Pharmacokinetics and tissue distribution of dodeca-2 E,4 E,8 E,10 e / Z -tetraenoic acid isobutylamides after Oral administration in rats

Planta Medica

Volumn 75, Issue 12, 2009, Pages 1306-1313

  Woelkart, Karin ^a,b   Frye, Reginald F ^a   Derendorf, Hartmut ^a   Bauer, Rudolf ^b   Butterweck, Veronika ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

Asteraceae; Bioavailability; Dodeca 2E,4E,8E,10E Z tetraenoic acid isobutylamides; Echinacea; LC MS; Pharmacokinetics; Tissue distribution

Indexed keywords

AMIDE; DODECATETRAENOIC ACID ISOBUTYLAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SYNTHESIS; HIPPOCAMPUS; LIPOPHILICITY; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, LIQUID; ECHINACEA; FATTY ACIDS, UNSATURATED; HALF-LIFE; MALE; MASS SPECTROMETRY; POLYUNSATURATED ALKAMIDES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

ASTERACEAE; ECHINACEA (ASTERACEAE); RATTUS;

EID: 70449379198     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185631     Document Type: Article

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