Evaluation of the association between the PPARGC1A genetic polymorphisms and type 2 diabetes in Han Chinese population

Diabetes Research and Clinical Practice

Volumn 86, Issue 3, 2009, Pages 168-172

  Zhu, Shuying ^a   Liu, Yang ^a   Wang, Xin ^a   Wu, Xiaopan ^a   Zhu, Xilin ^a   Li, Jingyun ^a   Ma, Juan ^a   Gu, Harvest F ^b   Liu, Ying ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Chinese; Haplotypes; PPARGC1A; Single nucleotide polymorphism; Type 2 diabetes

Indexed keywords

CYSTEINE; GLYCINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; THREONINE;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; BODY MASS INDEX; CHINA; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; FEMALE; GENOTYPE; HEAT-SHOCK PROTEINS; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION FACTORS;

EID: 70449134625     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.09.020     Document Type: Article

References (20)

1. Yoon J.C., Xu G., Deeney J.T., Yang S.N., Rhee J., Puigserver P., et al. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev. Cell 5 (2003) 73-83
2. Soyal S., Krempler F., Oberkofler H., and Patsch W. PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes. Diabetologia 49 (2006) 1477-1488
3. Wu Z., Puigserver P., Andersson U., Zhang C., Adelmant G., Mootha V., et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
4. Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 8466-8471
5. Mootha V.K., Lindgren C.M., Eriksson K.F., Subramanian A., Sihag S., Lehar J., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
6. Pratley R.E., Thompson D.B., Prochazka M., Baier L., Mott D., Ravussin E., et al. An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J. Clin. Invest. 101 (1998) 1757-1764
7. Ek J., Andersen G., Urhammer S.A., Gaede P.H., Drivsholm T., Borch-Johnsen K., et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 44 (2001) 2220-2226
8. Andersen G., Hansen T., Gharani N., Frayling T.M., Owen K.R., Sampson M., et al. A common Gly482Ser polymorphism of PGC-1 is associated with Type 2 diabetes mellitus in two European population (abstract). Diabetes 51 (2002) A49
9. Bhat A., Koul A., Rai E., Sharma S., Dhar M.K., and Bamezai R.N. PGC-1alpha Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study. Hum. Genet. 121 (2007) 609-614
10. Lacquemant C., Chikri M., Boutin P., Samson C., and Froguel P. No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. Diabetologia 45 (2002) 602-603 604
11. Muller Y.L., Bogardus C., Pedersen O., and Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes 52 (2003) 895-898
12. Oberkofler H., Linnemayr V., Weitgasser R., Klein K., Xie M., Iglseder B., et al. Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes. Diabetes 53 (2004) 1385-1393
13. Barroso I., Luan J., Sandhu M.S., Franks P.W., Crowley V., Schafer A.J., et al. Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia 49 (2006) 501-505
14. Vimaleswaran K.S., Radha V., Ghosh S., Majumder P.P., Deepa R., Babu H.N., et al. Peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians. Diabet. Med. 22 (2005) 1516-1521
15. Kim J.H., Shin H.D., Park B.L., Cho Y.M., Kim S.Y., Lee H.K., et al. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population. Diabetologia 48 (2005) 1323-1330
16. Hara K., Tobe K., Okada T., Kadowaki H., Akanuma Y., Ito C., et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 45 (2002) 740-743
17. Liu Y., Niu N., Zhu X., Du T., Wang X., Chen D., et al. Genetic variation and association analyses of the nuclear respiratory factor 1 (nRF1) gene in Chinese patients with type 2 diabetes. Diabetes 57 (2008) 777-782
18. Ling C., Del G.S., Lupi R., Ronn T., Granhall C., Luthman H., et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 51 (2008) 615-622
19. Elbein S.C. Perspective: the search for genes for type 2 diabetes in the post-genome era. Endocrinology 143 (2002) 2012-2018
20. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., and Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92 (1998) 829-839