Antidiabetic effects of scoparic acid D isolated from scoparia dulcis in rats with streptozotocin-induced diabetes

Natural Product Research

Volumn 23, Issue 16, 2009, Pages 1528-1540

  Latha, Muniappan ^a   Pari, Leelavinothan ^a   Ramkumar, Kunga Mohan ^b   Rajaguru, Palanisamy ^b   Suresh, Thangaraj ^c   Dhanabal, Thangavel ^c   Sitasawad, Sandhya ^d   Bhonde, Ramesh ^d  

^a ANNAMALAI UNIVERSITY   (India)

^b BHARATHIDASAN UNIVERSITY   (India)

^c BHARATHIAR UNIVERSITY   (India)

^d NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Diabetes; Natural products; RINm5F cells; Scoparia dulcis; Scoparic acid D, insulin secretion

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE; HYPERGLYCEMIC AGENT; INSULIN; NITRIC OXIDE; SCOPARIC ACID D; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LINE; CELL PROTECTION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULINOMA; MALE; NONHUMAN; PANCREAS ISLET; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCOPARIA; SCOPARIA DULCIS; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; DITERPENES; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; PLANT EXTRACTS; RATS; RATS, WISTAR; SCOPARIA;

RATTUS; RATTUS NORVEGICUS; SCOPARIA DULCIS;

EID: 70449123931     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/14786410902726126     Document Type: Article

References (31)

1. Ahmed, M., & Jakupovic, J. (1990). Diterpenoids from Scoparia dulcis. Phytochemistry, 29, 3035-3037.
2. Anderson, L., Dinesen, B., Jorgensen, P.N., Poulsen, F., & Roder, M.F. (1993). Enzyme immunoassay for intact human insulin in serum or plasma. Clinical Chemistry, 38, 578-582.
3. Brownlee, M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature, 414, 813-820.
4. Day, C. (1998). Traditional plant treatments for diabetes mellitus: Pharmaceutical foods. British Journal of Nutrition, 80, 5-6.
5. Devendra, D., & Eisenbarth, G.S. (2003). Immunologic endocrine disorders. Journal of Allergy and Clinical Immunology, 111, S624-S636.
6. Gray, A.M., Abdel-Wahab, Y.H., & Flatt, P.R. (2000). The traditional plant treatment, Sambuscus nigra (elder) exhibits insulin-like and insulin releasing actions in vitro. Journal of Nutrition, 130, 15-20.
7. Hayashi, T., Asano, S., Mizutani, M., Takeguchi, N., Okamura, K., & Morita, N. (1991). Scopadulciol, an inhibitor of gastric H+, K+ - ATPase from Scoparia dulcis and its structure activity relationships. Journal of Natural Products, 54, 802-809.
8. Hayashi, T., Kawasaki, M., Miwa, Y., Taga, T., & Morita, N. (1990). Antiviral agents of plant origin III. Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chemical and Pharmaceutical Bulletin, 38, 945-947.
9. Hayashi, T., Kawasaki, M., Okamura, K., Tamada, Y., Idia, A., Fujita, T., et al. (1993). A new chemotype of Scoparia dulcis. Phytochemistry, 32, 349-352.
10. Hayashi, T., Kishi, M., Kawasaki, M., Arisawa, M., Shimuzu, S., Bohlmann, F., et al. (1987). Scopadulcic acid A and acid-B, new diterpenoids with novel skeleton, from a paraguayan crude drug Typycha kuratu (Scoparia dulcis). Tetrahedron Letters, 28, 3693.
11. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E., & Chaushury, G. (1987). Endothelium derived relaxing factor produced and released from artery and vein is nitric oxide. Proceedings of National Academic Sciences USA, 84, 9265-9269.
12. Jeppesen, P.B., Gregersen, S., Alstrup, K.K., & Hermann, K. (2002). Stevioside induces antihyperglycemic, insulinotropic and glucagonostatic effect in vivo: Studies in the diabetic Goto-kakizaki (GK) rats. Phytomedicine, 9, 9-14.
13. Kurihara, H., Fukami, H., Kusumoto, A., Toyoda, Y., Shibata, H., Matsui, Y., et al. (2003). Hypoglycemic action of Cyclocarya palirus (Batal.) iljinskaja in normal and diabetic mice. Bioscience, Biotechnology and Biochemistry, 67, 877-880.
14. Latha, M., & Pari, L. (2003). Modulatory effect of Scoparia dulcis in oxidative stress induced lipid peroxidation in streptozotocin diabetic rats. Journal of Medicinal Food, 6, 379-386.
15. Latha, M., & Pari, L. (2004). Efficacy of aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and polyol pathway in experimental diabetes. Brazilian Journal of Medical and Biological Research, 37, 577-586.
16. Latha, M., Pari, L., Sandhya, S., & Bhonde, R. (2004a). Scoparia dulcis, a traditional antidiabetic plant, protects against streptozotocin induced oxidative stress and apoptosis in vitro and in vivo. Journal of Biochemical and Molecular Toxicology, 18(5), 261-272.
17. Latha, M., Pari, L., Sandhya, S., & Bhonde, R. (2004b). Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed). Life Science, 75, 2003-2014.
18. Li, W.L., Zheng, H.C., Bukuru, J., & De kimpe, J. (2004). Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology, 92, 1-21.
19. Ni, J.S., Wu, J.X., Xiao, R.Q., Shi, B., Wang, X.X., & Liu, S.X. (1998). Effect of total saponoins of radix of Acanthopanax senticosus on diabetic rat serum lipid peroxide and superoxide dismutase activity. Journal of Norman Bethane University of Medical Sciences, 24, 33-34.
20. Nishimura, H., Ogino, T., Morota, T., & Sasaki, H. (1991). Extraction of monocyclic sesquiterpenes and their glycosides from Rehmannia glutinosa and Rehmannia rupestris as aldose reductase inhibitors. Japan Kokai Tokyo Koho (Patent), p. 9. Patent No. JP 03163035.
21. Ojewole, J.A.O. (2002). Hypoglycemic effect of Clausena anisata (Willd.) Hook mehtanolic root extract in rats. Journal of Ethnopharmacology, 81, 231-237.
22. Pari, L., & Latha, M. (2004). Effect of Scoparia dulcis (Sweet Broomweed) plant extract on plasma antioxidants in streptozotocin-induced experimental diabetes in male albino Wistar rats. Die Pharmazie, 59, 557-560.
23. Plumb, J.A., Milroy, R., & Kaye, S.B. (1989). Effects of the pH dependence of 3-(4,5- dimethylthiazole-2-yl)-2,5-diphenyl-tetrazoliumbromide- formazan) absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Research, 49, 4435-4440.
24. Raza, H., Ahmed, I., John, A., & Sharma, A.K. (2000). Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. Journal of Biochemical and Molecular Toxicology, 14, 131-139.
25. Sandhya, S., Shewade, Y., & Bhonde, R. (2000). Role of Bittergourd fruit juice in STZ induced diabetic state in vivo and in vitro. Journal of Ethnopharmacology, 73, 71-79.
26. Shewade, Y.M., Umrani, M., & Bhonde, R.R. (1999). Large scale isolation of islets by tissue culture of adult mouse pancreas. Transplantation Proceedings, 31, 1721-1723.
27. Siddique, O., Sun, Y., Lin, J.C., & Chien, Y.W. (1987). Facilitated transdermal transport of insulin. Journal of Pharmaceutical Sciences, 76, 341-345.
28. Spinas, G.A. (1999). The dual role of nitric oxide in islet-cells. News in Physiological Sciences, 14, 49-54.
29. White, J.R., Kramer, J., Cammpbell, R.K., & Bernsten, R. (1994). Oral use of a topical preparation containing an extract of Stevia rebaudiana and the chrysanthemum flower in the management of hyperglycemia. Diabetes Care, 17, 940.
30. Yamasaki, K. (1995). Effect of saponins on glucose transport system. Book of Abstracts, 21th ACS National Meeting, Part 1, Chicago, ACS, Washington DC (p. 223).
31. Zimmet, P.Z., Alberti, K.G.M.M., & Shaw, J. (2001). Global and societal implications of the diabetes epidemic. Nature, 414, 782-786.