignant and non-malignant cell lines. Anticancer Res 13: 475-480, 1993. (Pubitemid 23196790)
22. Wells WW, Rocque PA, Xu DP, Meyer EB, Charamella LJ and Dimitrov NV: Ascorbic acid and cell survival of adriamycin resistant and sensitive MCF-7 breast tumor cells. Free Radic Biol Med 18: 699-708, 1995.
23. Takenaga M, Igarashi R, Nakayama T and Mizushima Y: Lecithinized ascorbic acid (PC-AS) effectively inhibits murine pulmonary metastasis. Anticancer Res 19: 1085-1091, 1999. (Pubitemid 29257541)
24. Cui YQ, Luo DZ and Wang XM: Fucoidan: advances in the study of its anti-inflammatory and anti-oxidative effects. Yao Xue Xue Bao 43: 1186-1189, 2008.
25. Yamamoto I, Takahashi M, Suzuki T, Seino H and Mori H: Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum. Jpn J Exp Med 54: 143-151, 1984. (Pubitemid 14010593)
26. Coombe DR, Parish CR, Ramshaw IA and Snowden JM: Analysis of the inhibition of tumour metastasis by sulphated polysaccharides. Int J Cancer 39: 82-88, 1987.
27. Soeda S, Ishida S, Shimeno H and Nagamatsu A: Inhibitory effect of oversulfated fucoidan on invasion through reconstituted basement membrane by murine Lewis lung carcinoma. Jpn J Cancer Res 85: 1144-1150, 1994. (Pubitemid 24356087)
28. Koyanagi S, Tanigawa N, Nakagawa H, Soeda S and Shimeno H: Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities. Biochem Pharmacol 65: 173-179, 2003. (Pubitemid 36015820)
29. Shevde LA and Welch DR: Metastasis suppressor pathways - an evolving paradigm. Cancer Lett 198: 1-20, 2003.
30. Zannoni V, Lynch M, Goldstein S and Sato P: A rapid micromethod for the determination of ascorbic acid in plasma and tissues. Biochem Med 11: 41-48, 1974.
31. Rasheed S, Nelson-Rees WA, Toth EM, Arnstein P and Gardner MB: Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33: 1027-1033, 1974.
32. Schrenzel J, Serrander L, Banfi B, Nusse O, Fouyouzi R, Lew DP, Demaurex N and Krause KH: Electron currents generated by the human phagocyte NADPH oxidase. Nature 392: 734-737, 1998. (Pubitemid 28207797)
33. Mignatti P and Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73: 161-195, 1993. (Pubitemid 23065437)
34. MacDougall JR and Matrisian LM: Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metastasis Rev 14: 351-362, 1995. (Pubitemid 26030973)
35. Johnsen M, Lund LR, R¢mer J, Almholt K and Dan¢ K: Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr Opin Cell Biol 10: 667-671, 1998. (Pubitemid 28477027)
36. Kähäri VM and Saarialho-Kere U: Matrix metalloproteinases and their inhibitors in tumour growth and invasion. Ann Med 31: 34-45, 1999. (Pubitemid 29134483)
37. Loo G: Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). J Nutr Biochem 14: 64-73, 2003. (Pubitemid 36349516)
38. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG and Galis ZS: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98: 2572-2579, 1996.
39. Nelson KK and Melendez JA: Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med 37: 768-784, 2004. (Pubitemid 39078549)