RhBMP-2 modulation of gene expression in infected segmental bone defects

Clinical Orthopaedics and Related Research

Volumn 467, Issue 12, 2009, Pages 3096-3103

  Brick, Katherine E ^a   Chen, Xinqian ^a   Lohr, Jamie ^b   Schmidt, Andrew H ^c   Kidder, Louis S ^a,b   Lew, William D ^a  

^a Midwest Orthopaedic Research Foundation   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c HENNEPIN COUNTY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; COLLAGEN TYPE 1; COLLAGEN TYPE 2; MESSENGER RNA; OSTEOCALCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; BONE DEFECT; CONFERENCE PAPER; CONTROLLED STUDY; EUTHANASIA; FEMUR; FRACTURE; GENE EXPRESSION; GENE EXPRESSION REGULATION; INFECTION; INFECTION RISK; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSEUDARTHROSIS; QUANTITATIVE ANALYSIS; SPRAGUE DAWLEY RAT; STAPHYLOCOCCUS AUREUS; UPREGULATION;

EID: 70449527793     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-008-0599-3     Document Type: Conference Paper

References (55)

1. ME Bolander 1992 Regulation of fracture repair by growth factors Proc Soc Exp Biol Med. 200 165 170 1374563 1:CAS:528:DyaK38XktVGitLg%3D
2. KL Bost WK Ramp NC Nicholson JL Bento I Marriott MC Hudson 1999 Staphylococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production J Infect Dis. 180 1912 1920 10.1086/315138 10558948 1:CAS:528:DC%2BD3cXivVSrtw%3D%3D
3. MP Bostrom 1998 Expression of bone morphogenetic proteins in fracture healing Clin Orthop Relat Res 355 Suppl S116 S123 10.1097/00003086-199810001- 00013 9917632
4. X Chen LS Kidder WD Lew 2002 Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur J Orthop Res. 20 142 150 10.1016/S0736-0266(01)00060-2 11853081 1:CAS:528:DC%2BD38XitFOjs7g%3D (Pubitemid 34071433)
5. X Chen AH Schmidt S Mahjouri DW Polly Jr W Lew 2007 Union of a chronically infected internally stabilized segmental defect in the rat femur after debridement and application of BMP-2 and systemic antibiotic J Orthop Trauma. 21 693 700 10.1097/BOT.0b013e31815a7e91 17986886 (Pubitemid 350073453)
6. X Chen AH Schmidt DT Tsukayama CA Bourgeault WD Lew 2006 Recombinant human osteogenic protein-1 induces bone formation in a chronically infected, internally stabilized segmental defect in the rat femur J Bone Joint Surg Am. 88 1510 1523 10.2106/JBJS.E.01136 16818977
7. X Chen DT Tsukayama LS Kidder CA Bourgeault AH Schmidt WD Lew 2005 Characterization of a chronic infection in an internally-stabilized segmental defect in the rat femur J Orthop Res. 23 816 823 10.1016/j.orthres.2005.01.009 16022995 (Pubitemid 40960033)
8. P Chomczynski N Sacchi 1987 Single step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem. 162 156 159 10.1016/0003-2697(87)90021-2 2440339 1:CAS:528:DyaL2sXitFSns7Y%3D
9. BM Clancy JD Johnson AJ Lambert S Rezvankhah A Wong C Resmini JL Feldman S Leppanen DD Pittman 2003 A gene expression profile for endochondral bone formation: oligonucleotide microarrays establish novel connections between known genes and BMP-2-induced bone formation in mouse quadriceps Bone. 33 46 63 10.1016/S8756-3282(03)00116-9 12919699 1:CAS:528:DC%2BD3sXmt1KjsLo%3D (Pubitemid 36952687)
10. SD Cook SL Salkeld LP Patron MC Sargent 2002 Healing course of primate ulna segmental defects treated with osteogenic protein-1 J Invest Surg. 15 69 79 10.1080/08941930290085822 12028617 (Pubitemid 34662002)
11. J Dai Y Kitagawa J Zhang Z Yao A Mizokami S Cheng J Nör LK McCauley RS Taichman ET Keller 2004 Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein Cancer Res. 64 994 999 10.1158/0008-5472.CAN-03-1382 14871830 1:CAS:528:DC%2BD2cXhtFCgurg%3D (Pubitemid 38176902)
12. MM Deckers RL van Bezooijen G van der Horst J Hoogendam C van Der Bent SE Papapoulos CW Löwik 2002 Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A Endocrinology. 143 1545 1553 10.1210/en.143.4.1545 11897714 1:CAS:528: DC%2BD38XisFGitr0%3D (Pubitemid 34274386)
13. TA Einhorn 1998 The cell and molecular biology of fracture healing Clin Orthop Relat Res 355 Suppl S7 S21 10.1097/00003086-199810001-00003 9917622
14. KR Emslie LM Fenner SM Nade 1984 Acute haematogenous osteomyelitis: II. The effect of a metaphyseal abscess on the surrounding blood supply J Pathol. 142 129 134 10.1002/path.1711420203 6699754 1:STN:280:DyaL2c7jvVWnsA%3D%3D (Pubitemid 14159375)
15. A Gentle F Anastasopoulos NA McBrien 2001 High-resolution semi-quantitative real-time PCR without the use of a standard curve Biotechniques. 31 502 508 11570493 1:CAS:528:DC%2BD3MXmvFSgsbs%3D
16. G Gibson 1998 Active role of chondrocyte apoptosis in endochondral ossification Microsc Res Tech. 43 191 204 10.1002/(SICI)1097-0029(19981015)43: 2<191::AID-JEMT10>3.0.CO;2-T 9823004 1:CAS:528:DyaK1cXntlKrsL8%3D (Pubitemid 28518821)
17. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, Atar D, Bishay M, Börner MG, Chiron P, Choong P, Cinats J, Courtenay B, Feibel R, Geulette B, Gravel C, Haas N, Raschke M, Hammacher E, van der Velde D, Hardy P, Holt M, Josten C, Ketterl RL, Lindeque B, Lob G, Mathevon H, McCoy G, Marsh D, Miller R, Munting E, Oevre S, Nordsletten L, Patel A, Pohl A, Rennie W, Reynders P, Rommens PM, Rondia J, Rossouw WC, Daneel PJ, Ruff S, Rüter A, Santavirta S, Schildhauer TA, Gekle C, Schnettler R, Segal D, Seiler H, Snowdowne RB, Stapert J, Taglang G, Verdonk R, Vogels L, Weckbach A, Wentzensen A, Wisniewski T; BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred fifty patients. J Bone Joint Surg Am. 2002;84:2123-2134.
18. AG Gristina JW Costerton 1985 Bacterial adherence to biomaterials and tissue: the significance of its role in clinical sepsis J Bone Joint Surg Am. 67 264 273 3881449 1:STN:280:DyaL2M7gsFWhuw%3D%3D
19. M Hadjiargyrou F Lombardo S Zhao W Ahrens J Joo H Ahn M Jurman DW White CT Rubin 2002 Transcriptional profiling of bone regeneration J Biol Chem. 33 30177 30182 10.1074/jbc.M203171200 1:CAS:528:DC%2BD38XmsVKhsbo%3D
20. S Hassel S Schmitt A Hartung M Roth A Nohe N Petersen M Ehrlich YI Henis W Sebald P Knaus 2003 Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes J Bone Joint Surg Am 85 Suppl 3 44 51 12925609
21. E Hay M Hott AM Graulet A Lomri PJ Marie 1999 Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation J Cell Biochem. 72 81 93 10.1002/(SICI)1097-4644(19990101)72:1<81::AID-JCB9>3.0. CO;2-N 10025669 1:CAS:528:DyaK1cXnvVegs7w%3D (Pubitemid 28541483)
22. CH Heldin K Miyazono P ten Dijke 1997 TGF-beta signaling from cell membrane to nucleus through SMAD proteins Nature. 390 465 471 10.1038/37284 9393997 1:CAS:528:DyaK2sXnvFyrtLo%3D (Pubitemid 28013118)
23. K Hirakawa S Hirota T Ikeda A Yamaguchi T Takemura J Nagoshi S Yoshiki T Suda Y Kitamura S Nomura 1994 Localization of the mRNA for bone matrix proteins during fracture healing as determined by in situ hybridization J Bone Miner Res. 9 1551 1557 7817800 1:CAS:528:DyaK2cXmvFynsr4%3D
24. K Hoshi N Amizuka T Sakou T Kurokawa H Ozawa 1997 Fibroblasts express BMP-R and differentiate into chondroblasts with enhanced BMP-R expression Bone. 21 155 162 10.1016/S8756-3282(97)00106-3 9267691 1:CAS:528:DyaK2sXlvV2qtLw%3D (Pubitemid 27395403)
25. SJ Hyun DK Han SH Choi JK Chai KS Cho CK Kim CS Kim 2005 Effect of recombinant human bone morphogenetic protein-2, -4, and -7 on bone formation in rat calvarial defects J Periodontol. 76 1667 1674 10.1902/jop.2005.76.10.1667 16253088 1:CAS:528:DC%2BD2MXhtF2ntr3O (Pubitemid 41645575)
26. S Jingushi ME Joyce ME Bolander 1992 Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair J Bone Miner Res. 7 1045 1055 1414497 1:CAS:528:DyaK3sXpvFKgsw%3D%3D
27. M Kawabata A Chytil HL Moses 1995 Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-β receptor Biol Chem. 270 5625 5630 10.1074/jbc.270.10.5625 1:CAS:528:DyaK2MXksVSksLw%3D
28. P Kloen SB Doty E Gordon IF Rubel MJ Goumans DL Helfet 2002 Expression and activation of the BMP-signaling components in human fracture nonunions J Bone Joint Surg Am. 84 1909 1918 10.1302/0301-620X.84B1.12191 12429748
29. CF Lai SL Cheng 2002 Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-β in normal human osteoblastic cells J Biol Chem. 277 15514 15522 10.1074/jbc.M200794200 11854297 1:CAS:528:DC%2BD38Xjs1Squ7s%3D (Pubitemid 34967818)
30. F Lecanda LV Avioli SL Cheng 1997 Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2 J Cell Biochem. 67 386 396 10.1002/(SICI)1097-4644(19971201)67:3<386::AID-JCB10>3.0.CO;2-B 9361193 1:CAS:528:DyaK2sXnslensLg%3D (Pubitemid 27509474)
31. F Liu F Ventura J Doody J Massagué 1995 Human type II receptor for bone morphogenetic proteins (BMPs): extension of the two-kinase receptor model to the BMPs Mol Cell Biol. 15 3479 3486 7791754 1:CAS:528:DyaK2MXmsVCmu7w%3D
32. -ΔΔCT method Methods. 25 402 408 10.1006/meth.2001.1262 11846609 1:CAS:528: DC%2BD38XhtFelt7s%3D (Pubitemid 34164012)
33. L Marinova-Mutafchieva P Taylor K Funa RN Maini NJ Zvaifler 2000 Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint Arthritis Rheum. 43 2046 2055 10.1002/1529-0131(200009)43:9<2046::AID-ANR16>3.0.CO;2-8 11014356 1:CAS:528:DC%2BD3cXnt1KnsL8%3D (Pubitemid 30953269)
34. I Marriott DL Gray Tranguch Sl VG Fowler Sr M Stryjewski L Scott Levin MC Hudson KL Bost 2004 Osteoblasts express the inflammatory cytokine interleukin-6 in a murine model of Staphylococcus aureus osteomyelitis and infected human bone tissue Am J Pathol 164 1399 1406 15039227 1:CAS:528:DC%2BD2cXjsFemu7Y%3D
35. GA Melcher C Hauke A Metzdorf SM Perren G Printzen U Schlegel WJ Ziegler 1996 Infection after intramedullary nailing: an experimental investigation on rabbits Injury 27 Suppl 3 SC23 SC26 9039350
36. RA Meyer MH Meyer LS Phieffer DM Banks 2001 Delayed union of femoral fractures in older rats: decreased gene expression BMC Musculoskelet Disord. 2 2 10.1186/1471-2474-2-2 11454240 1:STN:280:DC%2BD3szhslGitg%3D%3D
37. RA Meyer MH Meyer M Tenholder S Wondracek R Wasserman P Garges 2003 Gene expression in older rats with delayed union of femoral fractures J Bone Joint Surg Am. 85 1243 1254 12851349
38. Y Nakamura S Wakitani N Saito K Takaoka 2005 Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells J Bone Miner Metab. 23 426 434 10.1007/s00774-005-0624-5 16261448 1:CAS:528:DC%2BD2MXhtFKktr7E (Pubitemid 41571108)
39. A Nohe S Hassel M Ehrlich F Neubauer W Sebald YI Henis P Knaus 2002 The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways J Biol Chem. 277 5330 5338 10.1074/jbc.M102750200 11714695 1:CAS:528:DC%2BD38XhsFCjsLc%3D (Pubitemid 34968578)
40. T Onishi Y Ishidou T Nagamine K Yone T Imamura M Kato TK Sampath P ten Dijke T Sakou 1998 Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats Bone. 22 605 612 10.1016/S8756-3282(98)00056-8 9626398 1:CAS:528:DyaK1cXjvVeltLs%3D (Pubitemid 28284608)
41. M Raida JH Clement RD Leek K Ameri R Bicknell D Niederwieser AL Harris 2005 Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis J Cancer Res Clin Oncol. 131 741 750 10.1007/s00432-005-0024-1 16136355 1:CAS:528:DC%2BD2MXhtFKksbrF (Pubitemid 41577951)
42. AH Reddi 1998 Initiation of fracture repair by bone morphogenetic proteins Clin Orthop Relat Res 355 Suppl S66 S72 10.1097/00003086-199810001- 00008 9917627
43. AH Reddi R Gay S Gay EJ Miller 1977 Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation Proc Natl Acad Sci USA. 74 5589 5592 10.1073/pnas.74.12.5589 271986 1:CAS:528:DyaE1cXos12isw%3D%3D
44. BL Rosenzweig T Imamura T Okadome GN Cox H Yamashita P ten Dijke CH Heldin K Miyazono 1995 Cloning and characterization of a human type II receptor for bone morphogenetic proteins Proc Natl Acad Sci USA. 92 7632 7636 10.1073/pnas.92.17.7632 7644468 1:STN:280:DyaK2Mznt1egtg%3D%3D
45. M Sandberg H Aro P Multimaki H Aho E Vuorio 1989 In situ localization of collagen production by chondrocytes and osteoblasts in fracture callus J Bone Joint Surg Am. 71 69 77 2643609 1:STN:280:DyaL1M7gvFamsQ%3D%3D
46. K Soballe TB Jensen O Mouzin L Kidder JE Bechtold 2004 Differential effect of a bone morphogenetic protein-7 (OP-1) on primary and revision loaded, stable implants with allograft J Biomed Mater Res A. 71 569 576 10.1002/jbm.a.30115 15505829 1:CAS:528:DC%2BD2cXhtFSisrbF (Pubitemid 39585219)
47. I Tcacencu B Calsoo P Stierna 2005 Effect of recombinant human BMP-2 on the repair of cricoid cartilage defects in young and adult rabbits: a comparative study Intl J Pediatr Otorhinolaryngol. 69 1239 1246 10.1016/j.ijporl.2005.03.026 (Pubitemid 41095449)
48. P ten Dijke K Miyazono C-H Heldin 1996 Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors Curr Opin Cell Biol. 8 139 145 10.1016/S0955-0674(96)80058-5 8791413 1:CAS:528: DyaK28XitVWktLY%3D (Pubitemid 26109085)
49. Z Thompson T Miclau D Hu JA Helms 2002 A model for intramembranous ossification during fracture healing J Orthop Res. 20 1091 1098 10.1016/S0736-0266(02)00017-7 12382977 1:CAS:528:DC%2BD38XmsVersrw%3D (Pubitemid 35050067)
50. JC Utting SP Robins A Brandao-Burch IR Orriss J Behar TR Arnett 2006 Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts Exp Cell Res. 312 1693 1702 10.1016/j.yexcr.2006.02.007 16529738 1:CAS:528:DC%2BD28Xlt1Clsbg%3D (Pubitemid 43776006)
51. JY Wang BH Wicklund RB Gustilo DT Tsukayama 1997 Prosthetic metals impair murine immune response and cytokine release in vivo and in vitro J Orthop Res. 15 688 699 10.1002/jor.1100150510 9420598 1:CAS:528:DyaK1cXkvFKgtQ%3D%3D (Pubitemid 28018995)
52. H Yaoita H Orimo Y Shirai T Shimada 2000 Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture J Bone Miner Metab. 18 63 70 10.1007/s007740050013 10701160 1:CAS:528: DC%2BD3cXjtlKlu74%3D
53. AW Yasko JM Lane EJ Fellinger V Rosen JM Wozney EA Wang 1992 The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2) J Bone Joint Surg Am. 74 659 670 1378056 1:STN:280: DyaK38zisFSqtg%3D%3D
54. YM Yu R Becvar Y Yamada AH Reddi 1991 Changes in the gene expression of collagens, fibronectin, integrin and proteoglycans during matrix-induced bone morphogenesis Biochem Biophys Res Commun. 177 427 432 10.1016/0006-291X(91) 92001-Z 2043127 1:CAS:528:DyaK3MXksVKktb8%3D
55. TA Zachos KA Shields AL Bertone 2006 Gene-mediated osteogenic differentiation of stem cells by bone morphogenetic proteins-2 or -6 J Orthop Res. 24 1279 1291 10.1002/jor.20068 16649180 1:CAS:528:DC%2BD2sXlsF2rsLw%3D (Pubitemid 43870891)