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Volumn 26, Issue 8, 2009, Pages 692-700

Formulation and in vitro characterization of spray-dried antisense oligonucleotide to NF-B encapsulated albumin microspheres

Author keywords

Antisense oligonucleotide; Microspheres; NF kB, albumin; Spray drying

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROSPHERE; PHOSPHATE BUFFERED SALINE; SERUM ALBUMIN;

EID: 70449558745     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040802666910     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 0025743216 scopus 로고
    • Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice
    • Agrawal S, Temsamani J, Tang JY. 1991. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc Natl Acad Sci USA 88:7595-7599.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7595-7599
    • Agrawal, S.1    Temsamani, J.2    Tang, J.Y.3
  • 2
    • 0037133126 scopus 로고    scopus 로고
    • Targeting to macrophages: Role of physicochemical properties of particulate carriers- liposomes and microspheres-on the phagocytosis by macrophages
    • Ahsan F, Rivas IP, Khan MA, Torres Suarez AI. 2002. Targeting to macrophages: Role of physicochemical properties of particulate carriers- liposomes and microspheres-on the phagocytosis by macrophages. J Contr Rel 79:29-40.
    • (2002) J Contr Rel , vol.79 , pp. 29-40
    • Ahsan, F.1    Rivas, I.P.2    Khan, M.A.3    Torres Suarez, A.I.4
  • 4
    • 15444358157 scopus 로고    scopus 로고
    • Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease
    • Ardite E, Panes J, Miranda M, Salas A, Elizalde JI, Sans M, et al. 1998. Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease. Br J Pharmacol 124:431-433.
    • (1998) Br J Pharmacol , vol.124 , pp. 431-433
    • Ardite, E.1    Panes, J.2    Miranda, M.3    Salas, A.4    Elizalde, J.I.5    Sans, M.6
  • 5
    • 33751183754 scopus 로고    scopus 로고
    • Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems
    • Arifin DY, Lee LY, Wang CH. 2006. Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems. Adv Drug Deliv Rev 58:1274-1325.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1274-1325
    • Arifin, D.Y.1    Lee, L.Y.2    Wang, C.H.3
  • 6
    • 0037026277 scopus 로고    scopus 로고
    • Albumin nanoparticles as carriers for a phosphodiester oligonucleotide
    • Arnedo A, Espuelas S, Irache JM. 2002. Albumin nanoparticles as carriers for a phosphodiester oligonucleotide. Int J Pharm 244:59-72.
    • (2002) Int J Pharm , vol.244 , pp. 59-72
    • Arnedo, A.1    Espuelas, S.2    Irache, J.M.3
  • 7
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of i kappa B synthesis
    • Auphan N, Didonato JA, Rosette C, Helmberg A, Karin M. 1995. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science 270:286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 8
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. 1997. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 9
    • 0028231892 scopus 로고
    • Oligonucleotides in the treatment of leukemia
    • Bayever E, Iversen P. 1994. Oligonucleotides in the treatment of leukemia. Hematol Oncol 12:9-14.
    • (1994) Hematol Oncol , vol.12 , pp. 9-14
    • Bayever, E.1    Iversen, P.2
  • 10
    • 2642517290 scopus 로고    scopus 로고
    • Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    • Benito MJ, Murphy E, Murphy EP, Van Den Berg WB, Fitzgerald O, Bresnihan B. 2004. Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 50:1781-1787.
    • (2004) Arthritis Rheum , vol.50 , pp. 1781-1787
    • Benito, M.J.1    Murphy, E.2    Murphy, E.P.3    Van Den Berg, W.B.4    Fitzgerald, O.5    Bresnihan, B.6
  • 11
    • 0034807801 scopus 로고    scopus 로고
    • Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles
    • Berton M, Turelli P, Trono D, Stein CA, Allemann E, Gurny R. 2001. Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles. Pharm Res 18:1096-1101.
    • (2001) Pharm Res , vol.18 , pp. 1096-1101
    • Berton, M.1    Turelli, P.2    Trono, D.3    Stein, C.A.4    Allemann, E.5    Gurny, R.6
  • 12
    • 0034255285 scopus 로고    scopus 로고
    • Development of spraydried acetaminophen microparticles using experimental designs
    • Billon A, Bataille B, Cassanas G, Jacob M. 2000. Development of spraydried acetaminophen microparticles using experimental designs. Int J Pharm 203:159-168.
    • (2000) Int J Pharm , vol.203 , pp. 159-168
    • Billon, A.1    Bataille, B.2    Cassanas, G.3    Jacob, M.4
  • 13
    • 0028340595 scopus 로고
    • The effect of process and formulation variables on the properties of spray-dried beta-galactosidase
    • Broadhead J, Rouan SK, Hau I, Rhodes CT. 1994. The effect of process and formulation variables on the properties of spray-dried beta-galactosidase. J Pharm Pharmacol 46:458-467.
    • (1994) J Pharm Pharmacol , vol.46 , pp. 458-467
    • Broadhead, J.1    Rouan, S.K.2    Hau, I.3    Rhodes, C.T.4
  • 14
    • 0030000245 scopus 로고    scopus 로고
    • Progress in antisense oligonucleotide therapeutics
    • Crooke ST, Bennett CF. 1996. Progress in antisense oligonucleotide therapeutics. Annu Rev Pharmacol Toxicol 36:107-129.
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 107-129
    • Crooke, S.T.1    Bennett, C.F.2
  • 15
    • 0033771299 scopus 로고    scopus 로고
    • Microspheres containing neutralizing antibodies to tumor necrosis factor-alpha and interleukin- 1 beta protect rats from Staphylococcus aureus-induced peritonitis
    • D'Souza M, Oettinger CW, Milton GV. 2000. Microspheres containing neutralizing antibodies to tumor necrosis factor-alpha and interleukin- 1 beta protect rats from Staphylococcus aureus-induced peritonitis. J Interferon Cytokine Res 20:907-913.
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 907-913
    • D'Souza, M.1    Oettinger, C.W.2    Milton, G.V.3
  • 16
    • 21344441677 scopus 로고    scopus 로고
    • Treatment of experimental septic shock with microencapsulated antisense oligomers to NF-kappaB
    • D'Souza MJ, Jin Z, Oettinger CW. 2005. Treatment of experimental septic shock with microencapsulated antisense oligomers to NF-kappaB. J Interferon Cytokine Res 25:311-320.
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 311-320
    • D'Souza, M.J.1    Jin, Z.2    Oettinger, C.W.3
  • 17
    • 0032941902 scopus 로고    scopus 로고
    • Improved efficacy of a microencapsulated macrophage colony stimulating factor and methotrexate in melanoma
    • D'Souza MJ, Pourfarzib R. 1999. Improved efficacy of a microencapsulated macrophage colony stimulating factor and methotrexate in melanoma. Drug Dev Ind Pharm 25:583-590.
    • (1999) Drug Dev Ind Pharm , vol.25 , pp. 583-590
    • D'Souza, M.J.1    Pourfarzib, R.2
  • 18
    • 0011986806 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappa B (NF-B): An emerging theme in anti-inflammatory therapies
    • D'Acquisto F, May MJ, Ghosh S. 2002. Inhibition of nuclear factor kappa B (NF-B): An emerging theme in anti-inflammatory therapies. Mol Interv 2:22-35.
    • (2002) Mol Interv , vol.2 , pp. 22-35
    • D'Acquisto, F.1    May, M.J.2    Ghosh, S.3
  • 19
    • 0000015743 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Basic concepts and mechanisms
    • Dias N, Stein CA. 2002. Antisense oligonucleotides: Basic concepts and mechanisms. Mol Cancer Ther 1:347-355.
    • (2002) Mol Cancer Ther , vol.1 , pp. 347-355
    • Dias, N.1    Stein, C.A.2
  • 21
    • 4444246813 scopus 로고    scopus 로고
    • Polymer microspheres for controlled drug release
    • Freiberg S, Zhu XX. 2004. Polymer microspheres for controlled drug release. Int J Pharm 282:1-18.
    • (2004) Int J Pharm , vol.282 , pp. 1-18
    • Freiberg, S.1    Zhu, X.X.2
  • 22
    • 0028864495 scopus 로고
    • Bovine serum albumin is a major oligonucleotide-binding protein found on the surface of cultured cells
    • Geselowitz DA, Neckers LM. 1995. Bovine serum albumin is a major oligonucleotide-binding protein found on the surface of cultured cells. Antisense Res Dev 5:213-217.
    • (1995) Antisense Res Dev , vol.5 , pp. 213-217
    • Geselowitz, D.A.1    Neckers, L.M.2
  • 23
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl:S81-96.
    • (2002) Cell , vol.109 , Issue.SUPPL
    • Ghosh, S.1    Karin, M.2
  • 24
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260.
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 25
    • 0022971784 scopus 로고
    • Albumin microspheres. II. Effect of stabilization temperature on the release of adriamycin
    • Gupta PK, Hung CT, Perrier DG. 1986. Albumin microspheres. II. Effect of stabilization temperature on the release of adriamycin. Int J Pharm 33:147-153.
    • (1986) Int J Pharm , vol.33 , pp. 147-153
    • Gupta, P.K.1    Hung, C.T.2    Perrier, D.G.3
  • 26
    • 34147191553 scopus 로고    scopus 로고
    • Vitro evaluation and targeting of E. coli internalized by endothelial cells using albumin microspheres loaded with gentamicin
    • Haswani DK, Nettey H, D'Souza MJ, Oettinger CW. 2007. In vitro evaluation and targeting of E. coli internalized by endothelial cells using albumin microspheres loaded with gentamicin. Drug Dev Ind Pharm 33:181-190.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 181-190
    • Haswani, D.K.1    Nettey, H.2    D'Souza, M.J.3    Oettinger, C.W.4
  • 29
    • 0036846993 scopus 로고    scopus 로고
    • Antisense therapy for cancer-the time of truth
    • Jansen B, Zangemeister-Wittke U. 2002. Antisense therapy for cancer-the time of truth. Lancet Oncol 3:672-683.
    • (2002) Lancet Oncol , vol.3 , pp. 672-683
    • Jansen, B.1    Zangemeister-Wittke, U.2
  • 30
    • 0024954901 scopus 로고
    • Albumin microspheres as vehicles for the sustained and controlled release of doxorubicin
    • Jones C, Burton MA, Gray BN. 1989. Albumin microspheres as vehicles for the sustained and controlled release of doxorubicin. J Pharm Pharmacol 41:813-816.
    • (1989) J Pharm Pharmacol , vol.41 , pp. 813-816
    • Jones, C.1    Burton, M.A.2    Gray, B.N.3
  • 31
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
    • Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 32
    • 0031150163 scopus 로고    scopus 로고
    • Inhibition of the p50 (NKkappaB1) subunit of NF-kappaB by phosphorothioate-modified antisense oligodeoxynucleotides reduces NF-kappaB expression and immunoglobulin synthesis in murine B cells
    • Khaled AR, Soares LS, Butfiloski EJ, Stekman I, Sobel ES, Schiffenbauer J. 1997. Inhibition of the p50 (NKkappaB1) subunit of NF-kappaB by phosphorothioate-modified antisense oligodeoxynucleotides reduces NF-kappaB expression and immunoglobulin synthesis in murine B cells. Clin Immunol Immunopathol 83:254-263.
    • (1997) Clin Immunol Immunopathol , vol.83 , pp. 254-263
    • Khaled, A.R.1    Soares, L.S.2    Butfiloski, E.J.3    Stekman, I.4    Sobel, E.S.5    Schiffenbauer, J.6
  • 33
    • 0032973889 scopus 로고    scopus 로고
    • New approaches to modify glomerular inflammation
    • Kluth DC, Rees AJ. 1999. New approaches to modify glomerular inflammation. J Nephrol 12:66-75.
    • (1999) J Nephrol , vol.12 , pp. 66-75
    • Kluth, D.C.1    Rees, A.J.2
  • 34
    • 70449601328 scopus 로고    scopus 로고
    • Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system
    • Lanke SS, Gayakwad SG, Strom JG, D MJ. 2008. Oral delivery of low molecular weight heparin microspheres prepared using biodegradable polymer matrix system. J Microencapsulation 1-8.
    • (2008) J Microencapsulation , pp. 1-8
    • Lanke, S.S.1    Gayakwad, S.G.2    Strom, J.G.3
  • 36
    • 0032845248 scopus 로고    scopus 로고
    • Encapsulation of ethanol by spray drying technique: Effects of sodium lauryl sulfate
    • Lee SW, Kim MH, Kim CK. 1999. Encapsulation of ethanol by spray drying technique: Effects of sodium lauryl sulfate. Int J Pharm 187:193-218
    • (1999) Int J Pharm , vol.187 , pp. 193-218
    • Lee, S.W.1    Kim, M.H.2    Kim, C.K.3
  • 37
    • 0035848399 scopus 로고    scopus 로고
    • Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles
    • Lin W, Garnett MC, Davis SS, Schacht E, Ferruti P, Illum L. 2001. Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles. J Contr Rel 71:117-126.
    • (2001) J Contr Rel , vol.71 , pp. 117-126
    • Lin, W.1    Garnett, M.C.2    Davis, S.S.3    Schacht, E.4    Ferruti, P.5    Illum, L.6
  • 38
    • 33947616216 scopus 로고    scopus 로고
    • Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration
    • Mathew ST, Devi SG, Kv S. 2007. Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration. AAPS PharmSciTech 8:14.
    • (2007) AAPS Pharm Sci Tech , vol.8 , pp. 14
    • Mathew, S.T.1    Devi, S.G.2    Kv, S.3
  • 39
    • 34147174882 scopus 로고    scopus 로고
    • Vitro antimicrobial effect of encapsulated vancomycin on internalized Staphylococcus aureus within endothelial cells
    • Nettey H, Haswani D, D'Souza M, Oettinger C. 2007. In vitro antimicrobial effect of encapsulated vancomycin on internalized Staphylococcus aureus within endothelial cells. Drug Dev Ind Pharm 33:133-139.
    • (2007) Drug Dev Ind Pharm , vol.33 , pp. 133-139
    • Nettey, H.1    Haswani, D.2    D'Souza, M.3    Oettinger, C.4
  • 41
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl HL. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18:6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 42
    • 0035083556 scopus 로고    scopus 로고
    • Spray-drying as a method for microparticulate controlled release systems preparation: Advantages and limits. I. Water-soluble drugs
    • Palmieri GF, Bonacucina G, Di Martino P, Martelli S. 2001. Spray-drying as a method for microparticulate controlled release systems preparation: Advantages and limits. I. Water-soluble drugs. Drug Dev Ind Pharm 27:195-204.
    • (2001) Drug Dev Ind Pharm , vol.27 , pp. 195-204
    • Palmieri, G.F.1    Bonacucina, G.2    Di Martino, P.3    Martelli, S.4
  • 43
    • 0028879819 scopus 로고
    • Role of transcriptional activation of i kappa B alpha in mediation of immunosuppression by glucocorticoids
    • Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS Jr. 1995. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 270:283-286.
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin Jr., A.S.4
  • 44
    • 0034792176 scopus 로고    scopus 로고
    • Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septicshock induced by S. typhimurium in mice
    • Schlaak JF, Barreiros AP, Pettersson S, Schirmacher P, Meyer Zum Buscenfelde KH, Neurath MF. 2001. Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septicshock induced by S. typhimurium in mice. Scand J Immunol 54:396-403.
    • (2001) Scand J Immunol , vol.54 , pp. 396-403
    • Schlaak, J.F.1    Barreiros, A.P.2    Pettersson, S.3    Schirmacher, P.4    Meyer Zum Buscenfelde, K.H.5    Neurath, M.F.6
  • 45
    • 33645939916 scopus 로고    scopus 로고
    • Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer
    • Schottelius AJ, Dinter H. 2006. Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer. Cancer Treat Res 130:67-87.
    • (2006) Cancer Treat Res , vol.130 , pp. 67-87
    • Schottelius, A.J.1    Dinter, H.2
  • 46
    • 0036000111 scopus 로고    scopus 로고
    • Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
    • Schwendeman SP. 2002. Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. Crit Rev Ther Drug Carrier Syst 19:73-98.
    • (2002) Crit Rev Ther Drug Carrier Syst , vol.19 , pp. 73-98
    • Schwendeman, S.P.1
  • 47
    • 0032874409 scopus 로고    scopus 로고
    • Sustained-release interleukin-12 microspheres in the treatment of cancer
    • Shah AU, D'Souza MJ. 1999. Sustained-release interleukin-12 microspheres in the treatment of cancer. Drug Dev Ind Pharm 25:995-1004.
    • (1999) Drug Dev Ind Pharm , vol.25 , pp. 995-1004
    • Shah, A.U.1    D'Souza, M.J.2
  • 49
    • 0029086725 scopus 로고
    • Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin
    • Srinivasan SK, Tewary HK, Iversen PL. 1995. Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin. Antisense Res Dev 5:131-139.
    • (1995) Antisense Res Dev , vol.5 , pp. 131-139
    • Srinivasan, S.K.1    Tewary, H.K.2    Iversen, P.L.3
  • 50
    • 0033991406 scopus 로고    scopus 로고
    • Preparation and application of liposome-incorporated oligodeoxynucleotides
    • Tari AM. 2000. Preparation and application of liposome-incorporated oligodeoxynucleotides. Methods Enzymol 313:372-388.
    • (2000) Methods Enzymol , vol.313 , pp. 372-388
    • Tari, A.M.1
  • 51
    • 0035544037 scopus 로고    scopus 로고
    • NF-kappaB in transplantation: Friend or foe?
    • Tsoulfas G, Geller DA. 2001. NF-kappaB in transplantation: Friend or foe? Transpl Infect Dis 3:212-219.
    • (2001) Transpl Infect Dis , vol.3 , pp. 212-219
    • Tsoulfas, G.1    Geller, D.A.2
  • 52
    • 42049094490 scopus 로고    scopus 로고
    • Pharmaceutical particle engineering via spray drying
    • Vehring R. 2008. Pharmaceutical particle engineering via spray drying. Pharm Res 25:999-1022.
    • (2008) Pharm Res , vol.25 , pp. 999-1022
    • Vehring, R.1
  • 53
    • 2142702848 scopus 로고    scopus 로고
    • Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles
    • Wartlick H, Spankuch-Schmitt B, Strebhardt K, Kreuter J, Langer K. 2004. Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles. J Contr Rel 96:483-495.
    • (2004) J Contr Rel , vol.96 , pp. 483-495
    • Wartlick, H.1    Spankuch-Schmitt, B.2    Strebhardt, K.3    Kreuter, J.4    Langer, K.5
  • 54
    • 4644340922 scopus 로고    scopus 로고
    • Control of encapsulation efficiency and initial burst in polymeric microparticle systems
    • Yeo Y, Park K. 2004. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch Pharm Res 27:1-12.
    • (2004) Arch Pharm Res , vol.27 , pp. 1-12
    • Yeo, Y.1    Park, K.2
  • 55
    • 34547528717 scopus 로고    scopus 로고
    • Reversal of LPS induced endothelial cell TNF synthesis and increased permeability with microencapsulated antisense oligomers to NF-kappaB
    • Zhaowei J, D'Souza MJ, Oettinger CW. 2007. Reversal of LPS induced endothelial cell TNF synthesis and increased permeability with microencapsulated antisense oligomers to NF-kappaB. J Microencapsulation 24:596-607.
    • (2007) J Microencapsulation , vol.24 , pp. 596-607
    • Zhaowei, J.1    D'Souza, M.J.2    Oettinger, C.W.3


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