CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis

Blood

Volumn 114, Issue 17, 2009, Pages 3567-3577

  Seo, Wooseok ^a   Ziltener, Hermann J ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; GROWTH FACTOR; LEUKOSIALIN; SUMO 1 PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CELL LEVEL; CELL MEMBRANE; CELL NUCLEUS; CELL NUCLEUS INCLUSION BODY; CELL VIABILITY; CHIMERA; CONTROLLED STUDY; CYTOPLASM; GRANULOCYTE; HOMEOSTASIS; MACROPHAGE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE;

EID: 70449493989     PISSN: 00064971     EISSN: 15280020     Source Type: None    
DOI: 10.1182/blood-2009-06-228791     Document Type: Article

References (40)

1. Fukuda M. Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy. Glycobiology. 1991;1:347-356.
2. Ostberg JR, Barth RK, Frelinger JG. The Roman god Janus: a paradigm for the function of CD43. Immunol Today. 1998;19:546-550.
3. Mody PD, Cannon JL, Bandukwala HS, et al. Signaling through CD43 regulates CD4 T-cell trafficking. Blood. 2007;110:2974-2982.
4. Piller V, Piller F, Fukuda M. Phosphorylation of the major leukocyte surface sialoglycoprotein, leukosialin, is increased by phorbol 12-myristate 13-acetate. J Biol Chem. 1989;264:18824-18831. (Pubitemid 19277635)
5. Sperling AI, Green JM, Mosley RL, et al. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995; 182:139-146.
6. Pedraza-Alva G, Merida LB, Burakoff SJ, Rosenstein Y. CD43-specific activation of T cells induces association of CD43 to Fyn kinase. J Biol Chem. 1996;271:27564-27568. (Pubitemid 26367320)
7. Pedraza-Alva G, Merida LB, Burakoff SJ, Rosenstein Y. T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. J Biol Chem. 1998;273:14218-14224. (Pubitemid 28319133)
8. Wong RC, Remold ODE, Vercelli D, et al. Signal transduction via leukocyte antigen CD43 (sialophorin): feedback regulation by protein kinase C. J Immunol. 1990;144:1455-1460. (Pubitemid 20072921)
9. Santana MA, Pedraza-Alva G, Olivares-Zavaleta N, et al. CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFκB transcription factors in human T lymphocytes. J Biol Chem. 2000;275:31460-31468. (Pubitemid 30757818)
10. Bazil V, Strominger JL. CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes. Proc Natl Acad Sci U S A. 1993;90:3792-3796. (Pubitemid 23134111)
11. Bazil V, Strominger JL. Metalloprotease and serine protease are involved in cleavage of CD43, CD44, and CD16 from stimulated human granulocytes: induction of cleavage of L-selectin via CD16. J Immunol. 1994;152:1314-1322. (Pubitemid 24134359)
12. Remold ODE, Parent D. Two proteolytic pathways for down-regulation of the barrier molecule CD43 of human neutrophils. J Immunol. 1994; 152:3595-3605. (Pubitemid 24098057)
13. Schmid K, Hediger MA, Brossmer R, et al. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). Proc Natl Acad Sci U S A. 1992;89:663-667.
14. Carlow DA, Corbel SY, Ziltener HJ. Absence of CD43 fails to alter T cell development and responsiveness. J Immunol. 2001;166:256-261.
15. Jones AT, Federsppiel B, Ellies LG, et al. Characterization of the activation-associated isoform of CD43 on murine T lymphocytes. J Immunol. 1994;153:3426-3439. (Pubitemid 24313845)
16. Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity. 2005;22:43-57. (Pubitemid 40143450)
17. Baecher-Allan CM, Kemp JD, Dorfman KS, Barth RK, Frelinger JG. Differential epitope expression of Ly-48 (mouse leukosialin). Immunogenetics. 1993;37:183-192. (Pubitemid 23011431)
18. Andersson CX, Fernandez-Rodriguez J, Laos S, et al. CD43 has a functional NLS, interacts with β-catenin, and affects gene expression. Biochem Biophys Res Commun. 2004;316:12-17. (Pubitemid 38299121)
19. Boehmelt G, Walker A, Kabrun N, et al. Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression. EMBO J. 1992;11:4641-4652.
20. Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998;188:287-296.
21. Andersson CX, Fernandez-Rodriguez J, Laos S, Baeckstrom D, Haass C, Hansson GC. Shedding and γ-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43. Biochem J. 2005;387:377-384. (Pubitemid 40571223)
22. Mambole A, Baruch D, Nusbaum P, et al. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/γ-secretase. J Biol Chem. 2008;283:23627-23635.
23. Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 1998;393: 382-386. (Pubitemid 28269713)
24. Seeler JS, Dejean A. Nuclear and unclear functions of SUMO. Nat Rev Mol Cell Biol. 2003;4: 690-699.
25. Muller S, Hoege C, Pyrowolakis G, Jentsch S. SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol. 2001;2:202-210.
26. Hay RT. SUMO: a history of modification. Mol Cell. 2005;18:1-12.
27. Nacerddine K, Lehembre F, Bhaumik M, et al. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell. 2005;9:769-779. (Pubitemid 41724105)
28. Seufert W, Futcher B, Jentsch S. Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature. 1995;373:78-81.
29. Dadke S, Cotteret S, Yip SC, et al. Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007;9:80-85. (Pubitemid 46024200)
30. + channel K2P1. Cell. 2005; 121:37-47.
31. Salomoni P, Pandolfi PP. The role of PML in tumor suppression. Cell. 2002;108:165-170.
32. Zhong S, Hu P, Ye TZ, Stan R, Ellis NA, Pandolfi PP. A role for PML and the nuclear body in genomic stability. Oncogene. 1999;18:7941-7947. (Pubitemid 30050554)
33. Zhong S, Salomoni P, Pandolfi PP. The transcriptional role of PML and the nuclear body. Nat Cell Biol. 2000;2:E85-E90. (Pubitemid 30781107)
34. Hofmann TG, Will H. Body language: the function of PML nuclear bodies in apoptosis regulation. Cell Death Differ. 2003;10:1290-1299. (Pubitemid 37536734)
35. Bernardi R, Pandolfi PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. 2003;22:9048-9057.
36. Randhawa AK, Ziltener HJ, Merzaban JS, Stokes RW. CD43 is required for optimal growth inhibition of Mycobacterium tuberculosis in macrophages and in mice. J Immunol. 2005;175:1805-1812.
37. Kursar M, Koch M, Mittrucker HW, et al. Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J Immunol. 2007;178:2661-2665. (Pubitemid 46333142)
38. Scott-Browne JP, Shafiani S, Tucker-Heard G, et al. Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. J Exp Med. 2007;204:2159-2169. (Pubitemid 47360876)
39. Sikut R, Andersson CX, Sikut A, Fernandez-Rodriguez J, Karlsson NG, Hansson GC. Detection of CD43 (leukosialin) in colon adenoma and adenocarcinoma by novel monoclonal antibodies against its intracellular domain. Int J Cancer. 1999;82:52-58. (Pubitemid 29266106)
40. Sikut R, Nilsson O, Baeckstrom D, Hansson GC. Colon adenoma and cancer cells aberrantly express the leukocyte-associated sialoglycoprotein CD43. Biochem Biophys Res Commun. 1997; 238:612-616. (Pubitemid 27464437)