Immune responses of human immature dendritic cells can be modulated by the recombinant Aspergillus fumigatus antigen Aspf1

Clinical and Vaccine Immunology

Volumn 16, Issue 10, 2009, Pages 1485-1492

  Ok, Michael ^a   Latge, Jean Paul ^c   Baeuerlein, Carina ^a   Ebel, Frank ^d   Mezger, Markus ^a   Topp, Max ^a   Kurzai, Oliver ^b   Killian, Doreen ^a   Kapp, Markus ^a   Grigoleit, Goetz Ulrich ^a   Sennefelder, Helga ^a   Arroyo, Javier ^e   Einsele, Hermann ^a   Loeffler, Juergen ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Inst für Hyg un Mikrobiologie   (Germany)

^c INSTITUT PASTEUR   (France)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASPF1 ANTIGEN; CRF1 ANTIGEN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 23; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FUMIGATUS; CELL MATURATION; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; MONOCYTE; PRIORITY JOURNAL;

EID: 70449565798     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00175-08     Document Type: Article

References (35)

1. Akira, S., and H. Hemmi. 2003. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85:85-95.
2. Arroyo, J., J. Sarfati, M. T. Baixench, E. Ragni, M. Guillén, J. M. Rodriguez-Peña, L. Popolo, and J. P. Latgé. 2007. The GRI-anchored Gas and Crh families are fungal antigens. Yeast 4:289-296.
3. Arruda, L. K., T. A. Platts-Mills, J. W. Fox, and M. D. Chapman. 1990. Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins. J. Exp. Med. 172:1529-1532.
4. Barnes, P. D., and K. A. Marr. 2007. Risks, diagnosis and outcomes of invasive fungal infections in haematopoietic stem cell transplant recipients. Br. J. Haematol. 139:519-531.
5. Beauvais, A., M. Monod, J. P. Debeaupuis, M. Diaquin, H. Kobayashi, and J. P. Latgé. 1997. Biochemical and antigenic characterization of a new dipeptidyl-peptidase isolated from Aspergillus fumigatus. J. Biol. Chem. 272:6238-6244.
6. Bozza, S., K. Perruccio, C. Montagnoli, R. Gaziano, S. Bellocchio, E. Burchielli, G. Nkwanyuo, L. Pitzurra, A. Velardi, and L. Romani. 2003. A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102:3807-3814. (Pubitemid 37409405)
7. Bustin, S. A., V. Benes, J. A. Garson, J. Hellemans, J. Huggett, M. Kubista, R. Mueller, T. Nolan, M. W. Pfaffl, G. L. Shipley, J. Vandesompele, and C. T. Wittwer. 2009. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55:611-622.
8. Einsele, H., G. Rauser, U. Grigoleit, H. Hebart, C. Sinzger, S. Riegler, and G. Jahn. 2002. Induction of CMV-specific T-cell lines using Ag-presenting cells pulsed with CMV protein or peptide. Cytotherapy 4:49-54. (Pubitemid 34752391)
9. Gafa, V., R. Lande, M. C. Gagliardi, M. Severa, E. Giacomini, M. E. Remoli, R. Nisini, C. Ramoni, P. Di Francesco, D. Aldebert, R. Grillot, and E. M. Coccia. 2006. Human dendritic cells following Aspergillus fumigatus infection express the CCR7 receptor and a differential pattern of interleukin-12 (IL-12), IL-23, and IL-27 cytokines, which lead to a Th1 response. Infect. Immun. 74:1480-1489.
10. Gafa, V., M. E. Remoli, E. Giacomini, M. C. Gagliardi, R. Lande, M. Severa, R. Grillot, and E. M. Coccia. 2007. In vitro infection of human dendritic cells by Aspergillus fumigatus conidia triggers the secretion of chemokines for neutrophil and Th1 lymphocyte recruitment. Microbes Infect. 9:971-980.
11. Grigoleit, U., M. Kapp, H. Hebart, K. Fick, R. Beck, G. Jahn, and H. Einsele. 2007. Dendritic cell vaccination in allogeneic stem cell recipients: induction of human cytomegalovirus (HCMV)-specific cytotoxic T lymphocyte responses even in patients receiving a transplant from an HCMV-seronegative donor. J. Infect. Dis. 196:699-704.
12. Grigoleit, U., S. Riegler, H. Einsele, K. Laib Sampaio, G. Jahn, H. Hebart, P. Brossart, F. Frank, and C. Sinzger. 2002. Human cytomegalovirus induces a direct inhibitory effect on antigen presentation by monocyte-derived immature dendritic cells. Br. J. Haematol. 119:189-198.
13. Hayden, M. S., and S. Ghosh. 2004. Signaling to NFκB. Genes Dev. 18:2195-2224.
14. Holt, P. G. 2000. Antigen presentation in the lung. Am. J. Respir. Crit. Care Med. 162:151-156.
15. Iordanov, M. S., D. Pribnow, J. L. Magun, T. H. Dinh, J. A. Pearson, S. L. Y. Chen, and B. E. Magun. 1997. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA. Mol. Cell. Biol. 17:3373-3381.
16. Kao, R., and J. Davies. 1995. Fungal ribotoxins: a family of naturally engineered targeted toxins? Biochem. Cell Biol. 73:1151-1159.
17. Kim, S., K. B. Elkon, and X. Ma. 2004. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Immunity 21:643-653.
18. Kubach, J., C. Becker, E. Schmitt, K. Steinbrink, E. Huter, A. Tuettenberg, and H. Jonuleit. 2005. Dendritic cells: sentinels of immunity and tolerance. Int. J. Hematol. 81:197-203.
19. Lacadena, J., E. Álvarez-García, N. Carreras-Sangrà, E. Herrero-Galán, J. Alegre-Cebollada, L. García-Ortega, M. Onaderra, J. G. Gavilanes, and Á. M. del Pozo. 2007. Fungal ribotoxins: molecular dissection of a family of natural killers. FEMS Microbiol. Rev. 31:212-237.
20. Lamy, B., M. Moutaouakil, J. P. Latgé, and J. Davies. 1991. Secretion of a potential virulence factor, a fungal ribonucleotoxin, during human aspergillosis infections. Mol. Microbiol. 5:1811-1815.
21. Lanzavecchia, A., and F. Sallusto. 2001. Regulation of T cell immunity by dendritic cells. Cell 106:263-266. (Pubitemid 32772609)
22. -ΔΔCT method. Methods 25:402-408.
23. Mezger, M., S. Kneitz, I. Wozniok, O. Kurzai, H. Einsele, and J. Loeffler. 2008. Pro-inflammatory response of human immature dendritic cells is mediated by dectin-1 after exposure to Aspergillus fumigatus germ tubes. J. Infect. Dis. 15:924-931.
24. Netea, M. G., J. W. Van der Meer, and B. J. Kullberg. 2006. Role of the dual interaction of fungal pathogens with pattern recognition receptors in the activation and modulation of host defence. Clin. Microbiol. Infect. 12:404-409.
25. Olmo, N., J. Turnay, G. González de Buitrago, I. López de Silames, J. G. Gavilanes, and M. A. Lizarbe. 2001. Cytotoxic mechanism of the ribotoxin α-sarcin. Eur. J. Biochem. 268:2113-2123.
26. Paris, S., M. Monod, M. Diagiun, B. Lamy, L. K. Arruda, P. J. Punk, and J. P. Latgé. 1993. A transformant of Aspergillus fumigatus deficient in the antigenic cytotoxin ASPFI. FEMS Microbiol. Lett. 111:31-36.
27. Perruccio, K., S. Bozza, C. Montagnoli, S. Bellocchio, F. Aversa, M. Martelli, F. Bistoni, A. Velardi, and L. Romani. 2004. Prospects for dendritic cell vaccination against fungal infections in hematopoietic transplantation. Blood Cells Mol. Dis. 33:248-255.
28. Sarfati, J., M. Monod, P. Recco, A. Sulahian, C. Pinel, E. Candolfi, T. Fontaine, J. P. Debeaupuis, M. Tabouret, and J. P. Latgé. 2006. Recombinant antigens as diagnostic markers for aspergillosis. Diagn. Microbiol. Infect. Dis. 55:279-291.
29. Shortman, K., and W. R. Heath. 2001. Immunity or tolerance? That is the question for dendritic cells. Nat. Immunol. 2:988-989.
30. Stanzani, M., E. Orciuolo, R. Lewis, D. P. Kontoyiannis, S. L. Martins, L. S. St. John, and K. V. Komanduri. 2005. Aspergillus fumigatus suppresses the human cellular immune response via gliotoxin-mediated apoptosis of monocytes. Blood 105:2258-2265.
31. Svirshchevskaya, E., E. Frolova, L. Alekseeva, O. Kotzareva, and V. P. Kurup. 2000. Intravenous injection of major and cryptic peptide epitopes of ribotoxin, Asp f 1 inhibits T cell response induced by crude Aspergillus fumigatus antigens in mice. Peptides 21:1-8.
32. Tong, K. B., C. J. Lau, K. Murtagh, A. J. Layton, and R. Seifeldin. 2009. The economic impact of aspergillosis: analysis of hospital expenditures across patient subgroups. Int. J. Infect. Dis. 13:24-36.
33. Tsatsanis, C., A. Androulidaki, M. Venihaki, and A. N. Margioris. 2006. Signalling networks regulating cyclooxygenase-2. Int. J. Biochem. Cell Biol. 38:1654-1661.
34. Watts, C., R. Zaru, A. R. Prescott, R. P. Wallin, and M. A. West. 2007. Proximal effects of Toll-like receptor activation in dendritic cells. Curr. Opin. Immunol. 19:73-78.
35. Wierecky, J., M. Mueller, and P. Brossart. 2006. Dendritic cell-based cancer immunotherapy targeting MUC-1. Cancer Immunol. Immunother. 55:63-67.