Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-δ and PKC-ε in the shedding of epidermal growth factor receptor ligands

European Journal of Pharmaceutical Sciences

Volumn 38, Issue 5, 2009, Pages 504-511

  Uchiyama, Kotomi ^a   Saito, Masaki ^a   Sasaki, Masako ^a   Obara, Yutaro ^a   Higashiyama, Shigeki ^b   Nakahata, Norimichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Epidermal growth factor receptor; Gq protein; Heparin binding epidermal growth factor; Protein kinase C; Thromboxane A2 receptor; Transactivation

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ALKALINE PHOSPHATASE; CALCIUM ION; EGTAZIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MESSENGER RNA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; SMALL INTERFERING RNA; THROMBOXANE A2 RECEPTOR; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; HYDRAZINE DERIVATIVE; ISOENZYME; LIGAND;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL STRAIN; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EXTRACELLULAR FLUID; GENETICS; INTRACELLULAR FLUID; METABOLISM; PHYSIOLOGY; RAT; SECRETION; TRANSCRIPTION INITIATION; TUMOR CELL CULTURE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; CELL LINE; EXTRACELLULAR FLUID; HUMANS; HYDRAZINES; INTRACELLULAR FLUID; ISOENZYMES; LIGANDS; PC12 CELLS; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; TRANSCRIPTIONAL ACTIVATION; TUMOR CELLS, CULTURED;

EID: 70449522901     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.09.016     Document Type: Article

References (49)

1. Bassi D.E., Fu J., Lopez de Cicco R., and Klein-Szanto A.J. Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Mol. Carcinog. 44 (2005) 151-161
2. Coleman R.A., Smith W.L., and Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46 (1994) 205-229
3. Daub H., Weiss F.U., Wallasch C., and Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379 (1996) 557-560
4. 2 receptors. J. Biol. Chem. 274 (1999) 14325-14330
5. Drin G., and Scarlata S. Stimulation of phospholipase Cβ by membrane interactions, interdomain movement, and G protein binding-how many ways can you activate an enzyme?. Cell. Signal. 19 (2007) 1383-1392
6. Eguchi S., Numaguchi K., Iwasaki H., Matsumoto T., Yamakawa T., Utsunomiya H., Motley E.D., Kawakatsu H., Owada K.M., Hirata Y., Marumo F., and Inagami T. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J. Biol. Chem. 273 (1998) 8890-8896
7. Endres K., Anders A., Kojro E., Gilbert S., Fahrenholz F., and Postina R. Tumor necrosis factor-α converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation. Eur. J. Biochem. 270 (2003) 2386-2393
8. 2-dependent extracellular-signal-regulated kinase activation. Biochem. J. 371 (2003) 733-742
9. 2 receptors: where have you gone?. Prostaglandins Other Lipid Mediat. 60 (2000) 175-189
10. Hao L., Du M., Lopez-Campistrous A., and Fernandez-Patron C. Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Circ. Res. 94 (2004) 68-76
11. Harris R.C., Chung E., and Coffey R.J. EGF receptor ligands. Exp. Cell Res. 284 (2003) 2-13
12. Higashiyama S., Iwabuki H., Morimoto C., Hieda M., Inoue H., and Matsushita N. Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands. Cancer Sci. 99 (2008) 214-220
13. 2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J. Clin. Invest. 97 (1996) 949-956
14. 12/13-dependent glial morphological change. Eur. J. Pharmacol. 545 (2006) 100-108
15. 2 receptors. Cell. Signal. 16 (2004) 521-533
16. Izumi Y., Hirata M., Hasuwa H., Iwamoto R., Umata T., Miyado K., Tamai Y., Kurisaki T., Sehara-Fujisawa A., Ohno S., and Mekada E. A metalloprotease-disintegrin, MDC9/meltrin-γ/ADAM9 and PKCδ are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J. 17 (1998) 7260-7272
17. 2-induced activation of mitogen-activated protein kinase in astrocytoma cells. J. Neurochem. 74 (2000) 2167-2173
18. Lee D.C., Sunnarborg S.W., Hinkle C.L., Myers T.J., Stevenson M.Y., Russell W.E., Castner B.J., Gerhart M.J., Paxton R.J., Black R.A., Chang A., and Jackson L.F. TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann. N. Y. Acad. Sci. 995 (2003) 22-38
19. Loechel F., Overgaard M.T., Oxvig C., Albrechtsen R., and Wewer U.M. Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch. J. Biol. Chem. 274 (1999) 13427-13433
20. Lu Y., Li X., Liang K., Luwor R., Siddik Z.H., Mills G.B., Mendelsohn J., and Fan Z. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer Res. 67 (2007) 8240-8247
21. Mackay H.J., and Twelves C.J. Targeting the protein kinase C family: are we there yet?. Nat. Rev. Cancer 7 (2007) 554-562
22. Milla M.E., Leesnitzer M.A., Moss M.L., Clay W.C., Carter H.L., Miller A.B., Su J.L., Lambert M.H., Willard D.H., Sheeley D.M., Kost T.A., Burkhart W., Moyer M., Blackburn R.K., Pahel G.L., Mitchell J.L., Hoffman C.R., and Becherer J.D. Specific sequence elements are required for the expression of functional tumor necrosis factor-α-converting enzyme (TACE). J. Biol. Chem. 274 (1999) 30563-30570
23. Mochizuki S., and Okada Y. ADAMs in cancer cell proliferation and progression. Cancer Sci. 98 (2007) 621-628
24. Moss M.L., and Rasmussen F.H. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening. Anal. Biochem. 366 (2007) 144-148
25. Moussa O., Yordy J.S., Abol-Enein H., Sinha D., Bissada N.K., Halushka P.V., Ghoneim M.A., and Watson D.K. Prognostic and functional significance of thromboxane synthase gene overexpression in invasive bladder cancer. Cancer Res. 65 (2005) 11581-11587
26. 2: physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol. Ther. 118 (2008) 18-35
27. 2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein. Eur. J. Pharmacol. 162 (1989) 407-417
28. 2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets. Res. Commun. Mol. Pathol. Pharmacol. 87 (1995) 243-251
29. 2 regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem. Biophys. Res. Commun. 267 (2000) 245-251
30. O'Donovan N., and Crown J. EGFR and HER-2 antagonists in breast cancer. Anticancer Res. 27 (2007) 1285-1294
31. 2 and thrombin receptors in human platelets. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 504-508
32. Ouyang X., Gulliford T., Huang G., and Epstein R.J. Transforming growth factor-α short-circuits downregulation of the epidermal growth factor receptor. J. Cell. Physiol. 179 (1999) 52-57
33. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., and Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402 (1999) 884-888
34. Putheti R.R., and Patil M.C. Pharmaceutical formulation and development of floating and swellable sustained drug delivery systems: a review. e-J. Sci. Technol. 4 (2009) 1-12
35. Sahin U., Weskamp G., Kelly K., Zhou H.M., Higashiyama S., Peschon J., Hartmann D., Saftig P., and Blobel C.P. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J. Cell Biol. 164 (2004) 769-779
36. Saito M., Hori M., Obara Y., Ohizumi Y., Ohkubo S., and Nakahata N. Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C. Eur. J. Pharm. Sci. 28 (2006) 263-271
37. Saito M., Sugai M., Katsushima Y., Yanagisawa T., Sukegawa J., and Nakahata N. Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G. Biochem. J. 392 (2005) 75-81
38. Sanghera J.S., Charlton L.A., Paddon H.B., and Pelech S.L. Purification and characterization of echinoderm casein kinase II. Regulation by protein kinase C. Biochem. J. 283 Pt 3 (1992) 829-837
39. q-coupled receptor agonists. Cell. Signal. 19 (2007) 1348-1357
40. 2 receptor β-isoform through the negative regulation of its membrane traffic by proteasomes. Prostaglandins Other Lipid Mediat. 83 (2007) 237-249
41. Schafer B., Marg B., Gschwind A., and Ullrich A. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J. Biol. Chem. 279 (2004) 47929-47938
42. Seals D.F., and Courtneidge S.A. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 17 (2003) 7-30
43. Seiki M. The cell surface: the stage for matrix metalloproteinase regulation of migration. Curr. Opin. Cell Biol. 14 (2002) 624-632
44. Shah B.H., and Catt K.J. GPCR-mediated transactivation of RTKs in the CNS: mechanisms and consequences. Trends Neurosci. 27 (2004) 48-53
45. q family. J. Biol. Chem. 266 (1991) 9309-9313
46. Steiner D.F. The proprotein convertases. Curr. Opin. Chem. Biol. 2 (1998) 31-39
47. Tokumaru S., Higashiyama S., Endo T., Nakagawa T., Miyagawa J.I., Yamamori K., Hanakawa Y., Ohmoto H., Yoshino K., Shirakata Y., Matsuzawa Y., Hashimoto K., and Taniguchi N. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J. Cell. Biol. 151 (2000) 209-220
48. Vezza R., Habib A., and FitzGerald G.A. Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh. J. Biol. Chem. 274 (1999) 12774-12779
49. Zhao Y., He D., Saatian B., Watkins T., Spannhake E.W., Pyne N.J., and Natarajan V. Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cδ, Lyn kinase, and matrix metalloproteinases. J. Biol. Chem. 281 (2006) 19501-19511