메뉴 건너뛰기




Volumn 15, Issue 5, 2009, Pages 733-738

The effect of L-carnitine administration on doxorubicine induced hepatoxicity and nephrotoxicity in rabbits;L-carnitin uygulamasının tavşanlarda doksorubisin kaynaklı hepatopatoksisite ve nefrotoksisite üzerine etkisi

Author keywords

Doxorubucine; Hepatoxicity; L carnitine; Nephrotoxicity; Rabbit

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 70449381307     PISSN: 13006045     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (33)
  • 1
    • 35548970387 scopus 로고    scopus 로고
    • Chronic supplementation of creatine and vitamins C and E increases survival and improves biochemical parameters after doxorubicin treatment in rats
    • Santos RVT, Batirsta Jr ML, Caperuto EC, Costa Rosa LFBP: Chronic supplementation of creatine and vitamins C and E increases survival and improves biochemical parameters after doxorubicin treatment in rats. Clin Exp Pharmacol Physiol, 34, 1294-1299, 2007.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 1294-1299
    • Santos, R.V.T.1    Batirsta Jr, M.L.2    Caperuto, E.C.3    Costa Rosa, L.F.B.P.4
  • 2
    • 13944283745 scopus 로고    scopus 로고
    • Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin
    • Kalender Y, Yel M, Kalender S: Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209, 39-45, 2005.
    • (2005) Toxicology , vol.209 , pp. 39-45
    • Kalender, Y.1    Yel, M.2    Kalender, S.3
  • 3
    • 0035213759 scopus 로고    scopus 로고
    • Attenuation of the acute adriamycin-induced cardiac and hepatic oxidative toxicity by N-(2-mercaptopropionyl) glycine in rats
    • El-Missiry MA, Othman AI, Amer MA, Abd El-Aziz MA: Attenuation of the acute adriamycin-induced cardiac and hepatic oxidative toxicity by N-(2-mercaptopropionyl) glycine in rats. Free Radic Res, 35, 575-581, 2001.
    • (2001) Free Radic Res , vol.35 , pp. 575-581
    • El-Missiry, M.A.1    Othman, A.I.2    Amer, M.A.3    Abd El-Aziz, M.A.4
  • 4
    • 0030248675 scopus 로고    scopus 로고
    • Doxorubicin-induced apoptosis in spontaneously hypertensive rats: Differential effects in heart, kidney and intestine, and inhibition by ICRF-187
    • Zhang J, Clark JR, Herman EH, Ferrans VJ: Doxorubicin-induced apoptosis in spontaneously hypertensive rats: Differential effects in heart, kidney and intestine, and inhibition by ICRF-187. J Mol Cell Cardiol, 28, 1931-1943, 1996.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 1931-1943
    • Zhang, J.1    Clark, J.R.2    Herman, E.H.3    Ferrans, V.J.4
  • 6
    • 0032982416 scopus 로고    scopus 로고
    • L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats
    • Luo X, Reichetzer B, Trines J, Benson LN, Lehotay DC: L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats. Free Radic Biol Med, 26 (9-10): 1158-1165, 1999.
    • (1999) Free Radic Biol Med , vol.26 , Issue.9-10 , pp. 1158-1165
    • Luo, X.1    Reichetzer, B.2    Trines, J.3    Benson, L.N.4    Lehotay, D.C.5
  • 7
    • 0003136932 scopus 로고
    • The Role of Free Radical Formation in the Cardiotoxicity of Anthracycline
    • In, Muggia FM, Green MD, Speyer JL (Eds), The John Hopkins University Press, Baltimore
    • Gianni L, Myers CE: The Role of Free Radical Formation in the Cardiotoxicity of Anthracycline. In, Muggia FM, Green MD, Speyer JL (Eds): Cancer Treatment and the Heart. pp. 9-46. The John Hopkins University Press, Baltimore, 1992.
    • (1992) Cancer Treatment and the Heart , pp. 9-46
    • Gianni, L.1    Myers, C.E.2
  • 10
    • 33746129545 scopus 로고    scopus 로고
    • Lcarnitine ameliorates doxorubicin-induced nephrotic syndrome in rats
    • Boonsanit D, Kanchanapangka S, Buranakarl C: Lcarnitine ameliorates doxorubicin-induced nephrotic syndrome in rats. Nephrology, 11, 313-320, 2006.
    • (2006) Nephrology , vol.11 , pp. 313-320
    • Boonsanit, D.1    Kanchanapangka, S.2    Buranakarl, C.3
  • 11
    • 70449435422 scopus 로고    scopus 로고
    • Doksorubisin uygulanan tavsanlarda plazma sialik asit, malondialdehit ve redükte glutatyon düzeylerine Lkarnitinin etkileri
    • Karapehlivan M, Uzlu E, Atakisi O, Erdogan HM, Uzun M, Citil M: Doksorubisin uygulanan tavsanlarda plazma sialik asit, malondialdehit ve redükte glutatyon düzeylerine Lkarnitinin etkileri. Kafkas Univ Vet Fak Derg, 13 (2): 155-160. 2007.
    • (2007) Kafkas Univ Vet Fak Derg , vol.13 , Issue.2 , pp. 155-160
    • Karapehlivan, M.1    Uzlu, E.2    Atakisi, O.3    Erdogan, H.M.4    Uzun, M.5    Citil, M.6
  • 13
    • 0035501243 scopus 로고    scopus 로고
    • Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition
    • Furuno T, Kanno T, Arita K, Asami M, Utsumi T, Doi Y, Inoue M, Utsumi K: Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. Biochem Pharmacol, 62 (8): 1037-1046, 2001.
    • (2001) Biochem Pharmacol , vol.62 , Issue.8 , pp. 1037-1046
    • Furuno, T.1    Kanno, T.2    Arita, K.3    Asami, M.4    Utsumi, T.5    Doi, Y.6    Inoue, M.7    Utsumi, K.8
  • 14
    • 0036240776 scopus 로고    scopus 로고
    • Delaying brain mitochondrial decay and aging with mitochondrial anti- oxidants and metabolites
    • Liu J, Atamna H, Kuratsune H, Ames BN: Delaying brain mitochondrial decay and aging with mitochondrial anti- oxidants and metabolites. Ann N Y Acad Sci, 959, 133-166, 2002.
    • (2002) Ann N Y Acad Sci , vol.959 , pp. 133-166
    • Liu, J.1    Atamna, H.2    Kuratsune, H.3    Ames, B.N.4
  • 16
    • 0027156357 scopus 로고
    • Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
    • Pastorino JG, Snyder JW, Serroni A, Hoek JB, Farber JL: Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition. J Biol Chem, 268 (19): 13791-1398, 1993.
    • (1993) J Biol Chem , vol.268 , Issue.19 , pp. 13791-11398
    • Pastorino, J.G.1    Snyder, J.W.2    Serroni, A.3    Hoek, J.B.4    Farber, J.L.5
  • 17
    • 0032189158 scopus 로고    scopus 로고
    • Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats
    • Kalaiselvi T, Panneersalvam C: Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats. J Nutr Biochem, 9, 575-581, 1998.
    • (1998) J Nutr Biochem , vol.9 , pp. 575-581
    • Kalaiselvi, T.1    Panneersalvam, C.2
  • 18
    • 0034769470 scopus 로고    scopus 로고
    • L-carnitine as a free radical scavenger in aging
    • Arockia Rani PJ, Panneerselvam C: L-carnitine as a free radical scavenger in aging. Exp Gerontol, 36, 1713-1726, 2001.
    • (2001) Exp Gerontol , vol.36 , pp. 1713-1726
    • Arockia Rani, P.J.1    Panneerselvam, C.2
  • 20
    • 45049088133 scopus 로고    scopus 로고
    • Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas
    • Injac R, Perse M, Obermajer N, Djordjevic-Milic V, Prijatelj M, Djordjevic A, Cerar A, Strukelj B: Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas. Biomaterials, 29, 3451-3460, 2008.
    • (2008) Biomaterials , vol.29 , pp. 3451-3460
    • Injac, R.1    Perse, M.2    Obermajer, N.3    Djordjevic-Milic, V.4    Prijatelj, M.5    Djordjevic, A.6    Cerar, A.7    Strukelj, B.8
  • 21
    • 34547728723 scopus 로고    scopus 로고
    • Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity
    • Gokcimen A, Cim A, Tola HT, Bayram D, Kocak A, Ozguner F, Ayata A: Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity. Hum Exp Toxicol, 26, 519-525, 2007.
    • (2007) Hum Exp Toxicol , vol.26 , pp. 519-525
    • Gokcimen, A.1    Cim, A.2    Tola, H.T.3    Bayram, D.4    Kocak, A.5    Ozguner, F.6    Ayata, A.7
  • 22
    • 33749995779 scopus 로고    scopus 로고
    • The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor- bearing mice
    • Kwiecien I, Michalska M, Wlodek L: The selective effect of cystathionine on doxorubicin hepatotoxicity in tumor- bearing mice. Eur J Pharmacol, 550, 39-46, 2006.
    • (2006) Eur J Pharmacol , vol.550 , pp. 39-46
    • Kwiecien, I.1    Michalska, M.2    Wlodek, L.3
  • 23
    • 0034533719 scopus 로고    scopus 로고
    • Progressive cardiac dysfunction in adriamycin-induced cardiomyopathy rats
    • Teraoka K, Hirano M, Yamaguchi K, Yamashina A: Progressive cardiac dysfunction in adriamycin-induced cardiomyopathy rats. Eur J Heart Fail, 2, 373-378 2000.
    • (2000) Eur J Heart Fail , vol.2 , pp. 373-378
    • Teraoka, K.1    Hirano, M.2    Yamaguchi, K.3    Yamashina, A.4
  • 24
    • 0035863469 scopus 로고    scopus 로고
    • Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin
    • Zhou S, Starkov A, Froberg MK, Leino RL, Wallace KB: Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res, 61, 771-777, 2001.
    • (2001) Cancer Res , vol.61 , pp. 771-777
    • Zhou, S.1    Starkov, A.2    Froberg, M.K.3    Leino, R.L.4    Wallace, K.B.5
  • 25
    • 24944451508 scopus 로고    scopus 로고
    • The influence of a single dose of adriamycin on the pregnant rat female liver- histological and histochemical evaluation
    • Pedrycz A, Wieczorski M, Czerny K: The influence of a single dose of adriamycin on the pregnant rat female liver- histological and histochemical evaluation. Ann Univ Mariae Curie Sklodowska, 59, 319-323, 2004.
    • (2004) Ann Univ Mariae Curie Sklodowska , vol.59 , pp. 319-323
    • Pedrycz, A.1    Wieczorski, M.2    Czerny, K.3
  • 26
    • 0036652156 scopus 로고    scopus 로고
    • Differential long term subcellular response to heart and liver to adriamycin stress
    • Zeidan Q, Strauss M, Porras N, Anselmi G: Differential long term subcellular response to heart and liver to adriamycin stress. J Submicrosc Cytol Pathol, 34, 315-321, 2002.
    • (2002) J Submicrosc Cytol Pathol , vol.34 , pp. 315-321
    • Zeidan, Q.1    Strauss, M.2    Porras, N.3    Anselmi, G.4
  • 28
    • 0345713153 scopus 로고    scopus 로고
    • L-carnitine prevents doxorubicin- induced apoptosis of cardiac myocytes: Role of inhibition of ceramide generation
    • Andrieu-Abadie N, Jaffrezou JP, Hatem S, Laurent G, Levade T, Mercadier JJ: L-carnitine prevents doxorubicin- induced apoptosis of cardiac myocytes: Role of inhibition of ceramide generation. FASEB J, 13, 1501-1510, 1999.
    • (1999) FASEB J , vol.13 , pp. 1501-1510
    • Andrieu-Abadie, N.1    Jaffrezou, J.P.2    Hatem, S.3    Laurent, G.4    Levade, T.5    Mercadier, J.J.6
  • 29
    • 0033106025 scopus 로고    scopus 로고
    • Effect of captopril on doxorubicin-induced nephrotoxicity in normal rats
    • Mansour MA, El-Kashef HA, Al-Shabanah OA: Effect of captopril on doxorubicin-induced nephrotoxicity in normal rats. Pharmacol Res, 39 (3): 233-237, 1999.
    • (1999) Pharmacol Res , vol.39 , Issue.3 , pp. 233-237
    • Mansour, M.A.1    El-Kashef, H.A.2    Al-Shabanah, O.A.3
  • 30
    • 24944564710 scopus 로고    scopus 로고
    • Increased apoptosis in the adult rat liver after a single dose of adriamycin administration
    • Pedrycz A, Wieczorski M, Czerny K: Increased apoptosis in the adult rat liver after a single dose of adriamycin administration. Ann UMCS Sect D, 59, 313-318, 2004.
    • (2004) Ann UMCS Sect D , vol.59 , pp. 313-318
    • Pedrycz, A.1    Wieczorski, M.2    Czerny, K.3
  • 31
    • 32544449165 scopus 로고    scopus 로고
    • Ultrastructural and immunohistochemical evaluation of apoptosis in foetal rat liver after adriamycin administration
    • Pedrycz A, Boratynski Z, Wieczorski M, Visconti J: Ultrastructural and immunohistochemical evaluation of apoptosis in foetal rat liver after adriamycin administration. Bull Vet Inst Pulawy, 49, 475-479, 2005.
    • (2005) Bull Vet Inst Pulawy , vol.49 , pp. 475-479
    • Pedrycz, A.1    Boratynski, Z.2    Wieczorski, M.3    Visconti, J.4
  • 32
    • 0023731887 scopus 로고
    • Adriamycin induced lipid peroxidation in mitochondria and microsomes
    • Griffin Green EA, Zaleska MM, Erecsinska M: Adriamycin induced lipid peroxidation in mitochondria and microsomes. Biochem Pharmacol, 37, 3071-3077, 1988.
    • (1988) Biochem Pharmacol , vol.37 , pp. 3071-3077
    • Griffin Green, E.A.1    Zaleska, M.M.2    Erecsinska, M.3
  • 33
    • 0030948224 scopus 로고    scopus 로고
    • Influence of L-carnitine on CD95 cross-linking-induced apoptosis and ceramide generation in human cell lines: Correlation with its effects on purified acidic and neutral sphingomyelinases invitro
    • Di Marzio L, Alesse E, Roncaioli P, Muzi P, Moretti S, Marcellini S, Amicosante G, De Simone C, Cifone MG: Influence of L-carnitine on CD95 cross-linking-induced apoptosis and ceramide generation in human cell lines: Correlation with its effects on purified acidic and neutral sphingomyelinases invitro. Proc Assoc Am Physicians, 109, 154-163, 1997.
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 154-163
    • di Marzio, L.1    Alesse, E.2    Roncaioli, P.3    Muzi, P.4    Moretti, S.5    Marcellini, S.6    Amicosante, G.7    de Simone, C.8    Cifone, M.G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.