Computer-assisted analysis of cell proliferation markers in oral lesions

Acta Histochemica

Volumn 109, Issue 5, 2007, Pages 377-387

  Teresa, Debora Barreto ^a   Neves, Karina Antunes ^a   Neto, Carlos Benatti ^a   Fregonezi, Paula Andrea Gabrielli ^a   de Oliveira, Maria Rita Brancini ^a   Zuanon, José Antonio Sampaio ^a   Donadi, Eduardo Antonio ^b   Mendes Junior, Celso Teixeira ^b   Soares, Christiane Pienna ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AgNOR; Computer assisted system; Image analysis; Immunohistochemistry; Ki 67 antigen; Oral cancer; Proliferative markers

Indexed keywords

BIOPSY; GROWTH RATE; MORPHOLOGY; ONCOLOGY; TUMORS;

COMPUTER-ASSISTED SYSTEM; IMMUNOHISTOCHEMISTRY; ORAL CANCER; PROLIFERATIVE MARKERS;

CELLS;

KI 67 ANTIGEN; SILVER;

ANTIBODY LABELING; ARTICLE; CANCER DIAGNOSIS; CELL PROLIFERATION; COMPUTER ANALYSIS; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE SEVERITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; MAJOR CLINICAL STUDY; MORPHOMETRICS; MOUTH CANCER; MOUTH LESION; ORAL BIOPSY; ORAL SQUAMOUS CELL CARCINOMA; STAINING;

EID: 34748881761     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2007.03.007     Document Type: Article

References (39)

1. Axéll T.T., Pindborg J.J., Smith C.J., and Van Der Waal I. Oral white lesions with special reference to precancerous and tobacco-related lesions: conclusions of an International Symposium held in Uppsala, Sweden, May 18-21. J Oral Pathol Med 25 (1996) 49-54
2. Ceccarelli C., Trerè D., Santind I., Taffurelli M., Chieco P., and Derenzini M.M. AgNORs in breast tumors. Micron 31 (2000) 143-149
3. Chattopadhyay A., Ray J.G., and Caplan D.J. AgNOR count as objective marker for dysplastic features in oral leukoplakia. J Oral Pathol Med 31 (2002) 512-517
4. Coletta R.D., Cotrim P., Vargas P.A., Villalba H., Pires F.R., Moraes M., et al. Basaloid squamous carcinoma of the oral cavity: report of 2 cases and study of AgNOR, PCNA, p53, and MMP expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91 (2001) 563-569
5. Derenzini M. The AgNORs. Micron 31 (2000) 117-120
6. Garcia-Pola V.M.J., Roldan A.M.J., Alvarez F.B.E., Martin G.J.M., and Lopez-Muniz A. Study comparative of Ki-67 expression in oral lichen planus and oral leukoplakia. Quantitative analysis. Med Oral 6 (2001) 364-370
7. Gervásio O.L.A.S., Dutra R.A., Tartaglia S.M.A., Vasconcellos W.A., Barbosa A.A., and Aguiar M.C.F. Oral squamous cell carcinoma: a retrospective study of 740 cases in a Brazilian population. Braz Dent J 12 (2001) 57-61
8. Gonzalez-Moles M.A., Caballero R., Rodriguez-Archilla A., Ruiz-Avila I., and Bravo I. Prognosis value of the expression of Ki-67 for squamous cell carcinoma of the oral cavity. Acta Stomatol Belg 93 (1996) 159-165
9. Irazusta S.P., Vassallo J., Magna L.A., Metze K., and Trevisan M. The value of PCNA and AgNOR staining in endoscopic biopsies of gastric mucosa. Pathol Res Pract 194 (1998) 33-39
10. Janczukowicz J. The prognosis role of proliferation activity in human CNS tumors: the determination of AgNOR, PCNA and Ki-67 expression. Part 1: AgNOR expression in CNS tumors. Folia Neuropathol 41 (2003) 97-101
11. Kahn M.A., Mincer H.H., Dockter M.E., and Hermann-Petrin J.M. Comparing flow cytometric analysis and nucleolar organizer region enumeration in archival oral premalignant lesions. J Oral Pathol Med 22 (1993) 257-262
12. Kannan S., Chandran G.J., and Pillai K.R. Expression of p53 in leukoplakia and squamous cell carcinoma of the oral mucosa: correlation with expression of Ki-67. J Clin Pathol 49 (1996) 170-175
13. Kill I.R. Localization of the Ki-67 antigen within the nucleolus. Evidence for a fibrillarin-deficient region of the dense fibrillar component. J Cell Sci 109 (1996) 1253-1263
14. Kobayashi I., Ozeki S., Ishibashi Y., and Sakai H. The proliferative activity in oral epithelial dysplasia analyzed by proliferating cell nuclear antigen immunostaining and argyrophilic nucleolar organizer region staining. Hum Pathol 26 (1995) 907-913
15. Kuffer R., and Lombardi T. Premalignant lesions of the oral mucosa. A discussion about the place of oral intraepithelial neoplasia (OIN) - review. Oral Oncol 38 (2002) 125-130
16. Le C.T. Introductory biostatistics (2003), Wiley, Hoboken, NJ, USA
17. Llewellyn C.D., Johnson N.W., and Warnakulasuriya S. Factors associated with delay in presentation among younger patients with oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97 (2004) 707-713
18. Lorenzato M., Abboud P., Lechki C., Browarnyj F., O'donohue M.F., Ploton D., et al. Proliferation assessment in breast cancer: a double-staining technique for AgNOR quantification in MIB-1 positive cells especially adapted for image cytometry. Micron 31 (2000) 151-159
19. Loukas C.G., Wilson G.D., Vojnovic B., and Linney A. An image analysis-based approach for automated counting of cancer cell nuclei in tissue sections. Cytometry 55A (2003) 30-42
20. Matsumoto M., Komiyama K., Okaue M., Shimoyama Y., Iwakami K., Namaki S., et al. Predicting tumor metastasis in patients with oral cancer by means of the proliferation marker Ki67. J Oral Sci 41 (1999) 53-56
21. Miller C.S., Henry R.G., and Rayens M.K. Disparities in risk of and survival from oropharyngeal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95 (2003) 570-575
22. Munakata S., and Hendricks J.B. A multilabeling technique for simultaneous demonstration and quantification of Ki-67 and nucleolar organizer regions (AgNORs) in paraffin-embedded tissue. J Histochem Cytochem 42 (1994) 789-793
23. Öfner D., Aubele M., Biesterfeld S., Derenzine M., Gimenez-Mas J.A., Hufnagl P., et al. Guideline of AgNOR quantitation - first update. Virchows Arch 427 (1995) 341
24. Pandit S., and Aithal D.A. Qualitative and quantitative estimation of AgNORs in dysplastic and non-dysplastic leukoplakias. Indian J Dent Res 13 (2002) 27-30
25. Piattelli A., Rubini C., Fioroni M., Iezzi G., and Santinelli A. Prevalence of p53, bcl-2, and Ki-67 immunoreactivity and of apoptosis in normal oral epithelium and in premalignant and malignant lesions of the oral cavity. J Oral Maxillofac Surg 60 (2002) 532-540
26. Piffko J., Bankfalvi A., Ofner D., Rasch D., Joos U., and Schmid K.W. Standardized AgNOR analysis of the invasive tumor front in oral squamous cell carcinomas. J Pathol 182 (1997) 450-456
27. Ploton D., Menager M., Jeannesson P., Himber G., Pigeon F., and Adnet J.J. Improvement in staining and in the visualization of the argyrophilic proteins of the nucleolar organizing regions at the optical level. Histochem J 18 (1986) 5-14
28. Ray J.G., Chattopadhyay A., and Caplan D.J. Usefulness of AgNOR counts in diagnosing epithelial dysplasia. J Oral Pathol Med 32 (2003) 71-76
29. Schoelch M.L., Regezi J.A., Dekker N.P., Ng I.O.L., Mcmillan A., Ziober B.L., et al. Cell cycle proteins and the development of oral squamous cell carcinoma. Oral Oncol 35 (1999) 333-342
30. Schwint A.E., Folco A., Morales A., Cabrini R.L., and Itoiz M.E. AgNOR mark epithelial foci in malignant transformation in hamster cheek pouch carcinogenesis. J Oral Pathol Med 25 (1996) 20-24
31. Silverman J.R.S., Gorsky M., and Lozada F. Leucoplakia, dysplasia, and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82 (1996) 117
32. Sittel C., Ruiz S., Volling P., Kvasnkcka H.M., Jungehulsing M., and Eckel H.E. Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity. Oral Oncol 35 (1999) 583-589
33. Spolidorio L.C., Neves K.A., Soares C.P., Spolidorio D.M.P., Basso M.F.M., Malavazzi I., et al. Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression. Micron 33 (2002) 605-608
34. Tipoe G.L., Jin Y., and Qhite F.H. The relationship between vascularity and cell proliferation in human normal and pathological lesions of the oral cheek epithelium. Eur J Cancer B Oral Oncol 32B (1996) 24-31
35. Treré D. AgNOR staining and quantification. Micron 31 (2000) 127-131
36. Tsuji T., Mimura Y., Wen S., Li X., Kanekawa A., Sasaki K., et al. The significance of PCNA and P53 protein in some oral tumors. Int J Oral Maxillofac Surg 24 (1995) 221-225
37. Van Der Waal I., and Axéll T. Oral leukoplakia: a proposal for uniform reporting. Oral Oncol 38 (2002) 521-526
38. Warnakulasuriya K.A., and Macdonald D.G. Epithelial cell kinetics in oral leukoplakia. J Oral Pathol Med 24 (1995) 165-169
39. Yue L., Iwai M., and Furuta I. Evaluation of argyrophilic nucleolar organizer regions in tongue squamous cell carcinoma. Oral Oncol 35 (1999) 70-76