Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 353-359

  Ohno, Shuji ^a   Yukinawa, Fumihiko ^a   Noda, Mariko ^a   Nakajin, Shizuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

CYP19 suppression; GIOT 1 induction; KGN cells; MEHP exposure; NR4A induction

Indexed keywords

AROMATASE; FORSKOLIN; GONADOTROPIN INDUCIBLE OVARIAN TRANSCRIPTION FACTOR 1; LIVER RECEPTOR HOMOLOG 1; MESSENGER RNA; NUCLEAR RECEPTOR NUR77; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PROTEIN GIOT 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; EXON; GENE CONSTRUCT; GENE EXPRESSION; GRANULOSA CELL TUMOR; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FAMILY; PROTEIN INDUCTION; SEQUENCE ANALYSIS; TRANSACTIVATION; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

AROMATASE; BINDING SITES; CELL LINE, TUMOR; DIETHYLHEXYL PHTHALATE; FEMALE; GENE EXPRESSION; GRANULOSA CELLS; HUMANS; LUCIFERASES; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; PLASMIDS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 70449518957     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.10.004     Document Type: Article

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