Response to antiretroviral therapy after a single, peripartum dose of nevirapine

New England Journal of Medicine

Volumn 356, Issue 2, 2007, Pages 135-147

  Lockman, Shahin ^a,b,d,f   Shapiro, Roger L ^b,c,d   Smeaton, Laura M ^b   Wester, Carolyn ^b,e   Thior, Ibou ^b,d   Stevens, Lisa ^b,d   Chand, Fatima ^d   Makhema, Joseph ^b,d   Moffat, Claire ^d   Asmelash, Aida ^d   Ndase, Patrick ^d   Arimi, Peter ^d   Van Widenfelt, Erik ^d   Mazhani, Loeto ^e   Novitsky, Vladimir ^b,d   Lagakos, Stephen ^b   Essex, Max ^b,d  

^a Brigham and Womens Hospital   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BOTSWANA HARVARD AIDS INSTITUTE PARTNERSHIP   (Botswana)

^e Department of HIV AIDS Prevention and Care   (Botswana)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; NEVIRAPINE; PLACEBO; ZIDOVUDINE;

ADULT; ARTICLE; BOTSWANA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE TRANSMISSION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; PERINATAL PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE;

EID: 33846156885     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa062876     Document Type: Article

References (26)

1. Antiretroviral drugs for treating pregnant women and preventing HIV infection in infants in resource-limited settings: towards universal access: recommendations for a public health approach. Geneva: World Health Organization, 2006.
2. Antiretroviral therapy for HIV infection in adults and adolescents in resource-limited settings: towards universal access: recommendations for a public health approach. Geneva: World Health Organization, 2006.
3. Guay LA, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999;354:795-802.
4. Jackson JB, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet 2003;362:859-68.
5. Viramune donation programme. (Accessed December 14, 2006, at http://www.boehringeringelheim.com/wecare/en/subpages/our_society_1.htm.)
6. Eshleman SH, Mracna M, Guay LA, et al. Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012). AIDS 2001;15:1951-7.
7. Jackson JB, Becker-Pergola G, Guay LA, et al. Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to prevent HIV-1 vertical transmission. AIDS 2000;14:F111-F115.
8. Lee EJ, Kantor R, Zijenah L, et al. Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine. J Infect Dis 2005;192:1260-4.
9. Eshleman SH, Hoover DR, Chen S, et al. Nevirapine (NVP) resistance in women with HIV-1 subtype C, compared with subtypes A and D, after the administration of single-dose NVP. J Infect Dis 2005;192:30-6.
10. Shapiro RL, Thior I, Gilbert PB, et al. Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana. AIDS 2006;20:1281-8.
11. Eshleman SH, Hoover DR, Chen S, et al. Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns. AIDS 2005;19:2167-75.
12. Pillay CCN, Gray G, Chezzi C, et al. Nevirapine resistance mutations among HIV-1 infected infants following single dose nevirapine. In: Program and abstracts of the XVth International AIDS Conference, Bangkok, Thailand, July 11-16, 2004. abstract.
13. Eshleman SH, Hoover DR, Hudelson SE, et al. Development of nevirapine resistance in infants is reduced by use of infant-only single-dose nevirapine plus zidovudine postexposure prophylaxis for the prevention of mother-to-child transmission of HIV-1. J Infect Dis 2006;193:479-81.
14. Jourdain G, Ngo-Giang-Huong N, Le Coeur S, et al. Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy. N Engl J Med 2004;351:229-40.
15. Thior I, Lockman S, Smeaton LM, et al. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child transmission in Botswana: a randomized trial: the Mashi Study. JAMA 2006;296:794-805.
16. Stanford University HIV drug resistance database. (Accessed December 14, 2006, at http://hivdb.stanford.edu.)
17. Coovadia H, Marais B, Abrams E, et al. Virologic responses to NNRTI treatment among women who took single-dose nevirapine 18 to 36 months earlier. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections, Denver, February 5-8, 2006. abstract.
18. Bedikou G, Viho I, Towne-Gold B, et al. 6-Month immunological response with HAART containing nevirapine in HIV infected women post exposure to single dose of Nevirapine for PMTCT: the MTCT-Plus Initiative in Abidjan, Cote d'Iviore (2003-2005). In: Program and abstracts of the 3rd IS Conference on HIV Pathogenesis and Treatment, Rio de Janiero, July 24-27, 2005. abstract.
19. Loubser S, Balfe P, Sherman G, Hammer S, Kuhn L, Morris L. Decay of K103N mutants in cellular DNA and plasma RNA after single-dose nevirapine to reduce mother-to-child HIV transmission. AIDS 2006;20:995-1002.
20. Flys T, Nissley DV, Claasen CW, et al. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J Infect Dis 2005;192:24-9.
21. Palmer S, Boltz V, Martinson N, et al. Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission. Proc Natl Acad Sci U S A 2006;103:7094-9.
22. Lallemant M. Response to therapy after prior exposure to nevirapine. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, July 24-27, 2005. abstract.
23. Chaix ML, Ekouevi DK, Rouet F, et al. Low risk of nevirapine resistance mutations in the prevention of mother-to-child transmission of HIV-1: Agence Nationale de Recherches sur le SIDA Ditrame Plus, Abidjan, Cote d'Ivoire. J Infect Dis 2006;193:482-7.
24. McIntyre JA, Martinson N, Gray GE, et al. Addition of short course Combivir to single dose Viramune for the prevention of mother to child transmission of HIV-1 can significantly decrease the subsequent development of maternal and paediatric NNRTI-resistant virus. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment, Rio de Janeiro, July 24-27, 2005. abstract.
25. McCutchan FE. Global epidemiology of HIV. J Med Virol 2006;78:Suppl 1:S7-S12.
26. Flys TS, Chen S, Jones DC, et al. Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D. J Acquir Immune Defic Syndr 2006;42:610-3.