Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation

European Journal of Immunology

Volumn 39, Issue 11, 2009, Pages 3078-3083

  Miyata, Masanori ^a   Nakamura, Yuki ^a   Shimokawa, Naomi ^a   Ohnuma, Yuko ^a   Katoh, Ryohei ^a   Matsuoka, Shuji ^b   Okumura, Ko ^b   Ogawa, Hideoki ^b   Masuyama, Keisuke ^a   Nakao, Atsuhito ^a,b  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

Allergic inflammation; Epithelial cells; IL 13; Thymic stromal lymphopoietin

Indexed keywords

INTERLEUKIN 13; STAT6 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EOSINOPHILIA; FEMALE; GOBLET CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NOSE ALLERGY; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION;

ANIMALS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPERSENSITIVITY; INFLAMMATION; INTERLEUKIN-13; MICE; NASAL MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 70449407847     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939302     Document Type: Article

References (31)

1. Ziegler, S. F. and Liu, Y. J., Thymic stromal lymphopoietin in normal and pathogenic T cell development and function. Nat. Immunol. 2006. 7: 709-714.
2. Leonard, W. J., TSLP: finally in the limelight. Nat. Immunol. 2002. 3: 605-607.
3. Sims, J. E., Williams, D. E., Morrissey, P. J., Garka, K., Foxworthe, D., Price, V., Friend, S. L. et al., Molecular cloning and biological characterization of a novel murine lymphoid growth factor. J. Exp. Med. 2000. 192: 671-680.
4. Liu, Y. J., Thymic stromal lymphopoietin: master switch for allergic inflammation. J. Exp. Med. 2006. 203: 269-273.
5. Yoo, J., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A., Comeau, M. R. et al., Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J. Exp. Med. 2005. 202: 541-549.
6. Zhou, B., Comeau, M. R., De Smedt, T., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D. et al., Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat. Immunol. 2005. 6: 1047-1053.
7. Al-Shami, A., Spolski, R., Kelly, J., Keane-Myers, A. and Leonard, W. J., A role for TSLP in the development of inflammation in an asthma model. J. Exp. Med. 2005. 202: 829-839.
8. Wills-Karp, M., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L. and Donaldson, D. D., Interleukin-13: central mediator of allergic asthma. Science 1998. 282: 2258-2261. (Pubitemid 29004074)
9. Grünig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D. et al., Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998. 282: 2261-2263. (Pubitemid 29004075)
10. Zhu, Z., Homer, R. J., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y. and Elias, J. A., Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest. 1999. 103: 779-788.
11. Kuperman, D. A., Huang, X., Koth, L. L., Chang, G. H., Dolganov, G. M., Zhu, Z., Elias, J. A. et al., Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 2002. 8: 885-889.
12. Zhou, B., Headley, M. B., Aye, T., Tocker, J., Comeau, M. R. and Ziegler, S. F., Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J. Immunol. 2008. 181: 6557-6562.
13. Jessup, H. K., Brewer, A. W., Omori, M., Rickel, E. A., Budelsky, A. L. and Yoon, B. R., Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J. Immunol. 2008. 181: 4311-4319.
14. McDevitt, A. L., Deming, M. S., Rosenberg, H. R. and Dyer, K. D., Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2. Gene 2001. 267: 23-30.
15. Zuhdi Alimam, M., Piazza, F. M., Selby, D. M., Letwin, N., Huang, L. and Rose, M. C., Muc-5/5acmucin messenger RNA and protein expression is a marker of goblet cell metaplasia in murine airways. Am. J. Respir. Cell. Mol. Biol. 2000. 22: 253-260.
16. Holgate, S. T., The epithelium takes center stage in asthma and atomic dermatitis. Trends Immunol. 2007. 28: 248-251.
17. Li, M., Hener, P., Zhang, Z., Kato, S., Metzger, D. and Chambon, P., Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc. Nat. Acad. Sci. USA 2006. 103: 11736-11741.
18. Kato, A., Favoreto, S., Jr., Avila, P. C. and Schleimer, R. P., TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol. 2007. 179: 1080-1087.
19. Bogiatzi, S. I., Fernandez, I., Bichet, J. C., Marloie-Provost, M. A., Volpe, E., Sastre, X. and Soumelis, V., Cutting Edge: Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J. Immunol. 2007. 178: 3373-3377. (Pubitemid 46417601)
20. Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. et al., Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 2002. 3: 673-680.
21. Allakhverdi, Z., Comeau, M. R., Jessup, H. K., Yoon, B. R., Brewer, A., Chartier, S., Paquette, N. et al., Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 2007. 204: 253-258.
22. Miyahara, S., Miyahara, N., Matsubara, S., Takeda, K., Koya, T. and Gelfand, E. W., IL-13 is essential to the late-phase response in allergic rhinitis. J. Allergy Clin. Immunol. 2006. 118: 1110-1116.
23. Pawankar, R. U., Okuda, M., Hasegawa, ., Suzuki, K., Yssel, H., Okubo, K., Okumura, K. and Ra, C., Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am. J. Respir. Crit. Care Med. 1995. 152: 2059-2067.
24. Ghaffar, O., Laberge, S., Jacobson, M. R., Lowhagen, O., Rak, S ., Durham, S. R. and Hamid, Q ., IL-13 mRNA and immunoreactivity in allergen-induced rhinitis: comparison with IL-4 expression and modulation by topical glucocorticoid therapy. Am. J. Respir. Cell Mol. Biol. 1997. 17: 17-24.
25. He, R., Oyoshi, M. K., Garibyan, L., Kumar, L., Ziegler, S. F. and Geha, R. S., TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc. Natl. Acad. Sci. USA 2008. 105: 11875-11880.
26. Wang, Y. H., Ito, T., Wang, Y. H., Homey, B., Watanabe, N., Martin, R., Barnes, C. J. et al., Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006. 24: 827-838. (Pubitemid 43867361)
27. Ohba, T., Haro, H., Ando, T., Koyama, K., Hatsushika, K., Suenaga, F., Ohnuma, Y. et al., potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum. 2008. 58: 3510-3519.
28. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M. and Kashiwamura, S., Essential role of Stat6 in IL-4 signalling. Nature 1996. 380: 627-630. (Pubitemid 26119015)
29. Adachi, O., Kawai, T., Takeda, K., Matsumoto, T., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S., Targeted disruption of the Myd88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998. 9: 143-150. (Pubitemid 28361303)
30. Nakamura, Y., Miyata, M., Ohba, T., Ando, T., Hatsushika, K., Suenaga, F., Shimokawa, N. et al., Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T(H)2-type immune responses and airway inflammation. J. Allergy Clin. Immunol. 2008. 122: 1208-1214.
31. Miyata, M., Hatsushika, K., Ando, T., Shimokawa, N., Ohnuma, Y., Katoh, R., Suto, H. et al., Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur. J. Immunol. 2008. 38: 1487-1492.