Antiretroviral strategies to prevent mother-to-child transmission of HIV: Striking a balance between efficacy, feasibility, and resistance

PLoS Medicine

Volumn 6, Issue 10, 2009, Pages

  Lehman, Dara A ^a   John Stewart, Grace C ^b   Overbaugh, Julie ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIVUDINE PLUS ZIDOVUDINE; NEVIRAPINE; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; LAMIVUDINE;

DRUG EFFICACY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; SHORT SURVEY; SINGLE DRUG DOSE; TREATMENT OUTCOME; VIRUS TRANSMISSION; ANTIVIRAL RESISTANCE; DISEASE TRANSMISSION; DRUG EFFECT; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; NOTE; PREGNANCY; PREGNANCY COMPLICATION; VERTICAL TRANSMISSION; VIROLOGY;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DRUG RESISTANCE, VIRAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LAMIVUDINE; NEVIRAPINE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; ZIDOVUDINE;

EID: 70449090324     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1000169     Document Type: Short Survey

References (15)

1. World Health Organization (2006) Antiretroviral drugs for treating pregnant women and preventing HIV infection in infant: towards universal access. Recommendations for a public health approach. Available: http://www.who.int/ hiv/pub/guidelines/pmtctguidelines3.pdf. Accessed 4 September 2009.
2. Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, et al. (1999) Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 354: 795-802.
3. Arrive E, Dabis F (2008) Prophylactic antiretroviral regimens for prevention of mother-to-child transmission of HIV in resource-limited settings. Curr Opin HIV AIDS 3: 161-165. (Pubitemid 351322830)
4. Jourdain G, Ngo-Giang-Huong N, Le Coeur S, Bowonwatanuwong C, Kantipong P, et al. (2004) Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med 351: 229-240. (Pubitemid 38922817)
5. Lockman S, Shapiro RL, Smeaton LM, Wester C, Thior I, et al. (2007) Response to antiretroviral therapy after a single, peripartum dose of nevirapine. N Engl J Med 356: 135-147. (Pubitemid 46089674)
6. Lockman S (2008) Prevention of mother-to-child transmission, drug resistance, and implications for response to therapy. Curr Opin HIV AIDS 3: 166-172.
7. Dao H, Mofenson LM, Ekpini R, Gilks CF, Barnhart M, et al. (2007) International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update. Am J Obstet Gynecol 197: S42-S55. (Pubitemid 47354183)
8. World Health Organization, UNAIDS, Unicef (2008) Towards universal access. Scaling up priority HIV/AIDS interventions in the health sector. Available: http://www.who.int/hiv/pub/2008progressreport/en/. Accessed 4 September 2009.
9. Kilewo C, Karlsson K, Ngarina M, Massawe A, Lyamuya E, et al. (2009) Prevention of mother-to-child transmission of HIV-1 through breastfeeding by treating mothers with triple antiretroviral therapy in Dar es Salaam, Tanzania: the Mitra Plus Study. J Acquir Immune Defic Syndr, In press.
10. Lehman DA, Chung MH, Mabuka JM, John-Stewart GC, Kiarie J, et al. (2009) Lower risk of resistance after short-course HAART compared with zidovudine/single-dose nevirapine used for prevention of HIV-1 mother-to-child transmission. J Acquir Immune Defic Syndr 51: 522-529.
11. Eshleman SH, Hoover DR, Hudelson SE, Chen S, Fiscus SA, et al. (2006) Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1. J Infect Dis 193: 479-481. (Pubitemid 43202737)
12. McIntyre JA, Hopley M, Moodley D, Eklund M, Gray GE, et al. (2009) Efficacy of short-course AZT+3TC to reduce nevirapine resistance in the prevention of mother-to-child HIV transmission. PLoS Med 6: e1000172. doi:10.1371/journal.pmed.1000172.
13. McIntyre J, Martinson N, Gray G, Hopley M, Kimura T, et al. (2005) Addition of short course Combivir (CBV) to single dose Viramune (sdNVP) for the prevention of mother to child transmission (pMTCT) of HIV-1 can significantly decrease the subsequent development of maternal and paediatric NNRTI-resistant virus TuFo0204. In: Proceedings of the 3rd International Aids Society Conference on HIV Pathogenesis and Treatment; 24-27 July, 2005; Rio de Janeiro, Brazil. Available: http://www.iasociety.org/Default.aspx?pageId=11&abstractId= 2176901. Accessed 4 September 2009.
14. Chaix ML, Ekouevi DK, Rouet F, Tonwe-Gold B, Viho I, et al. (2006) Low risk of nevirapine resistance mutations in the prevention of mother-to-child transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Cote d'Ivoire. J Infect Dis 193: 482-487. (Pubitemid 43202738)
15. Chi BH, Sinkala M, Mbewe F, Cantrell RA, Kruse G, et al. (2007) Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial. Lancet 370: 1698-1705. (Pubitemid 350100773)